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| 1 | Drift and deposition of ultra-low altitude and low volume application in paddy field显示文摘Field trials were performed to evaluate various techniques for measuring spray deposition and aerial drift during spray application to paddy field.The application of a spraying agent containing the fluorescent dye Rhodamine-B was applied by an unmanned aerial vehicle(UAV)which flew at a height of 5 m,a speed of 3 m/s,and the wind speed of 3 m/s.The results showed that because the downdraft produced by a helicopter rotor increased the penetrability of crops,there is a higher deposition on the upper layer and the under layer than the traditional spraying.The average deposition on the upper layer accounts for 28% of the total spraying,the deposition on the under layer accounts for 26% of the total spraying.The deposition on the under layer takes up 92.8% of the deposition on the upper layer.Droplets drift data showed that the drift of non-target area took up 12.9% of the total liquid spray.The 90% drifting droplets were located within a range of 8 m of the target area;the drift quantity was almost zero at a distance of 50 m away from the treated area. | Xue Xinyu Tu Kang Qin Weicai Yubin Lan Huihui Zhang | 2014 | International Journal of Agricultural and Biological Engineering2014，7，4： | 40 |
| 2 | Numerical simulation and experimental verification on downwash air flow of six-rotor agricultural unmanned aerial vehicle in hover显示文摘Recently,multi-rotor unmanned aerial vehicle(UAV)becomes more and more significantly irreplaceable in the field of plant protection against diseases,pests and weeds of crops.The easy takeoff and landing performance,hover function and high spraying efficiency of UAV are urgently required to spray pesticide for crop timely and effectively,especially in dispersed plots and hilly mountains.In such situations,the current researches about UAV spray application mainly focus on studying the influence of the UAV spraying parameters on the droplet deposition,such as operation height,operation velocity and wind velocity.The deposition and distribution of pesticide droplets on crops which depends on installation position of nozzle and airflow distribution characteristics of UAV are directly related to the control effect of pesticide and crop growth in different growth periods.As a preliminary step,this study focuses on the dynamic development law and distribution characteristics of the downwash air flow for the SLK-5 six-rotor agricultural UAV.Based on compressible Reynolds-averaged Navier-Stokes(RANS)equations with an RNG k-εturbulence model and dynamic mesh technology,the efficient three-dimensional computational fluid dynamics(CFD)method was established to analyze the flow field distribution characteristics of UAV in hover.Then the unsteady interaction flow field of the wing was investigated in detail.The downwash wind speed of the marked points for the SLK-5 UAV in hover was also tested by weather tracker.It was found that the maximum velocity value of the downwash flow was close to 10 m/s;the z-direction velocity was the main body of the wind velocity in the downwash airflow,and the comparison of the wind velocity experiment test and simulation showed that the relative error was less than 12%between the experimental and simulated values of the z-direction velocity at the marked points.Then the flow characteristics of the longitudinal and cross section were analyzed in detail,the results obtained can be used as a reference for drift and sedimentation studies for multi-rotor unmanned aerial vehicle. | Yang Fengbo Xue Xinyu Zhang Ling Sun Zhu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 28 |
| 3 | Droplet deposition and efficiency of fungicides sprayed with small UAV against wheat powdery mildew显示文摘Small unmanned aerial vehicle(UAV),a timely and effective pesticide sprayer,can be used to spray pesticide in a high efficiency without harming the crop,and is especially suitable for spraying for small farms and hills in Asian countries.In recent years,it has been chosen as a key and new technique for pesticide application.This paper studied the impact of UAV(UAV N-3)spraying parameters(different working height and different spraying concentrations)on the deposition of droplets on the wheat canopy and the prevention of powdery mildew.Water sensitive paper was used as the sampler to collect the pesticide droplets and image processing software Deposit Scan was used to compute the coverage rate of droplets on the wheat top layer to acquire the proportional distribution of droplets on the wheat lower layer.The experimental results showed the impact of spraying height on the distribution of droplets on the wheat upper layer was quite