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| 1 | Targeting the alternative bile acid synthetic pathway for metabolic diseases显示文摘The gut microbiota is profoundly involved in glucose and lipid metabolism,in part by regulating bile acid(BA)metabolism and affecting multiple BA-receptor signaling pathways.BAs are synthesized in the liver by multi-step reactions catalyzed via two distinct routes,the classical pathway(producing the 12α-hydroxylated primary BA,cholic acid),and the alternative pathway(producing the non-12α-hydroxylated primary BA,chenodeoxycholic acid).BA synthesis and excretion is a major pathway of cholesterol and lipid catabolism,and thus,is implicated in a variety of metabolic diseases including obesity,insulin resistance,and nonalcoholic fatty liver disease.Additionally,both oxysterols and BAs function as signaling molecules that activate multiple nuclear and membrane receptor-mediated signaling pathways in various tissues,regulating glucose,lipid homeostasis,inflammation,and energy expenditure.Modulating BA synthesis and composition to regulate BA signaling is an interesting and novel direction for developing therapies for metabolic disease.In this review,we summarize the most recent findings on the role of BA synthetic pathways,with a focus on the role of the alternative pathway,which has been under-investigated,in treating hyperglycemia and fatty liver disease.We also discuss future perspectives to develop promising pharmacological strategies targeting the alternative BA synthetic pathway for the treatment of metabolic diseases. | Wei Jia Meilin Wei Cynthia Rajani Xiaojiao Zheng | 2021 | Protein & Cell2021，12，5： | 17 |
| 2 | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma显示文摘Colorectal cancer(CRC)and hepatocellular carcinoma(HCC)are the second and third most common causes of death by cancer,respectively.The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol,smoking,diet,obesity and diabetes.Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC.However,the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors.In this review,we examine the changes that occur in the composition of the gut microbiota across the stages of the HCC and CRC.Based on the idea that the gut microbiota are an additional“lifeline”and contribute to the tumor microenvironment,we can observe from previously published literature how the microbiota can cause a shift in the balance from normal→inflammation→diminished inflammation from early to later disease stages.This pattern leads to the hypothesis that tumor survival depends on a less proinflammatory tumor microenvironment.The differences observed in the gut microbiota composition between different disease etiologies as well as between HCC and CRC suggest that the tumor microenvironment is unique for each case. | Wei Jia Cynthia Rajani Hongxi Xu Xiaojiao Zheng | 2021 | Protein & Cell2021，12，5： | 14 |
| 3 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 4 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 5 | Calorie restriction and its impact on gut microbial composition and global metabolism显示文摘Calorie restriction (CR)is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.It has long been recognized as a natural strategy for promoting health, extending longevity,and prevents the development of metabolic and age-related diseases.In the present review,we focus on the general effect of CR on gut microbiota composition and global metabolism.We also propose mechanisms for its beneficial effect.Results showed that probiotic and butyrate-producing microbes increased their relative abundance,whereas proinflammatory strains exhibited suppressed relative abundance following CR.Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR.Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism,p-oxidation,glycogenolysis,and gluconeogenesis.The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease.Thus,improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases. | Xiaojiao Zheng Shouli Wang Wei Jia | 2018 | Frontiers of Medicine2018，12，6： | 3 |
| 6 | An Estimation Method for Multi-channel EEG Data Based on Canonical Correlation Analysis显示文摘Electroencephalogram(EEG) signal is often contaminated by electronic noise as well as movement artifacts. This paper presented an algorithm based on Canonical correlation analysis(CCA) to estimate multichannel EEG data. Different from previous studies, in which CCA was mainly used to detect the invariant features specific to each brain state, in this paper, the canonical variates computed by CCA were used to reconstruct the multi-channel EEG data. Firstly, two data sets, EEG signals and the reference signals based on prior knowledge were constructed. Next, canonical variates were computed by pro jecting the two data sets onto basis vectors. Finally,a least squares solution was used to estimate the multichannel EEG data. The experiment results suggested that the algorithm is capable of reconstructing the actual specific components with high quality. We also hint future possible application of the algorithm in the estimation of functional connectivity patterns at the end of the paper. | YAN Zheng WAN Xiaojiao LING Chaodong | 2015 | Chinese Journal of Electronics2015，24，3： | 2 |
