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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Characteristic-based operator-splitting finite element method for Navier-Stokes equations显示文摘A new finite element method, which is the characteristic-based operator-splitting (CBOS) algorithm, is developed to solve Navier-Stokes (N-S) equations. In each time step, the equations are split into the diffusive part and the convective part by adopting the operator-splitting algorithm. For the diffusive part, the temporal discretization is performed by the backward difference method which yields an implicit scheme and the spatial discretization is performed by the standard Galerkin method. The convective part can be discretized using the characteristic Galerkin method and solved explicitly. The driven square flow and backward-facing step flow are conducted to validate the model. It is shown that the numerical results agree well with the standard solutions or existing experimental data, and the present model has high accuracy and good stability. It provides a prospective research method for solving N-S equations. | WANG DaGuo WANG HaiJiao XIONG JuHua THAM L G | 2011 | Science China(Technological Sciences)2011，54，8： | 13 |
| 3 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 4 | Do-nor-acceptor pair luminescence of nitrogenimplanted ZnO single crystal显示文摘 | XIONG G UCER K B WILLIAMS R T | 2005 | J Appl Phys2005，97，4： | 1 |
| 5 | Preparation of novel uniform mesoporotm alumina catalysts by the sol-gel method显示文摘 | Xiong G Zhang Y | 2001 | Catal-ysis Today2001，68，1： | 1 |
| 6 | Investigation on POM reaction in a new perovskite membrane reactor 显示文摘 | Dong H Shao Z P Xiong G X | 2001 | Catal Today2001，67，： | 1 |
| 7 | Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation - sensitive amplification polymorphism technique 显示文摘 | Xiong L Z Xu C G Saghai Maroof M A Zhang Q F | 1999 | Molecular and General Genetics1999，261，3： | 1 |
| 8 | Friction and wear properties of UHMWPE against ion implanted titanium alloy显示文摘 | Xiong DS Zhan G Jin ZG | | 0，，15： | 1 |
| 9 | Study of W/HZSM-5-based catalysts for dehydro-aromatization of CH4 in absence of 02 (11):Action of promoters Zn and Li 显示文摘 | Xiong Z T Zhang H B Lin G D Zeng J L | 2001 | Catalysis Letters2001，74，34： | 1 |
| 10 | A Mononuclear Complex of Norfloxacin with Silver ( I) and Properties 显示文摘 | Li Y X Chen Z F Xiong R G ef al | 2003 | IrwrgChem Comm2003，6，7： | 1 |
| 11 | Chemical, physical, and gel-forming properties of oxidized myofibrils and whey-and soy- protein isolates显示文摘 | LIU G XIONG Y L BUTTERFIELD D A | 2000 | Journal of Food Science2000，65，5： | 1 |
| 12 | Spatial and temporal prediction of flash floods in ungauged area based on GIS显示文摘 | CHEN G XIE P XIONG L | 2009 | Advances in water ~tuces & hydraulic engineering2009，1，： | 1 |
| 13 | Brain Injury Impairs Working Memory and Prefrontal Circuit Function 显示文摘 | Smith C J Xiong G Elkind JA | 2015 | Front Neurol2015，6，240： | 1 |
| 14 | Azimuthal AVO inversion of 3-D P-wave and analysis of resistibility to noise 显示文摘 | Xiong J L Zhang B Q Li G F | 2004 | Expanded Abstracts of 74^th Annual Internat CPS/ SEG Mtg2004，，： | 1 |
| 15 | The first run of the final year project with CDIO element programs显示文摘 | Lin P Wang Y Z Xiong G J | 2006 | UNESCO World Transaction on Engineering and Technology Education2006，5，2： | 1 |
| 16 | Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent 显示文摘 | WANG Y G XIONG Y MENG S L | 2004 | Journal of Talanta2004，102，： | 1 |
| 17 | Hydrothermal preparation and visible-light photocatalytic activity of Bi2WO6 powders显示文摘 | YU J G XIONG J F CHENG B | 2005 | J Solid State Chem2005，178，6： | 1 |
| 18 | Catalpol attenuates MPTF re- duced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neuro- trophic factor in striatum 显示文摘 | Xu G Xiong Z Yong Y | 2010 | Neuroscience2010，167，1： | 1 |
| 19 | Combining AHP with GIS insynthetic evaluation of eco-environment quality-A case study of HunanProvince,China显示文摘 | XIONG Y ZENG G M CHEN G Q | 2007 | Ecological Modelling2007，209，： | 1 |
| 20 | Lignans and neolignans from Sinocalamus affinis and their absolute configurations 显示文摘 | Xiong L Zhu C G Li Y R | 2011 | J Nat Prod2011，74，： | 1 |
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