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| 1 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 2 | Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms显示文摘Traumatic brain injury induces potent inflammatory responses that can exacerbate secondary blood-brain barrier(BBB) disruption, neuronal injury, and neurological dysfunction. Dexmedetomidine is a novel α2-adrenergic receptor agonist that exert protective effects in various central nervous system diseases. The present study was designed to investigate the neuroprotective action of dexmedetomidine in a mouse traumatic brain injury model, and to explore the possible mechanisms. Adult male C57 BL/6 J mice were subjected to controlled cortical impact. After injury, animals received 3 days of consecutive dexmedetomidine therapy(25 μg/kg per day). The modified neurological severity score was used to assess neurological deficits. The rotarod test was used to evaluate accurate motor coordination and balance. Immunofluorescence was used to determine expression of ionized calcium binding adapter molecule-1, myeloperoxidase, and zonula occluden-1 at the injury site. An enzyme linked immunosorbent assay was used to measure the concentration of interleukin-1β(IL-1β), tumor necrosis factor α, and IL-6. The dry-wet weight method was used to measure brain water content. The Evans blue dye extravasation assay was used to measure BBB disruption. Western blot assay was used to measure protein expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3), caspase-1 p20, IL-1β, nuclear factor kappa B(NF-κB) p65, occluding, and zonula occluden-1. Flow cytometry was used to measure cellular apoptosis. Results showed that dexmedetomidine treatment attenuated early neurological dysfunction and brain edema. Further, dexmedetomidine attenuated post-traumatic inflammation, up-regulated tight junction protein expression, and reduced secondary BBB damage and apoptosis. These protective effects were accompanied by down-regulation of the NF-κB and NLRP3 inflammasome pathways. These findings suggest that dexmedetomidine exhibits neuroprotective effects against acute(3 days) post-traumatic inflammatory responses, potentially via suppression of NF-κB and NLRP3 inflammasome activation. | Dong Wang Xin Xu Yin-Gang Wu Li Lyu Zi-Wei Zhou Jian-Ning Zhang | 2018 | Neural Regeneration Research2018，13，5： | 19 |
| 3 | Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease显示文摘Forest bathing trip is a short,leisurely visit to forest.In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease(COPD).The patients were randomly divided into two groups.One group was sent to forest,and the other was sent to an urban area as control. | JIA Bing Bing YANG Zhou Xin MAO Gen Xiang LYU Yuan Dong WEN Xiao Lin XU Wei Hong LYU XIAO Ling CAO Yong Bao WANG Guo Fu | 2016 | Biomedical and Environmental Sciences2016，29，3： | 15 |
| 4 | Semi-tightly coupled integration of multi-GNSS PPP and S-VINS for precise positioning in GNSS-challenged environments显示文摘Because of its high-precision,low-cost and easy-operation,Precise Point Positioning(PPP)becomes a potential and attractive positioning technique that can be applied to self-driving cars and drones.However,the reliability and availability of PPP will be significantly degraded in the extremely difficult conditions where Global Navigation Satellite System(GNSS)signals are blocked frequently.Inertial Navigation System(INS)has been integrated with GNSS to ameliorate such situations in the last decades.Recently,the Visual-Inertial Navigation Systems(VINS)with favorable complementary characteristics is demonstrated to realize a more stable and accurate local position estimation than the INS-only.Nevertheless,the system still must rely on the global positions to eliminate the accumulated errors.In this contribution,we present a semi-tight coupling framework of multi-GNSS PPP and Stereo VINS(S-VINS),which achieves the bidirectional location transfer and sharing in two separate navigation systems.In our approach,the local positions,produced by S-VINS are integrated with multi-GNSS PPP through a graph-optimization based method.Furthermore,the accurate