significant,when the spraying height was 5.0 m and the spraying speed was 4 m/s,the coverage rate of droplets on the wheat lower layer was the largest,as it was 45.6%of that on the upper layer,the droplets distribution was the most uniform,and the coefficient of variation was 33.13%.450 g/hm^(2)(dosage registered)of triadimefon SC(44%)was sprayed by the UAV,the control efficiency reached 55.1%after applying which was better than 20%and 40%of dosage decreased for each hectare,and the applying effect(35.6%)of 20%dosage decreased for each hectare had no significant difference from the applying effect(34.6%)applied by a knapsack-type electric sprayer.At 10 d after applying,the prevention effect realized by UAV was lower than that realized by a knapsack-type electric sprayer,and it may be correlated to the meteorological condition and water amount in the pesticide sprayed.Thus,when UAV spraying was chosen to prevent wheat powdery mildew under a serious disease situation,an auxiliary agent for spraying could be added to prolong the retention of pesticide on the plant surface to extend the pesticide effect.This study can provide a reference for the optimized design,performance upgrade and reasonable application of small UAV sprayers. | Weicai Qin Xinyu Xue Shaoming Zhang Wei Gu Baokun Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 16 |
| 4 | Downwash distribution of single-rotor unmanned agricultural helicopter on hovering state显示文摘The effective coverage and velocity of downwash are directly related to the assemblage of spraying system and spraying effect.The downwash of the unmanned agricultural helicopter(UAH)N-3 was discussed in the paper.The computational fluid dynamics(CFD)methods were used to simulate and analyze the distribution of the downwash,and a wind field measurement device had been designed to test the downwash of UAH N-3.In the tests,the UAH N-3 was raised up to 5.0 m,6.0 m and 7.0 m from the ground,“annular-radial-distribution-point”method was introduced,8 directions separated by an angle of 45°(the radial direction)with the intersection point of the main rotor shaft and the ground plane as the center,0.5 m as the step length for the longitudinal(to 2.5 m)and radial(to 4.0 m)direction to set the sample points,considering the range of the rotor rotating circular area mainly.The 5 m height results of N-3 were fully discussed to describe the downwash distribution with the longitudinal altitude increased and the radial distance increased.The standard deviations of five test altitudes for eight directions were comparatively analyzed,the results showed that the total standard deviation was not greater than 0.6 m/s.The overall relative maximum margin of error calculated from the simulation and measurement data was between 0.6 and 0.7,which verified the credibility of the simulation data.High-order polynomials were used to fitting the simulation and measurement data,the fitting results showed that the polynomial coefficient of determination R^(2) met or exceeded 0.75 when the altitudes were more than 1 m,indicating the fit equation having the reference values.When the altitudes equal or less than 0.5 m,the polynomial coefficient of determination R^(2) was smaller,ranging during 0.3 to 0.7.The study would provide some foundations for the optimization of the assemblage of spraying system on the single-rotor UAH,which would promote China aviation plant protection. | Zhang Songchao Xue Xinyu Sun Zhu Zhou Lixin Jin Yongkui | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 13 |
| 5 | Transition towards higher penetration of renewables: an overview of interlinked technical, environmental and socio-economic challenges显示文摘Investment for renewables has been growing rapidly since the beginning of the new century, and the momentum is expected to sustain in order to mitigate the impact of anthropogenic climate change.Transition towards higher renewable penetration in the power industry will not only confront technical challenges, but also face socio-economic obstacles.The connected between environment and energy systems are also tightened under elevated penetration of renewables.This paper will provide an overview of some important challenges related to technical, environmental and socio-economic aspects at elevated renewable penetration.An integrated analytical framework for interlinked technical, environmental and socio-economic systems will be presented at the end. | Xinyu CHEN Michael B.MCELROY Qiuwei WU Yinbiao SHU Yusheng XUE | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 11 |
