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| 1 | Potential risks and challenges of climate change in the arid region of northwestern China显示文摘In the arid region of northwestern China(ARNC),water resources are the most critical factor restricting socioeconomic development and influencing the stability of the area’s ecological systems.The region’s complex water system and unique hydrological cycle show distinctive characteristics.Moreover,the intensified hydrological cycle and extreme climatic and hydrological events resulting from global warming have led to increased uncertainty around water resources as well as heightened conflict between water supply and water demand.All of these factors are exerting growing pressures on the socioeconomic development and vulnerable ecological environment in the region.This research evaluates the impacts of climate change on water resources,hydrological processes,agricultural system,and desert ecosystems in the ARNC,and addresses some associated risks and challenges specific to this area.The temperature is rising at a rate of 0.31C per decade during 1961–2017 and hydrological processes are being significantly influenced by changes in glaciers,snow cover,and precipitation form,especially in the rivers recharged primarily by melt water.Ecosystems are also largely influenced by climate change,with the Normalized Difference Vegetation Index(NDVI)of natural vegetation exhibited an increasing trend prior to 1998,and then reversed in Xinjiang while the Hexi Corridor of Gansu showed the opposite trends.Furthermore,the desert-oasis transition zone showed a reduction in area due to the warming trend and the recent rapid expansion of irrigated area.Both the warming and intensified drought are threatening agriculture security.The present study could shed light on sustainable development in this region under climate change and provides scientific basis to the construction of the“Silk Road Economic Belt”. | Yaning Chen Xueqi Zhang Gonghuan Fang Zhi Li Fei Wang Jingxiu Qin Fan Sun | 2020 | Regional Sustainability2020，1，1： | 6 |
| 2 | Variability of microphysical characteristics in the “21·7” Henan extremely heavy rainfall event显示文摘In this study, significant rainfall microphysical variability is revealed for the extremely heavy rainfall event over Henan Province in July 2021(the “21·7” Henan EHR event) using a dense network of disdrometers and two polarimetric radars.The broad distributions of specific drop size distribution(DSD) parameters are identified in heavy rainfall from the disdrometer observations, indicating obvious microphysical variability on the surface. A K-means clustering algorithm is adopted to objectively classify the disdrometer datasets into separate groups, and distinct DSD characteristics are found among these heavy rainfall groups. Combined with the supporting microphysical structures obtained through radar observations, comprehensive microphysical features of the DSD groups are derived. An extreme rainfall group is dominantly formed in the deep convection over the plain regions, where the high number of concentrations and large mean sizes of surface raindrops are underpinned by both active ice-phase processes and efficient warm-rain collision-coalescence processes in the vertical direction. Convection located near orographic regions is characterized by restricted ice-phase processes and high coalescence efficiency of liquid hydrometeors, causing the dominant DSD group to comprise negligible large raindrops. Multiple DSD groups can coexist within certain precipitation episodes at the disdrometer stations, indicating the potential microphysical variability during the passage of convective system on the plain regions. | Gang CHEN Kun ZHAO Yinghui LU Yuanyuan ZHENG Ming XUE Zhe-Min TAN Xin XU Hao HUANG Haonan CHEN Fen XU Ji YANG Shushi ZHANG Xueqi FAN | 2022 | Science China Earth Sciences2022，65，10： | 4 |
| 3 | Burden of Disease Due to Cancer——China,2000-2019显示文摘Summary What is already known about this topic?Cancer is a major global public health problem and the leading cause of death in China.China has a large population,and therefore has a significant proportion of the global burden of cancer.What is added by this report?The age-standardized incidence of cancer has increased in China,while the cancer mortality rate has decreased.Compared with younger age groups,individuals over 70 have a greater burden of cancer.Digestive tract cancer and breast cancer should be targeted for prevention,treatment,and control. | Xueqi Fan Bin Zhang Yuan He Xiaolong Zhou Yingying Zhang Li Ma Xudong Li Jing Wu | 2022 | China CDC weekly2022，4，15： | 3 |
| 4 | A survey on sentiment detection of reviews 显示文摘 | Tang tluifeng 'Fan Songbo Cheng Xueqi | 2009 | Expert Systems with Applications2009，36，10： | 1 |
| 5 | ^(18)F-FDG PET/CT findings of paratesticular alveolar rhabdomyosarcoma显示文摘Rhabdomyosarcoma(RMS)originates from primitive mesenchymal cells and is the most common soft tissue tumor in childhood.^(18)F-fluoro-deoxyglucose(^(18)F-FDG)positron emission tomography(PET)/computed tomography(CT)has been reported to be valuable in RMS staging and risk stratification.Paratesticular RMS is a relatively uncommon form of RMS,most of which are of the embryonal histologic type.Paratesticular alveolar RMS is associated with aggressive behavior,high metastatic potential,and poor outcomes.To the best of our knowledge,^(18)F-FDG PET/CT imaging findings of paratesticular alveolar RMS have never been described.Here,we report on a 16-year-old boy's rare paratesticular alveolar RMS with multiple metastases and its findings on^(18)F-FDG PET/CT.This case also demonstrates the potential value of^(18)F-FDG PET/CT in RMS staging and treatment decisions,and may aid in the differential diagnosis. | Xueqi Chen Jiayin Shou Shanshi Li Yan Fan Jianhua Zhang | 2024 | Cancer Innovation2024，3，2： | 0 |
