|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Digital Twins and Cyber Physical Systems toward Smart Manufacturing and Industry 4.0:Correlation and Comparison显示文摘State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important prerequisite for smart manufacturing is cyber-physical integration,which is increasingly being embraced by manufacturers.As the preferred means of such integration,cyber-physical systems(CPS)and digital twins(DTs)have gained extensive attention from researchers and practitioners in industry.With feedback loops in which physical processes affect cyber parts and vice versa,CPS and DTs can endow manufacturing systems with greater efficiency,resilience,and intelligence.CPS and DTs share the same essential concepts of an intensive cyber-physical connection,real-time interaction,organization integration,and in-depth collaboration.However,CPS and DTs are not identical from many perspectives,including their origin,development,engineering practices,cyber-physical mapping,and core elements.In order to highlight the differences and correlation between them,this paper reviews and analyzes CPS and DTs from multiple perspectives. | Fei Tao Qinglin Qi Lihui Wang A.Y.C.Nee | 2019 | Engineering2019，5，4： | 84 |
| 2 | Detection and parameter estimation of multicomponent LFM signal based on the fractional Fourier transform显示文摘This paper presents a new method for the detection and parameter estimation of multicomponent LFM signals based on the fractional Fourier transform. For the optimization in the fractional Fourier domain, an algorithm based on Quasi-Newton method is proposed which consists of two steps of searching, leading to a reduction in computation without loss of accuracy. And for multicomponent signals, we further propose a signal separation technique in the fractional Fourier domain which can effectively suppress the interferences on the detection of the weak components brought by the stronger components. The statistical analysis of the estimate errors is also performed which perfects the method theoretically, and finally, simulation results are provided to show the validity of our method. | QI Lin1, 2, TAO Ran1, ZHOU Siyong1 & WANG Yue1 1. Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China 2. School of Information Engineering, Zhengzhou University, Zhengzhou 450052, China Correspondence should be addressed to QI Lin (email: qilin@bit.edu.cn) | 2004 | Science in China(Series F)2004，47，2： | 143 |
| 3 | Effects of different resuscitation fluid on severe acute pancreatitis显示文摘AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP were enrolled at the Pancreatic Disease Institute between January 2007 and March 2010. The patients were randomly treated with normal saline (NS group), combination of normal saline and hydroxyethyl starch (HES) (SH group), combination of normal saline, hydroxyethyl starch and glutamine (SHG group) in resuscitation. The ratio of normal saline to HES in the SH and SHG groups was 3:1. The glutamine (20% glutamine dipeptide, 100 mL/d) was supplemented into the resuscitation liquid in the SHG group. Complications and outcomes including respiratory and abdominal infection, sepsis, abdominal hemorrhage, intra-abdominal hypertension, abdominal compartment syndrome (ACS), renal failure, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), operation intervention, length of intensive care unit stay, length of hospital stay, and mortality at 60 d were compared. Moreover, blood oxygen saturation (SpO 2 ), gastric intramucosal pH value (pHi), intra-abdominal pressure (IAP), inflammation