|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model: In vitro and in vivo studies显示文摘Bone defects are commonly caused by severe trauma,malignant tumors,or congenital diseases and remain among the toughest clinical problems faced by orthopedic surgeons,especially when of critical size.Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility,suitable degradation rate,and favorable osteogenesis-promoting properties.The biphasic activity of Sr promotes osteogenesis and inhibits osteoclastogenesis,which imparts Zn-Sr alloys with the ideal theoretical osteogenic properties.Herein,a biodegradable Zn-Sr binary alloy system was fabricated.The cytocompatibility and osteogenesis of the Zn-Sr alloys were significantly better than those of pure Zn in MC3T3-E1 cells.RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/β-catenin,PI3K/Akt,and MAPK/Erk signaling pathways.Furthermore,rat femoral condyle defects were repaired using Zn-0.8Sr alloy scaffolds,with pure Ti as a control.The scaffold-bone integration and bone ingrowth confirmed the favorable in vivo repair properties of the Zn-Sr alloy,which was verified to offer satisfactory biosafety based on the hematoxylin-eosin(H&E)staining and ion concentration testing of important organs.The Zn-0.8Sr alloy was identified as an ideal bone repair material candidate,especially for application in critical-sized defects on load-bearing sites due to its favorable biocompatibility and osteogenic properties in vitro and in vivo. | Bo Jia Hongtao Yang Zechuan Zhang Xinhua Qu Xiufeng Jia Qiang Wu Yu Han Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，6： | 9 |
| 2 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 3 | Effects of dietary protein levels on the long-term growth response and fitting growth models of gibel carp(Carassius auratus gibelio)显示文摘A 41-wk growth trial was conducted to evaluate the effects of dietary protein levels on the long-term growth response and fitting growth models of gibel carp(Carassius auratus gibelio) with an initial body weight of 1.85 ± 0.17 g. The dietary protein levels were designed at 320(P32), 360(P36). 400(P40).and 440 g/kg(P44), respectively. The growth curves of the gibel carp for each group were fitted and analyzed with four nonlinear regression models(Gompertz. logistic. von Bertalanffy and Richards). The final body weights(mean ± SD) of the fish were 226 ± 6.231 ± 7.242 ± 2, and 236 ± 2 g for P32, P36, P40,and P44. respectively. Feed conversion ratio of P40 and P44 groups was significantly lower than that of P32 and P36 groups(P < 0.05). Productive protein value of P44 group was significantly lower than that of P32 and P36 groups, but not different from that of P40 group(P > 0.05). The growth response of the gibel carp for each group was the best fitted by Richards model with the lowest Chi^2, residual sum of squares and residual variance, then Gompertz and von Bertalanffy growth models, but the logistic model did not fit the data well justified by Chi^2 values. The optimal protein level(400 g/kg) prolonged the stage of fast growth and predicted the highest asymptotic weight, which was close to the harvest size in practice. | Biao Yun Xiaotong Yu Min Xue Ying Liu Jia Wang Xiufeng Wu Fang Han Xufang Liang | 2015 | Animal Nutrition2015，，2： | 4 |
| 4 | MgO(001) barrier based magnetic tunnel junctions and their device applications显示文摘Spintronics has received a great attention and significant interest within the past decades,and provided considerable and remarked applications in industry and electronic information etc.In spintronics,the MgO based magnetic tunnel junction(MTJ) is an important research advancement because of its physical properties and excellent performance,such as the high TMR ratio in MgO based MTJs.We present an overview of more than a decade development in MgO based MTJs.The review contains three main sections.(1) Research of several types of MgO based MTJs,including single-crystal MgO barrier based-MTJs,double barrier MTJs,MgO based MTJs with interlayer,novel electrode material MTJs based on MgO,novel barrier based MTJs,novel barrier MTJs based on MgO,and perpendicular MTJs.(2) Some typical physical effects in MgO based MTJs,which include six observed physical effects in MgO based MTJs,namely spin transfer torque(STT) effect,Coulomb blockade magnetoresistance(CBMR) effect,oscillatory magnetoresistance,quantum-well resonance tunneling effect,electric field assisted magnetization switching effect,and spincaloric effect.(3) In the last section,a brief introduction of some important device applications of MgO based MTJs,such as GMR & TMR read heads and magneto-sensitive sensors,both field and current switching MRAM,spin nano oscillators,and spin logic devices,have been provided. | HAN XiuFeng ALI Syed Shahbaz LIANG ShiHeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，1： | 4 |
