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| 1 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 2 | Design,methodology,and baseline of whole city‑million scale children and adolescents myopia survey(CAMS)in Wenzhou,China显示文摘Background:Myopia is the most common visual impairment in children and adolescents worldwide.This study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey(CAMS),which will shed light on the further study of myopia from the level of epidemiology and precision medicine.Methods:We developed a novel population-based screening pattern,an intelligent screening process and internetbased information transmission and analysis system to carry out the survey consisting of school children in Wenzhou,China.The examination items include unaided distance visual acuity,presenting distance visual acuity,and noncycloplegic autorefraction.Myopia and high myopia were defined as spherical equivalent(SE)≤−1.00 diopters(D)and SE≤−6.00 D,respectively.Next,the reports of the vision checking were automatically sent to parents and the related departments.The CAMS project will be done two to four times annually with the support of the government.An online eyesight status information management system(OESIMS)was developed to construct comprehensive and efficient electronic vision health records(EVHRs)for myopia information inquiry,risk pre-warning,and further study.Results:The CAMS completed the first-round of screening within 30 days for 99.41%of Wenzhou students from districts and counties,in June 2019.A total of 1,060,925 participants were eligible for CAMS and 1,054,251(99.37%participation rate)were selected through data quality control,which comprised 1305 schools,and 580,609,251,050 and 170,967 elementary,middle,and high school students.The mean age of participants was 12.21±3.32 years(6-20 years),the female-to-male ratio was 0.82.The prevalence of myopia in elementary,middle,and high school students was 38.16%,77.52%,and 84.00%,respectively,and the high myopia incidence was 0.95%,6.90%,and 12.98%.Conclusions:The CAMS standardized myopia screening model involves automating large-scale information collection,data transmission,data analysis and early warning,thereby supporting myopia prevention and control.The entire survey reduced 90%of staff,cost,and time consumption compared with previous surveys.This will provide new insights for decision support for public health intervention. | Liangde Xu Youyuan Zhuang Guosi Zhang Yunlong Ma Jian Yuan Changseng Tu MiaoMiao Li Wencan Wang Yaru Zhang Xiaoyan Lu Jing Li Xinting Liu Zhengbo Xue Meng Zhou Jie Sun Jinhua Bao Ming Li Fan Lu Hong Wang Jianzhong Su Jia Qu | 2021 | Eye and Vision2021，8，1： | 7 |
| 3 | Mitochondrial Genome of Episesarma lafondii(Brachyura:Sesarmidae)and Comparison with Other Sesarmid Crabs显示文摘Complete mitochondrial genomes(mitogenomes)can provide useful information for phylogenetic relationships,gene rearrangement,and molecular evolution.Here,the complete mitogenome of Episesarma lafondii(Brachyura:Grapsoidea:Sesarmidae)was sequenced through next-generation sequencing technique for the first time.The 15640 bp mitogenome contains the entire set of 37 genes and an AT-rich region.The rearrangements of two tRNA genes(tRNA-His and tRNA-Gln)are compared with that in the pancrustacean ground pattern,and the tandem duplication/random loss model was selected to explain the observed gene rearrangements.The phylogenetic results showed that all sesarmid crabs belong to the same group,wherein the genus Episesarma showed the closest relationship with Clistocoeloma.Furthermore,the monophyly of each family was well supported except for Xanthidae,Gecarcinidae,and Homolidae.The correlation between the phylogeny of Sesarmidae species and the gaps in the QIM region was analyzed.Evidently,the gaps between Q and I(Gap3 and between I and M(Gap4)degenerated with the evolution process.In general,the results will contribute to the in-depth understanding of gene rearrangements in Sesarmidae mitogenomes and provide new insights into the phylogeny of Brachyura. | ZHANG Ying GAO Yan GONG Li LU Xinting JIANG Lihua LIU Bingjian LIU Liqin LU Zhenming LI Pengfei | 2021 | Journal of Ocean University of China2021，20，6： | 4 |
| 4 | Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS)显示文摘The multifunctional protein p100 is a vital transcriptional regulator that increases gene transcription by forming a physical bridge between promoter-specific transcription factors and the basal transcription machinery.To identify potential signal transduction pathways in which human p100 acts as a coregulator and to find target promoter regions that may interact with p100,we performed a promoter microarray assay called chromatin immunoprecipitation-guided ligation and selection(ChIP-GLAS).From this assay,we determined that a set of promoter fragments,including several factors in the transforming growth factor beta(TGF-β)signaling pathway,exhibited interaction with p100.The ChIP-GLAS data were validated by RT-PCR assessing the mRNA expression of various factors in the TGF-b signaling pathway in cell lines. | Xin Liu Lijie Dong Xuejun Zhang Baoya Wang Xinting Wang Hu Li Jinyan He Lin Ge Xiang Jing Zhi Yao Jie Yang | 2011 | Cellular & Molecular Immunology2011，8，1： | 3 |