cytokines, urine lactulose/mannitol (L/M) ratio, and serum endotoxin were investigated to evaluate the inflammatory reaction and gut barrier. RESULTS: Compared to the NS group, patients in the SH and SHG groups accessed the endpoint more quickly (3.9 ± 0.23 d and 4.1 ± 0.21 d vs 5.8 ± 0.25 d, P < 0.05) with less fluid volume (67.26 ± 28.53 mL/kg/d, 61.79 ± 27.61 mL/kg per day vs 85.23 ± 21.27 mL/kg per day, P < 0.05). Compared to the NS group, incidence of renal dysfunction, ARDS, MODS and ACS in the SH and SHG groups was obviously lower. Furthermore, incidence of respiratory and abdominal infection was significantly decreased in the SH and SHG groups, while no significant difference in sepsis was seen. Moreover, less operation time was needed in the SH and SHG group than the NS group, but the difference was not significant. The mortality did not differ significantly among these groups. Blood SpO 2 and gastric mucosal pHi in the SH and SHG groups increased more quickly than in the NS group, while IAP was significantly decreased in the SH and SHG group. Moreover, the serum tumor necrosis factor-α, interleukin-8 and C-reactive protein levels in the SH and SHG groups were obviously lower than in the NS group at each time point. Furthermore, urine L/M ratio and serum endotoxin were significantly lower in the SH group and further decreased in the SHG group.CONCLUSION: Results indicated that combination of normal saline, HES and glutamine are more efficient in resuscitation of SAP by relieving inflammation and sustaining the intestinal barrier. | Gang Zhao Jun-Gang Zhang He-Shui Wu Jin Tao Qi Qin Shi-Chang Deng Yang Liu Lin Liu Bo Wang Kui Tian Xiang Li Shuai Zhu Chun-You Wang | 2013 | World Journal of Gastroenterology2013，19，13： | 56 |
| 4 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 5 | Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor显示文摘AIM: To investigate the functions of promoter hyper- methylation of secreted frizzled-related proteins (sFRPs) genes in colorectal tumorigenesis and progression. METHODS: The promoter hypermethylation and expression of sFRP genes in 72 sporadic colorectal carcinomas, 33 adenomas, 18 aberrant crypt foci (ACF) and colorectal cancer cell lines RKO, HCT116 and SW480 were detected by methylation-specific PCR and reverse transcription PCR, respectively. RESULTS: None of the normal colorectal mucosa tissues showed methylated bands of any of four sFRP genes. sFRP1, 2, 4 and 5 were frequently methylated in colorectal carcinoma, adenoma and ACF (sFRP1 > 85%, sFRP2 >75%, sFRP5 > 50%), and the differences between three colorectal tissues were not significant (P > 0.05). Methylation in colorectal tumors was more frequent than in normal mucosa and adjacent normal mucosa. The mRNA of sFRP1-5 genes was expressed in all normal colorectal mucosa samples. Expression of sFRP1, 2, 4 and 5 and sFRP1 , 2 and 5 was downregulated in carcinoma and adenoma, respectively. The downregulation of sFRP2, 4 and 5 was more frequent in carcinoma than in adenoma. Expression of sFRP3 which promoter has no CpG island was downregulated in only a few of colorectal tumor samples (7/105). The downregulation of sFRP1, 2, 4 and 5 expression was significantly associated with promoter hypermethylation in colorectal tumor. After cells were treated by DAC/TSA combination, the silenced sFRP mRNA expression could be effectively re-expressed in colorectal cancer cell lines.CONCLUSION: Hypermethylation of sFRP genes is acommon early event in the evolution of colorectal tumor, occurring frequently in ACF, which is regarded as the earliest lesion of multistage colorectal carcinogenesis. It appears to functionally silence sFRP genes expression. Methylation of sFRP1, 2 and 5 genes might serve as indicators for colorectal tumor. | Jian Qi You-Qing Zhu Jun Luo Wen-Hui Tao | 2006 | World Journal of Gastroenterology2006，12，44： | 34 |