| 6 | Determination of 27 pharmaceuticals and personal care products(PPCPs)in water:The benefit of isotope dilution显示文摘Pharmaceuticals and personal care products(PPCPs)are a unique group of emerging and nonpersistent contaminants.In this study,27 PPCPs in various water samples were extracted by solid phase extraction(SPE),and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer(LC-MS/MS).A total of 27 isotopically labeled standards(ILSs)were applied to correct the concentration of PPCPs in spiked ultrapure water,drinking water,river,effluent and influent sewage.The corrected recoveries were 73%-122%with the relative standard deviation(RSD)<16%,except for acetaminophen.The matrix effect for all kinds of water samples was<22%and the method quantitation limits(MQLs)were 0.45-8.6 ng/L.The developed method was successfully applied on environmental water samples.The SPE extracts of spiked ultrapure water,drinking water,river and wastewater effluent were stored for 70 days,and the ILSscorrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences.The recoveries of 27 PPCPs over 70 days were within the scope of 72%-140%with the recovery variation<37%in all cases.The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis. | Xueqi Fan Jie Gao Wenchao Li Jun Huang Gang Yu | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 0 |
| 7 | Research Progress of Porcine Reproductive and Respiratory Syndrome显示文摘Porcine Reproductive and Respiratory Syndrome(PRRS)is caused by Porcine Reproductive and Respiratory Syndrome Virus(PRRSV),which is characterized by sow reproductive disorder and piglet respiratory syndrome.The complex pathogenesis of PPRS includes antibody-dependent enhancement,immune suppression and persistent infection in the body and viral genetic diversity.In order to have a better understanding of the occurrence and prevalence of porcine reproductive and respiratory syndrome in China.The review of PRRS etiology,epidemiology,pathogenesis,genetic variation,diagnosis and control technology and other aspects of the progress were carried out. | Xueqi liao Xianming Fan Fengxue Qu | 2018 | Insight-Veterinary Science2018，1，1： | 0 |
| 8 | Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial显示文摘Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to trastuzumab.In this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the treatment.Methods In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were recruited.Patients received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable toxicity.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and safety.Results Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this study.The median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral metastasis.The median PFS was 8.63 months(95%confidence interval[CI]4.15-13.12 months).The median OS was not reached.The ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths occurred.Conclusions The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients. | Nan Jin Yi Xu Siqi Wang Chunxiao Sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen Xiang Huang | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 9 | The Incidence,Mortality,and DALYs Trends Associated with Esophageal Cancer-China,1990-2019显示文摘What is already known about this topic?Esophageal cancer(EC)is one of the most common malignant tumors in China.The new cases and deaths in China account for more than half of the world,and the disease burden of esophageal cancer is serious.What is added by this report?From 1990 to 2019,the disease burden of EC in China showed a decrease overall;it first increased between 1990 and 2004,but then decreased between 2004 and 2019.The burden of EC in men was much higher than that in women.Age was an important factor affecting the burden of EC,with disease burden rising rapidly after 40 years old.What are the implications for public health practices?The screening,early diagnosis,and treatment for EC should continue to be strengthened in China.Middleaged and elderly men are high-risk groups of EC and should be a key population for EC prevention and control. | Li Ma Xudong Li Miaomiao Wang Yingying Zhang Jing Wu Yuan He Xueqi Fan Bin Zhang Xiaolong Zhou | 2022 | China CDC weekly2022，4，43： | 0 |
| 10 | Disease Burden of Pancreatic Cancer--China,1990−2019显示文摘Summary What is already known about this topic?Pancreatic cancer is one of the most malignant tumors of the digestive tract,and the etiology is not clear.Pancreatic cancer has a poor prognosis and high mortality.What is added by this report?Compared with 1990,the burden of pancreatic cancer in China increased significantly in 2019.In 1990 and 2019,the disease burden indicator of male pancreatic cancer was higher than that of females,and pancreatic cancer became more common as age increased,especially above 50 years old.What are the implications for public health practices?This study mainly provided scientific data and references for the prevention and control of pancreatic cancer in people aged 50 and above. | Yuan He Xiaolong Zhou Xueqi Fan Bin Zhang Li Ma Jing Wu Xudong Li | 2022 | China CDC weekly2022，4，24： | 0 |
| 11 | Insight into the evolution of breast cancer driven by genetic alterations显示文摘Breast cancer originates primarily from the epithelial cells of the mammary gland.Repeated mammary gland expansion and degeneration are accompanied by an increased risk of genetic alterations in the breast1.These mutations in breast epithelial cells dynamically occur in response to pregnancy,labor and delivery,breastfeeding,and the menstrual cycle,with a decline in mutation rates after menopause,which may be related to a decrease in estrogen levels.The breast epithelial cell mutations are also consistent with epidemiologic observations2. | Canbin Fang Xueqi Fan Wanling Lin Guojun Zhang | 2023 | Cancer Biology & Medicine2023，20，12： | 0 |
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