|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 2 | A Summary and Evaluation of Current Evidence for Myocardial Infarction with Chinese Medicine显示文摘Objective: To provide evidence-based recommendations for clinical application and provoke thoughts for future researchers by conducting a comprehensive summary and evaluation of the current evidence profile for the role of Chinese medicine(CM) in treating myocardial infarction(MI). Methods: Online databases including Pub Med, EMBase, Cochrane Library, Chinese National Knowledge Infrastructure(CNKI), Chinese Biomedical Medicine(CBM), VIP Journal Integration Platform, and Wanfang database were systematically searched for literatures on CM in treating MI. After screening, studies were categorized into 5 types, i.e. systematic review(SR), randomized controlled trial(RCT), observational study, case report and basic research. General information was abstracted, and the quality levels of these studies and their conclusions were summarized and assessed. Results: A total of 452 studies including 10 SRs, 123 RCTs, 47 observational studies, 28 case reports, and 244 basic researches were selected. Clinical studies centered primarily on herbal decoction and mostly were not rigorously performed. High-quality studies were predominantly on Chinese patent medicines(CPMs) such as Danshen Injection(丹参注射液), Shenmai Injection(参麦注射液), Shengmai Injection(生脉注射液) and Qishen Yiqi Dripping Pills(芪参益气滴丸). The most frequently observed pattern of drug combination was decoction plus injection. Results of SRs and clinical studies showed that CM may reduce mortality, decrease risk of complication, reduce myocardial injury, improve cardiac function and inhibit ventricular remodeling. Findings from basic researches also supported the positive role of CM in reducing infarct size and myocardial injury, promoting angiogenesis, preventing ventricular remodeling and improving cardiac function. According to the current evidence body, CM has proven effects in the prevention and treatment of MI. It is also found that the effects of CPMs vary with indications. For instance, Shenmai Injection has been found to be especially effective for reducing the incidence of acute clinical events, while CPMs with qi-nourishing and bloodcirculating properties have been proven to be effective in inhibiting ventricular remodeling. High quality evidence supports the use of CM injection for acute MI and CPM for secondary prevention. Reports on adverse events and other safety outcomes associated with CM for MI are scarce. Conclusions: Sufficient evidence supported the use of CM as an adjuvant to Western medicine for preventing and treating MI. The choice of drug use varies with disease stage and treatment objective. However, the quality of the evidence body remains to be enhanced. | WANG Yue XIAO Lu MU Wei YU Hai-long ZHANG Shuo TIAN Gui-hua SHANG Hong-cai | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 12 |
| 3 | Hepatitis C virus RNA detection in serum and peripheral blood mononuclear cells of patients with hepatitis C显示文摘HepatitisCvirusRNAdetectioninserumandperipheralbloodmononuclearcelsofpatientswithhepatitisCZHOUPing,CAIQing,CHENYouChun,ZHA... | ZHOU Ping, CAI Qing, CHEN You Chun, ZHANG Mu Sen, GUAN Jian and LI Xiao Juan | 1997 | World Journal of Gastroenterology1997，3，2： | 10 |
| 4 | Recent Progress on Visible Light Responsive Heterojunctions for Photocatalytic Applications显示文摘Photocatalysis has attracted much attention in recent years due to its potential in solving energy and environmental issues.Even though numerous achievements have been made,the photocatalytic systems developed to date are still far from practical applications due to the low efficiency and poor durability.Efficient light absorption and charge separation are two of the key factors for the exploration of high performance photocatalytic systems,which is generally difficult to be obtained in a single photocatalyst.The combination of various materials to form heterojunctions provides an effective