| 5 | Fingerprint Liveness Detection from Different Fingerprint Materials Using Convolutional Neural Network and Principal Component Analysis显示文摘Fingerprint-spoofing attack often occurs when imposters gain access illegally by using artificial fingerprints,which are made of common fingerprint materials,such as silicon,latex,etc.Thus,to protect our privacy,many fingerprint liveness detection methods are put forward to discriminate fake or true fingerprint.Current work on liveness detection for fingerprint images is focused on the construction of complex handcrafted features,but these methods normally destroy or lose spatial information between pixels.Different from existing methods,convolutional neural network(CNN)can generate high-level semantic representations by learning and concatenating low-level edge and shape features from a large amount of labeled data.Thus,CNN is explored to solve the above problem and discriminate true fingerprints from fake ones in this paper.To reduce the redundant information and extract the most distinct features,ROI and PCA operations are performed for learned features of convolutional layer or pooling layer.After that,the extracted features are fed into SVM classifier.Experimental results based on the LivDet(2013)and the LivDet(2011)datasets,which are captured by using different fingerprint materials,indicate that the classification performance of our proposed method is both efficient and convenient compared with the other previous methods. | Chengsheng Yuan Xinting Li Q.M.Jonathan Wu Jin Li Xingming Sun | 2017 | Computers, Materials & Continua2017，，4： | 3 |
| 6 | Segmentation of thermal infrared images of cucumber leaves using K-means clustering for estimating leaf wetness duration显示文摘Leaf wetness duration(LWD)is a critical parameter used to predict plant disease,but its determination under actual field conditions is a major challenge.In this study,a method for determining LWD using thermal infrared imaging was developed and applied to cucumber plants grown in a solar greenhouse.Thermal images of the plant leaves were captured using an infrared scanning camera,and a leaf wetness area segmentation method consisting of two procedures was applied.First,a color space conversion was performed automatically by an image-processing algorithm.Then,the K-means clustering algorithm was applied to enable the segmentation of the wetness area on the thermal image.Subsequently,to enable overall thermal image analysis,an initial leaf wetness threshold(LWT)of 5%was defined(where wetness values higher than 5%indicated that the leaf was in a wet state).The results of comparative experiments conducted using thermal images of plant leaves captured using an infrared scanning camera and human visual observation indicated that the estimated LWD values were generally higher than the observed LWD values,because slight leaf wetness condensations were overlooked by the human eye but detected by the infrared scanning camera.While these differences were not found to be statistically significant in this study,the proposed method for determining LWD using thermal infrared imaging may provide a new LWD detection method for cucumber and other plants grown in solar greenhouses. | Dongmei Wen Aixin Ren Tao Ji Isabel Maria Flores-Parra Xinting Yang Ming Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 3 |
| 7 | 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway显示文摘Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. | SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU | 2022 | BIOCELL2022，46，11： | 2 |
| 8 | Comparative mitochondrial genome analysis of Varunidae and its phylogenetic implications显示文摘Complete mitochondrial genomes(mitogenomes)can indicate phylogenetic relationships,as well as useful information for gene rearrangement mechanisms and molecular evolution.Currently,the phylogenetic location of the genus Varuna(Brachyura:Varunidae)has not been well resolved mainly because of limited representatives(only two extant species).Here,we determined a new mitogenome of this genus(Varuna litterata)and added the published mitogenomes to reconstruct the phylogeny of Varunidae.The 16368-bp mitogenome contains the entire set of 37 genes and a putative control region.The characteristics of this newly sequenced mitogenome were described and compared with the other 15 Varunidae mitogenomes.All 16 analyzed mitogenomes have identical gene order and similar molecular features.The sliding window and genetic distance analyses demonstrate highly variable nucleotide diversity,with comparatively low variability of COI and COII,and high variability of ND6.The nonsynonymous/synonymous substitution rates(dN/dS ratio)analysis shows that all 13 PCGs are under purifying selection and ATP8 gene evolves under the least selective pressure.Twelve tRNA genes,two rRNAs,one PCG,and the putative control region are found to be rearranged with respect to the pancrustacean ground pattern gene order.Tandem duplication/random loss model is adopted to explain the large-scale gene rearrangement events occurring in Varunidae mitogenomes.Phylogenetic analyses show that all Varunidae species are placed into one group,and form a sister clade with Macrophthalmidae.Nevertheless,the phylogenetic relationships within Varunidae are not completely consistent based on the two different datasets used in this study.These findings will contribute to a better understanding of gene rearrangement and molecular evolution in Varunidae mitogenomes,as well as provide insights into the phylogenetic studies of Brachyura. | Ying Zhang Li Gong Xinting Lu Zengliang Miao Lihua Jiang Bingjian Liu Liqin Liu Pengfei Li Xu Zhang Zhenming Lü | 2022 | Acta Oceanologica Sinica2022，41，6： | 2 |
