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| 1 | Exercise as a prescription for patients with various diseases显示文摘A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy.Because each sport has its own set of characteristics and physiological complications that tend to occur during exercise training,the effects and underlying mechanisms of exercise remain unclear.Thus,the first step in probing the effects of exercise on different diseases is the selection of an optimal exercise protocol.This review summarizes the latest exercise prescription treatments for 26 different diseases:musculoskeletal system diseases(low back pain,tendon injury,osteoporosis,osteoarthritis,and hip fracture),metabolic system diseases(obesity,type 2 diabetes,type 1 diabetes,and nonalcoholic fatty liver disease),cardio-cerebral vascular system diseases(coronary artery disease,stroke,and chronic heart failure),nervous system diseases(Parkinson’s disease,Huntington’s disease,Alzheimer’s disease,depression,and anxiety disorders),respiratory system diseases(chronic obstructive pulmonary disease,interstitial lung disease,and after lung transplantation),urinary system diseases(chronic kidney disease and after kidney transplantation),and cancers(breast cancer,colon cancer,prostate cancer,and lung cancer).Each exercise prescription is displayed in a corresponding table.The recommended type,intensity,and frequency of exercise prescriptions are summarized,and the effects of exercise therapy on the prevention and rehabilitation of different diseases are discussed. | Xin Luan Xiangyang Tian Haixin Zhang Rui Huang Na Li Peijie Chen Ru Wang | 2019 | Journal of Sport and Health Science2019，8，5： | 61 |
| 2 | Engineering exosomes as refined biologica nanoplatforms for drug delivery显示文摘 | Xin LUAN Kanokwan SANSANAPHONGPRICHA Ila MYERS Hongwei CHEN Hebao YUAN Duxin SUN | 2017 | Acta Pharmacologica Sinica2017，38，6： | 40 |
| 3 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 4 | Impact of Smoking on Anal Abscess and Anal Fistula Diseases显示文摘 | Li-Hua Zheng Ao-Zhe Zhang Yu-Ying Shi Xin Li Lan-Si Jia Cong-Cong Zhi Qiu-Xiang Yu Wen Zhang Yan-Jun Liu Luan Wang Dan Xiao Chen Wang | 2018 | Chinese Medical Journal2018，，9： | 10 |
| 5 | The application of back-scattered electron imaging for characterization of pearlitic steels显示文摘The microstructures of pearlitic steel wire rods and steel wires are commonly characterized by secondary electron imaging (SEI)technique using scanning electron microscopy(SEM).In this work,a back-scattered electron imaging(BSEI)method is proposed to determine the microstructures of undeformed and deformed pearlitic steels with nanometer scale pearlite lamellae.The results indicate that BSEI technique can characterize the pearlite lamellas veritably and is effective in quantitative measurement of the mean size of pearlite interlamellar spacing.To some extent,BSEI method is more suitable than SEI technique for studying undeformed and not severely deformed pearlitic steels. | GUO Ning LIU Qing XIN YunChang LUAN BaiFeng ZHOU Zheng | 2011 | Science China(Technological Sciences)2011，54，9： | 9 |
| 6 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 7 | Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to hypoxia.Bruceine D(BD)is an isolated natural quassinoid with multiple anti-cancer effects.Here,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell metabolism.Using biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of BD.By targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α expression.Furthermore,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in vitro.Our data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism. | Rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 8 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 9 | Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues显示文摘增加的注意在最近的年里为卵巢的癌症对潜在的 biomarker 和治疗学的目标的决心被给予了。然而,量的即时 PCR 的正规化是重要的获得精确基因表示数据。我们在不同条件下面在卵巢的纸巾调查了 20 参考基因的稳定性决定为这应用最足够。学习在包含正常、非恶意、主要的卵巢的癌的 52 件卵巢的织物样品之中描绘了 20 可能的参考基因的表示。变化(ANOVA ) 的单程的分析方法被用来比较疾病前进引起的候选人基因变化。没有统计差别的基因的稳定性和适用性是进一步的采用 geNorm 和 NormFinder 软件验证。