way to better harvest solar energy and to facilitate charge separation and transfer,thus enhancing the photocatalytic activity and stability.This review concisely summarizes the recent development of visible light responsive heterojunctions,including the preparation and performances of semiconductor/semiconductor junctions,semiconductor/cocatalyst junctions,semiconductor/metal junctions,semiconductor/nonmetal junctions,and surface heterojunctions,and their mechanism for enhanced light harvesting and charge separation/transfer. | Songcan Wang Jung-Ho Yun Bin Luo Teera Butburee Piangjai Peerakiatkhajohn Supphasin Thaweesak Mu Xiao Lianzhou Wang | 2017 | Journal of Materials Science & Technology2017，33，1： | 9 |
| 5 | Solar energy conversion on g-C3N4 photocatalyst:Light harvesting,charge separation,and surface kinetics显示文摘Photocatalysis, which utilizes solar energy to trigger chemical reactions, is one of the most desirable solar-energy-conversion approaches. Graphitic carbon nitride(g-C_3N_4), as an attractive metal-free photocatalyst, has drawn worldwide research interest in the area of solar energy conversion due to its easy synthesis, earth-abundant nature, physicochemical stability and visible-light-responsive properties. Over the past ten years, g-C_3N_4 based photocatalysts have experienced intensive exploration, and great progress has been achieved. However, the solar conversion efficiency is still far from industrial applications due to the wide bandgap, severe charge recombination, and lack of surface active sites. Many strategies have been proposed to enhance the light absorption, reduce the recombination of charge carriers and accelerate the surface kinetics. This work makes a crucial review about the main contributions of various strategies to the light harvesting, charge separation and surface kinetics of g-C_3N_4 photocatalyst. Furthermore, the evaluation measurements for the enhanced light harvesting, reduced charge recombination and accelerated surface kinetics will be discussed. In addition, this review proposes future trends to enhance the photocatalytic performance of g-C_3N_4 photocatalyst for the solar energy conversion. | Mu Xiao Bin Luo Songcan Wang Lianzhou Wang | 2018 | Journal of Energy Chemistry2018，27，4： | 9 |
| 6 | Correlation of Betel Quid with Oral Cancer from 1998 to 2017: A Study Based on Bibliometric Analysis显示文摘 | Mu Wang Chang Xiao Ping Ni Jian-Jun Yu Xiao-Wan Wang Hong Sun | 2018 | Chinese Medical Journal2018，，16： | 8 |
| 7 | Identification,bioinformatic analysis and expression profiling of candidate mRNA-like non-coding RNAs in Sus scrofa显示文摘Messenger RNA-like non-coding RNAs(mlncRNAs) are a newly identified group of non-coding RNAs(ncRNAs) that may be in-volved in a number of critical cellular events.In this study,93 candidate porcine mlncRNAs were obtained by computational prediction and screening,among which 72 were mapped to the porcine genome.Further analysis of 8 representative candidates revealed that these mlncRNA candidates are not highly conserved among species.Remarkably,one of the candidates,sTF35495,was found to be precursor of a putative porcine microRNA.By RACE PCR,we determined that the full length of sTF35495 was 3 kb.The protein-coding potential of this RNA was tested in silico with no significant finding.Semi-quantitative RT-PCR analysis of the subgroup of 8 candidates revealed two distinct expression profiles and two molecules were further validated by real-time PCR.The predicted pre-microRNA sequence in this study provides a potentially interesting insight into the in vivo function of porcine mlncRNAs and our findings suggest that they play key biological roles in Sus scrofa. | Bang Xiao Xingju Zhang Yong Li Zhonglin Tang Shulin Yang Yulian Mu Wentao Cui Hong Ao Kui Li | 2009 | Journal of Genetics and Genomics2009，36，12： | 7 |
| 8 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 9 | Tantalum (Oxy)Nitride: Narrow Bandgap Photocatalysts for Solar Hydrogen Generation显示文摘 | Mu Xiao Songcan Wang Supphasin Thaweesak Bin Luo Lianzhou Wang | 2017 | Engineering2017，3，3： | 7 |