| 6 | Biomechanical Comparison of Two Kinds of Internal Fixation in a Type C Zone II Pelvic Fracture Model显示文摘 | Tao Wu Wei Chen Qi Zhang Zhan-Le Zheng Hong-Zhi Lyu Yun-Wei Cui Xiao-Dong Cheng Ying-Ze Zhang Yan-Jiang Yang | 2015 | Chinese Medical Journal2015，，17： | 27 |
| 7 | Derivation of human embryonic stem cell lines from parthenogenetic blastocysts显示文摘单性生殖是之一主要、很有用,方法到导出胚胎的干细胞(转换字符) ,它可以为房间治疗是 histocompatible 房间和纸巾的重要来源。这里,我们描述从在 vitro 的线(hPES-1 和 hPES-2 ) 开发了胚囊列在后面的二个转换字符的推导和描述人的卵母细胞的单性生殖的激活。典型转换字符形态学被看见,并且转换字符标记的表示是是为碱的磷酸酶期望, octamer 有约束力的抄写因素 4,阶段特定的胚胎的抗原 3,阶段特定的胚胎的抗原 4, TRA-1-60,和 TRA-1-81,并且有否定标记例如的表示的缺席阶段特定的胚胎的抗原 1。为不同胚胎的细菌层特定的基因的表示从两根 hESC 线的胚胎植物或动物身体(EB ) 被检测,建议他们在 vitro 的区别潜力。在 vivo,然而,仅仅 hPES-1 形成了由所有三胚胎的细菌层组成的 teratoma (hPES-2 ) 。在为超过 100 个段落的连续增长以后,有趣地, hPES-1 房间仍然维持了正常 46 XX karyotype;hPES-2 在长期的段落以后显示了象染色体 translocation 那样的畸形。短双人脚踏车重复(STR ) 结果证明 hPES 线是有鸡蛋施主的基因火柴,并且基因印数据证实了这些 ES 房间的单性生殖的起源。染色体宽的 SNP 分析显示出典型地代表单性生殖的一个模式。所有这些结果表明了可行性孤立并且建立人的单性生殖的转换字符线,它提供一个重要工具因为学习 epigenetic 在一个临床的背景在转换字符以及为未来完成治疗学的干预。 | Qingyun Mai Yang yu Tao Li Liu Wang Mei-jue Chen Shu-zhen Huang Canquan Zhou Qi Zhou | 2007 | Cell Research2007，17，12： | 23 |
| 8 | A Simple and Rapid Colloidal Gold-based Immunochromatogarpic Strip Test for Detection of FMDV Serotype A显示文摘A sandwich format immunochromatographic assay for detecting foot-and-mouth disease virus (FMDV) serotypes was developed. In this rapid test,affinity purified polyclonal antibodies from Guinea pigs which were immunized with sucking-mouse adapted FMD virus (A/AV88(L) strain) were conjugated to colloidal gold beads and used as the capture antibody,and affinity purified polyclonal antibodies from rabbits which were immunized with cell-culture adapted FMD virus (A/CHA/09 strain) were used as detector antibody. On the nitrocellulose membrane of the immunochromatographic strip,the capture antibody was laid on a sample pad,the detector antibody was printed at the test line(T) and goat anti-guinea pigs IgG antibodies were immobilized to the control line(C). The lower detection limit of the test for a FMDV 146S antigen is 11.7ng/ml as determined in serial tests after the strip device was assembled and the assay condition optimization. No cross reactions were found with FMDV serotype C,Swine vesicular disease (SVD),Vesicular stomatiti svirus (VSV) and vesicular exanthema of swine virus (VES) viral antigens with this rapid test. Clinically,the diagnostic sensitivity of this test for FMDV serotypes A was 88.7% which is as same as an indirect-sandwich ELISA. The specificity of this strip test was 98.2% and is comparable to the 98.7% obtained with indirect-sandwich ELISA. This rapid strip test is simple,easy and fast for clinical testing on field sites; no special instruments and skills are required,and the result can be obtained within 15 min. To our knowledge,this is the first rapid immunochromatogarpic assay for serotype A of FMDV. | Tao Jiang Zhong Liang Wei-wei Ren Juan Chen Xiao-ying Zhi Guang-yu Qi Xiang-tao Liu Xue-peng Cai | 2011 | Virologica Sinica2011，26，1： | 22 |
