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| 1 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 2 | Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma显示文摘AIM To explore the effect and mechanism ofgastrin and its antagonists proglumide and somatostatin on coIorectal carcinoma and their clinical significance.METHODS A model of transplanted human colonic carcinoma was established from SW480cell line in gymnomouse body. The volume andweight of transplanted carcinoma was observedunder the effect of pentagatrin (PG), proglumide (PGL) and octapeptide somotostatin (SMS201-995, SMS). The cAMP content ot carcinoma cell was determined by redioimmunoassay and the DNA, protein content and cell cycle were determined by flow-cytometry. The amount of viabIe cells was determined by MTT colorimetric analysis, lP3 content was determined by radioimmunoassay, Ca2+ concentration in cell by fluorometry and PKC activity by isotopic enzymolysis. The expression of gastrin, c-myc,C-fos and rasP21 in 48 cases of colorectal carcinoma tissue was detected by the immunocytochemistry SP method. Argyrophilianucleolar organizer regions was determined withargyrophilia stain.RESULTS The volume, weight, cAMP, DNAand protein content in carcinoma cell, cellamount and proliferation index of S and G2Mphase in PG group were all significantly higher than those of control group. When PG was at theconcentration of 25 mg/ L, the amount of viablecells, lP3 content and Ca2+ concentration in celland membrane PKC activity in PG group weresigniticantly higher than those in control group;when PGL was at a concentration ot 32 mg/L,they dropped to the lowest level in PG (25 mg/L)+ PGL group, but without significant differencefrom the control group. The positive expression rate of gastrin, c-myc, c-fos and rasp21 in carcinoma tissue was 39 .6%, 54 .2%, 47. 9% and54 .2% resPectively and significantly higher than that in mucosa 3 cm and 6 cm adjacent tocarcinoma tissue and normal colorectal mucosa.The positive expression rate of gastrin of highlydifferentiated adenocarcinoma group was significantly higher than that of poorly differentiated and mucinous adenocarcinoma groups. The AgNORs count of carcinoma tissue was significantly higher than that in mucosa 3 cm and 6 cm adjacent to carcinoma tissue and normal colorectal mucosa; and the positive expression of c-myc and c-fos and the AgNORs count in gastrin-positive group was significantly higher than those in gastrin-negative group.CONCLUSION Pentagastrin has a promoting effect on the growth of transplanted human colonic carcinoma from SW480 cell line. PGL hasno obvious effect on the growth of human colonic carcinoma SW480 cell line, but couldinhibit the growth-promoting effect of PG on transplanted carcinoma. Somatostatin can not only inhibit the growth of transplanted human colonic carcinoma from SW480 cell line directlybut also depress the growth-promoting effect ofgastrin on the transplanted carcinoma. Somecolorectal carcinoma cells can produce and secrete gastrin through autocrine, highly-differentiated adenocarcinoma express the highest level gastrin. Endogenous gastrin can stimulate the cell division and proliferation of carcinoma cell and promote the growth of colorectal carcinoma regulating the expression of oncogene omyc, c-fos. Our study has provided experimental basis for the adjuvant treatment using gastrin antagonist such as PGL,somatostatin of patients with colorectalcarcinoma. | He SW Shen KQ He YJ Xie B Zhao YM | 1999 | World Journal of Gastroenterology1999，5，5： | 20 |
| 3 | P-wave velocities of alkaline olivine basalt at high pressure and temperature and its controlling factors显示文摘SEISMIC wave inversion is one of the most important means for us to recognize the compositionand structure of the Earth’s interior.Although the experimental techniques of elastic wave ve-locity measurement at in situ high pressure and temperature develop very fast in recent | Song, MS Xie, HS Zhang, YM Hou, W Xu, J Xu, YS | 1997 | Chinese Science Bulletin1997，42，9： | 3 |