| 10 | Toxicity of Multi-Walled Carbon Nanotubes,Graphene Oxide,and Reduced Graphene Oxide to Zebrafish Embryos显示文摘Objective This study was aimed to investigate the toxic effects of 3 nanomaterials, i.e. multi-walled carbon nanotubes(MWCNTs), graphene oxide(GO), and reduced graphene oxide(RGO), on zebrafish embryos. Methods The 2-h post-fertilization(hpf) zebrafish embryos were exposed to MWCNTs, GO, and RGO at different concentrations(1, 5, 10, 50, 100 mg/L) for 96 h. Afterwards, the effects of the 3 nanomateria on spontaneous movement, heart rate, hatching rate, length of larvae, mortality, and malformations ls were evaluated. Results Statistical analysis indicated that RGO significantly inhibited the hatching of zebrafish embryos. Furthermore, RGO and MWCNTs decreased the length of the hatched larvae at 96 hpf. No obvious morphological malformation or mortality was observed in the zebrafish embryos after exposure to the three nanomaterials. Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed. | LIU Xiao Tong MU Xi Yan WU Xiao Li MENG Li Xuan GUAN Wen Bi MA Yong Qiang SUN Hua WANG Cheng Ju LI Xue Feng | 2014 | Biomedical and Environmental Sciences2014，27，9： | 6 |
| 11 | Surface Amendments Can Ameliorate Subsoil Acidity in Tea Garden Soils of High-Rainfall Environments显示文摘强烈酸的土壤(pH < 5.0 ) 对茶(山茶 sinensis ) 有害生产和质量。很少信息都不在表面修正案的能力上存在改善在茶花园土壤的心土酸味。A 120-d 温室列沥滤实验用通常可得到的土壤改良物被进行。碱的炉渣(作为) 并且器官的残余,猪粪肥(下午) 和在灰碱度和 C/N 比率不同的油菜籽蛋糕(RC ) 独自并且在联合被合并到土壤列的表面(0-15 厘米)(10 厘米内部的直径 ×
50 厘米长) 从 Ultisol 的酸的土壤层(15-30 厘米) 与土壤收拾行李(起始的 pH = 4.4 ) 。在 120-d 实验期间,土壤列被浇(在 9 应用上的大约 127 公里) 根据长期的平均数,年度降雨(1 143 公里) 和 leachates 镇定、分析。在实验的结束,土壤列被划分成各种各样的深度,土壤的化学性质被测量。有更高的 C/N 比率的下午增加了心土 pH,而有更低的 C/N 比率的 RC 减少了心土 pH。然而,联合了有的修正案独自修正案比也减少心土酸味的一个极有能力。心土的 pH 的增加主要被归功于到减少的基础阳离子集中和在溶解的器官的碳(文档) 和从修改的层被沥滤在下面的硝酸盐的固定在场的器官的阴离子的分解。一重要(P < 0.05 ) 在碱度生产之间的关联(减少的可交换的酸味 -N 周期碱度) 并且碱度平衡(网碱度生产 -N 周期碱度) 在实验的结束被观察。另外,联合了显著地增加的修正案(P < 0.05 ) 心土阳离子集中和减少的心土艾尔浸透(P < 0.05 ) 。联合应用就象表面的器官的修正案,土壤在在高降雨的区域减少心土酸味是有效的。在地条件下面并且在更长的 timeframes 上的进一步的调查被需要充分在改善理解他们的实际有效性在自然地发生沥滤下面的更深的土壤层的酸味政体。 | WANG Lei Clayton R. BUTTERLY CHEN Qiuhui MU Zhibo WANG Xia XI Yunguan ZHANG Jibing XIAO Xingji | 2016 | Pedosphere2016，26，2： | 5 |
| 12 | Effect of posterior condylar offset on clinical results after posterior-stabilized total knee arthroplasty显示文摘 | Jian-Tao Wang Yu Zhang Qing Liu Qiang He Dong-Liang Zhang Ying Zhang Ji-Xuan Xiao Xin Mu Ming Hu | 2015 | Chinese Journal of Traumatology2015，18，5： | 5 |
| 13 | An Efficient Synthetic Method of Nordihydroguaiaretic Acid (NDGA)显示文摘Nordihydroguaiaretic acid (NDGA) has been synthesized in nine steps from piperonal using Stobbe condensation as the key step with high yield. By this approach, five relative natural products were obtained. | Ya Mu XIA, Xiao Ping CAO, Kun PENG, Xin Feng REN, Xin Fu PAN* Department of Chemistry and National Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000 | 2003 | Chinese Chemical Letters2003，14，4： | 5 |
| 14 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 15 | Liquid biopsy for esophageal cancer: Is detection of circulating cell-free DNA as a biomarker feasible?显示文摘Esophageal cancer(EC)is a common cancer and is histopathologically classified into esophageal squamous cell carcinoma and esophageal adenocarcinoma.EC is a worldwide public health issue because of late diagnosis and lack of effective therapy.In contrast to standard tumor biopsies,liquid biopsies are emerging as a tool which is minimally invasive that can complement or even substitute more classical approaches.Specifically,cell-free DNA(cfDNA)has shown promise in cancer-related clinical applications.Indeed,cfDNA has been shown to be an effective circulating biomarker for non-invasive cancer diagnosis and monitoring of cancer patients.Although the clinical application of cfDNA has been reported on other cancers,few studies have evaluated its use in EC.Here,we review this relevant literature and discuss limitations and advantages of its application in the diagnosis and monitoring of EC. | Zuyang Yuan Xinfeng Wang Xiao Geng Yin Li Juwei Mu Fengwei Tan Qi Xue Shugeng Gao Jie He | 2021 | Cancer Communications2021，41，1： | 4 |