forecast positions with S-VINS are fed back to assist PPP in GNSS-challenged environments.The statistical analysis of a GNSS outage simulation test shows that the S-VINS mode can effectively suppress the degradation of positioning accuracy compared with the INS-only mode.We also carried out a vehicle-borne experiment collecting multi-sensor data in a GNSS-challenged environment.For the complex driving environment,the PPP positioning capability is significantly improved with the aiding of S-VINS.The 3D positioning accuracy is improved by 49.0%for Global Positioning System(GPS),40.3%for GPS+GLOANSS(Global Navigation Satellite System),45.6%for GPS+BDS(BeiDou navigation satellite System),and 51.2%for GPS+GLONASS+BDS.On this basis,the solution with the semi-tight coupling scheme of multi-GNSS PPP/S-VINS achieves the improvements of 41.8-60.6%in 3D position-ing accuracy compared with the multi-GNSS PPP/INS solutions. | Xingxing Li Xuanbin Wang Jianchi Liao Xin Li Shengyu Li Hongbo Lyu | 2021 | Satellite Navigation2021，2，1： | 10 |
| 5 | Psychophysiological Effects of Bamboo Plants on Adults显示文摘The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic(female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic(female,P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate(female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation(all P < 0.05) and lower anxiety scores(P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults. | Ahmad Hassan CHEN Qi Bing JIANG Tao LYU Bing Yang LI Nian LI Shu SHANGGUAN Zi Yue LI Yun Ting JUN Zhou Li LUO Qian CHEN Xin Yi WANG Yi Yan ZENG Cheng Cheng YANG Jun Muhammad Sohaib Tahir | 2017 | Biomedical and Environmental Sciences2017，30，11： | 8 |
| 6 | Spatial and Temporal Evolution of Surface Subsidence in Tianjin from 2015 to 2020 Based on SBAS-InSAR Technology显示文摘Tianjin is one of the inland cities with the most severe cases of subsidence hazard in China.The majority of the existing studies have mainly focused on Beijing-Tianjin-Hebei,and little attention has been given to Tianjin.In addition,these existing studies are short-term investigations,lacking long-term monitoring of surface subsidence.In the present study,we use the Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-InSAR)technique to monitor the subsidence process in Tianjin between 2015 and 2020 and reveal its spatial and temporal variation.We divided the 44-view Sentinel-1A image data into three periods to avoid the effect of temporal and spatial decoherence by extracting the surface deformation field in Tianjin.We finally verified the accuracy and reliability of the inversion results using second-order leveling data.Results showed that the correlation coefficient r between the two reached 0.89,and the root mean square error was 4.84 mm/y.Obvious subsidence funnels exist in Tianjin,mainly in the towns of Wangqingtuo and Shengfang.These subsidence funnels have a subsidence deformation rate of-136.2 mm/y and a maximum cumulative settlement of-346.3 mm within the study period.The subsidence area tends to extend to the southwest.The analysis of annual rainfall,groundwater resource extraction,spatial location distribution of industrial areas combined with SBAS-InSAR inversion results indicates that overextraction of groundwater resources is the main cause of land subsidence in the area.Therefore,strict control of groundwater extraction is the main approach to mitigate land subsidence effectively. | Lyu ZHOU Yizhan ZHAO Zilin ZHU Chao REN Fei YANG Ling HUANG Xin LI | 2022 | Journal of Geodesy and Geoinformation Science2022，5，1： | 8 |
| 7 | Association between Perceived Stressfulness of Stressful Life Events and the Suicidal Risk in Chinese Patients with Major Depressive Disorder显示文摘 | Jing-Yu Lin Yu Huang Yun-Ai Su Xin Yu Xiao-Zhen Lyu Qi Liu Tian-Mei Si | 2018 | Chinese Medical Journal2018，，8： | 7 |