| 7 | Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a meta-analysis显示文摘 | Wang Ming Zheng Xiaofeng Ruan Xiaojiao Ye Bailiang Cai Long Lin Feizhuan Tu Jinfu Jiang Feizhao Li Shaotang | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 8 | Pu-erh tea: A review of a healthful brew显示文摘Pu-erh tea has been used for thousands of years to treat metabolic diseases.Recognized in Shen Nong's Herbal Classic,a compendium kept by the first traditional Chinese practitioners,it is still highly valued for its hypocholesterolemic and hypolipidemic effects.This review reports the processing and bioactive components of pu-erh tea.Recent human and animal studies of pu-erh tea and its potential therapeutic mechanisms have also been summarized.The interaction of liver and gut microbiome regulates the puerh tea biotransformation and endogenous metabolism,and thus contributes to the health benefits. | Wei Jia Cynthia Rajani Aiping Lv Tai-Ping Fan Xiaojiao Zheng | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 2 |
| 9 | 3D flame-retardant skeleton reinforced polymer electrolyte for solid-state dendrite-free lithium metal batteries显示文摘For solid polymer electrolytes(SPEs),improving their mechanical and electrochemical properties is the key to obtaining batteries with higher safety and higher energy density.Herein,a novel synergistic strategy proposed is preparing a 3D flame-retardant skeleton(3DPA)and adding nano-multifunctional fillers(Li-ILs@ZIF-8).In addition to providing mechanical support for the polyethylene oxide(PEO)matrix,3DPA also has further contributed to the system’s flame retardancy and further improved the safety.Simultaneously,the electrochemical performance is fully guaranteed by rigid Li-ILs@ZIF-8,which provides fast migration channels forLi^(+),reduces the crystallinity of PEO and effectively inhibits lithium dendrites.The limiting oxygen index of the optimal sample(PL3Z/PA)is as high as 20.5%,and the ionic conductivity reaches 2.89×10^(-4) and 0.91×10^(-3) S cm^(-1) at 25 and 55°C,respectively.The assembled Li|PL3Z/PA|Li battery can be cycled stably for more than 1000 h at a current density of 0.1 m A cm^(-2) without short circuit being pierced by lithium dendrites.The specific capacity of the LFP|PL3Z/PA|Li battery was 160.5 m Ah g^(-1) under a current density of 0.5 C,and the capacity retention rate was 90.0%after 300 cycles. | Xiaojiao Zheng Jiawei Wu Jing Chen Xiaodong Wang Zhenglong Yang | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 10 | Ultrathin poly(cyclocarbonate-ether)-based composite electrolyte reinforced with high-strength functional skeleton显示文摘Composite polymer electrolytes(CPEs)are considered to be the most promising to break through the performance and safety limitations of traditional lithium-ion batteries because of their excellent electrochemical and mechanical properties.Aiming at the performance limitations of the most common polyether matrix such as poly(ethylene oxide)(PEO),a novel poly(cyclocarbonate-ether)polymer matrix was prepared by in-situ thermal curing,the weaker interaction between its C=O bond and Li^(+)can promote the rapid transport of Li^(+).Adding ionic liquid and active filler LLZTO to the matrix can synergistically reduce the crystallinity of matrix and promote the dissociation of lithium salts.In addition,a 3D functional skeleton made of polyacrylonitrile(PAN)and lithium fluoride(LiF)can greatly improve the mechanical strength of polymer matrix after cold pressing,and Li F is also conducive to interface stability.The thickness of the optimal sample(VP6L/CPL)was only 25μm,and its ionic conductivity,lithium ion transference number,and electrochemical stability window were as high as 7.17×10^(-4)S cm^(-1)(25℃),0.54 and 5.4 V,respectively,while the mechanical strength reaches 6.1 MPa,which can fully inhibit the growth of lithium dendrites.The excellent electrochemical performance and mechanical strength enable the assembled Li|VP6L/CPL|Li battery to be continuously charged for over 200 h and cycled stably for more than 2300 h,and Li|VP6L/CPL|LFP battery can be stably cycled for more than 400 and 550 cycles at 1 C(40℃)and 0.5 C(25℃),respectively. | Xiaojiao Zheng Da Xu Ning Fu Zhenglong Yang | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 11 | Hyocholic acid and glycemic regulation:comments on‘Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism’显示文摘Hyocholic acid species(HCA,hyodeoxycholic acid,and their glycine and taurine conjugated forms)comprise 80%of the composition of pig bile(Haslewood,1956).An interesting fact about pigs is that they do not get diabetes even though they eat almost everything and in abundant amounts,a diabetes-promoting diet.The first use of pig bile for treatment of‘xiao-ke’. | Wei Jia Cynthia Rajani Xiaojiao Zheng Weiping Jia | 2021 | Journal of Molecular Cell Biology2021，13，6： | 1 |
