3篇
您的检索式：作者名="Xuting Xue"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The performances of carboxymethyl chitosan in wash-off reactive dyeings 显示文摘 | Xuting Xue Ling Li Jinxin He | 2009 | Carbohydrate Polymers2009，75，： | 1 |
| 2 | Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence显示文摘Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin resistance.Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and atherosclerosis.However,it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy.Methods:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko mice.Rapamycin was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce hypertrophy.Human vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic studies.Results:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ISO.Conversely,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and senescence.Furthermore,vaspin significantly potentiated the ISO-induced decrease in autophagy.Both rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated cardioprotection.Moreover,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and NRVMs.Our data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination degradation.Conclusion:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hypertrophy. | Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu Jinxin Wang Li Xue | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 3 | 新抗氧化因子iASPP通过与Nrf2竞争结合Keap1的方式促进肿瘤细胞生长和耐药显示文摘文章简介人类细胞不可避免地暴露于来自于外界(如UV)以及细胞内有氧代谢所产生的活性氧(reactive oxygen species,ROS)。少量ROS是调控细胞正常生理活动的重要信号分子,高水平ROS则会作用于细胞内包括DNA在内的生物大分子,致其损伤,破坏其功能,成为肿瘤发生的重要推动力。 | 葛文杰 赵坤明 Xingwen Wang Huayi Li Miao Yu Mengmeng He Xuting Xue Yifu Zhu 张诚 程易为 Shijian Jiang 胡颖 | 2018 | 科学新闻2018，0，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员