| 8 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 9 | A novel experience of deferential vessel-sparing microsurgical vasoepididymostomy显示文摘Microsurgical 纵的摄取 vasoepididymostomy (实时) 广泛地被用来对待 epididymal 妨碍的精子缺乏自从 2004。尽管恭敬 vasculature 在供应血到睾丸和 epididymis 起一个重要作用,注意对潜力被给予了的很少在吻合期间 sparing 有益于恭敬容器在实时。这研究试图在人现场评估恭敬容器圆材的功效和安全。从 2013 年 12 月到 2015 年 12 月,有 epididymal 阻塞的 69 个 azoospermic 人在孙中山大学的首先隶属于的医院里现场由于生殖器的感染,损伤,或自发的因素经历了恭敬容器圆材,广州,中国。这些病人的结果回顾地被分析。吝啬的年龄为他们的搭挡是为人和 28.3 年的 31.1 年。59 (85.5% , 59/69 ) 人们被跟随在上面在为约 16 个月的外科以后。明显被精液分析注意并且证实(> 10 000 sperm/ml ) 在 83.1%(49/59 ) 人。自然怀孕率是 40.7%(24/59 ) 在学习底,(21/24 ) 与 87.5% ,这些,自然怀孕在外科以后在 12 以内完成了月。没有严重不利事件或复杂并发症被观察。在这研究,我们在场为 sparing 的一种新奇技术恭敬容器在期间生活。初步的结果显示这种技术与有利明显和怀孕率安全。 | Kun-Long Lyu Jin-Tao Zhuang Philip S Li Yong Gao Liang Zhao Ya-Dong Zhang Ming-Kuan Zhou Jing-Wei Yu Xin Feng Xiang-Zhou Sun Chun-Hua Deng Xiang-An Tu | 2018 | Asian Journal of Andrology2018，20，6： | 6 |
| 10 | Outlier screening for ironmaking data on blast furnaces显示文摘Blast furnace data processing is prone to problems such as outliers.To overcome these problems and identify an improved method for processing blast furnace data,we conducted an in-depth study of blast furnace data.Based on data samples from selected iron and steel companies,data types were classified according to different characteristics;then,appropriate methods were selected to process them in order to solve the deficiencies and outliers of the original blast furnace data.Linear interpolation was used to fill in the divided continuation data,the Knearest neighbor(KNN)algorithm was used to fill in correlation data with the internal law,and periodic statistical data were filled by the average.The error rate in the filling was low,and the fitting degree was over 85%.For the screening of outliers,corresponding indicator parameters were added according to the continuity,relevance,and periodicity of different data.Also,a variety of algorithms were used for processing.Through the analysis of screening results,a large amount of efficient information in the data was retained,and ineffective outliers were eliminated.Standardized processing of blast furnace big data as the basis of applied research on blast furnace big data can serve as an important means to improve data quality and retain data value. | Jun Zhao Shao-fei Chen Xiao-jie Liu Xin Li Hong-yang Li Qing Lyu | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，6： | 5 |
| 11 | Assessment of FY-4A and Himawari-8 Cloud Top Height Retrieval through Comparison with Ground-Based Millimeter Radar at Sites in Tibet and Beijing显示文摘The accuracy of passive satellite cloud top height (CTH) retrieval shows regional dependence. This paper assesses the CTH derived from the FY-4A and Himawari-8 satellites through comparison with those from the ground-based millimeter radar at two sites: Yangbajing, Tibet, China (YBJ), and the Institute of Atmospheric Physics (IAP), Beijing, China. The comparison shows that Himawari-8 missed more CTHs at night than FY-4A, especially at YBJ. It is found that the CTH difference (CTHD;radar CTH minus satellite CTH) for FY-4A and Himawari-8 is 0.06 ± 1.90 km and −0.02 ± 2.40 km at YBJ respectively, and that is 0.93 ± 2.24 km and 0.99 ± 2.37 km at IAP respectively. The discrepancy between the satellites and radar at IAP is larger than that at YBJ. Both satellites show better performance for mid-level and low-level clouds than for high-level clouds at the two sites. The retrievals from FY-4A agree well with those from Himawari-8, with a mean difference of 0.08 km at YBJ and 0.06 km at IAP. It is found that the CTHD decreases as the cloud depth increases at both sites. However, the CTHD has no obvious dependence on cloud layers and fractions. Investigations show that aerosol concentration has little impact on the CTHD. For high and thin clouds, the CTHD increases gradually with the increase of the surface temperature, which might be a key factor causing the regional discrepancy between IAP and YBJ. | Bo LIU Juan HUO Daren LYU Xin WANG | 2021 | Advances in Atmospheric Sciences2021，38，8： | 5 |
| 12 | Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease显示文摘Background::Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD.Methods::Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by 'cardio-cerebral AS burden (CCAB)' as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models.Results::A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD ( r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063;95% confidence interval, 7.572-16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397). Conclusions::Plasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD. | Kong Qi Ma Xin Lyu Jun-Xuan Wang Chen Du Xiang-Ying Guan Yun-Qian | 2020 | Chronic Diseases and Translational Medicine2020，6，1： | 5 |