| 5 | Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment显示文摘Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth.Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable bloodbrain barrier(BBB).Accumulation studies prove that low density lipoprotein receptor-related protein 1(LRP1)is promising target for BBB transcytosis.However,as the primary clearance receptor for amyloid beta and tissue plasminogen activator,LRP1 at abluminal side of BBB can clear LRP1-targeting therapeutics.Matrix metalloproteinase-1(MMP1)is highly enriched in metastatic niche to promote growth of BCBMs.Herein,it is reported that nanoparticles(NPs-K-s-A)tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2(A),can surmount the BBB and escape LRP1-mediated clearance in metastatic niche.NPs-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice,while comparable brain accumulation in normal mice.The delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing BCBMs.Due to the efficient BBB penetration,special and remarkable clearance escape,and facilitated therapeutic outcome,the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs. | Naveed Ullah Khan Jiang Ni Xiufeng Ju Tongtong Miao Haiyan Chen Liang Han | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 6 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 7 | Large -scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors 显示文摘 | LI Xiufeng XU Han WU Qingyu | 2007 | Biotechnologyand Bioengineering2007，98，4： | 1 |
| 8 | 显示文摘 | Wang Yizhong Li Hongshuo Han Xiufeng | 1997 | Journal of Alloys and Compounds1997，260，： | 1 |
| 9 | Nonreciprocal coherent coupling of nanomagnets by exchange spin waves显示文摘Nanomagnets are widely used to store information in non-volatile spintronic devices.Spin waves can transfer information with low-power consumption as their propagations are independent of charge transport.However,to dynamically couple two distant nanomagnets via spin waves remains a major challenge for magnonics.Here we experimentally demonstrate coherent coupling of two distant Co nanowires by fast propagating spin waves in an yttrium iron garnet thin film with sub-50 nm wavelengths.Magnons in two nanomagnets are unidirectionally phase-locked with phase shifts controlled by magnon spin torque and spin-wave propagation.The coupled system is finally formulated by an analytical theory in terms of an effective non-Hermitian Hamiltonian.Our results are attractive for analog neuromorphic computing that requires unidirectional information transmission. | Hanchen Wang Jilei Chen Tao Yu Chuanpu Liu Chenyang Guo Song Liu Ka Shen Hao Jia Tao Liu Jianyu Zhang Marco A.Cabero Z Qiuming Song Sa Tu Mingzhong Wu Xiufeng Han Ke Xia Dapeng Yu Gerrit E.W.Bauer Haiming Yu | 2021 | Nano Research2021，14，7： | 1 |
| 10 | Genome assembly and resequencing analyses provide new insights into the evolution, domestication and ornamental traits of crape myrtle显示文摘Crape myrtle(Lagerstroemia indica)is a globally used ornamental woody plant and is the representative species of Lagerstroemia.However,studies on the evolution and genomic breeding of L.indica have been hindered by the lack of a reference genome.Here we assembled the first high-quality genome of L.indica using PacBio combined with Hi-C scaffolding to anchor the 329.14-Mb genome assembly into 24 pseudochromosomes.We detected a previously undescribed independent whole-genome triplication event occurring 35.5 million years ago in L.indica following its divergence from Punica granatum.After resequencing 73 accessions of Lagerstroemia,the main parents of modern crape myrtle cultivars