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| 1 | First identification of kdr allele F1534S in VGSC gene and its association with resistance to pyrethroid insecticides in Aedes albopictus populations from Haikou City,Hainan Island,China显示文摘Background:Aedes albopictus is distributed widely in China,as a primary vector of Dengue fever and Chikungunya fever in south of China.Chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases.Long-term applications of pyrethroids have resulted in the development of resistance in Ae.albopictus populations in China.However,the susceptibility of Ae.albopictus to pyrethroids in Hainan Island was unclear.Knockdown resistance(kdr),caused by point mutations in the VGSC gene,is one of the mechanisms that confer resistance to DDT and pyrethroids.This study was to investigate the resistance level of Ae.albopictus populations in Haikou City to three pyrethroid insecticides,and elucidate the relationship between the resistant phenotype and kdr mutations.Methods:The Aedes albopictus samples were collected in Xinbu Island(XI),Longtang Town(LT),Shishan Town(ST),Baishamen Park(BP),and Flower Market(FM)from Haikou City,Hainan Island,China.The larval susceptibility to deltamethrin,permethrin and beta-cypermethrin was tested by larval bioassays,and adult susceptibility to deltamethrin and DDT was determined by adult bioassays.The degree of resistance was determined by resistance ratio value(RR50>3)for larvae and by mortality for adult.The kdr alleles at codon 1534 of the VGSC gene were genotyped.The relationship between kdr genotypes and resistant phenotypes was analyzed by Chi-square test.Results:Out of five populations,assessed by larval bioassays,XI was susceptible to deltamethrin and permethrin;LT was susceptible to permethrin and beta-cypermethrin;and ST was susceptible to permithrin.FM and BP both were resistant to all of the three pyrethroids,and FM showed the highest degree of resistance,with RR50 values from 65.17 to 436.36.A total of 493 individuals from the larval bioassays were genotyped for kdr alleles.Five alleles were detected,including two wildtype alleles,TTC(F)(67.04%)and TTT(F)(0.41%),and three mutant alleles,TGC(C)(0.30%),TCC(S)(31.54%)and TTG(L)(0.71%).There was a clear correlation between mutant alleles(or F1534S)and resistant phenotypes(P<0.01).Conclusion:Two novel kdr mutant alleles F1534S and F1534L were detected in the pyrethroid resistant populations of Ae.albopictus in Haikou Hainan,China.For the first time,the mutant F1534S was associated with pyrethroid resistance in Ae.albopictus. | Huiying Chen Kaili Li Xiaohua Wang Xinyan Yang Yi Lin Fang Cai Wenbin Zhong Chunyan Lin Zhongling Lin Yajun Ma | 2016 | Infectious Diseases of Poverty2016，5，1： | 19 |
| 2 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 3 | Effect of scraping therapy on weightlifting ability显示文摘OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters. | Xingze Wang Wichai Eungpinichpong Jinsheng Yang Uraiwan Chatchawan Saowanee Nakmareong Yingying Wang Xinyan Gao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 11 |
| 4 | Seasonal Variations of Several Main Water Masses in the Southern Yellow Sea and East China Sea in 2011显示文摘The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the observations for the Yellow Sea Warm Current (YSWC) ,the Yellow Sea Cold Water Mass (YSCWM) and the Changjiang Diluted Water (CDW) during that year.The YSWC was confirmed to be a seasonal current and its source was closely associated with the Kuroshio onshore intrusion and the northerly wind.It was also found that the YSCWM in the summer of 2011 occupied a more extensive area in comparison with the climatologically-mean case due to the abnormally powerful wind prevailing in the winter of 2010 and decaying gradually thereafter.Resulting from the reduced Changjiang River discharge,the CDW spreading toward the Cheju Island in the summer of 2011 was weaker than the long-term mean and was confined to flow southward in the other seasons.The other water masses seemed normal without noticeable anomalies in 2011.The Yellow Sea Coastal Current (YSCC) water,driven by the northerly wind,flowed southeastward as a whole except for its northeastward surface layer in summer.The Taiwan Warm Current (TWC) was the strongest in summer and the weakest in winter in its northward movement.The Kuroshio water with an enhanced onshore intrusion in autumn was stable in hydrographic features apart from the seasonal variation of its surface layer. | QUAN Qi MAO Xinyan YANG Xiaodan HU Yingying ZHANG Haiyan JIANG Wensheng | 2013 | Journal of Ocean University of China2013，12，4： | 5 |