| 13 | Effect of high temperature on compression property and deformation recovery of ceramic fiber reinforced silica aerogel composites显示文摘Ceramic fiber reinforced silica aerogel composites are novel insulation materials in the thermal protection field for hypersonic vehicles. Before the aerogel composites are applied in load-bearing structures, it is necessary to investigate their mechanical properties including load-bearing and deformation recovery capabilities. High temperature from service conditions will have important effects on the mechanical properties of thermal protection materials. In this paper, compression tests including loading and unloading stages were conducted for ceramic fiber reinforced silica aerogel composites at room temperature and elevated temperatures(300℃, 600℃ and 900℃). Influences of thermal exposure to high temperature and high temperature service environment on the compression property and deformation recovery were both investigated. Scanning electron microscopy(SEM), Fourier transform infrared spectroscopy(FT-IR) and X-ray diffraction(XRD) were applied to help understand the mechanisms of mechanical property variations. The experimental results show that the compression modulus and strength both increase with the increasing thermal exposure temperature and testing temperature,but the deformation recovery capability decreases. The micro structure changes caused by thermal sintering are considered as the main reason for the property variations.Viscous flow and matter transport due to high temperature resulted in the fusion of aerogel particles. This made the particle skeleton thicker and stronger, which led to higher stiffness and strength of the composites. However, matrix cracks induced by the formation and fracture of larger pores made unrecoverable deformation more serious. In the tests at elevated temperatures,the aggregation of aerogel particles in a fused state got more severe because of the addition of mechanical load. As a result, the degradation of deformation recovery capability became more significant. | LYU ShuangQi YANG XiaoGuang SHI DuoQi QI HongYu JING Xin LI ShaoLin | 2017 | Science China(Technological Sciences)2017，60，11： | 4 |
| 14 | MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients显示文摘充满半胱氨酸的能分泌的蛋白质(CRISP2 ) 2 是在在 modulating 精子 flagellar 活动性, acrosome 反应,和配偶子熔化起作用的精子的重要蛋白质。精子缺乏 CRISP2 展览低精子活动性和反常形态学。然而,在 asthenoteratozoospermia (ATZ ) 位于 CRISP2 的减小下面的分子的机制仍然保持未知。在这研究, CRISP2 蛋白质而非它的 mRNA 的低表示作为与 normozoospermic 男性相比从 ATZ 病人在呼喊的精子被观察。随后,生物信息的预言,酶记者试金,和 microRNA-27a (miR-27a ) transfection 实验表明 miR-27a 明确地由绑定指向 CRISP2 到它的 3 untranslated 区域(3-UTR ) , posttranscriptionally 压制 CRISP2 表示。进一步的证据被高 miR-27a 表示的临床的观察从在 miR-27a 表示和 CRISP2 蛋白质表示之间的 ATZ 病人和否定关联在呼喊的精子提供。最后,回顾的后续研究支持了那两高 miR-27a 表情和低 CRISP2 蛋白质表示与低进步精子活动性,反常形态学,和不孕被联系。这研究在 ATZ 表明为减少的 CRISP2 表示负责的新奇机制,它可以为对待男不孕,或为男避孕提供一个潜在的治疗学的目标。 | Jun-Hao Zhou Qi-Zhao Zhou Jian-Kun Yang Xiao-Ming Lyu Jun Bian Wen-Bin Guo Zi-Jian Chen Ming Xia Hui Xia Tao Qi Xin Li Cun-Dong Liu | 2017 | Asian Journal of Andrology2017，19，5： | 4 |
| 15 | Responses of biotic interactions of dominant and subordinate species to decadal warming and simulated rotational grazing in Tibetan alpine meadow显示文摘Warming increases competition among plant species in alpine communities by ameliorating harsh environmental conditions,such as low temperatures. Grazing, as the main human activity, may mitigate the effect of warming, as previously reported.However, it is critical to refine the effects of warming on biotic interactions among species, for example, by taking the competitive ability of species into consideration. Based on a 10-year warming and grazing experiment in a Tibetan alpine meadow, we evaluated interspecific biotic interactions of dominant and subordinate species, using the