当尽管有不同卵巢的织物条件, RPL4, RPLP0, HSPCB, TPT1, RPL13A, 18S rRNA, PPIA, TBP,和 GUSB 使稳定性统计时,结果证明 20 参考基因的表示层次变化了。RPL4, RPLP0,和 HSPCB 作为最稳定的参考基因和 RPLP0 的联合被表明, RPL4 应该被推荐为更可靠的正规化策略。 | Jie Fu Lihong Bian Li Zhao Zhouhuan Dong Xin Gao Haofei Luan Yunjuan Sun Haifeng Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 10 | Flanking sequence determination and event-specific detection of genetically modified wheat B73-6-1显示文摘以便建立一个特定的鉴定方法因为遗传上修改了(美国通用汽车公司) 小麦,外长在外长的碎片和美国通用汽车公司小麦 B73-6-1 的 recombinant 染色体之间插入 DNA 和 flanking 顺序成功地借助于常规聚合酶链反应(PCR ) 被获得并且热不对称交叉(尾巴)-PCR 策略。最新获得的外长的碎片包括标记 uidA,除草剂抵抗的酒吧, ubiquitin 倡导者,和 high-molecular-weight 面筋子单元盖住象转变 plasmid 那样的转变基因和相应功能的基因的全身的顺序。flanking 顺序在之间插入高揭示的 DNA 有 Triticum turgidum 的类似基因(GenBank:AY494981.1 ) 。为美国通用汽车公司小麦 B73-6-1 的一个特定的 PCR 察觉方法根据根据 flanking 顺序设计的教材被建立。这个特定的 PCR 方法被美国通用汽车公司小麦,美国通用汽车公司玉米,美国通用汽车公司大豆,美国通用汽车公司米饭,和非美国通用汽车公司小麦验证。明确地放大的目标乐队仅仅在美国通用汽车公司小麦 B73-6-1 被观察。这个方法具有为美国通用汽车公司小麦 B73-6-1 的鉴定的高特性,高重制度,快速的鉴定,和优秀精确性。 | Junyi Xu Jijuan Cao Dongmei Cao Tongtong Zhao Xin Huang Piqiao Zhang Fengxia Luan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 4 |
| 11 | Nematode-Encoded RALF Peptide Mimics Facilitate Parasitism of Plants through the FERONIA Receptor Kinase显示文摘The molecular mechanism by which plants defend against plant root-knot nematodes(RKNs)is largely unknown.The plant receptor kinase FERONIA and its peptide ligands,rapid alkalinization factors(RALFs),regulate plant immune responses and cell expansion,which are two important factors for successful RKN parasitism.In this study,we found that mutation of FERONIA in Arabidopsis thaliana resulted in plants showing low susceptibility to the RKN Meloidogyne incognita.To identify the underlying mechanisms associated with this phenomenon,we identified 18 novel RALF-likes from multiple species of RKNs and showed that two RALF-likes(i.e.,MiRALF1 and MiRALF3)from M.incognita were expressed in the esophageal gland with high expression during the parasitic stages of nematode development.These nematode RALF-likes also possess the typical activities of plant RALFs and can directly bind to the extracellular domain of FERONIA to modulate specific steps of nematode parasitism-related immune responses and cell expansion.Genetically,both MiRALF1/3 and FERONIA are required for RKN parasitism in Arabidopsis and rice.Collectively,our study suggests that nematode-encoded RALFs facilitate parasitism via plant-encoded FERONIA and provides a novel paradigm for studying host-pathogen interactions. | Xin Zhang Huan Peng Sirui Zhu Junjie Xing Xin Li Zhaozhong Zhu Jingyuan Zheng Long Wang Bingqian Wang Jia Chen Zhenhua Ming Ke Yao Jinzhuo Jian Sheng Luan Devin Coleman-Derr Hongdong Liao Yousong Peng Deliang Peng Feng Yu | 2020 | Molecular Plant2020，13，10： | 3 |
| 12 | Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor in triggering RE immunopathogenesis. In this study, we analyzed the expression of Epstein-Barr virus(EBV) antigens as well as of Toll-like receptor 3(TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β(TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry(IHC). In the RE group, EBV antigens were detected in 53% of individuals at various expression levels. In contrast, there was no detectable EBV antigen expression in control brain tissues. Moreover, we found marked increases in the expression of TLR3, TLR9, and TRIF in the brain tissues of RE patients compared with levels in the control group. Furthermore, among RE cases, EBV expression and high TLR3 expression were associated with more severe brain atrophy. Our results suggest that the elevated expression of EBV and TLRs may be involved in RE occurrence through the activation of downstream molecules. | Xin Wang Yisong Wang Dong Liu Peigang Wang Dongying Fan Yuguang Guan Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，5： | 3 |
