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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclinl to negatively regulate antiviral innate immunity显示文摘 | Xiaojuan Chen Kai Wang Yaling Xing Jian Tu Xingxing Yang Qian Zhao Kui Li Zhongbin Chen | 2014 | Protein & Cell2014，5，12： | 14 |
| 3 | Microporous bamboo biochar for lithium-sulfur batteries显示文摘简单、便宜、可伸缩、环境地友好,多微孔的生物资源 biochars 在锂硫(Li-S ) 为申请一直在吸引热心注意电池。此处,多孔的竹子 biochar 经由创造多微孔的结构的一个 KOH/annealing 过程被激活,增加表面区域并且提高电子电导率。对待的样品被用来包含硫准备多微孔的竹子碳硫(英国计算机学会) 用作为 Li-S 电池的阴极的 nanocomposite 第一次。有 50 wt.% 硫内容的英国计算机学会 nanocomposite 交付 1,295 妈的一个高起始的能力 ??? ?? | Xingxing Gu Yazhou Wang Chao Lai Jingxia Qiu Sheng Li Yanglong Hou Wayde Martens Nasir Mahmood Shanqing Zhang | 2015 | Nano Research2015，8，1： | 11 |
| 4 | Novel Water-Based Drilling and Completion Fluid Technology to Improve Wellbore Quality During Drilling and Protect Unconventional Reservoirs显示文摘The efficient exploration and development of unconventional oil and gas are critical for increasing the self-sufficiency of oil and gas supplies in China.However,such operations continue to face serious problems(e.g.,borehole collapse,loss,and high friction),and associated formation damage can severely impact well completion rates,increase costs,and reduce efficiencies.Water-based drilling fluids possess certain advantages over oil-based drilling fluids(OBDFs)and may offer lasting solutions to resolve the aforementioned issues.However,a significant breakthrough with this material has not yet been made,and major technical problems continue to hinder the economic and large-scale development of unconventional oil and gas.Here,the international frontier external method,which only improves drilling fluid inhibition and lubricity,is expanded into an internal-external technique that improves the overall wellbore quality during drilling.Bionic technologies are introduced into the chemical material synthesis process to imitate the activity of life.A novel drilling and completion fluid technique was developed to improve wellbore quality during drilling and safeguard formation integrity.Macroscopic and microscopic analyses indicated that in terms of wellbore stability,lubricity,and formation protection,this approach could outperform methods that use typical OBDFs.The proposed method also achieves a classification upgrade from environmentally protective drilling fluid to an ecologically friendly drilling fluid.The developed technology was verified in more than 1000 unconventional oil and gas wells in China,and the results indicate significant alleviation of the formation damage attributed to borehole collapse,loss,and high friction.It has been recognized as an effective core technology for exploiting unconventional oil and gas resources.This study introduces a novel research direction for formation protection technology and demonstrates that observations and learning from the natural world can provide an inexhaustible source of ideas and inspire the creation of original materials,technologies,and theories for petroleum engineering. | Guancheng Jiang Jinsheng Sun Yinbo He Kaixiao Cui Tengfei Dong Lili Yang Xukun Yang Xingxing Wang | 2022 | Engineering2022，，11： | 11 |
| 5 | Semi-tightly coupled integration of multi-GNSS PPP and S-VINS for precise positioning in GNSS-challenged environments显示文摘Because of its high-precision,low-cost and easy-operation,Precise Point Positioning(PPP)becomes a potential and attractive positioning technique that can be applied to self-driving cars and drones.However,the reliability and availability of PPP will be significantly degraded in the extremely difficult conditions where Global Navigation Satellite System(GNSS)signals are blocked frequently.Inertial Navigation System(INS)has been integrated with GNSS to ameliorate such situations in the last decades.Recently,the Visual-Inertial Navigation Systems(VINS)with favorable complementary characteristics is demonstrated to realize a more stable and accurate local position estimation than the INS-only.Nevertheless,the system still must rely on the global positions to eliminate the accumulated errors.In this contribution,we present a semi-tight coupling framework of multi-GNSS PPP and Stereo VINS(S-VINS),which achieves the bidirectional location transfer and sharing in two separate navigation systems.In our approach,the local positions,produced by S-VINS are integrated with multi-GNSS PPP through a graph-optimization based method.Furthermore,the accurate forecast positions with S-VINS are fed back to assist PPP in GNSS-challenged environments.The