| 5 | An Energy Ratio Feature Extraction Method for Optical Fiber Vibration Signal显示文摘在光纤维警告前系统(OFPS ) 的侵入事件被划分成是有害侵入事件和无害的干扰事件的二种类型。目前,事件的这二种类型的信号特征抽取方法通常从时间领域的看法被设计。然而,为不同有害侵入事件的时间域特征的差别不是明显的,它不能详细反映他们的差异。我们发现不同侵入信号的光谱分发有明显的差别。为这个原因,侵入信号被转变成频率域。在这份报纸,有害侵入事件的一个精力比率特征抽取方法上被拉。第一,侵入信号被预先处理并且力量光谱密度(PSD ) 被计算。然后,不同频率乐队的精力比率被计算,并且侵入事件的每种类型的相应特征向量进一步被形成。线性判别式分析(LDA ) 分类器被用来在纸识别有害侵入事件。试验性的结果证明算法改进侵入信号的识别率,并且进一步验证算法的可行性和有效性。 | Zhiyong SHENG Xinyan ZHANG Yanping WANG Weiming HOU Dan YANG | 2018 | Photonic Sensors2018，8，1： | 2 |
| 6 | Comprehensive energy, economic, environmental assessment of a building integrated photovoltaic-thermoelectric system with battery storage for net zero energy building显示文摘To realize the goal of net zero energy building(NZEB),the integration of renewable energy and novel design of buildings is needed.The paths of energy demand reduction and additional energy supply with renewables are separated.In this study,those two are merged into one integration.The concept is based on the combination of photovoltaic,thermoelectric modules,energy storage and control algorithms.Five types of building envelope systems,namely PV+TE(S1),Grid+TE(S2),PV+Grid+TE(S3),PV+Battery+TE(S4)and PV+Grid+Battery+TE(S5)are studied,from aspects of energy,economic and environmental(E3)performance.The new envelope systems can achieve thermal load reduction while providing additional cooling/heating supply,which can promote advance of NZEBs.It is found that there is a typical optimum setting of thermal energy load for each one of them with minimum annual power consumption.Except for the S1 system,the rest can realize negative accumulated power consumption in a year-round operation,which means the thermal load of building envelope could be zero.The uniform annual cost for S1 to S5 under interest rate of 0.04 are 19.78,14.77,23.83,60.53,64.94$/m2,respectively.The S5 system has the highest environmental effect with 3.04 t/m2 reduction of CO_(2) over 30 years of operation. | Yongqiang Luo Nan Cheng Shicong Zhang Zhiyong Tian Guozhi Xu Xinyan Yang Jianhua Fan | 2022 | Building Simulation2022，15，11： | 2 |
| 7 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma显示文摘Endometrial cancer is the most common gynecological malignancy,affecting up to 3%of women at some point during their lifetime(Morice et al.,2016;Li and Wang,2021).Based on the pathogenesis and bio‑logical behavioral characteristics,endometrial cancer can be divided into estrogen-dependent(I)and non-estrogen-dependent(II)types(Ulrich,2011).Type I accounts for approximately 80%of cases,of which the majority are endometrioid carcinomas,and the remaining are mucinous adenocarcinomas(Setiawan et al.,2013). | Xinyan WANG Xiuling XU Ting ZHANG Yang JIN Sheng XU Lifeng CHEN Yucheng LAI Ling ZHANG Ruolang PAN Yan YU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 2 |
| 8 | Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study显示文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death. | Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 9 | Boosting the kinetics of PF_(6)^(-) into graphitic layers for the optimal cathode of dual-ion batteries:The rehearsal of pre-intercalating Li^(+)显示文摘Large anions exhibit slow diffusion kinetics in graphite cathode of dual-ion batteries(DIBs);particularly at high current density,it suffers severely from the largely-reduced interlayer utilization of graphite cathode,which as a bottleneck limits the fast charge application of DIBs.To maximize interlayer