| 1 | CDR3δ-grafted γ9δ2T cells mediate effective antitumor reactivity显示文摘采纳房间转移治疗(幕) 被报导了压制成长肿瘤并且在动物模型克服肿瘤逃跑。作为一个候选人幕受动器, γ 9 δ 2T 房间能在 vitro 并且在 vivo 和显示被激活并且膨胀对 colorectal 的强壮的 antitumor 活动,肺,前列腺,卵巢、肾的房间癌。然而,获得 γ 的一个足够大的数字是困难的; δ为能克服癌症病人的有免疫力的镇压肿瘤微型环境的免疫疗法满足需要的 T 房间。在以前的研究,我们的实验室证实了那 γ 9 δ 2T 房间经由 CDR3δ 认出了肿瘤房间;γ 的区域; δ -T-cell 受体(TCR ) 。我们构造了导出的全身的人的外部血 mononuclear 房间(PBMC )γ 9 并且 δ CDR3 区域被卵巢的上皮的癌(OEC ) 在代替的 2 链导出 CDR3。我们转移了 CDR3δ -grafted γ 9 δ进外部血淋巴细胞(PBL ) 的 2TCR 修改了 γ 遗传上发展; 9 δ 2T 房间。在 vitro,研究显示出那这些 CDR3δ -grafted γ 9 δ 2T 房间能向肿瘤房间与肿瘤房间摘录和展览 cytotoxicity 在刺激以后生产 cytokines,包括人的 OEC 和颈的腺癌。CDR3δ -grafted γ 9 δ采纳地变成忍受一根人的 OEC 房间线的裸体老鼠的 2T 房间表明了重要 antitumor 效果。这些结果显示那 CDR3δ -grafted γ 9 δ 2T 房间可能是临床的肿瘤免疫疗法的候选人。 | Hui Zhao Xueyan Xi Lianxian Cui Wei He | 2012 | Cellular & Molecular Immunology2012，9，2： | 10 |
| 2 | Kinetic Model of LCO Selective Hydrogenation on NiMoW/Al_(2)O_(3) Catalyst显示文摘In order to investigate the hydrofining process of LCO for producing aromatics and gasoline,the selective hydrogenation of polycyclic aromatic hydrocarbons(PAHs),a major component of light cycle oil(LCO),was studied using a NiMoW/Al_(2)O_(3)catalyst.Based on the study of the reversible hydrogenation reaction,PAHs in the selective hydrogenation process could be effectively simulated by the modeled CH and CH_(2) groups,and the hydrodesulfurization and hydrodenitrogenation kinetic models could be further established in this process.The results showed that the kinetic models developed could fit the experimental data effectively and predict the content of S,N,and aromatics in the selective hydrogenation products of LCO. | Ju Xueyan Zhang Kui Xi Yuanbing Wang Zhe Nie Hong | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，3： | 2 |
| 4 | Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy显示文摘We report the clinical and laboratory findings and successful management of seven patients with critical coronavirus disease 2019(COVID-19)requiring mechanical ventilation(MV).The patients were diagnosed based on epidemiological history,clinical manifestations,and nucleic acid testing.Upon diagnosis with COVID-19 of critical severity,the patients were admitted to the intensive care unit,where they received early noninvasive-invasive sequential ventilation,early prone positioning,and bundle pharmacotherapy regimen,which consists of antiviral,anti-inflammation,immune-enhancing,and complication-prophylaxis medicines.The patients presented fever(n=7,100%),dry cough(n=3,42.9%),weakness(n=2,28.6%),chest tightness(n=1,14.3%),and/or muscle pain(n=1,14.3%).All patients had normal or lower than normal white blood cell count/lymphocyte count,and chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs.Nucleic acid testing confirmed COVID-19 in all seven patients.The median MV duration and intensive care unit stay were 9.9 days(interquartile range,6.5-14.6 days;range,5-17 days)and 12.9 days(interquartile range,9.7-17.6 days;range,7-19 days),respectively.All seven patients were extubated,weaned off MV,transferred to the common ward,and discharged as of the writing of this report.Thus,we concluded that good outcomes for patients with critical COVID-19 can be achieved with early noninvasive-invasive sequential ventilation and bundle pharmacotherapy. | Mian Peng Xueyan Liu Jinxiu Li Di Ren Yongfeng Liu Xi Meng Yansi Lyu Ronglin Chen Baojun Yu Weixiong Zhong | 2020 | Frontiers of Medicine2020，14，5： | 0 |
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