statistical analysis of a GNSS outage simulation test shows that the S-VINS mode can effectively suppress the degradation of positioning accuracy compared with the INS-only mode.We also carried out a vehicle-borne experiment collecting multi-sensor data in a GNSS-challenged environment.For the complex driving environment,the PPP positioning capability is significantly improved with the aiding of S-VINS.The 3D positioning accuracy is improved by 49.0%for Global Positioning System(GPS),40.3%for GPS+GLOANSS(Global Navigation Satellite System),45.6%for GPS+BDS(BeiDou navigation satellite System),and 51.2%for GPS+GLONASS+BDS.On this basis,the solution with the semi-tight coupling scheme of multi-GNSS PPP/S-VINS achieves the improvements of 41.8-60.6%in 3D position-ing accuracy compared with the multi-GNSS PPP/INS solutions. | Xingxing Li Xuanbin Wang Jianchi Liao Xin Li Shengyu Li Hongbo Lyu | 2021 | Satellite Navigation2021，2，1： | 10 |
| 6 | Changes in palaeoproductivity of Genggahai Lake over the past 16 ka in the Gonghe Basin,northeastern Qinghai-Tibetan Plateau显示文摘Sequential samples of a 7.82-m sediment core from Genggahai Lake in the central Gonghe Basin,controlled with 12 accelerator mass spectrometry (AMS) 14 C dates,have been analysed for total organic carbon (TOC) and total nitrogen (TN) contents,carbon isotope of bulk organic matter (δ 13 C org),and carbonate content.Plant macrofossils and stem encrustations,derived mainly from the species of P.pectinatus,M.spicatum and Chara spp.,were identified,and they dominated the aquatic plant community of the lake.Alternations of plant macrofossils of Chara spp.and the vascular species reflect the changing productivity of the lake over time.In such a shallow lake,the carbonate content is highly related to photosynthesis of aquatic macrophytes and thus indirectly indicates variations in productivity,consistent with a quantitative estimate of palaeoproductivity.Based on these results,the palaeoproductivity history was reconstructed over the past ca.16 ka.The lake was formed or recharged at 15.3 cal ka BP,as indicated by aeolian sand deposits at the core base.A marked increase in palaeoproductivity occurred from 15.3 to 11.6 cal ka BP.Between 11.6 and 9.2 cal ka BP,a sharply increased water-level,modulated probably by the enhanced Asian summer monsoon,might have exceeded the optimum water depth for macrophyte vegetation,causing a marked decline in coverage of aquatic macrophytes and low palaeoproductivity.The palaeoproductivity appeared to be high in the early stage of the period from 9.2 to 7.4 cal ka BP,and then decreased at approximately 8.6 cal ka BP.The palaeoproductivity sustained an overall high level between 7.4 and 2.1 cal ka BP,and decreased gradually since 2.1 cal ka BP.Our results suggest that the variability of Genggahai Lake palaeoproductivity may be associated with fluctuations of the lake level controlled by the strength of the Asian summer monsoon,probably indicating changes in the Asian summer monsoon. | SONG Lei QIANG MingRui LANG LiLi LIU XingXing WANG Qin LI MingZhi | 2012 | Chinese Science Bulletin2012，57，20： | 9 |
| 7 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 8 | The computational fluid dynamic modeling of downwash flow field for a six-rotor UAV显示文摘The downwash flow field of the multi-rotor unmanned aerial vehicle(UAV), formed by propellers during operation, has a significant influence on the deposition, drift and distribution of droplets as well as the spray width of the UAV for plant protection. To study the general characteristics of the distribution of the downwash airflow and simulate the static wind field of multi-rotor UAVs in hovering state, a 3 D full-size physical model of JF01-10 six-rotor plant protection UAV was constructed using Solid Works. The entire flow field surrounding the UAV and the rotation flow fields around the six rotors were established in UG software. The physical model and flow fields were meshed using unstructured tetrahedral elements in ANSYS software.Finally, the downwash flow field of UAV was simulated.With an increased hovering height, the ground effect was reduced and the minimum current velocity increased initially and then decreased. In addition, the spatial proportion of the turbulence occupied decreased. Furthermore, the appropriate operational hovering height for the JF01-10 is considered to be 3 m. These results can be applied to six-rotor plant protection UAVs employed in pesticide spraying and spray width detection. | Yongjun ZHENG Shenghui YANG Xingxing LIU Jie WANG Tomas NORTON Jian CHEN Yu TAN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 8 |
