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| 1 | High-Efficiency Reduction of Rice Amylose Content via CRISPR/Cas9-Mediated Base Editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,rice production must increase by 40%to meet the growing demand(Khush,2005).In addition,with the improvement of people's living standards,the demand for elite rice with better eating and cooking quality(ECQ)is increasing.ECQ is determined by several factors,including amylose content(AC),gel consistency(GC),gelatinization temperature(GT)and viscosity,where AC is the predominant factor(Juliano,1998). | Li He Li Xiufeng Xu Yang Liu Hualong He Mingliang Tian Xiaojie Wang Zhenyu Wu Xiuju Bu Qingyun Yang Jie | 2020 | Rice science2020，27，6： | 7 |
| 2 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 3 | Vegetation Restoration Monitoring in Yingxiu Landslide Area after the 2008 Wenchuan Earthquake显示文摘A total of more than 50000 landslides has occurred in Sichuan province since the'5·12'Wenchuan earthquake,resulting in serious damage to the surface vegetation in southwestern China.In this study,we select Yingxiu,the epicenter of Wenchuan earthquake,as the experimental area.The vegetation coverage information of the experimental area is extracted from the remote sensing images collected in the year of 2005,2011 and 2013,respectively.The surface vegetation coverage in different periods is analyzed,and the vegetation recovery rate of the whole area is calculated.The experimental results show that in the first three years after the earthquake,the speed of vegetation restoration is slow,and the vegetation coverage rate is less than 20%better than 0.241,while in 2013,the vegetation coverage increases significantly. | HE Jing ZHANG Keke LIU Xiuju LIU Gang ZHAO Xuqiang XIE Zhongyuan LU Heng | 2020 | Earthquake Research in China2020，34，1： | 1 |
| 4 | An 11-bit 200 MS/s subrange SAR ADC with low-cost integrated reference buffer显示文摘This paper presents an 11-bit 200MS/s subrange S AR ADC with an integrated reference buffer in 65nm CMOS.The proposed ADC employs a 3.5-bit flash ADC for coarse conversion,and a compact timing scheme at the flash/SAR boundary to speed up the conversion.The flash decision is used to control charge compensating for the reference voltage to reduce its input-dependent fluctuation.Measurement results show that the fabricated ADC has achieved significant improvement by applying the reference charge compensation.In addition,the ADC achieves a maximum signal-to-noise-and-distortion ratio of 59.3dB at 200MS/s.It consumes 3.91mW from a 1.2V supply,including the reference buffer. | Xiuju He Xian Gu Weitao Li Hanjun Jiang Fule Li Zhihua Wang | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 5 | Multifunctional nanoparticle-mediated combining therapy for human diseases显示文摘Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment.In preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human diseases.Attributed to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative diseases.Combinatorial therapy involves combining or co-delivering two or more drugs for treating a specific disease.Nanoparticle(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected areas.This review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical diseases.Ultimately,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the limitations.This review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases. | Xiaotong Li Xiuju Peng Makhloufi Zoulikha George Frimpong Boafo Kosheli Thapa Magar Yanmin Ju Wei He | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 6 | Earthquake-triggered landslide interpretation model of high resolution remote sensing imageries based on bag of visual word显示文摘Traditional visual interpretation is often inefficient due to its excessively workload professional knowledge and strong subjectivity.Therefore,building an automatic interpretation model on high spatial resolution remote sensing images is the key to the quick and efficient interpretation of earthquake-triggered landslides.Aiming at addressing this problem,a landslide interpretation model of high-resolution images based on bag of visual word(BoVW)feature was proposed.The high-resolution images were pre-processed,and then BoVW feature and support vector machine(SVM)was adopted to establish an automatic landslide interpretation model.This model was further compared with the currently widely used Histogram of Oriented Gradient(HoG)feature extraction model.In order to test the effectiveness of the method,typical landslide images were selected to construct a landslide sample library,which was subsequently utilized as the foundation for conducting an experimental study.The results show that the accuracy of landslide extraction using this method reaches as high as 89%,indicating that the method can be used for the automatic interpretation of landslides in disaster-prone areas,and has high practical value for regional disaster prevention and damage reduction. | Ruyue Bai Zegen Wang Heng Lu Chen Chen Xiuju Liu Guohao Deng Qiang He Zhiming Ren Bin Ding Xin Ye | 2023 | Earthquake Research Advances2023，3，2： | 0 |
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