utilization and achieve faster anion diffusion kinetics,a fast and uncrowded anion transport channel must be established.Herein,Li^(+)was pre-intercalated into the graphite paper(GP)cathode to increase the interlayer spacing,and then hosted for the PF_(6)^(-)anion storage.Combined with theoretical calculation,it shows that the local interlayer spacing enlargement and the residual Li^(+)reduce the anion intercalation energy and diffusion barrier,leading to better rate stability.The obtained GP with Li^(+)pre-intercalation(GP-Li)electrode exhibits a discharge capacity of 23.1 m Ah g^(-1) at a high current of 1300 m A g^(-1).This work provides a facile method to efficiently improve the interlayer utilization of graphite cathode at large currents. | He Yang Tingting Qin Xinyan Zhou Yu Feng Zizhun Wang Xin Ge Nailin Yue Dabing Li Wei Zhang Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 10 | Flesh quality of hybrid grouper(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)fed with hydrolyzed porcine mucosasupplemented low fishmeal diet显示文摘Iso-nitrogenous and iso-lipidic diets containing 0%,3%,6%,9%,and 12%hydrolyzed porcine mucosa(namely,HPM0,HPM3,HPM6,HPM9,and HPM12)were prepared to evaluate their effects on the growth performance,muscle nutrition composition,texture property,and gene expression related to muscle growth of hybrid groupers(Epinephelus fuscoguttatus\Epinephelus lanceolatus_).Groupers were fed to apparent satiation at 08:00 and 16:00 every day for a total of 56 days.It was found that the weight gain percentage in the HPM0,HPM3,and HPM6 groups did not differ(P>0.05).The cooking loss and drip loss of the dorsal muscle in the HPM3 group were lower than those in the HPM6 and HPM9 groups(P<0.05).The hardness and chewiness of the dorsal muscle in the HPM3 group were higher than those in the HPM0,HPM9,and HPM12 groups(P<0.05).The gumminess in the HPM3 group was higher than that in the HPM9 and HPM12 groups(P<0.05).The total essential amino acid content of the dorsal muscle in the HPM12 group was higher than that in the HPM0 group(P<0.05).The contents of total n-3 polyunsaturated fatty acid and total n-3 highly unsaturated fatty acid,as well as the ratio of n-3/n-6 polyunsaturated fatty acid in the dorsal muscle was higher in the HPM0 group than in all other groups(P<0.05).The relative expressions of gene myogenic factor 5,myocyte enhancer factor 2c,myocyte enhancer factor 2a,myosin heavy chain,transforming growth factor-beta 1(TGF-b1),and follistatin(FST)were the highest in the dorsal muscle of the HPM3 group.The results indicated that the growth performance of hybrid grouper fed a diet with 6%HPM and 27%fish meal was as good as that of the HPM0 group.When fish ingested a diet containing 3%HPM,the expression of genes TGF-β1 and FST involved in muscle growth were upregulated,and then the muscle quality related to hardness and chewiness were improved.An appropriate amount of HPM could be better used in grouper feed. | Xuanyi Yang Xinyan Zhi Ziling Song Guanghui Wang Xumin Zhao Shuyan Chi Beiping Tan | 2022 | Animal Nutrition2022，，1： | 2 |
| 11 | Pd/TiO2 Nanospheres with Three-dimensional Hyperstructure for Enhanced Photodegradation of Organic Dye显示文摘Pd/TiO2 nanospheres assembled from nanorods with three-dimensional hyperstructure for enlianced photodegradation of organic dye was prepared by a sample solvothemial method. Further, it was used for degradation of methyl orange(MO) under the illumination of visible-light(simulated).The results show that Pd/TiO2 with 2%(mass fraction) Pd exhibits the noticeable activity in photodegrading of MO.The detailed analysis shows that this enhancement is attributed to the reduction of the rate of electron-hole recombination and surface plasmon resonance of Pd. The high activity and good stability of the obtained Pd/TiO2 nano spheres make it a promising photocatalyst for solving the environmental pollution problems. | WANG Huan XIAO Liguang WANG Chao LIN Bin LYU Sa CHU Xuefeng CHI Yaodan YANG Xiaotian WANG Xinyan | 2019 | Chemical Research in Chinese Universities2019，35，4： | 1 |