| 9 | A review:Photonics devices,architectures,and algorithms for optical neural computing显示文摘The explosive growth of data and information has motivated various emerging non-von Neumann computational approaches in the More-than-Moore era.Photonics neuromorphic computing has attracted lots of attention due to the fascinating advantages such as high speed,wide bandwidth,and massive parallelism.Here,we offer a review on the optical neural computing in our research groups at the device and system levels.The photonics neuron and photonics synapse plasticity are presented.In addition,we introduce several optical neural computing architectures and algorithms including photonic spiking neural network,photonic convolutional neural network,photonic matrix computation,photonic reservoir computing,and photonic reinforcement learning.Finally,we summarize the major challenges faced by photonic neuromorphic computing,and propose promising solutions and perspectives. | Shuiying Xiang Yanan Han Ziwei Song Xingxing Guo Yahui Zhang Zhenxing Ren Suhong Wang Yuanting Ma Weiwen Zou Bowen Ma Shaofu Xu Jianji Dong Hailong Zhou Quansheng Ren Tao Deng Yan Liu Genquan Han Yue Hao | 2021 | Journal of Semiconductors2021，42，2： | 7 |
| 10 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 11 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 12 | Determination of Eight Organophosphorus Pesticide Residues in Pepper by QuEChERS-Gas Chromatography显示文摘[Objectives] This study was conducted to establish a QuEChERS-gas chromatography method for determination of eight kinds of organophosphorus pesticide residues in pepper. [Methods] The samples were extracted by acetonitrile,and anhydrous magnesium sulfate was used for salting out. The extracts were then purified by dispersive solid phase extraction combining with GCB,C18 and PSA. Samples were analyzed by FPD detector. External standard was used as quantitive method. [Results]The detection limits were in the range of 0. 001-0. 008 mg/kg,the average recoveries ranged from 83. 5% to 101. 2%,and the relative standard deviation( RSD) of the eight organophosphorus pesticide residues were below 5%. [Conclusions] The method is simple,quick,easy and effective for the determination of pepper. | Siyuan BI Zhiqiang ZHU Wenhua CHI Mingshan CHEN Xingxing WANG Shouan ZHOU | 2018 | Agricultural Biotechnology2018，7，1： | 7 |
| 13 | MODIS-based Daily Lake Ice Extent and Coverage dataset for Tibetan Plateau显示文摘The Tibetan Plateau houses numerous lakes,the phenology and duration of lake ice in this region are sensitive to regional and global climate change,and as such are used as key indicators in climate change research,particularly in environment change comparison studies for the Earth three poles.However,due to its harsh natural environment and sparse population,there is a lack of conventional in situ measurement on lake ice phenology.The Moderate Resolution Imaging Spectroradiometer(MODIS)Normalized Difference Snow Index(NDSI)data,which can be traced back 20 years with a 500 m spatial resolution,were used to monitor lake ice for filling the observation gaps.Daily lake ice extent and coverage under clear-sky conditions was examined by employing the conventional SNOWMAP algorithm,and those under cloud cover conditions were re-determined using the temporal and spatial continuity of lake surface conditions through a series of steps.Through time series analysis of every single lake with size greater than 3 km2 in size,308 lakes within the Tibetan Plateau were identified as the effective records of lake ice extent and coverage to form the Daily Lake Ice Extent and Coverage dataset,including 216 lakes that can be further retrieved with four determinable lake ice parameters:Freeze-up Start(FUS),Freeze-up End(FUE),Break-up Start(BUS),and Break-up End(BUE),and 92 lakes with two parameters,FUS and BUE.Six lakes of different sizes and locations were selected for verification against the published datasets by passive microwave remote sensing.The lake ice phenology information obtained in this paper was highly consistent with that from passive microwave data at an average correlation coefficient of 0.91 and an RMSE value varying from 0.07 to 0.13.The present dataset is more effective at detecting lake ice parameters for smaller lakes than the coarse resolution passive microwave remote sensing observations.The published data are available in http://gffzz324c53c67c144612sxv5o6ocuvk9n6o0p.ffgz.tsg.suse.edu.cn/repository/uuid:fdfd8c76-6b7c-4bbf-aec8-98ab199d9093 and http://gffzzc14d9fd2be724b39hxv5o6ocuvk9n6o0p.ffgz.tsg.suse.edu.cn/dataSet/handle/744. | Yubao Qiu Pengfei Xie Matti Leppäranta Xingxing Wang Juha Lemmetyinen Hui Lin Lijuan Shi | 2019 | Big Earth Data2019，3，2： | 7 |