| 9 | Using Interrupted Time Series Design to Analyze Changes in Hand, Foot, and Mouth Disease Incidence during the Declining Incidence Periods of 2008-2010 in China显示文摘Objective To identify patterns of hand, foot and mouth disease (HFMD) incidence in China during declining incidence periods of 2008, 2009, and 2010. Methods Reported HFMD cases over a period of 25 months were extracted from the National Disease Reporting System (NDRS) and analyzed. An interrupted time series (ITS) technique was used to detect changes in HFMD incidence rates in terms of level and slope between declining incidence periods of the three years. Results Over 3.58 million HFMD cases younger than 5 years were reported to the NDRS between May 1, 2008, and May 31, 2011. Males comprised 63.4% of the cases. ITS analyses demonstrated a significant increase in incidence rate level (P<0.0001) when comparing the current period with the previous period. There were significant changes in declining slopes when comparing 2010 to 2009, and 2010 to 2008 (all P<0.005), but not 2009 to 2008. Conclusion Incremental changes in incidence rate level during the declining incidence periods of 2009 and 2010 can potentially be attributed to a few factors. The more steeply declining slope in 2010 compared with previous years could be ascribed to the implementation of more effective interventions and preventive strategies in 2010. Further investigation is required to examine this possibility. | YU Shi Cheng HAO Yuan Tao ZHANG Jing XIAO Ge Xin LIU Zhuang ZHU Qi MA Jia Qi WANG Yu | 2012 | Biomedical and Environmental Sciences2012，25，6： | 23 |
| 10 | Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia显示文摘背景为更低的手足局部缺血的许多治疗选择是困难的与差的动脉的流出或与医疗的一般 conditions.The 效果独自远离的穷人一起申请病人 ideal.especially 在学习试图探索移植的效果的这些 patients.This 在有糖尿病的 foot.A 高水平切断的病人是不可避免的自体同源更低的手足局部缺血并且到的治疗上的骨头髓 mononuclear 房间比较 intra-artedal | GU Yong-quan ZHANG Jian GUO Lian-rui QI Li-xing ZHANG Shu-wen XU Juan LI Jian-xin LUO Tao JI Bing-xin LI Xue-feng YU Heng-xi CUI Shi-jun WANG Zhong-gao | 2008 | Chinese Medical Journal2008，，11： | 21 |
| 11 | Spatial patterns, driving forces, and urbanization effects of China's internal migration: County-level analysis based on the 2000 and 2010 censuses显示文摘China has witnessed unprecedented urbanization over the past decades.The rapid expansion of urban population has been dominantly contributed by the floating population from rural areas,of which the spatiotemporal patterns,driving forces,and multidimensional effects are scrutinized and evaluated in this study by using the latest national censuses conducted in 2000 and 2010.Analysis based on the county-level data comes to conclusions as follows.The spatial pattern of floating population has remained stable over the first decade of the new century.The top 1%cities with the largest floating population received 45.5% of all migrants in China.As the rapid development of mega-city regions,the coastal concentration areas of floating population tended to geographically united as a whole,whereas the spatial distribution of migrants within each region varied significantly.The migrant concentration area in the Yangtze River Delta was the largest and its expansion was also the most salient.However,the floating population has growingly moved into provincial capitals and other big cities in the inland regions and its gravity center has moved northward for around 110 km during the study period.The spatial pattern of floating population has been formed jointly by the state and market forces in transitional China and the impacts of state forces have been surpassed by those of market forces in the country as a whole.The attractiveness of coastal cities and counties to the floating population comes mainly from the nonagricultural employment opportunities and