| 12 | The Value of c-TCD in the Diagnosis of Migraine and Cryptogenic Stroke Caused by PFO显示文摘Objective:To investigate the value of contrast-enhanced transcranial doppler(c-TCD)in the diagnosis of patent foramen ovale(PFO)of patients with migraine and cryptogenic stroke.Methods:A retrospective analysis of 160 patients undergoing c-TCD monitoring in our hospital from June 2014 to June 2019 was performed.Among them,there were 80 cases of patients with migraine(38 cases with aura and 42 cases without aura)in group A,and 80 cases of patients with cryptogenic stroke in group B.The positive detectable rate of PFO in the two groups were calculated and analyzed.Results:The detectable rate was 50.00%in group A,and 40.00%in group B.There was no statistical significance between the two groups(P>0.05).Among them,the detectable rate of PFO in migraine with aura in group A(62.50%)was higher than that in group B(37.50%).The difference was statistically significant(P<0.05);In the two groups of PFO-positive patients,the difference didn’t have statistical significance,comparing the proportion of the inherent type to that of potential type(P>0.05);There was no statistical significance of the difference between the RLS incidence of grade I and that of grade II among two groups of PFO-positive patients(P>0.05);the incidence of RLS in grade III in group B(50.00%)was higher than that in group A(25.00%),and the difference was statistically significant(P<0.05).Conclusion:c-TCD can accurately screen migraine and cryptogenic stroke caused by PFO,and grade and classify it as a clinical diagnosis of migraine and cryptogenic caused by PFO.It can also act as a objective reference of estimating the effect of treatment in different diseases and preventing cryptogenic stroke. | Xinyan Yu Jianyun Yang Dan Wu | 2020 | Journal of Clinical and Nursing Research2020，4，2： | 1 |
| 13 | Structural revolution of atomically dispersed Mn sites dictates oxygen reduction performance显示文摘An efficient preparation and local coordination environment regulation of isolated single-atom sites catalysts(ISASC)for improved activity is still challenging.Herein,we develop a solid phase thermal diffusion strategy to synthesize Mn ISASC on highly uniform nitrogen-doped carbon nanotubes by employing MnO_(2) nanowires@ZIF-8 core-shell structure.Under high-temperature,the Mn species break free from core-MnO_(2) lattice,which will be trapped by carbon defects derived from shell-ZIF-8 carbonization,and immobilized within carbon substrate.Furthermore,the poly-dispersed Mn sites with two nitrogen-coordinated centers can be controllably renovated into four-nitrogen-coordinated Mn sites using NH3 treatment technology.Both experimental and computational investigations indicate that the symmetric coordinated Mn sites manifest outstanding oxygen reduction activity and superior stability in alkaline and acidic solutions.This work not only provides efficient way to regulate the coordination structure of ISASC to improve catalytic performance but also paves the way to reveal its significant promise for commercial application. | Zhengkun Yang Xiaolin Wang Mengzhao Zhu Xinyan Leng Wenxing Chen Wenyu Wang Qian Xu Li-Ming Yang Yuen Wu | 2021 | Nano Research2021，14，12： | 1 |
| 14 | Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus显示文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. | Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 15 | Treatment of mature landfill leachate by a continuous modular internal micro-electrolysis fenton reactor 显示文摘 | YING Diwen XU Xinyan YANG Chen | 2012 | Research on Chemical Intermediates2012，，39： | 1 |