| 6 | Optimization and test for structural parameters of UAV spraying rotary cup atomizer显示文摘Small unmanned aerial vehicle(UAV)pesticide application technology is developing rapidly in China.However,the spray efficiency of UAV sprayer is not stable,one important reason is that the lack of specialized aviation nozzle.Rotary cup atomizer is not easily to be blocked and has broad application foreground in UAV spray.In order to obtain good spraying quality and narrow droplet spectrum aviation spraying centrifugal nozzle,the impacts of rotary cup atomizer structural parameters on atomization property were studied.In this research,a centrifugal atomization test device was designed,on which a frequency converter was used to adjust the rotary speed,and a return valve was used to stabilize the flow rate and pressure of spray liquid.The droplet volume medium diameter(VMD)and droplet spectrum relative width(SRW)were tested by using laser particle analyzer and particle analysis system.The analysis results of variance and quadratic regression orthogonal test were used to optimize the structural parameters of rotary cup atomizer.The influences of rotary cup atomizer structural parameters on atomization property,such as groove shape,diameter,teeth number,cone angle and height were evaluated and analyzed by conducting single-factor test.The results showed that:the best optimized rotary groove shape was square,diameter and teeth number had significant effects on droplet VMD and SRW,while cone angle had no effect on the droplet VMD and SRW,height affected droplet VMDbut did not affect droplet SRW.Therefore,diameter and teeth number were selected as the variables of quadratic regression orthogonal test,droplet VMD and SRW regression model was established by using response surface analysis method.The optimized structural parameters respectively were:groove shape square,cone angle 60°,height 20 mm,diameter 61.5 mm and teeth number 149.Droplet VMD and SRW simulation value respectively were 200μm and 0.562.The differences between simulation value and test value were 0.68%and 9.90%respectively,indicating that the regression model is accurate.The research result can provide a reference for further optimizing the structure parameters of rotary cup atomizer to meet the requirement of UAV spraying. | Zhou Qingqing Xue Xinyu Qin Weicai Cai Chen Zhou Liangfu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 10 |
| 7 | Optimization and test for spraying parameters of cotton defoliant sprayer显示文摘Boom sprayer is widely used in large farm crops because of its high working efficiency and favorable spraying effect.But there are still some problems in cotton defoliant spraying in Xinjiang,China.Cotton is planted in a high density in Xinjiang,the row space is(10+66)cm,leaves in two adjacent rows are seriously overlapped,the lower leavers are poorly sprayed,so the defoliation effect is poor,and the cotton quality is degraded.To solve this problem and improve the defoliant droplets coverage on the cotton canopy,the original boom spraying was modified,and the spraying pardameters was optimized by the central combination test and design concept of Box-Behnken based on a single-factor test.A quadratic polynomial model of droplets coverage was created by using working parameters including horizontal spraying boom height,hang boom height and nozzles angle as the influential factors and the mean droplets coverage on cotton canopy as the target function,and the effectiveness of mode and interaction of factors were analyzed.The model was optimized and analyzed using the regression analysis method and response surface analysis method of software Design-Expert 7.0.0,and the optimal combination of spraying parameters was obtained.The results showed that the droplets coverage on cotton canopy were influenced by boom height,sprayer height and angled nozzles sequentially from large to small,and the optimal combination of spraying parameters was under horizontal spraying boom height of 134 cm,hang spraying boom height of 27.5 cm and nozzles angle of 21°.The mean droplets coverage of experimental value and predicted value on cotton canopy were 19.6%and 20.43%respectively in such conditions,and the relative error to the estimated value on the model was–4.25%.The research result can provide a reference for further optimizing the spraying parameters of cotton defoliant sprayer. | Qin Weicai Xue Xinyu Cui Longfei Zhou Qingqing Xu Zhufeng Chang Feilong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 9 |
| 8 | Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo显示文摘Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skinlike glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment. | Wanglinhan Zhang Linlin Zhang Huiling Gao Wenyan Yang Shuai Wang Lili Xing Xinyu Xue | 2018 | Nano-Micro Letters2018，10，2： | 9 |