| 16 | The Influence of Fuel-Air Swirl Intensity on Flame Structures of Syngas Swirl-Stabilized Diffusion Flame显示文摘Flame structures of a syngas swirl-stabilized diffusion flame in a model combustor were measured using the OH-PLIF method under different fuel and air swirl intensity.The flame operated under atmospheric pressure with air and a typical low heating-value syngas with a composition of 28.5% CO,22.5% H2 and 49% N2 at a thermal power of 34 kW.Results indicate that increasing the air swirl intensity with the same fuel,swirl intensity flame structures showed little difference except a small reduction of flame length;but also,with the same air swirl intensity,fuel swirl intensity showed great influence on flame shape,length and reaction zone distribution.Therefore,compared with air swirl intensity,fuel swirl intensity appeared a key effect on the flame structure for the model combustor.Instantaneous OH-PLIF images showed that three distinct typical structures with an obvious difference of reaction zone distribution were found at low swirl intensity,while a much compacter flame structure with a single,stable and uniform reaction zone distribution was found at large fuel-air swirl intensity.It means that larger swirl intensity leads to efficient,stable combustion of the syngas diffusion flame. | Weiwei Shao Yan Xiong Kejin Mu Zhedian Zhang Yue Wang Yunhan Xiao | 2010 | Journal of Thermal Science2010，19，3： | 4 |
| 17 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 18 | Defect-mediated reactivity of Pt/TiO2 catalysts:the different role of titanium and oxygen vacancies显示文摘Defects are ubiquitous in oxide supports and can often tune the catalytic property of supported metal catalysts.This work describes the distinct role of titanium and oxygen vacancies of TiO2 supports in the catalytic performance of supported Pt catalysts for CO oxidation.Pt was loaded on the TiO2 supports with oxygen vacancies(VO-TiO2)and titanium vacancies(VTiTiO2).It was found that different defects of TiO2 could distinctively modify the electron property of Pt and thereby CO adsorption strength.The strength of CO adsorption on Pt/VTi-TiO2 is enhanced,while that of Pt/VO-TiO2 becomes weaker.Additionally,the presence of defects would also promote the reducibility of catalysts.On the account of the superior redox ability,both Pt/VTi-TiO2 and Pt/VO-TiO2 exhibit a higher activity than Pt supported on normal TiO2 for CO oxidation. | Quan Xiao Yanan Wang Zhi-Jian Zhao Chunlei Pei Sai Chen Lijun Gao Rentao Mu Qiang Fu Jinlong Gong | 2020 | Science China Chemistry2020，63，9： | 4 |
| 19 | Using intra-operative GeneSearchTM Breast Lymph Node Assay to detect breast cancer metastases in sentinel lymph nodes: results from a single institute in China显示文摘背景哨兵淋巴节点(SLN ) 活体检视为早乳癌病人成为了一个普通过程。GeneSearchTM 胸淋巴节点(十亿) 试金是为检测的即时 RT-PCR 试金比 0.2 公里大的节的转移。中国乳癌临床的学习组(CBCSG )-001a 是一个未来的多中心被进行验证 GeneSearchTM 的临床的试用在 China.Methods 的十亿试金从 90 个连续病人的 SLN 被识别并且把,然后沿着进多重块的短轴的 sectioned。Intra-operatively,奇怪的块被十亿试金测试,偶的被用于冻结的节,当所有块被触摸印记细胞学评估时。Post-operatively,留下的纸巾被组织学的 evaluation.Results 估计 189 SLN 的一个总数被十亿试金测试。敏感,特性,积极预兆的价值,和否定预兆的价值是 88.9%,97.4%,88.9% 并且 97.4% ,分别地为十亿试金, 75.0%,100%,100% 并且 94.4% ,分别地为冻结的节,和 63.9%,100%,100% 并且分别地, 92.2% 为触觉印细胞学。十亿试金的敏感比触觉的高印记细胞学(P=0.01 ) 和冻结的节(P=0.13 ) 。当估计节点与时微转移,十亿试金比冻结的节(P=0.023 ) 和触摸印记细胞学(P=0.005 ).Conclusion 有重要更高的敏感十亿试金是的 GeneSearchTM 为胸 SLN 和它的精确、快速的 intra 起作用的试金一般来说对申请合适诊所。 | SUN Xiao LIU Juan-juan WANG Yong-sheng SONG Xian-rang ZHONG Wei-xia ZHOU Chang-chun MU Dian-bin ZUO Wen-shu YU Zhi-yong ZHOU Zheng-bo | 2011 | Chinese Medical Journal2011，，7： | 4 |
| 20 | Design and Experiments of Biomimetic Stubble Cutter显示文摘 | Zhiyong Chang Wei Liu Jin Tong Li Guo Heng Xie Xiao Yang Haifeng Mu Donghui Chen | 2016 | Journal of Bionic Engineering2016，13，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员