approach of interspecific spatial associations. Warming significantly increased competition between subordinate and dominant species as well as among subordinate species, but not among dominant species. Moreover, facilitation of dominant-subordinate species also increased under warming. Simulated rotational grazing had similar effects to warming, with increasing interspecific competition. Our results show that, when studying the effects of warming on biotic interactions among species, it is necessary to characterize different species pairs relative to their competitive ability, and that simulated rotational grazing does not mitigate the effects of warming in the long term. Our results also provide evidence that the spatial pattern of species is a critical mechanism in species coexistence. | Xin'e Li Xiaoxue Zhu Shiping Wang Shujuan Cui Caiyun LUO Zhenhua Zhang Lirong Zhang Lili Jiang Wangwang Lyu | 2018 | Science China(Life Sciences)2018，61，7： | 4 |
| 16 | Principle and performance of multi-frequency and multi-GNSS PPP-RTK显示文摘PPP-RTK which takes full advantages of both Real-Time Kinematic(RTK)and Precise Point Positioning(PPP),is able to provide centimeter-level positioning accuracy with rapid integer Ambiguity Resolution(AR).In recent years,with the development of BeiDou Navigation Satellite System(BDS)and Galileo navigation satellite system(Galileo)as well as the modernization of Global Positioning System(GPS)and GLObal NAvigation Satellite System(GLONASS),more than 140 Global Navigation Satellite System(GNSS)satellites are available.Particularly,the new-generation GNSS satellites are capable of transmitting signals on three or more frequencies.Multi-GNSS and multi-frequency observations become available and can be used to enhance the performance of PPP-RTK.In this contribution,we develop a multi-GNSS and multi-frequency PPP-RTK model,which uses all the available GNSS observations,and comprehensively evaluate its performance in urban environments from the perspectives of positioning accuracy,convergence and fxing percentage.In this method,the precise atmospheric corrections are derived from the multi-frequency and multi-GNSS observations of a regional network,and then disseminated to users to achieve PPP rapid AR.Furthermore,a cascade ambiguity fxing strategy using Extra‐Wide‐Lane(EWL),Wide-Lane(WL)and L1 ambiguities is employed to improve the performance of ambiguity fxing in the urban environments.Vehicle experiments in diferent scenarios such as suburbs,overpasses,and tunnels are conducted to validate the proposed method.In suburbs,an accuracy of within 2 cm in the horizontal direction and 4 cm in the vertical direction,with the fxing percentage of 93.7%can be achieved.Compared to the GPS-only solution,the positioning accuracy is improved by 87.6%.In urban environments where signals are interrupted frequently,a fast ambiguity re-fxing can be achieved within 5 s.Moreover,multifrequency GNSS signals can further improve the positioning performance of PPP-RTK,particularly in the case of small amount of observations.These results demonstrate that the multi-frequency and multi-GNSS PPP-RTK is a promising tool for supporting precise vehicle navigation. | Xingxing Li Bo Wang Xin Li Jiaxin Huang Hongbo Lyu Xinjuan Han | 2022 | Satellite Navigation2022，3，1： | 3 |
| 17 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 18 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 19 | Epidemiological Characteristics of Plague in the Meriones unguiculatus Plague Focus--Inner Mongolia Autonomous Region,China,1950−2019显示文摘From 1950 to 2019,a total of 267 plague cases in humans were reported in the Inner Mongolia Autonomous Region with 133 deaths and 10,710 Yersinia pestis isolates;21 of these cases were reported from the Meriones unguiculatus(M.unguiculatus)plague focus with 6 deaths and 6,771 isolates.According to the plague situation in the Inner Mongolia Autonomous Region and the implementation of local preventive measures,the prevalence of plague in humans in the M.unguiculatus plague focus of the Inner Mongolia Autonomous Region could be divided into four stages.The first stage was the initial stage of