public services,reflecting that long-distance and long-term migrants have moved coastward not only to gain employment but also to enjoy city life.By contrast,in the central and western regions,places with a higher economic development level and at a higher administrative level are more attractive to floating populations,demonstrating that the state remains to play an important role in allocating economic resources and promoting regional development in inland China.As the main body of new urban residents,the floating population has contributed substantially to the elevation of the urbanization levels of migrant-sending and-receiving places,by 20.0% nd 49.5% respectively.Compared with extensively investigated interprovincial migrants,intra-provincial migrants have higher intention and ability to permanently live in cities and thus might become the main force of China's urbanization in the coming decades.The internal migration has also reshaped China's urban system in terms of its hierarchical organization and spatial structure. | LIU Tao QI Yuanjing CAO Guangzhong LIU Hui | 2015 | Journal of Geographical Sciences2015，25，2： | 21 |
| 12 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 13 | Laparoscopic management of gastric gastrointestinal stromal tumors: A retrospective 10-year single-center experience显示文摘AIM To determine the feasibility,safety,and oncological outcome of laparoscopic resection of gastric gastrointestinal stromal tumors(GISTs)based on favorable or unfavorable location.METHODS Our hospital database included 207 patients who underwent laparoscopic removal of gastric GISTs from January 2004 to September 2015.Patient demographics,clinical presentation,surgery,histopathology,postoperative course,and oncological outcomes were reviewed and analyzed.RESULTS Gastric GIST in favorable locations was present in81/207(39.1%)cases,and in unfavorable locations in 126/207(60.9%)cases.Overall mean tumor size was 3.28±1.82 cm.No conversions occurred,and complete R0 resection was achieved in 207(100%)cases.There were three incidences of iatrogenic tumor rupture.The feasibility and safety of laparoscopic surgery were comparable in both groups with no statistical difference between unfavorable and favorable location groups,respectively:for operative time:83.86±44.41 vs 80.77±36.46 min,P=0.627;conversion rate:0%vs 0%;estimated blood loss:27.74±45.2vs 29.59±41.18 m L,P=0.780;tumor rupture during surgery:0.90%vs 2.82%,P=0.322;or postoperative complications:3.74%vs 7.04%,P=0.325.The follow-up period recurrence rate was 1.89%with no significant differences between the two groups(3.03%vs 0%,P=0.447).Overall 5-year survival rate was98.76%and survival rates were similar between the two groups:98.99%vs 98.39%,P=0.623(unfavorable vs favorable,respectively).CONCLUSION The laparoscopic approach for gastric GISTs is safe and feasible with well-accepted oncological surgical outcomes.Strategies for laparoscopic resection should be selected according to the location and size of the tumor.Laparoscopic treatment of gastric GISTs in unfavorable locations should not be restricted in gastrointestinal centers. | Guan-qun Liao Tao Chen Xiao-Long qi Yan-feng Hu Hao Liu Jiang Yu Guo-Xin Li | 2017 | World Journal of Gastroenterology2017，23，19： | 18 |