| 9 | Agricultural cooperatives and the role of organisational models in new intelligent traceability systems and big data analysis显示文摘Traceability systems are key to assuring food safety,creating a benefit for food supply chain components.Currently,the appearance of new technologies such as IoT and Big Data Analysis leads to a new generation of more functional,but complex,traceability systems.Organisational models based on cooperation of multiple small/medium size agents,for example of small/family farming cooperatives,play an important role in high standard agricultural production and commercialization processes.These function as both social and economic networks,with high social and economic impact in the rural areas.The case of Almeria as an example of this model was used to analyze its cooperative model.The actual traceability systems in the Almeria model were studied,taking account of the different networked agents and their interrelation.This study includes two main parts:a)analysis of the net-chains that constitute the food supply chains and their different relationships,and b)actual traceability.The next step studied how the net-chain model,including many diverse agents,may be applied to develop a new generation of traceability systems based of IoT and Big Data.This implies extending the special and functional scope of the actual systems and defining clear rules of exchange of the results of the Big Data Analysis,taking account of the adequate Privacy Rules.This work analyses the current organisation as a base for a new generation of traceability systems considered in the European project IoF2020(Internet of the Food and Farm 2020).Some parallels between Almeria’s model and certain areas in China,mainly in the areas of Beijing-Tianjin-Hebei and Shandong were detected.Another of the objectives of this work is to deepen the understanding of these similarities and analyze the possible adaptation of the results from Almeria to China. | Cynthia Giagnocavo Fernando Bienvenido Li Ming Zhao Yurong Jorge Antonio Sanchez-Molina Yang Xinting | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 2 |
| 10 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 11 | Development and test verification of air temperature model for Chinese solar and Spainish Almeria-type greenhouses显示文摘Growth can be defined as an increment in biomass or an increment in weight or height of the organs of the plant influenced by physiological processes.Many of these processes have their limits genetically determined,but climate and irrigation play an important role.Because of its importance,microclimate has been extensively studied in the modeling as a surrounding condition which is imposed by the exterior climate.The main objective of this work was to develop a temperature model based on the energy balance dynamics at two different greenhouse locations-South-eastern Spain and Northern China,and the traditional structures of Chinese solar greenhouse and Almería-type multi-span greenhouse were taken into account.The final model was developed by combining the external conditions,the actuator influence and the crop growth,where the temperature is influenced by soil,crop,cover,actuators,back wall and greenhouse geometry.The model took into account the energy lost by convective and conductive fluxes,as well as the energy supplied by solar radiation and heating systems.The soil and the back wall are the main media for energy storage.The temperature dynamic was determined by a physical model,which considered the energy balance from a holistic point of view-as a sub-model for a customizable interface among the external climate,the plant and the greenhouse system.The influences of different subsystems included in the temperature model were analyzed and evaluated.The results showed a high R^(2)value of 0.94 for Beijing and 0.95 for Almeria,and the average error was low,of which the MAE and RMSE were 0.71 and 1.365 for Almeria and 0.62 and 1.102 for Beijing,respectively.Thus,the model can be considered as a powerful tool for control design purposes in microclimate systems. | Jorge Antonio Sanchez-Molina Li Ming Francisco Rodriguez Jose Luis Guzman Wang Hui Yang Xinting | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 2 |
| 12 | Optical detection of single celllactate release for cancer metabolic 显示文摘 | ZHENG Xinting YANG Hongbin LI Changming | 2010 | Anal Chem2010，82，12： | 1 |
| 13 | Early warning model for cucumber downy mildew in unheated greenhouses显示文摘 | Yang Xinting Li Ming Zhao Chunjiang | 2007 | New Zealand Journal of Agricultural Research2007，50，5： | 1 |
| 14 | A PDA based record-keeping and decision-support system for traceability in cucumber production 显示文摘 | Li Ming Qian Jianping Yang Xinting | 2009 | Computers and Electronics in Agri- culture2009，70，1： | 1 |