| 14 | Genome-wide identification of OSCA gene family and their potential function in the regulation of dehydration and salt stress in Gossypium hirsutum显示文摘Background:Cotton(Gossypium hirsutum) provides the largest natural fiber for the textile manufacturing industries,but its production is on the decline due to the effects of salinity.Soil salt-alkalization leads to damage in cotton growth and a decrease in yields.Hyperosmolality-gated calcium-permeable channels(OSCA) have been found to be involved in the detection of extracellular changes which trigger an increase in cytosolic free calcium concentration.Hyperosmolality-induced calcium ion increases have been widely speculated to be playing a role in osmosensing in plants.However,the molecular nature of the corresponding calcium ion channels remains unclearly.In this research work,we describe the OSCA genes and their putative function in osmosensing in plants by carrying out genomewide identification,characterization and functional analysis of the significantly up-regulated OSCA gene,GhOSCA1.1 through reverse genetics.Result:A total of 35,21 and 22 OSCA genes were identified in G.hirsutum,G.arboreum,and G.raimondii genomes,respectively,and were classified into four different clades according to their gene structure and phylogenetic relationship.Gene and protein structure analysis indicated that 35 GhOSCA genes contained a conserved RSN17 TM(PF02714) domain.Moreover,the cis-regulatory element analysis indicated that the OSCA genes were involved in response to abiotic stress.Furthermore,the knockdown of one of the highly up-regulated genes,GhOSCA1.1 showed that the virus-induced gene silenced(VIGS) plants were highly sensitive to dehydration and salinity stresses compared with the none VIGS plants as evident with higher concentration levels of oxidant enzymes compared with the antioxidant enzymes on the leaves of the stressed plants.Conclusion:This study provides the first systematic analysis of the OSCA gene family and will be important for understanding the putative functions of the proteins encoded by the OSCA genes in cotton.These results provide a new insight of defense responses in general and lay the foundation for further investigation of the molecular role played by the OSCA genes,thereby providing suitable approaches to improve crop performance under salinity and drought stress conditions. | YANG Xiu XU Yanchao YANG Fangfang MAGWANGA Richard Odongo CAI Xiaoyan WANG Xingxing WANG Yuhong HOU Yuqing WANG Kunbo LIU Fang ZHOU Zhongli | 2019 | Journal of Cotton Research2019，2，2： | 7 |
| 15 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 16 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 17 | Glycerol carbonate synthesis from glycerol and dimethyl carbonate using guanidine ionic liquids显示文摘A large number of surplus glycerol from the biodiesel production can be used as renewable feedstock to produce glycerol carbonate. In this paper, a series of guanidine-based ionic liquids were synthesized to catalyze the transesterification of glycerol and dimethyl carbonate. The tunable basicity and the anion–cation cooperative effect were responsible for the obtained results. The [TMG][TFE] showed the best activity turnover frequency(TOF)of 1754.0 h^(-1), glycerol(GL) conversion of 91.8%, glycerol carbonate(GC) selectivity of 95.5%) at 80 °C with 0.1 mol% catalyst for 30 min. The reaction mechanism of the transesterification was also proposed. | Xingxing Wang Peng Zhang Penglei Cui Weiguo Cheng Suojiang Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 5 |
| 18 | Spatiotemporal variations of deep-sea sediment components and their fluxes since the last glaciation in the northern South China Sea显示文摘Sediment components and their fluxes of Cores MD12-3428(water depth: 903 m), MD12-3433(water depth: 2125 m),and MD12-3434(water depth: 2995 m), obtained along a transect on the continental slope of the northern South China Sea, have been conducted to reveal the spatiotemporal variations and the controlling factors of the sediment components and of their fluxes.Results show that deep-sea sediments in the northern South China Sea are composed mainly of terrigenous(59–89%) and carbonate(6–38%) particles, with minor components of opal(1.6–9.4%) and organic matter(0.7–1.9%). Fluxes of terrigenous and carbonate particles reach up to 2.4–21.8 and 0.4–6.5 g