| 9 | Environmental impacts on the distribution of microbial tetraether lipids in Chinese lakes with contrasting pH: Implications for lacustrine paleoenvironmental reconstructions显示文摘Glycerol dialkyl glycerol tetraethers(GDGTs) in lake sediments are useful biomarkers for the continental paleoclimatic reconstruction. However, the environmental controls on the distribution of these compounds, in particular the 6-methyl isomers of bacterial branched GDGTs(bGDGTs), in the lakes with contrasting pH, are still unknown, hindering their application for paleo-reconstructions. Here, we investigated the environmental impacts on the distribution of GDGTs in 17 alkaline lakes and 1 acid lake in China. It was found that the dissolved oxygen content in water column may have an impact on the distribution of archaeal isoprenoid GDGTs(iGDGTs) by causing the change in archaeal communities. The ratio of GDGT-0/crenarchaeol increases with decreasing oxygen content, indicating that the relative abundance of anaerobic methanogenic archaea or Miscellaneous Crenarchaeotic Group(MCG) vs. aerobic Thaumarchaeota is controlled by the oxygen content dissolved in water of these lakes. Thaumarchaeota are likely to contribute only a small proportion of iGDGTs in the relatively oxygen-depleted lakes, and thus TEX_(86) is not suitable for the reconstruction of the surface temperature of these lakes. The abundance ratio of iGDGTs to bGDGTs(R_(i/b)) appears to show no relationship with water pH in all the lakes, but exhibits a significant positive correlation with the water depth of the acid Lake Qinghai in Tengchong. As expected, the methylation degree of bGDGTs(MBT′) was found to correlate with both mean annual air temperature(MAT) and water pH, and the cyclization degree of bGDGTs(CBT) correlates only with water pH in these lakes. However, the MBT′_(5ME), an index to measure the methylation degree of 5-methyl bGDGTs, exhibits no relationship with MAT, whereas MBT′_(6ME), the methylation degree of 6-methyl bGDGTs, was found to correlate significantly with MAT. This is opposite to the situation observed in the global soils, pointing to a different adaptation of b GDGT-producing bacteria to environmental variables or different microbial sources of bGDGTs in these lakes. The relative abundance of 6- vs. 5-methyl bGDGTs is controlled by pH in these lakes, similar to that observed in worldwide soils. Hence, the isomer ratio(IR) of 6-methyl bGDGTs or CBT′ can be used as a proxy for water pH, although they might be influenced by other environmental factors including temperature in the lakes with a narrow range of pH. | DANG XinYue XUE JianTao YANG Huan XIE ShuCheng | 2016 | Science China Earth Sciences2016，59，5： | 9 |
| 10 | Optimized design and test for a pendulum suspension of the crop spray boom in dynamic conditions based on a six DOF motion simulator显示文摘Spray deposit distribution from a field sprayer is mainly affected by the boom movements when the tractor is driven over a rough soil surface,the pendulum suspension that used to reduce and control the movement of spray boom by isolating the boom from vibrations of the tractor will directly enhance uniform deposition of chemicals.However,how to match the parameters of the suspension with the properties of the boom is the key problem.The dynamic rigid-flexible coupling model of the virtual prototype of the spray boom suspension system was established by using ADAMS and ABAQUS software.An optimization of the suspension parameters for a large spay boom was carried out based on the optimal Latin hypercube design,radial basis function neural network,and multi-objective genetic algorithm NSGA-II.After modified parameters of the suspension,the travel of the sprayer on a typical field motion track was simulated based on a six DOF motion simulator,and the dynamic behavior of the boom suspension was measured.The results show that RMS of the measured boom roll angle and the boom center displacement for optimized solution were reduced by 14.76%and 12.43%compared with the original suspension.Finally,the inertial measurement unit(IMU)was used to measure the movements of the sprayer vehicle during the pesticide application on the Hongze Lake Farm,the experiment of field condition reproduced by using the six DOF motion simulator,the standard deviation of the roll angle and vibration displacement for the optimized sprayer boom are only 0.6382°and 62.279 mm respectively.The research provides theoretical basis and experimental method for parameter optimization of large scale boom suspension. | Longfei Cui Hanping Mao Xinyu Xue Suming Ding Baiyu Qiao | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 9 |