| 16 | Degradation kinetics of functional components of honeysuckle flowers during controlled-atmosphere heat pump drying显示文摘To investigate the change law of functional components and exterior color of honeysuckle flowers(HF)during controlled-atmosphere heat pump drying,nitrogen was used as drying medium in this study to reduce the oxygen concentration.The influences of drying temperature,HF’s loading amount and oxygen concentration on chlorogenic acid content,cynaroside content and L value(on behalf of browning degree)were explored,and the degradation kinetics models of chlorogenic acid and cynaroside were constructed.The results showed that chlorogenic acid content,cynaroside content and L value decreased with the rise of temperature,HF’s loading amount and oxygen concentration.The degradation kinetics models of chlorogenic acid and cynaroside during the drying process were established through introducing an exponent r related to time t in the first order reaction kinetics equation.The models had good fitting precision and can be used to predict the degradation law of chlorogenic acid and cynaroside. | Luo Lei Yang Bin Zhu Wenxue Ren Guangyue Duan Xu Kang Xinyan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 1 |
| 17 | Impacts of PM_(2.5) on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment-Two Cities and Two Municipalities,China,2017−2019显示文摘Summary What is already known about this topic?Short-term PM_(2.5) exposure has been associated with hourly,24-hour,daytime,and nighttime blood pressure(BP)levels,and further studies focusing whether and how the associations with other ambulatory BP monitoring indicators are warranted. | Fangchao Liu Zhennan Lin Xinyan Wang Xueli Yang Qiong Liu Xiaolong Xing Jie Cao Jianxin Li Keyong Huang Weli Yan Tingting Liu Wei Li Shufeng Chen Xiangfeng Lu Dongfeng Gu Jianfeng Huang | 2021 | China CDC weekly2021，3，45： | 1 |
| 18 | The effect of lipid metabolism on biological characteristics of hepatic stellate cell显示文摘Hepatic stellate cells(HSCs) are a kind of fat-storing cells, the lipid droplets are rich in the Cytoplasm, in which retinyl ester accounts for 42%, triglyceride occupies 28%, cholesterol(total) occupies 13%, phospholipids occupies 4% respectively. Studies have confirmed that thetransforms of HSC phenotype follows the changing of the cell lipid. After the activation of HSC, with HSC phenotype changing from fat-storing cells into myofibroblast, the lipid droplets decreased or disappeared gradually, which means HSCs are under the differentiating process of removing adipose, meawhile triglyceride, and the main content of lipid droplets, also obviously reduced. It was ever declined that during the process of HSC re-fating, the activated HSC would turn into quiescent state. Therefore this shows HSCs fat metabolism is closely related to the biological activity. | JING Xinyan YANG Xuefeng | 2013 | Journal of Medical Colleges of PLA(China)2013，28，5： | 1 |
| 19 | A study of microstructure and microsegregation of aluminum 7050 alloy显示文摘 | XIE FangYou YANG XinYan | 2003 | Materials Science and Engineering A3552003，，： | 1 |
| 20 | Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma显示文摘Tongue squamous cell carcinoma is highly malignant and has a poor prognosis.In this study,we aimed to combine whole-genome sequencing,whole-genome methylation,and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma better.Oral tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired samples.After multi-omics sequencing,differentially methylated intervals,methylated loop sites,methylated promoters,and transcripts were screened for variation in all paired samples.Correlations were analyzed to determine biological processes in tongue squamous cell carcinoma.We found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression levels.Functional annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade,which is associated with cancer progression and the development of drug resistance during treatment.The prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype-gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical settings.We identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and lncRNAs.Collectively,changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients. | Libo Liang Yi Li Binwu Ying Xinyan Huang Shenling Liao Jiajin Yang Ga Liao | 2023 | International Journal of Oral Science2023，15，1： | 1 |
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