| 12 | Intestinal lysozyme releases Nod2 ligand(s) to promote the intestinal mucosal adjuvant activity of cholera toxin显示文摘Commensal bacteria boost serum IgG production in response to oral immunization with antigen and cholera toxin(CT)in a manner that depends on Nod2(nucleotide-binding oligomerization domain-containing protein 2).In this study,we examined the role of intestinal lysozyme(Lyz1)in adjuvant activity of CT.We found that Lyz1 released Nod2 ligand(s)from bacteria.Lyz1 deficiency reduced the level of circulating Nod2 ligand in mice.Lyz1 deficiency also reduced the production of IgG and T-cellspecific cytokines after oral immunization in mice.Supplementing Lyz1-deficient mice with MDP restored IgG production.Furthermore,overexpression of Lyz1 in intestinal epithelium boosted the antigen-specific IgG response induced by CT.Collectively,our results indicate that Lyz1 plays an important role in mediating the immune regulatory effect of commensal bacteria through the release of Nod2 ligand(s). | Haifang Wang Xueying Shen Xiaojiao Zheng Ying Pan Qin Zhang Zhihua Liu | 2021 | Science China(Life Sciences)2021，64，10： | 1 |
| 13 | Global research on cognitive behavioural therapy for schizophrenia from 2000 to 2019:a bibliometric analysis via CiteSpace显示文摘Background Cognitive behavioural therapy(CBT)is considered to be an effective treatment for schizophrenia.In recent years,researchers have published clinical research results on CBT for schizophrenia.However,there is currently a lack of bibliometric analysis on CBT for schizophrenia.Aims To understand the current situation and research trends of CBT for schizophrenia,and to provide valuable information for researchers in this field.Methods Literature was retrieved from the Web of Science Core Collection database.CiteSpace was used to visually analyse the current status of research on CBT for schizophrenia,as well as trends and points of general interest on this topic.Results A total of 1151 papers were retrieved.The annual number of publications has increased 417.65%from 2000 to 2019.Schizophrenia Research was the most active journal.McGorry enjoys considerable influence.The University of London is deemed to be the most active research institution.England and the USA retain the highest scientific productivity in this field.China and Norway might make more contributions to this field in the future.The most important research topics are randomised controlled trials of CBT for schizophrenia,meta-analysis,scale selection and research on the improvement of quality of life.Results from the following keywords‘psychoeducation’,‘insomnia’,‘individual’,‘mental illness’,‘major depressive disorder’,‘efficacy’,‘internalised stigma’and‘remediation’indicated new research frontiers in this field.Conclusions The field of CBT for schizophrenia is progressing and has great potential.The level and quality of research in this field is high.The proposal of research hotspots and frontiers serves as a direction for researchers in this field.Researchers around the world should strengthen their cooperation and communication to promote further development of this field. | Xinxing Fei Shiqi Wang Xiaojiao Zheng Kezhi Liu Xuemei Liang | 2021 | General Psychiatry2021，34，1： | 1 |
| 14 | An emerging probiotic with liver health benefits for smokers显示文摘Cigarette smoking is considered a risk factor for nonalcoholic fatty liver disease(NAFLD).In a study recently published in Nature,Chen et al.unveiled a mechanistic role of nicotine in NAFLD progression.In addition,they identified a gut bacterium Bacteroides xylanisolvens that can reduce intestinal nicotine levels,and thus improve nicotine-induced NAFLD phenotypes in mice.Tobacco use is a leading cause of preventable disease and death worldwide.The number of smokers worldwide has been reported to be over 1.1 billion,accounting for about 15%of the global population[1]. | Wei Jia Xiaojiao Zheng | 2023 | Life Metabolism2023，2，1： | 0 |