| 11 | Genetic-algorithm-based deep neural networks for highly efficient photonic device design显示文摘While deep learning has demonstrated tremendous potential for photonic device design,it often demands a large amount of labeled data to train these deep neural network models.Preparing these data requires high-resolution numerical simulations or experimental measurements and cost significant,if not prohibitive,time and resources.In this work,we present a highly efficient inverse design method that combines deep neural networks with a genetic algorithm to optimize the geometry of photonic devices in the polar coordinate system.The method requires significantly less training data compared with previous inverse design methods.We implement this method to design several ultra-compact silicon photonics devices with challenging properties including power splitters with uncommon splitting ratios,a TE mode converter,and a broadband power splitter.These devices are free of the features beyond the capability of photolithography and generally in compliance with silicon photonics fabrication design rules. | YANGMING REN LINGXUAN ZHANG WEIQIANG WANG XINYU WANG YUFANG LEI YULONG XUE XIAOCHEN SUN WENFU ZHANG | 2021 | Photonics Research2021，9，6： | 6 |
| 12 | A water-evaporation-induced self-charging hybrid power unit for application in the Internet of Things显示文摘A self-charging hybrid power unit has been developed by integrating a water-evaporation-induced nano- generator with a flexible nano-patterned supercapacitor. The nanogenerator can harvest environmental thermal energy and mechanical energy through the water evaporation process, and the supercapacitor can be charged simultaneously. The former offers stable electrical power as output, whereas the Ppy- based supercapacitor shows a capacitance of 12.497 m F/cm^2 with 96.42% retention after 4,000 cycles. After filling the power unit with water as the fuel, it can be fully charged in about 20 min. The power unit can be flexibly integrated with electronic devices such as sensor nodes and wireless transmitters employ- ing the Internet of Things. This new approach can offer new possibilities in continuous future operation of randomly distributed electronic devices incorporated in the Internet of Things. | Haoxuan He Tianming Zhao Hongye Guan Tianyan Zhong Hui Zeng Lili Xing Yan Zhang Xinyu Xue | 2019 | Science Bulletin2019，64，19： | 5 |
| 13 | The cotton WRKY transcription factor GhWRKY70 negatively regulates the defense response against Verticillium dahliae显示文摘WRKY transcription factors (TFs) play important roles in the regulation of biotic and abiotic stresses. However, the functions of most WRKY TFs in upland cotton (Gossypium hirsutum) are still unknown. In this study, we functionally identified a group Ⅲ WRKY transcription factor, GhWRKY70, in upland cotton. Reverse transcription-quantitative PCR analysis showed that GhWRKY70 expression was induced by Verticillium dahliae, salicylic acid (SA) and methyl jasmonate. Virus-induced gene silencing of GhWRKY70 increased the resistance of cotton to V. dahliae. Specifically, jasmonic acid (JA) response-associated genes were upregulated and SA-related genes were downregulated in GhWRKY70-silenced cotton plants. Overexpression of GhWRKY70 reduced tolerance to V. dahliae in Arabidopsis thaliana. Transgenic Arabidopsis plants showed increased expression of SA-associated genes and reduced expression of JA response-associated genes. These results suggest that GhWRKY70 negatively regulates tolerance to V. dahliae in at least two ways: (ⅰ) by upregulating the expression of SA-associated genes and (ⅱ) by reducing the expression of JA-associated genes. | Xianpeng Xiong Shichao Sun Yanjun Li Xinyu Zhang Jie Sun Fei Xue | 2019 | The Crop Journal2019，7，3： | 5 |
| 14 | Wearable Battery-Free Perspiration Analyzing Sites Based on Sweat Flowing on ZnO Nanoarrays显示文摘We fabricated wearable perspiration analyzing sites for actively monitoring physiological status during exercises without any batteries or other power supply.The device mainly consists of ZnO nanowire(NW)arrays and flexible polydimethylsiloxane substrate.Sweat on the skin can flow into the flow channels of the device through capillary action and flow along the channels to ZnO NWs.The sweat flowing on the NWs(with lactate oxidase modification)can output a DC electrical signal,and the outputting voltage is dependent on the lactate concentration in the sweat as the biosensing signal.ZnO NWs generate electric double layer(EDL)in sweat,which causes a potential difference between the upper and lower ends(hydrovoltaic effect).The product of the enzymatic reaction can adjust the EDL and influence the output.This device can be integrated with wireless transmitter and may have potential application in constructing sports big data.This work promotes the development of next generation of biosensors and expands the scope of self-powered physiological monitoring system. | Wanglinhan Zhang Hongye Guan Tianyan Zhong Tianming Zhao Lili Xing Xinyu Xue | 2020 | Nano-Micro Letters2020，12，8： | 5 |