| 13 | Efficacy and safety of intra-aortic balloon pump-assisted interventional therapy in different age groups of patients with acute coronary syndrome显示文摘背景当前 intra 大动脉的汽球泵(IABP ) 广泛地与急性冠的症候群(交流) 在病人被使用了经历经皮的冠的干预(一种总线标准) 。然而,很少研究在在年老的病人帮助一种总线标准交流用完了问候到 IABP 的临床的结果和安全。现在的学习的目的是在在人的解放军队的沈阳医院将军收到了帮助 IABP 的一种总线标准的 292 个交流病人上与 ACS.Methods 数据在病人的不同年龄组评估 IABP 的安全回顾地被分析。更明确地,成功的率,与治疗联系的死亡和复杂并发症在四年级生之间被比较(> 60 岁)并且非高级(< 60 岁) patients.Results 组织非圣片断举起交流的攻击率比在非高级的组在高级的组是显著地更高的(38.8%对21.1%, P < 0.01 )。联系 IABP 的复杂并发症的发生不在两个组之间是显著地不同的(P > 0.05 ) 在老病人的帮助 IABP 的一种总线标准的临床的结果和安全是的 .Conclusion 比得上那为非老的病人。 | WANG Shou-li LIU Ming-xin WANG Xiao-zeng WANG Bin JING Quan-min WANG Zu-lu WANG Dong-mei MA Ying-yan WANG Geng LUAN Bo ZHAO Xin HAN Ya-ling | 2009 | Chinese Medical Journal2009，，22： | 2 |
| 14 | Uncontrolled central hyperthermia by standard dose of bromocriptine:A case report显示文摘BACKGROUND Some patients present to the intensive care unit due to noninfectious pathologies resulting in fever,especially acute neurological injuries,including brain trauma and intracranial haemorrhage.The cause has been identified to be central hyperthermia characterized by a high core temperature and a poor response to antipyretics and antibiotics.However,no proper guidelines on how to treat central hyperthermia have been developed for clinical practice.CASE SUMMARY A 63-year-old woman was transferred to our hospital due to injury after a traffic accident.Eight hours after admission,her pupils enlarged bilaterally from 2.5 mm to 4.0 mm.She developed severe coma and underwent decompressive craniectomy.She was diagnosed with central hyperthermia after surgery and was prescribed bromocriptine.The standard dose of bromocriptine could not control her hyperpyrexia,and we prescribed 30 mg a day to control her temperature.CONCLUSION Bromocriptine may be effective in controlling central hyperthermia and have a dosage effect. | Xin Ge Xue Luan | 2020 | World Journal of Clinical Cases2020，8，23： | 2 |
| 15 | Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children显示文摘A total of 24 children with cerebral palsy were enrolled in this study and underwent ultrasound guided transplantation of neural stem cells through the lateral ventricle. Neural stem cells (3.8 × 106-7.3 × 107) were injected into the lateral ventricles. Mild injury of lateral ventricular blood vessels occurred in only two cases (8.3%). Seven cases (29.2%) experienced a fever. Clinical manifestations were improved to varying degrees in eight cases (28.0%) within 3 months after transplantation. Patient condition did not worsen, and no patient experienced severe adverse reactions. | Sheng He Zuo Luan Suqing Qu Xuan Qiu Daqing Xin Wenkai Jia Yanhua Shen Zehui Yu Tao Xu | 2012 | Neural Regeneration Research2012，7，32： | 2 |
| 16 | Methods used for evaluation of volume retention rate in autologous fat grafting for breast augmentation: a systematic review显示文摘Background:Autologous fat grafting has gained popularity in breast augmentation.Various methods can be used to estimate the volume retention rate.This systematic review aimed to establish whether the type of method used for measuring breast volume is a factor that influences the reported volume retention rate.Methods:Studies were identified using the electronic databases PubMed,Embase,Cochrane Central Register of Controlled Trials,and Web of Science from inception of the database up to February 2019.Articles describing autologous fat grafting for breast augmentation were selected based on pre-determined inclusion and exclusion criteria.The characteristics of the included studies were summarized,and the reported volume retention rate from the studies was compared.A quality assessment of all included articles was performed using the methodological index for non-randomized studies criteria.Results:A total of 618 articles were identified,of which 12 studies,with a total of 1337 cases,were eligible.The retention rate of injected adipose tissue varied when the method of fat grafting and volume analysis used were both the same,as well as when the method of fat grafting was the same but the method of volumetric evaluation used was different.Conclusions:Currently,the tools available for estimating the volume retention rate come with limitations.In order to objectively evaluate the percentage of graft retention,a standard protocol that applies to the different methods should be established in the future. | Cheng-Long Wang Si-Si Luan Adriana C.Panayi Min-Qiang Xin Jie Luan | 2019 | Chinese Medical Journal2019，，18： | 2 |