cm–2 kyr–1, respectively, values that are one to two orders of magnitude higher than the fluxes of opal and organic matter. Temporal variations of the percentages and fluxes of deep-sea sediment components have displayed clear glacial-interglacial cyclicity since the last glaciation. Terrigenous, opal, and organic matter percentages and their fluxes increas clearly during marine isotope stage 2, while carbonate percentages and fluxes show an opposite variation pattern or are characterized by an unremarkable increase. This implies that deep-sea carbonate in the South China Sea is affected by the dilution of terrigenous inputs during the sea-level lowstand. With increasing water depth along the transect, the terrigenous percentage increases but with largely decreased fluxes. Both the percentage and flux of carbonate decrease, while the percentages and fluxes of opal and organic matter display much more complicated variational features. The spatiotemporal variations of deep-sea sediment components and of their fluxes since the last glaciation in the northern South China Sea are strongly controlled by sea-level fluctuations. Simultaneously, terrigenous supply associated with monsoonal rainfall, marine primary productivity,and the dilution effect between terrigenous and biogenic particles, also play interconnected roles in the sediment accumulation processes. | ZHAO ShaoHua LIU ZhiFei CHEN Quan WANG XingXing SHI JiangNan JIN HaiYan LIU JingJing JIAN ZhiMin | 2017 | Science China Earth Sciences2017，60，7： | 5 |
| 19 | Development of Cementitious Materials Utilizing Alkali-activated Yellow River Silt显示文摘The possibility of preparing cementitious materials by the alkali-activated method using Yellow River sediment(The second largest river in China)as raw material and the modification effect on different slag addition were investigated.Sodium silicate and calcium hydroxide were used as the activator,and the specimens were prepared by the press molding method.The hydration process,hydration products,pore characteristics,and mechanical properties were investigated using SEM/EDS,FTIR,TG/DTG,XRD,MIP,and uniaxial compressive strength experiments,respectively.The results showed that the compressive strength of the modified yellow river silt-based cementitious material was significantly increased when the water glass dosage was 12 wt%(Ms=1.8)and the slag dosage was 40%,and its 90-day maximum compressive strength could reach 53 MPa. | 王宝民 WANG Wanli 梁晓霞 刘慧 HAN Junnan ZHAO Lu YANG Xingxing YAN Jifei | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 5 |
| 20 | Effect of precipitation pH and coexisting magnesium ion on phosphate adsorption onto hydrous zirconium oxide显示文摘To understand the effect of precipitation pH and coexisting Mg^(2+) on phosphate adsorption onto zirconium oxide(ZrO_2), ZrO_2 particles precipitated at pH 5.3, 7.1 and 10.5, i.e., ZrO_2(5.3), ZrO_2(7.1)and ZrO_2(10.5), respectively were prepared and characterized, then their adsorption performance and mechanism in the absence and presence of Mg^(2+) were comparatively investigated in this study. The results showed that the Elovich, pseudo-second-order and Langmuir isotherm models correlated with the experimental data well. The adsorption mechanism involved the complexation between phosphate and zirconium. Coexisting Mg^(2+) slightly inhibited the adsorption of phosphate on ZrO_2(5.3), including the adsorption capacity and rate, but coexisting Mg^(2+) greatly increased the adsorption capacity and rate for ZrO_2(7.1)and ZrO_2(10.5). The enhanced adsorption of phosphate on ZrO_2(7.1) and ZrO_2(10.5) in the presence of Mg^(2+) was mainly due to the formation of Mg^(2+)-HPO_4^(2-) ion pair(MgHPO_4~0) in the solution and then the adsorption of MgHPO_4~0 on the adsorbent surface, forming the phosphatebridged ternary complex Zr(OPO_3H)Mg. In the absence of Mg^(2+) , the maximum phosphate adsorption capacity at pH 7 calculated from the Langmuir isotherm model decreased in the order of ZrO 2(7.1)(67.3 mg/g) > ZrO_2(5.3)(53.6 mg/g) ≈ ZrO_2(10.5)(53.1 mg/g), but it followed the order of Zr O2(7.1)(97.0 mg/g) > ZrO_2(10.5)(79.7 mg/g) > ZrO_2(5.3)(51.3 mg/g) in the presence of Mg^(2+) . The results of this work suggest that ZrO_2(7.1) is more suitable for use as an adsorbent for the effective removal of phosphate from municipal wastewater than ZrO_2(5.3) and ZrO_2(10.5),because Mg^(2+) is generally present in this wastewater. | Jianwei Lin Xingxing Wang Yanhui Zhan | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
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