| 15 | Incorporation of NLR into NIH stratificationsystem increases predictive accuracy for surgically resected gastrointestinal stromal tumors显示文摘以前的研究报导了那外科手术前的 neutrophil-to-lymphocyte (NLR ) , platelet-to-lymphocyte 比率为癌症的各种各样的类型是预示的。这研究的目的是与胃肠的 stromal 肿瘤(大意) 在病人调查外科手术前的外部血计数的预兆的实用程序。我们注册了为主要、局部性的大意经历了外科的 510 个连续、以前未经治疗的病人。在没有复发的幸存和结果变量之间的关系被 univariate 和 multivariate 分析估计,当 NLR 的 clinicopathologic 关联用 Chi 平方测试是坚定的时。外科手术前的 NLR 2 在为主要、局部性的大意经历手术的病人与差的预后被联系。它在是分类的病人仅仅是一个独立预言者 ? 健康高风险然而并非在全部人口的国家研究所。外科手术前的 NLR 是帮助为集中的辅助治疗和经常的监视识别病人的可行、可再现的外部 biomarker。 | Anwei Xue Xiaodong Gao Yong Fang Ping Shu Jiaqian Ling Kuntang Shen Yihong Sun Jing Qin Xinyu Qin Yingyong Hou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 4 |
| 16 | Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays显示文摘The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process. | Bing Deng Zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue Qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng | 2019 | Science Bulletin2019，64，10： | 4 |
| 17 | A Self-Powered Breath Analyzer Based on PANI/PVDF Piezo-Gas-Sensing Arrays for Potential Diagnostics Application显示文摘The increasing morbidity of internal diseases poses serious threats to human health and quality of life.Exhaled breath analysis is a noninvasive and convenient diagnostic method to improve the cure rate of patients. In this study, a self-powered breath analyzer based on polyaniline/polyvinylidene fluoride(PANI/PVDF) piezogas-sensing arrays has been developed for potential detection of several internal diseases. The device works by converting exhaled breath energy into piezoelectric gassensing signals without any external power sources. The five sensing units in the device have different sensitivities to various gas markers with concentrations ranging from 0 to 600 ppm. The working principle can be attributed to the coupling of the in-pipe gas-flow-induced piezoelectric effect of PVDF and gas-sensing properties of PANI electrodes. In addition, the device demonstrates its use as an ethanol analyzer to roughly mimic fatty liver diagnosis.This new approach can be applied to fabricating new exhaled breath analyzers and promoting the development of self-powered systems. | Yongming Fu Haoxuan He Tianming Zhao Yitong Dai Wuxiao Han Jie Ma Lili Xing Yan Zhang Xinyu Xue | 2018 | Nano-Micro Letters2018，10，4： | 4 |
| 18 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 19 | Evaluation of COC183B2 antibody targeting ovarian cancer by near-infrared fluorescence imaging显示文摘Objective: To evaluate the imaging potential of a novel near-infrared(NIR) probe conjugated to COC183 B2 monoclonal antibodies(MAb) in ovarian cancer(OC).Methods: The expression of OC183 B2 antigen in OC was determined by immunohistochemical(IHC) staining using tissue microarrays with the H-score system and immunofluorescence(IF) staining of tumor cell lines.Imaging probes with the NIR fluorescent dye cyanine 7(Cy7) conjugated to COC183 B2 Mab were chemically engineered. OC183 B2-positive human OC cells(SKOV3-Luc) were injected subcutaneously into BALB/c nude mice. Bioluminescent imaging(BLI) was performed to detect tumor location and growth. COC183 B2-Cy7 at 1.1,3.3, 10, or 30 μg were used for in vivo fluorescence imaging, and phosphate-buffered saline(PBS), free Cy7 dye and mouse isotype immunoglobulin G(IgG)-Cy7(delivered at the same doses as COC183 B2-Cy7) were used as controls.Results: The expression of OC183 B2 with a high H-score was more prevalent in OC tissue than fallopian tube(FT) tissue. Among 417 OC patients, the expression of OC183 B2 was significantly correlated with the histological subtype, histological grade, residual tumor size, relapse state and survival status. IF staining demonstrated that COC183 B2 specifically expressed in SKOV3 cells but not HeLa cells. In vivo NIR fluorescence imaging indicated that COC183 B2-Cy7 was mainly distributed in the xenograft and liver with optimal tumor-to-background(T/B)ratios in the xenograft at 30 μg dose. The highest fluorescent signals in the tumor were observed at 96 h postinjection(hpi). Ex vivo fluorescence imaging revealed the fluorescent signals mainly from the tumor and liver. IHC analysis confirmed that xenografts were OC183 B2 positive.Conclusions: COC183 B2 is a good candidate for NIR fluorescence imaging and imaging-guided surgery in OC. | Chen Zhang Xinyu Ling Yanxiu Guo Cunzhong Yuan Hongyan Cheng Xue Ye Ruiqiong Ma Yinli Zhang Yi Li Xiaohong Chang Beihua Kong Tao Liu Heng Cui | 2019 | Chinese Journal of Cancer Research2019，31，4： | 4 |
| 20 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
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