| 17 | A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks显示文摘Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA(eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes(deoxyribonuclease), here we report a novel antibacterial surface by employing cerium(Ce(Ⅳ)) ion to mimic theDNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid(TA) works as an essential scaffold and Ce(Ⅳ) ion acts as both a cross-linker and a destructor of eDNA. The Ce(Ⅳ)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(Ⅲ)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections. | Ru-Jian Jiang Shun-Jie Yan Li-Mei Tian Shi-Ai Xu Zhi-Rong Xin Shi-Fang Luan Jing-Hua Yin Lu-Quan Ren Jie Zhao | 2018 | Chinese Journal of Polymer Science2018，36，5： | 2 |
| 18 | Application of confocal laser Raman spectroscopy on marine sediment microplastics显示文摘Marine sediment is the primary sink of microplastics and is an indicator of pollution levels.However,although there are well-developed detection methods,detection is rarely focused on lowmicrometer-sized particles,mainly due to technique limitations.In this study,a simplifi ed process omitting digestion procedures was developed to pretreat microplastics obtained from marine sediment and was coupled with micro-Raman spectroscopy to identify microplastics.Based on the overall analysis of the characteristic peak assignments,a Raman spectral reference library was constructed for 18 types of plastic.In addition,the eff ects of the measurement parameters were systematically described.Field research was then conducted to validate the developed process and investigate microplastic contamination in Huiquan Bay,Qingdao,China.This simplifi ed process could retain the original appearance of microparticles and accomplish the detection of<500μm-sized microplastics in environmental samples.Microplastics in the size range of 10-150μm accounted for 76%of all microplastics,and 56%of the total particles was particles smaller than 50μm.Polypropylene(42%)and polyethylene(20%)were predominant components of the particles.In particular,polypropylene particles smaller than 10μm were identifi ed in marine sediment.This work demonstrates that Raman spectroscopy is not only an eff ective tool for detecting environmental particles but also highly applicable for identifying particles extracted from marine sediment. | LIU Jing ZHANG Xin DU Zengfeng LUAN Zhendong LI Lianfu XI Shichuan WANG Bing CAO Lei YAN Jun | 2020 | Journal of Oceanology and Limnology2020，38，5： | 2 |
| 19 | Fate of adipose-derived stronml vas- cular fraction cells after co-implantation with fat grafts: evidence of cell survival and differentiation in ischemic adipose tissue显示文摘 | Fu S Luan J Xin M | 2013 | Plast Reconstr Surg2013，132，2： | 1 |
| 20 | Fine Mapping of QTLs for Stigma Exsertion Rate from Oryza glaberrima by Chromosome Segment Substitution显示文摘Stigma exsertion is an important trait for outcrossing ability in rice.Stigma exsertion rate(SER)of male sterile lines(MSLs)is a key factor affecting F1-seed production in hybrid rice.In this study,seven QTLs for SER were detected on five chromosomes using a set of single-segment substitution lines(SSSLs)derived from O.glaberrima.Three of the QTLs were mapped in the estimated intervals of 92.5–333.0 kb.qSER-5 was located in a substitution segment of 92.5 kb.qS ER-1 b and qS ER-8 b were respectively limited to 333.0 kb and 107.5 kb by secondary substitution mapping.qSER-1 b and qSER-3 had bigger additive effects of 11.5%and 11.9%,respectively,while the other five QTLs had smaller additive effects from 5.7%to 8.6%.Open reading frames were identified in the regions of qS ER-5 and qSER-8 b in O.sativa and O.glaberrima genomes.Fine mapping of the QTLs laid a foundation for the cloning of genes,and QTLs for SER will be used to develop MSLs with strong ability of outcrossing. | TAN Quanya ZHU Haitao LIU Hui NI Yuerong WU Shengze LUAN Xin LIU Junwei YANG Weifeng YANG Zifeng ZENG Ruizhen LIU Guifu WANG Shaokui ZHANG Guiquan | 2022 | Rice science2022，29，1： | 1 |
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