| 15 | 空肠间置术能快速改善非肥胖2型糖尿病大鼠的糖耐量并缓慢改善胰岛素抵抗显示文摘背景:许多研究已证实,回肠间置术能改善2型糖尿病(T2DM),同时胰高血糖素样肽-1(GLP-1)水平上升。我们采用糖尿病大鼠模型进行研究,评估回肠间置术对糖代谢的影响及其机制。方法:20只GK大鼠被随机分为回肠间置组和假手术组。分别于术前及术后1、4、8、16、24周检测大鼠体重、进食量、空腹血糖(FPG)、空腹胰岛素(F-ins)、口服葡萄糖耐量试验(OGTT)和GLP-1水平。计算稳态模型胰岛素抵抗指数(HOMA-IR)和OGTT曲线下面积(AUC)。术后24周处死大鼠,检测胰腺和回肠组织中GLP-1受体(GLP-1R)的表达水平。结果:与假手术组相比,回肠间置组大鼠术后4、8、16和24周血GLP-1水平更高(均P<0.05),术后8、16和24周FPG、F-ins和HOMAIR水平更低(均P<0.05)。与术前相比,回肠间置组术后各个时间点均可观察到血GLP-1、AUC和FPG水平的下降(均P<0.05);术后8、16和24周F-ins和HOMA-IR也显著下降(均P<0.05)。术后24周,无论是胰腺还是回肠组织,回肠间置组大鼠的GLP-1R表达水平均显著高于假手术组(均P<0.05)。结论:回肠间置可改善GK大鼠的糖代谢,且不会导致体重的下降和进食量的减少,这可能与GLP-1水平升高有关。而后期胰岛素抵抗的改善和胰岛素水平的下降可能并不直接受益于GLP-1水平的升高。 | Hengliang Zhu Huaiming Wang Zhihai Zheng Bailiang Ye Xiaojiao Ruan Xiaofeng Zheng Guoxin Li | 2018 | Gastroenterology Report2018，6，4： | 0 |
| 16 | Hot Deformation Behaviors in Ti-6Al-4V/(TiB+TiC)Composites显示文摘Thermal compression testing was investigated using the Gleeble 3800 thermal simulator,and thermal deformation behavior of particle-reinforced titanium matrix composites(TMCs)was studied under deformation temperatures of 750-900°C,strain rates of 0.001-1 s^(-1),and experimental deformation of 60%.According to obtained flow stress curves,the hot deformation characteristics were analyzed.Based on the Arrhenius hyperbolic sinusoidal model,the constitutive equation at high temperature was established.Based on the theory of dynamic material models,a hot processing map of TMCs at high temperature was established,and the peak region of power dissipation rate and the instability region in the hot processing map were both determined.At the same time,the corresponding microstructures in the peak power dissipation rate and rheological instability regions were observed.The results showed that flow stress decreased with increasing deformation temperature and increased with increasing strain rate.The thermal deformation activation energy of titanium matrix composites was 301.8 kJ/mol.The Ti-6Al-4V/(TiB+TiC)composites possessed only one instability zone under high-temperature compression at a strain of 0.5,with corresponding temperatures at 750-840°C and strain rates at 0.1-1 s^(-1).The optimal thermal deformation parameters included corresponding temperatures of 830-880°C and strain rates of 0.001-0.05 s^(-1).The microstructures corresponding to optimal hot working parameters in processing maps were more homogeneous than the microstructures in the instability zone,including the distribution uniformity of reinforcement and the degree of dynamic recrystallization,and no instability phenomena including abnormal grain growth,microcracks or intensive fracture of reinforcements were found,indicating that the hot processing map had a positive guiding effect on the option of desirable material thermal-working parameters. | Xuejian Lin Hongjun Huang Fuyu Dong Yue Zhang Xiaoguang Yuan Bowen Zheng Xiaojiao Zuo | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，12： | 0 |
| 17 | A Hot Cracking Initiation Criterion Based on Solidification Liquid Film Characteristic and Microstructure显示文摘Herein,a hot cracking initiation criterion based on the characteristics of solidification liquid film and the microstructure was proposed,which integrated both the mechanical and non-mechanical factors during solidification.The criterion also took the effect of the shrinkage volume of the solid-liquid two-phase in the mushy zone,the flow behavior of the liquid film and the microstructure on the feeding behavior into account.Meanwhile,the effect factors of hot cracking initiation such as alloy composition,microstructure,mold design and process condition were included in this criterion,and it could quantitatively calculate whether hot cracks occurred under a certain state or not during solidification.The criterion was utilized to predict whether hot cracks occurred in Al-4.0 wt%Cu alloy in different initial solidification states or not,which was consistent with the experimental results and verified its reliability.According to the criterion expression,Vfeeding*was related with five effect factors includingη,ΔP*,l*,r*and n,in which r*and n were in positive correlation with Vfeeding*whileη,ΔP*and l*were in negative correlation with that,which provided a good instructive significance for mold design,process optimization and composition and microstructure regulation of alloys and simultaneously further enriched the mechanism and influencing factors of hot cracking initiation.Furthermore,a multiscale simulation method for calculating the characteristic parameters of hot tearing behavior during solidification was also provided in this study. | Ming Su Wentao Zheng Chunyu Yue Bowen Zheng Xiaojiao Zuo Mengyuan He Xiaoguang Yuan | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，11： | 0 |
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