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| 1 | Vanadium recovery from clay vanadium mineral using an acid leaching method显示文摘包括直接酸的沥滤的一种技术,钒降水与碱,钠氢氧化物重新沥滤,杂质由由烤步调整 pH 价值,有铵氯化物的降水钒,和钒 pentoxide 搬迁根据 Xichuan 的特征被建议泥土钒矿物质。影响象温度和硫磺的酸的集中那样的沥滤的钒的因素被调查并且优化。试验性的结果显示 V2O5 的摘录比率能分别地在 3% 的钠氯酸盐比率和 3% 的锰二氧化物比率到达 94% 和 92% 。一个完全化学的降水方法被采用清除并且在酸的沥滤溶液充实钒。X 光检查衍射(XRD ) 模式和钒 pentoxide 的纯净分析显示最后的钒 pentoxide 的纯净能到达 99% 并且遇见标准说明。全部的恢复能到达大约 75% 。这种技术作为与传统的咸烤方法相比有简洁,更少的投资,和更多的环境安全的特征。 | LI Haoran FENG Yali LIANG Jianglong LUO Xiaobing DU Zhuwei | 2008 | Rare Metals2008，27，2： | 23 |
| 2 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 3 | Indication from finite-frequency tomography beneath the North China Craton: The heterogeneity of craton destruction显示文摘We picked new traveltime residual datasets in three frequency bands(0.02–0.1, 0.1–0.8, and 0.8–2.0 Hz) for P-waves from 793 teleseismic events and two frequency bands(0.02–0.1 and 0.1–0.8 Hz) for S-waves from 310 teleseismic events,recorded by 389 permanent stations of the China National Seismic Network and 832 broadband stations of 10 temporary arrays deployed in the North China Craton(NCC) region. The final datasets are composed of 65628 P-arrivals and 47050 S-arrivals.Based on previous research and our team's 2012 tomographic work, we constructed new three-dimensional P-velocity and Svelocity models of the NCC through some improvements, such as augmenting a much denser station coverage in the western NCC, considering the incident angle effect in crustal correction and using a multi-frequency joint inversion tomographic technique. The new velocity models provide several salient features, from which we draw possible inferences on regional dynamic processes. We observed high-velocity anomalies in the mantle transition zone(MTZ). Obvious morphological heterogeneities suggest buckling and/or fragmentation of the subducted Pacific slab, and some of the slab materials are visible below 660-km discontinuities. The velocity structure of the eastern NCC is dominated by small-scale lateral heterogeneities. At shallow depths, high-velocity anomalies beneath the southern part of the eastern NCC and the Yanshan region likely represent a remnant of cratonic lithosphere, which may suggest that the NCC destruction is spatially non-uniform. We also detected a highvelocity anomaly in the Sulu Orogen extending downward to ~300 km, which is seemingly controlled by the Tan-Lu Fault. The northern boundary of this anomaly spatially coincides with the Yantai-Qingdao-Wulian Fault, and is likely a remnant of the Yangtze cratonic lithosphere subducting northwestward. Significant low-velocity anomalies imaged beneath the central NCC show a spatial discordance between their northern and southern parts. The northern low-velocity anomaly extends downward to the top of MTZ with a lateral NW-SE strike, whereas the southern one tapers off at ~200–300 km. Low-velocity anomalies are present beneath the Phanerozoic orogenic belts surrounding the NCC, the Paleoproterozoic Trans-North China Orogen, and the Tan-Lu Fault. This feature not only shows excellent spatial correlation with the orogens at the surface, it also exhibits a consistent vertical continuity in a depth range of 60–250 km. This intriguing feature suggests that the collisional orogenic belts and Tan-Lu Fault are inherited weak zones, which may play a key role in craton destruction. By combining multidisciplinary results in this area, we suggest that the spatial heterogeneities associated with the NCC destruction most likely result from the combined effects of a spatially non-uniform distribution of wet upwellings triggered by the subducted Pacific slab and pre-existing weak zones in the cratonic lithosphere. | Xiaobing XU Liang ZHAO Kun WANG Jianfeng YANG | 2018 | Science China Earth Sciences2018，61，9： | 7 |
| 4 | Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells显示文摘Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始,渗入,和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里,我们发现那配对的相关 homeobox 1 (PRRX1 ) ,以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发,在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步, PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强,而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后, PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此,我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。 | Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong Kuan Tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 5 | Retrieval of Aerosol Optical Properties over a Vegetation Surface Using Multi-angular, Multi-spectral, and Polarized Data显示文摘An algorithm to retrieve aerosol optical properties using multi-angular, multi-spectral, and polarized data without a priori knowledge of the land surface was developed. In the algorithm, the surface polarized reflectance was estimated by eliminating the atmospheric scattering from measured polarized reflectance at 1640 nm. A lookup table(LUT) and an iterative method were adopted in the algorithm to retrieve the aerosol optical thickness(AOT, at 665 nm) and the Angstrom exponent(computed between the AOTs at 665 and 865 nm). Experiments were performed in Tianjin to verify the algorithm. Data were provided by a newly developed airborne instrument, the Advanced Atmosphere Multi-angle Polarization Radiometer(AMPR). The AMPR measurements over the target field agreed well with the nearby ground-based sun photometer. An algorithm based on Research Scanning Polarimeter(RSP) measurements was introduced to validate the observational measurements along a flight path over Tianjin. The retrievals were consistent between the two algorithms. The AMPR algorithm shows potential in retrieving aerosol optical properties over a vegetation surface. | WANG Han SUN Xiaobing SUN Bin LIANG Tianquan LI Cuili HONG Jin | 2014 | Advances in Atmospheric Sciences2014，31，4： | 5 |
| 6 | The role of the microenvironment on the fate of adult stem cells显示文摘Adult stem cells(SCs) exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differentiate, or remain dormant; these factors include neighboring cells, the extracellular matrix, soluble molecules, and physical stimuli. In disease and aging states, stable or transitory changes in the microenvironment can directly cause SC activation or inhibition in tissue healing as well as functional regulation. Here, we discuss the microenvironmental regulation of the behavior of SC and focus on plasticity approaches by which various environmental factors can enhance the function of SCs and more effectively direct the fate of SCs. | DONG Liang HAO HaoJie HAN WeiDong FU XiaoBing | 2015 | Science China(Life Sciences)2015，58，7： | 4 |
| 7 | Heterogeneous destruction of the North China Craton: Coupled constraints from seismology and geodynamic numerical modeling显示文摘The prevailing academic view regards mantle flow and the metasomatism triggered by the subduction of the Pacific plate as the cause and mechanism for the destruction of the North China Craton(NCC). However, the geodynamic destruction process remains ambiguous, necessitating detailed information at this stage. Combining the structural images obtained by the exploration of dense seismic arrays and the geodynamic simulations inspired by numerical modeling, this paper arrives at the following conclusions: the spatial variation of the P-and S-wave velocities, as well as their velocity ratio in the mantle transition zone, are key evidences of the nonuniform dehydration of the Pacific plate, the subducted plate induces hot upwellings in the mantle transition zone(MTZ), resulting in the heterogeneous distribution of the melt/fluid beneath the craton, characterized by small scale anomalies in the seismic velocity field, and as revealed by dense seismic array observation, the heterogeneities in the upper mantle structure and deformation are the synthetic results of lithospheric strain localization and the heterogeneous distribution of the melt/fluid. It is known that the nonuniform dehydration of the Pacific slab and the heterogeneous distribution of the melt/fluid have occured in the Cenozoic. If these scenarios could have already occurred in the Early Cretaceous, their interaction with the NCC lithosphere would be the dynamic mechanism for the heterogeneous lithospheric destruction of the NCC. The inference in this study is significant for further reconciling the multidisciplinary evidences in the NCC. | Kun WANG Liang ZHAO Xiaobing XU Jianfeng YANG | 2018 | Science China Earth Sciences2018，61，5： | 3 |
| 8 | Current approaches to reduce or eliminate mitochondrial DNA mutations显示文摘Mitochondrial DNA(mt DNA)mutations have been implicated in a broad range of disorders which severely affect human health(Wallace,1999).Some drugs have been developed to slow down pathological changes of mitochondrial disorders.However,there is no effective treatment for patients with mt DNA mutations.mt DNA is less protected and has fewer repair mechanisms than nuclear DNA(n DNA).Such a reality results in a much higher | Liang Yang Tingfang Mei Xiaobing Lin Haite Tang Yi Wu Rui Wang Jinglei Liu Zahir Shah Xingguo Liu | 2016 | Science China(Life Sciences)2016，59，5： | 3 |
| 9 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 10 | Detecting Integer Overflow Vulnerabilities in Binary Executables Based on Target Filtering and Dynamic Taint Tracing显示文摘The number of identified integer overflow vulnerabilities has been increasing rapidly in recent years.In this paper, a smart software vulnerability detection technology is presented, which is used for the identification of integer overflow vulnerabilities in binary executables. The proposed algorithm is combined with Target filtering and dynamic taint tracing(TFDTT). Dynamic taint tracing is used to reduce the mutation space and target filtering function is used to filter test cases during the process of test case generation. Theory analysis indicates that the efficiency of TFDTT is higher than Non TF-DTT and random Fuzzing technology. And the experiment results indicate that the detection technology based upon TFDTT can identify the possible integer vulnerabilities in binary program, meanwhile, it is more efficiency than other two technologies. | CUI Baojiang LIANG Xiaobing ZHAO Bing ZHAI Feng WANG Jianxin | 2014 | Chinese Journal of Electronics2014，23，2： | 2 |