| 14 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 15 | Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma显示文摘BACKGROUND Researchers have investigated the diagnostic value of protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and obtained abundant clinical diagnostic data. However, PIVKA-II and AFP have unsatisfactory specificity and sensitivity in the diagnosis of early-stage HBV-related HCC. Gamma-glutamyltransferase (γ-GT) and aspartate aminotransferase (AST) are common biomarkers for evaluating liver function, and we hypothesized that the γ-GT/AST ratio in combination with PIVKA-II and AFP would improve the diagnosis of early-stage HBV-related HCC. AIM To evaluate the diagnostic value of γ-GT/AST ratio alone or in combination with PIVKA-II and AFP in HBV-related HCC. METHODS Serum levels of γ-GT, AST, PIVKA-II, and AFP were detected and analysed in 176 patients with HBV-related HCC and in 359 patients with chronic hepatitis B. According to tumour size and serum level of HBV DNA, HBV-related HCC patients were divided into the following categories: Early-stage HCC patients, HCC patients, HBV DNA positive (HBV DNA+) HCC patients, and HBV DNA negative (HBV DNA-) HCC patients. Receiver-operating characteristic (ROC) curves were used to analyse and compare the diagnostic value of the single and combined detection of various biomarkers in different types of HBV-related HCC. RESULTS Tumour size was positively correlated with serum levels of PIVKA-II and AFP in HCC patients (r = 0.529, aP < 0.001 and r = 0.270, bP < 0.001, respectively), but there was no correlation between tumour size and the γ-GT/AST ratio (r = 0.073, P = 0.336). The areas under the receiver-operating characteristic curves (AUROCs) of the γ-GT/AST ratio in early-stage HCC patients, HBV DNA+ HCC patients and HBV DNA- HCC patients were not significantly different from that in the total HCC patients (0.754, 0.802, and 0.705 vs 0.779, respectively;P > 0.05). When PIVKA-II was combined with the γ-GT/AST ratio in the diagnosis of earlystage HCC, HCC, and HBV DNA+ HCC, the AUROCs of PIVKA-II increased, with values of 0.857 vs 0.835, 0.925 vs 0.913, and 0.958 vs 0.954, respectively. When AFP was combined with the γ-GT/AST ratio in the diagnosis of early-stage HCC, HCC, HBV DNA+ HCC, and HBV DNA- HCC, the AUROCs of AFP increased, with values of 0.757 vs 0.621, 0.837 vs 0.744, 0.868 vs 0.757, and 0.840 vs 0.828, respectively. CONCLUSION The γ-GT/AST ratio may be better than PIVKA-II and AFP in the diagnosis of early-stage HBV-related HCC, and its combination with PIVKA-II and AFP can improve the diagnostic value for HBV-related HCC. | Qiang Wang Qi Chen Xia Zhang Xiao-Lan Lu Qin Du Tao Zhu Guo-Yuan Zhang Dong-Sheng Wang Qu-Ming Fan | 2019 | World Journal of Gastroenterology2019，25，36： | 17 |
| 16 | Surgical treatment of 82 patients with diabetic lower limb ischemia by distal arterial bypass显示文摘背景糖尿病的更低的手足局部缺血是糖尿病 mellitus.This 学习的严肃的复杂并发症被进行调查有效性远侧动脉与更低的手足局部缺血在糖尿病的病人绕过治疗。从 2000 年 7 月的方法到 2004 年 7 月,有严重更低的手足局部缺血的 82 个糖尿病的病人(类型 2 ) 的 96 更低的手足在吴璇被对待医院。动脉与 femoro 腿弯部的 polytetrafluoroethylene (PTFE ) 和接枝胫骨的自体同源的接枝绕过在 311 手足(32.3%) 上被执行。腿弯部胫骨的动脉独自绕过在 22 手足(22.9%) 上被执行。联合肠骨的动脉 stenting, femoro 腿弯部的动脉 PTFE 接枝绕过,并且接枝胫骨的动脉自体同源的接枝绕过在 12 上被执行手足(12.5%) ,和 femoro 胫骨的动脉接枝绕过在 10 手足(10.4%) 上被执行。Popliteal-tibial-pedal 动脉接枝绕过在 7 手足(7.3%) 上被执行。结果在 79 个病人的 92 手足的动脉的接枝是分泌物上的专利。有 4 ischemic 手足(3.7%) 的三个病人死于呼吸失败在操作以后的 12 个小时, 3 天和 7 天分别地。早操作成功率是 96.3%(79/82 ) 。分泌物上的病人的接枝明显率是 95.8%(92/96 ) 。短期的全部的有效性率是 83.3%(80/96 ) 。脚溃疡愈合率是 35.7%(10/28 ) 。97.4%(75/77 ) 病人们被跟随在上面为 13.5 个月的一个平均数。长期的全部的有效的率是 80.7%(71/88 ) 。全部的切断率是 4.5%(4/88 ) 。死亡是 4.5% 。全部的接枝明显率是 90.9%(80/88 ) 在糖尿病的脚的治疗的 .Conclusion,远侧的更低的手足动脉绕过罐头帮助避免切断或降低切断水平,并且可以支持脚溃疡愈合并且改进病人生活的质量。 | GU Yong-quan ZHANG Jian QI Li-xing YU Heng-xi LI Jian-xin LI Xue-feng GUO Lian-rui LUO Tao CUI Shi-jun WANG Zhong-gao | 2007 | Chinese Medical Journal2007，，2： | 16 |