| 4 | Measurement of electrical conductivity of 0.001 mol NaCl solution under high pressures显示文摘The experiments were carried out in a YJ-3000 ton press fitted with a wedge-type cubic anvil. The samples were pressed using pyropgyllite as the pressure medium. The conductance cell for the experiments was made of Teflon and platinum metal was used as electrodes. The detailed method for setting up of sample has been reported. | Zheng, HF Xie, HS Xu, YS Song, MS Guo, J Zhang, YM | 1997 | Chinese Science Bulletin1997，42，18： | 2 |
| 5 | Effect of ingested immunoglobulin on SIga expression in pediatric rotavirus enteritis显示文摘 | Xie YM Wang LY Gao S | 2015 | Journal of Sichuan University: Medical Science Edition2015，46，1： | 1 |
| 6 | Ultrahigh-pressure (4.5-5.5 GPa) experimental research on pyroxene-garnet transition and its significance显示文摘Al-PYROXENE in nature may be regarded as garnet solid solution in Al-free pyroxene. The transition from Al-pyroxene to garnet + Al-poor pyroxen can be carried out under high-pressure conditions. Ultrahigh-pressure experiment on pyroxene-garnet transition was carried out in this work using natural soecimens to exolain the genesis of garnet peridotite. | Fan, QC Liu, RX Xie, HS Zhang, YM Lin, ZR | 1997 | Chinese Science Bulletin1997，42，17： | 1 |
| 7 | Increased intracellular concentra- tionof reactive oxygen species mediated the deficienthematopoiesis of iron overload bone marrow 显示文摘 | Zhao MF Xie F Li YM | 2010 | Blood2010，116，11： | 1 |
| 8 | Limbie and HPA axis function in an animal model of chronic neuropathic pain 显示文摘 | Ulrich-Lai YM Xie W Meij JT | 2006 | Physiol Behav2006，88，12： | 1 |
| 9 | Virtual Acupuncture Human Based on Chinese Visible Human Dataset 显示文摘 | Heng PA Xie YM Wang XH | 2006 | Studies in Health Technology and Informatics (S0926-9630)2006，119，： | 1 |
| 10 | Perimeter control in the bi-directional evolutionary optimization method显示文摘 | Yang XY Xie YM Liu JS | 2003 | Structural Multidiscipline Optimization2003，24，6： | 1 |
| 11 | A simple checkerboard suppression algorithm for evolutionary structural optimization显示文摘 | Li Q Steven GP Xie YM | 2001 | Struct Multidisc Optim2001，22，3： | 1 |
| 12 | Pedicled rectus abdomlnis muscle and fascia flap sling the bulbar urethra for treatment for male-acquired urinary incontinence: report of ten cases 显示文摘 | Xu YM Zhang XR Xie H et aI | 2014 | Int Urol Nephrol2014，46，： | 1 |
| 13 | Method of assessing clinical curative effect of complex intervention measures in preliminary exploration of new method of assessing TCM curative effect显示文摘 | Xie YM Zhi YJ Wang YY | | 0，，： | 1 |
| 14 | Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells显示文摘 | Xie JJ Xu LY Xie YM | 2009 | Int J Cancer2009，124，11： | 1 |
| 15 | Progesterone receptor expression is a marker for early stage breast cancer:implications for progesterone receptor as a therapeutic tool and target显示文摘 | Coyle YM Xie XJ Hardy DB | 2007 | Cancer Lett2007，258，2： | 1 |
| 16 | Primary leptomeningeal melanoma显示文摘 | Xie ZY Hsieh KLC Tsang YM | 2014 | J Clin Neurosci2014，21，： | 1 |
| 17 | DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma显示文摘 | Hou J Liao LD Xie YM | | 0，，： | 1 |
| 18 | Roles of ezrin in the growth and in- vasiveness of esophageal squamous carcinoma cells 显示文摘 | Xie JJ Xu LY Xie YM | 2009 | Int J Cancer2009，124，11： | 1 |
| 19 | Malignant mixed m? Ilerian tumor of the fallopian tube : reporl of two cases and review of literature 显示文摘 | Shen YM Xie YP Xu K | 2010 | Arch Gynecol Obstet2010，281，6： | 1 |
| 20 | An improved method for evolutionary structural optimization against buckling显示文摘 | Rong J H Xie YM Yang X Y | 2001 | Computer&Structures2001，79，： | 1 |
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