| 15 | Automatic greenhouse pest recognition based on multiple color space features显示文摘Recognition and counting of greenhouse pests are important for monitoring and forecasting pest population dynamics.This study used image processing techniques to recognize and count whiteflies and thrips on a sticky trap located in a greenhouse environment.The digital images of sticky traps were collected using an image-acquisition system under different greenhouse conditions.If a single color space is used,it is difficult to segment the small pests correctly because of the detrimental effects of non-uniform illumination in complex scenarios.Therefore,a method that first segments object pests in two color spaces using the Prewitt operator in I component of the hue-saturation-intensity(HSI)color space and the Canny operator in the B component of the Lab color space was proposed.Then,the segmented results for the two-color spaces were summed and achieved 91.57%segmentation accuracy.Next,because different features of pests contribute differently to the classification of pest species,the study extracted multiple features(e.g.,color and shape features)in different color spaces for each segmented pest region to improve the recognition performance.Twenty decision trees were used to form a strong ensemble learning classifier that used a majority voting mechanism and obtains 95.73%recognition accuracy.The proposed method is a feasible and effective way to process greenhouse pest images.The system accurately recognized and counted pests in sticky trap images captured under real greenhouse conditions. | Zhankui Yang Wenyong Li Ming Li Xinting Yang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 1 |
| 16 | Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019显示文摘Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries. | Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，4： | 1 |
| 17 | 血小板计数与胃癌分期及预后的关系(英文)显示文摘Objective:The aim of the research was to investigate the relationship between gastric cancer stage, prognosis and blood platelets count. Methods: Platelet (PLT) count was analyzed retrospectively in 203 patients with gastric cancer from 1998 to 2002. The survivals of gastric cancer were compared between normal PLT group and thrombocytosis group. Results: Among 203 cases, PLT increased in 21 cases. The average platelet counts of patients at different stages had statistically significant differences (P<0.01). The 3-and 5-year survivals in patients of thrombocytosis group were lower than those of the normal PLT group (P<0.01). Conclusion: Thrombocytosis in gastric cancers with advanced stage are common. And PLT count can be a prognostic indicator of survival in patients with gastric cancer undergoing gastrectomy. | Xinting Lv Yingjie Li Tao Chen Ning Li | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，4： | 1 |
| 18 | Early warning model for cucumber downy mildew in unheated greenhouses显示文摘 | Yang Xinting Li Ming Zhao Chunjiang | 2007 | New Zealand Journal of Agricultural Research2007，50，5： | 1 |
| 19 | A PDA-based record-keeping and decision support system for traceability in cucumber production 显示文摘 | LI Ming QIAN Jianping YANG Xinting | 2010 | Computers and Electronics in Agri- culture2010，70，1： | 1 |
| 20 | Genetic abnormalities assist in pathological diagnosis and EBVpositive cell density impact survival in Chinese angioimmunoblastic T-cell lymphoma patients显示文摘Objective:To explore the application of genetic abnormalities in the diagnosis of angioimmunoblastic T-cell lymphoma(AITL)and the reliable pathological prognostic factors.Methods:This study included 53 AITL cases,which were reviewed for morphological patterns,immunophenotypes,presence of Hodgkin and Reed-Sternberg(HRS)-like cells,and co-occurrence of B cell proliferation.The Epstein-Barr virus(EBV)-positive cells in tissues were counted,and cases were classified into“EBV encoded RNA(EBER)high-density”group if>50/HPF.Targeted exome sequencing was performed.Results:Mutation data can assist AITL diagnosis:1)with considerable HRS-like cells(20 cases):RHOA mutated in 14 cases(IDH2 co-mutated in 3 cases,4 cases with rare RHOA mutation),TET2 was mutated in 5 cases(1 case comutated with DNMT3A),and DNMT3A mutated in 1 case;2)accompanied with B cell lymphoma(7 cases):RHOA mutated in 4 cases(1 case had IDH2 mutation),TET2 mutated in 2 cases and DNMT3A mutated in 1 case;3)mimic peripheral T cell lymphoma,not otherwise specified(5 cases):RHOA mutated in 2 cases(IDH2 co-mutated in 1 case),TET2 mutated in 3 cases,and DNMT3A mutated in 1 case;4)pattern 1(1 case),RHOA and TET2 co-mutated.Besides RHOAG17V(30/35),rare variant included RHOAK18N,RHOAR68H,RHOAC83Y,RHOAD120G and RHOAG17del,IDH2R172 co-mutated with IDH2M397V in one case.There were recurrent mutations of FAT3,PCLO and PIEZO1 and genes of epigenetic remodeling,T-cell activation,APC and PI3K/AKT pathway.EBER high-density independently indicated adverse overall survival and progression-free survival(P=0.046 and P=0.008,KaplanMeier/log-rank).Conclusions:Over half AITL cases might be confused in diagnosis for certain conditions without mutation data.Targeted exome sequencing with a comprehensive panel is crucial to detect both hot-spot and rare mutation variants for RHOA and IDH2 and other recurrent mutated genes in addition to TET2 and DNMT3A.EBER highdensity independently indicated adverse survival. | Yunfei Shi Haojie Wang Yanfei Liu Mengping Long Ning Ding Lan Mi Yumei Lai Lixin Zhou Xinting Diao Xianghong Li Weiping Liu Jun Zhu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
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