plague prevention and control(1950–1959),with 0.80 cases annually and a case fatality rate of 37.50%.The second stage was the plague eradication stage(1960–1979),with 0.15 cases annually and a case fatality rate of 33.33%.The third stage was the plague surveillance stage(1980-1999),with 0.25 cases annually and a case fatality rate of 20.00%.The fourth stage is the comprehensive prevention and control stage under the emergency system(2000-2019),with 0.25 cases annually and a case fatality rate of 20.00%.The surveillance of rodent density(1981-2019)and studies on plague-related factors among M.unguiculatus have shown that the higher the M.unguiculatus density,the higher the nocturnal rodent capture rate(r=0.670,p<0.05)and the higher the indirect hemagglutination assay(IHA)positive rate of M.unguiculatus(r=0.344,p<0.05);the higher the percentage of hosts infected,the lower the M.unguiculatus density(r=-0.361,p<0.05)and the lower the IHA positive rate of M.unguiculatus(r=-0.337,p<0.05);the higher the percentage of nests infected with fleas,the lower the IHA positive rate of M.unguiculatus(r=-0.348,p<0.05).Together,these results suggest that it is necessary to simultaneously monitor the pathogens,serology,and vector index of M.unguiculatus to accurately reflect the plague prevalence among local animals.Although bubonic plague is the main plague type of the M.unguiculatus plague focus,severe pneumonic plague or septic plague may be secondary when the bubonic plague is misdiagnosed or not treated in time.In addition,the plague in animals is relatively virulent in the M.unguiculatus plague focus,and the risk of spreading to humans is higher.For plague in the Inner Mongolia Autonomous Region,comprehensive control efforts should be aimed at the M.unguiculatus focus,covering host animals,vector insects,and humans. | Boxi Liu Dayu Zhang Yuhuang Chen Zhaokai He Jun Liu Dongyue Lyu Weiwei Wu Ran Duan Shuai Qin Junrong Liang Huaiqi Jing Xin Wang | 2020 | China CDC weekly2020，2，49： | 3 |
| 20 | Risk prediction models for lung cancer:Perspectives and dissemination显示文摘Objective: The objective was to systematically assess lung cancer risk prediction models by critical evaluation of methodology, transparency and validation in order to provide a direction for future model development.Methods: Electronic searches(including PubMed, EMbase, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure, Wanfang, the Chinese BioMedical Literature Database, and other official cancer websites) were completed with English and Chinese databases until April 30 th, 2018. Main reported sources were input data, assumptions and sensitivity analysis. Model validation was based on statements in the publications regarding internal validation, external validation and/or cross-validation.Results: Twenty-two studies(containing 11 multiple-use and 11 single-use models) were included. Original models were developed between 2003 and 2016. Most of these were from the United States. Multivariate logistic regression was widely used to identify a model. The minimum area under the curve for each model was 0.57 and the largest was 0.87. The smallest C statistic was 0.59 and the largest 0.85. Six studies were validated by external validation and three were cross-validated. In total, 2 models had a high risk of bias, 6 models reported the most used variables were age and smoking duration, and 5 models included family history of lung cancer.Conclusions: The prediction accuracy of the models was high overall, indicating that it is feasible to use models for high-risk population prediction. However, the process of model development and reporting is not optimal with a high risk of bias. This risk affects prediction accuracy, influencing the promotion and further development of the model. In view of this, model developers need to be more attentive to bias risk control and validity verification in the development of models. | Wei Tang Qin Peng Yanzhang Lyu Xiaoshuang Feng Xin Li Luopei Wei Ni Li Hongda Chen Wanqing Chen Min Dai Ning Wu Jiang Li Yao Huang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
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