were found to be L.indica and L.fauriei.During the process of domestication,genetic diversity tended to decrease in many plants,but this was not observed in L.indica.We constructed a high-density genetic linkage map with an average map distance of 0.33 cM.Furthermore,we integrated the results of quantitative trait locus(QTL)using genetic mapping and bulk segregant analysis(BSA),revealing that the major-effect interval controlling internode length(IL)is located on chr1,which contains CDL15,CRG98,and GID1b1 associated with the phytohormone pathways.Analysis of gene expression of the red,purple,and white flower-colour flavonoid pathways revealed that differential expression of multiple genes determined the flower colour of L.indica,with white flowers having the lowest gene expression.In addition,BSA of purple-and green-leaved individuals of populations of L.indica was performed,and the leaf colour loci were mapped to chr12 and chr17.Within these intervals,we identified MYB35,NCED,and KAS1.Our genome assembly provided a foundation for investigating the evolution,population structure,and differentiation of Myrtaceae species and accelerating the molecular breeding of L.indica. | Yang Zhou Tangchun Zheng Ming Cai Lu Feng Xiufeng Chi Ping Shen Xin Wang Zhiting Wan Cunquan Yuan Man Zhang Yu Han Jia Wang Huitang Pan Tangren Cheng Qixiang Zhang | 2023 | Horticulture Research2023，10，9： | 1 |
| 11 | Large-scale biodieselproduction from microalga Chlorella protothecoides throughheterotrophic cultivation in bioreactors 显示文摘 | Xiufeng Li Han Xu Qingyu Wu | 2007 | Biotechnologyand Bioengineering2007，98，： | 1 |
| 12 | Editorial显示文摘Appreciation can be given to the editor of SCIENCE CHINA Physics, Mechanics & Astronomy for inviting Chinese experts and researchers in the field of spintronics to write a series of review articles in this special issue, in order to assist undergrad- | HAN XiuFeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，1： | 1 |
| 13 | A new image encryption algorithm based on chaos system显示文摘 | Zhang Han Wang Xiufeng | 2003 | IEEE2003，，10： | 1 |
| 14 | Organic-ferromagnetic hetero-structures with spin transport properties and fundamental physical effects显示文摘Organic spintronics refers to control spin dependent transport through organic materials.In the last two decades,extraordinary development has been achieved for organic-spintronics.A series of theoretical and experimental studies have been done to reveal the mechanisms of spin dependent transport properties.The theoretical analysis is based on the non-equilibrium Green's function formalism provides a mathematical framework for solving the transmission coefficients in the Landauer formula from atomistic first principles without any phenomenological parameters.In this article,we provide a brief theoretical review on organic spintronics devices and device physics therein. | LIU DongPing HAN XiuFeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，1： | 1 |
| 15 | Large- scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors 显示文摘 | LI Xiufeng XU Han WU Qingyu | 2007 | Biotechnol Bio- eng2007，98，4： | 1 |
| 16 | A clinical investigation of the relationship between different sedation depths and the restlessness after using midazolam as an adjuvant during regional anesthesia显示文摘Objective: To investigate the relationship between different sedation depth and the restlessness after using midazolam as an adjuvant during regional anesthesia. Methods: One hundred and fifty patients undergoing regional anesthesia were randomly divided into three groups. In group A, the patients were sedated at the level of OAA/S Ⅳ with midazolam during regional anesthesia. In group B and C, the sedation depths were kept at the levels of Ⅲ and Ⅱ respectively. The changes of BP, HR and SpO2 were recorded before and after midazolam. The rate of restlessness was also evaluated. Results: Blood pressures decreased in certain degree at 5 and 10 min after midazolam compared with those before in all three groups. BP decreased over 20% of the baseline in 4 cases in group A, in 5 cases in group B, and in 5 cases in group C. There was no significant difference in BP dropping among three groups. Compared with group B and C SpO2 dropped significantly at 3 and 5 min after midazolam in group C, in which SpO2 was less than 93% in 8 cases. The restlessness rate in group C was 22%, which was significantly higher than those in group A (2%,P < 0.01) and group B(4%,P < 0.05). Conclusion: The sedation depth is related to the rate of restlessness when midazolam is used as an adjuvant during regional anesthesia. It is suggested that the appropriate sedation depth for the patients under regional anesthesia is OAA/S Ⅲ. | Cunming Liu Guolou Zhang Mei Gao Zhongyun Wang Qianqing Wang Chuanbao Han Xiufeng Hao | 2006 | Journal of Nanjing Medical University2006，20，5： | 0 |