| 17 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 18 | Clinical Utility of the Ratio Between Circulating Fibrinogen and Fibrin (ogen) Degradation Products for Evaluating Coronary Artery Disease in Type 2 Diabetic Patients显示文摘Background: We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP) reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients. Methods: Plasma levels of Fg and FDP were determined, and Fg/FDP ratio was calculated in 344 consecutive patients with type 2 diabetes and chest pain on exertion undergoing coronary angiography. The severity of CAD was evaluated by the number of significant CAD (〉50% luminal diameter narrowing) and Gensini score. Results: Plasma Fg was higher, but Fg/FDP ratio was lower in patients with significant CAD (n = 255) compared with those without (n = 89), due to a disproportionate increase in FDP. Fg and FDP correlated positively, while Fg/FDP ratio negatively, with the number of diseased coronary arteries and the tertile of Gensini score (all P values for trend 〈 0.01). After adjusting for age, sex, risk factors for CAD, lipid profiles, glycosylated hemoglobin A1 c, creatinine, leukocyte count, and high-sensitivity C-reactive protein, Fg/FDP ratio remained an independent determinant for multivessel coronary disease (MVD) (odds ratio [OR], 0.869; 95% confidence interval [C/], 0.788~).958, P = 0.005) and high tertile of Gensini score (OR, 0.797, 95% CI, 0.682-0.930, P = 0.004). The area under the curve of Fg/FDP ratio was larger than that of Fg for predicting the presence of MVD (0.647 vs. 0.563, P = 0.048) and Gensini score 〉 30 (0.656 vs. 0.538, P = 0.026). Conclusions: Elevated plasma Fg and FDP level and reduced Fg/FDP ratio are associated with presence of CAD, and Fg/FDP ratio is superior to Fg in reflecting severe coronary atherosclerosis for patients with type 2 diabetes. | Wei-Xin Xiong Ying Shen Dao-Peng Dai Lin Lu Qi Zhang Rui-Yan Zhang Wei-Feng Shen Rong Tao | 2015 | Chinese Medical Journal2015，，6： | 16 |
| 19 | Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus显示文摘 | Cuiqing Zhong Meiling Zhang Qi Yin Han Zhao Yang Wang Sexin Huang Wenrong Tao Keliang Wu Zi-Jiang Chen Jinsong Li | 2016 | Cell Research2016，26，6： | 16 |
| 20 | Recovery of heavy metals from electroplating sludge and stainless steel pickle waste liquid by ammonia leaching method显示文摘A coordinative disposal process for treatment of electroplating sludge and stainless steel pickle waste liquid containing Cu, Ni, Zn, Cr and Fe etc., has been developed to recover valuable metals and to eliminate pollution. The recovery of Cu, Ni, Zn and Cr is 94%, 91%, 90% and 95%, respectively. The ammonia was recycled by the simplified process of CaO caustic distillation. The precipitated product of Cu, Ni and Zn obtained from caustic distillation of ammonia was separated by extraction or high\|pressure hydrogen reduction in an autoclave. The qualified metal salt products were obtained through extraction. The rich chromium residue from coordinative disposal was subjected to recover Cr by hydrothermal oxidation in NaOH medium and Fe\-3O\-4 was synthesized by wet methods from the residue produced by extracting Cr. Cr was a stable chemical fixed in Fe\-3O\-4 and harmless. The recovery process has been used in a pilot plant with sludge production capacity of 2000 t/a. | Zhang Yi, Wang Zhi\|kuan, Xu Xia, Chen Yong\|qi, Qi Tao Institute of Chemical Metallurgy, Chinese Academy of Sciences,P.O. Box 353, Beijing 100080, China | 1999 | Journal of Environmental Sciences1999，11，3： | 15 |
您所在的机构暂未开通此部分的功能，请联系管理员