| 11 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 12 | Degradation of organic matterin the sediments of Hongfeng Reservoir显示文摘In this work, the distribution of organic carbon, DNA and lipids in the sediments of Hongfeng Reservoir were described in addition to SO42? profile in pore water. The con- tents of organic carbon in the sediments range from 23.3 to 76.8 mg·g?1, with the peak value appearing at the depth of 8 cm bellow the sediments water interface (SWI), and tend to decrease gradually with sedimentation depth. The concentra- tions of SO42? decreased from 40.50 mg·L?1 to 12.00 mg·L?1 at SWI in top 4 cm sediment, and was kept at 12.0 mg·L?1 bel- low that depth. Newly produced organic carbon can be con- served as long as 14 years in the sediments. The contents of DNA were relatively high in top 9 cm surface sediments, as revealed by agarose gel images, close to those of organic car- bon and sulphate reduction index (SRI). This study shows that bacteria played an important role in organic matter degradation; SO42? is the primary electron acceptor under anaerobic condition in this reservoir; DNA in the lake sedi- ments can provide important information for the study of cycling of nutrient elements in the lake. | WEI Zhongqing LIU Congqiang LIANG Xiaobing WANG Fushun WANG Shaofeng | 2005 | Chinese Science Bulletin2005，50，20： | 2 |
| 13 | Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications显示文摘Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive applications.Borophene,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical applications.However,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties.In this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal properties.The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication.In the end,the challenges of borophene in the latest applications are presented and perspectives are discussed. | Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang | 2020 | Research2020，，1： | 2 |
| 14 | Occurrence of nativeselenium in Yutangba and its environmental implications显示文摘 | Jianming Zhu Wei Zuo Xiaobing Liang | 2004 | AppliedGeochemistry2004，19，： | 1 |
| 15 | Chemical fixa- tion of carbon dioxide to cyclic carbonates under extremely mild conditions with highly active bifunctional catalysts显示文摘 | Lu Xiaobing Zhang Yingju Liang Bin | 2004 | Journal of Molecular Catalysis A : Chemical Chem2004，210，12： | 1 |
| 16 | Salidroside protects against MPP + -induced apoptosis in PC12 cells by inhibiting the NO pathway显示文摘 | Xiaofeng Li Xiaoli Ye Xiaobing Li Xin Sun Qiang Liang Lizhen Tao Xiaogang Kang Jianzong Chen | 2011 | Brain Research2011，，： | 1 |
| 17 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 18 | Nanocarrier based on the assembly of protein and antisense oligonucleotide to combat multidrug resistance in tumor cells显示文摘Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide(ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment. | Xuan Yu Liang Gong Jing Zhang Zilong Zhao Xiaobing Zhang Weihong Tan | 2017 | Science China Chemistry2017，60，10： | 1 |
| 19 | Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery显示文摘The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers. | Xiaobing Chen Huan Yang Xu Song Hong Liang Yu Wei Jiao Lu Matthias Barz Rongrong Jin Yu Nie | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 20 | A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo显示文摘Laboratory research and pharmacoepidemiology provide support for metformin as a potential antitumor agent.However,the lack of a clear understanding of the indications of metformin limits its efficacy.Here,we performed a genome-wide CRISPR knockout negative screen to identify potential targets that might synergize with metformin.Next-generation sequencing of pooled genomic DNAs isolated from surviving cells after 18 days of metformin treatment(T18)compared to those of the untreated cells at day 0(T0)yielded candidate genes.Knockdown of a group of cyclin-dependent kinases(CDKs),including CDK1,CDK4,and CDK6,confirmed the results of the screen.Combination treatment of the CDKs inhibitor abemaciclib with metformin profoundly inhibited tumor viability in vitro and in vivo.Although cell cycle parameters were not further altered under the combination treatment,investigation of the metabolome revealed significant changes in cell metabolism,especially with regard to fatty acid oxidation,the tricarboxylic acid cycle and aspartate metabolism.Such changes appeared to be mediated through inhibition of the mTOR pathway.Collectively,our study suggests that the combination of CDKs inhibitor with metformin could be recognized as a potential therapy in future clinical applications. | Yarui Ma Qing Zhu Junbo Liang Yifei Li Mo Li Ying Zhang Xiaobing Wang Yixin Zeng Yuchen Jiao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
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