| 17 | Nonvolatile Multifunctional Programmable Spin Logic Cell显示文摘In this era of colossal data,more than 2 quintillion bytes of data were created every day.The huge amount of data brings us not only unprecedented convenience and opportunities but also incomparably severe challenges in data processing at the same time.The processing performance of computers is known to be determined almost entirely by the | HAN Xiufeng | 2017 | Bulletin of the Chinese Academy of Sciences2017，31，2： | 0 |
| 18 | Field-free approaches for deterministic spin–orbit torque switching of the perpendicular magnet显示文摘All-electrical driven magnetization switching attracts much attention in next-generation spintronic memory and logic devices,particularly in magnetic random-access memory(MRAM)based on the spin–orbit torque(SOT),i.e.SOT-MRAM,due to its advantages of low power consumption,fast write/read speed,and improved endurance,etc.For conventional SOT-driven switching of the magnet with perpendicular magnetic anisotropy,an external assisted magnetic field is necessary to break the inversion symmetry of the magnet,which not only induces the additional power consumption but also makes the circuit more complicated.Over the last decade,significant effort has been devoted to field-free magnetization manipulation by using SOT.In this review,we introduce the basic concepts of SOT.After that,we mainly focus on several approaches to realize the field-free deterministic SOT switching of the perpendicular magnet.The mechanisms mainly include mirror symmetry breaking,chiral symmetry breaking,exchange bias,and interlayer exchange coupling.Furthermore,we show the recent progress in the study of SOT with unconventional origin and symmetry.The final section is devoted to the industrial-level approach for potential applications of field-free SOT switching in SOT-MRAM technology. | Hao Wu Jing Zhang Baoshan Cui Seyed Armin Razavi Xiaoyu Che Quanjun Pan Di Wu Guoqiang Yu Xiufeng Han Kang L Wang | 2022 | Materials Futures2022，1，2： | 0 |
| 19 | Surface and internal magnetic domain structures of Fe-Ga alloy rods显示文摘The magnetic domain structures of the 100 oriented Fe 81 Ga 19 polycrystalline alloys with rapid quenching(RQ) and post-annealing(PA) thermal treatments are investigated by using magnetic force microscopy(MFM).The surfaces of the RQ alloy rods take on the dendritic domains after undergoing a standard mechanical polishing.While after PA processing,the distinct domain structures are observed at different temperatures.The wide stripe-like domain patterns appear in the surface of those PA rods at 550°C while the ramous domains remain at 400°C annealing.X-ray diffraction patterns indicate that a thin iron layer is formed on the surface of the specimens annealed at higher temperature.The soft magnetic iron layer,actually acting as a shield for the stray fields emerging from the internal magnetic structures underneath,brings about the presentation of the wide internal domains. | HAN YuNan LI YongSheng HAN XiuFeng YU DunBo | 2013 | Science China(Technological Sciences)2013，56，1： | 0 |
| 20 | Magnon Valve Effect Between Two Magnetic Insulators显示文摘Recently,a group headed by Prof.HAN Xiufeng at the State Key Laboratory of Magnetism under the Institute of Physics(IOP),Chinese Academy of Sciences reported in Physical Review Letters a novel type of magnon valve effect in a magnon-valve based on ferromagnetic insulators,rather than ferromagnetic metals as conventionally | HAN Xiufeng | 2018 | Bulletin of the Chinese Academy of Sciences2018，32，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员