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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 3 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 4 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 5 | Identification of a Newly Isolated Getah Virus in the China-Laos Border,China显示文摘In this study, we isolated a virus strain(YN12031) from specimens of Armigeres subalbatus collected in the China-Laos border. BHK-21 cells infected with YN12031 exhibited an evident cytopathic effect(CPE) 32 h post-infection. The virus particles were spherical, 70 nm in diameter, and enveloped; they also featured surface fibers. Molecular genetic analysis revealed that YN12031 was closely related to alpha viruses such as Chikungunya virus and Sindbis virus, and located in the same clade as MM2021, the prototype of Getahvirus(GETV) isolated in Malaysia in 1955. Phylogenetic analysis of the E2 and capsid genes further revealed that YN12031 was located in the same clade as the Russian isolate LEIV/16275/Mag. Analysis of the homology of nucleotides and amino acids in the coding area and E2 gene demonstrated that the YN12031 isolated from the China-Laos border(tropical region) was related closest to the LEIV/16275/Mag isolate obtained in Russia(North frigid zone area) among other isolates studied. These results suggest that GETV can adapt to different geographical environments to propagate and evolve. Thus, strengthening the detection and monitoring of GETV and its related diseases is very crucial. | LI Yuan Yuan FU Shi Hong GUO Xiao Fang LEI Wen Wen LI Xiao Long SONG Jing Dong CAO Lei GAO Xiao Yan LYU Zhi HE Ying WANG Huan Yu REN Xiao Jie ZHOU Hong Ning WANG Gui Qin LIANG Guo Dong | 2017 | Biomedical and Environmental Sciences2017，30，3： | 12 |
| 6 | Potato/Maize intercropping reduces infestation of potato tuber moth, Phthorimaea operculella(Zeller) by the enhancement of natural enemies显示文摘The potato tuber moth(PTM),Phthorimaea operculella(Zeller),is one of the most economically significant insect pests for potato in both field and storage worldwide.To evaluate the infestation,reduction of potato yield and the control efficacy for PTM,field tests were conducted in two seasons by intercropping of potato as the host plant with maize as a non-host plant of PTM.Three intercropping patterns were tested,which were 2 rows of potatoes with either 2,3,or 4 rows of maize(abbreviated 2 P:2 M,2 P:3 M,and 2 P:4 M),and the monocropped potato as the control,2 rows of potatoes,without maize,(abbreviated 2 P:0 M).Results showed that the population and infestation of PTM in the 2 P:3 M intercropping pattern was significantly lower than those in 2 P:2 M,2 P:4 M and the monocropping pattern of 2 P:0 M,due to the enhancement of natural enemies.Cumulative mines and tunneling in potato leaves in 2 P:3 M intercropping were significantly lower than those in 2 P:2 M and 2 P:4 M patterns.The population of parasitoids and the parasitism rate of PTM in intercropping pattern of 2 P:3 M were significantly higher than that in intercropping pattern of 2 P:2 M,2 P:4 M and monocropping pattern of 2 P:0 M.We conclude that the potato intercropped with maize reduced the adult and larva populations,and reduced the damage from PTM by enhancing the number of parasitoids and the level of parasitism.The greatest population density of parasitoids and parasitism rate were in the intercropping pattern of 2 rows of potatoes with 3 rows of maize.These data indicate that the host/non-host intercropping patterns can be used as a biological control tactic against PTM by enhancing the density of natural enemies in the agro-ecosystems. | ZHENG Ya-qiang ZHANG Li-min CHEN Bin YAN Nai-sheng GUI Fu-rong ZAN Qing-an DU Guang-zu HE Shu-qi LI Zheng-yue GAO Yu-lin XIAO Guan-li | 2020 | Journal of Integrative Agriculture2020，19，2： | 8 |
| 7 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 8 | Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases显示文摘INTRODUCTIONThetermbasaloidsquamouscarcinoma(BSC)wasfirstproposedbyWainetalin1986todescribearare,aggresiveneoplasmwithapredil... | ZHANG Xin Hua, SUN Gui Qin, ZHOU Xiao Jun, GUO Hui Fang and ZHANG Tai He | 1998 | World Journal of Gastroenterology1998，4，5： | 8 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | Effects of PM2.5 Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang, China显示文摘Asthma is a common chronic inflammatory disorder that is more prevalent in children than in adults. China has seen an increasing prevalence of childhood asthma in recent decades[1]. Earlier studies have shown that air particulate matter (PM), particularly fine particulate matter (PM2.5)[2], is an important factor triggering childhood asthma. Since national PM2.5 data were not available until 2013, the effects of PM2.5 on childhood asthma are less known, and most of the related research has been conducted primarily in some metropolises in China. Moreover, the majority of these studies focus on the impact of a unit increase (1 or 10 μg/m3) or an interquartile range increase in PM2.5 on childhood asthma based on the same pollutant background concentrations. Assessment of the impact of air quality grades (AQGs) based on PM2.5 concentration related to health effects is rarely considered[3]. Thus, the purpose of this study is to confirm the effects of PM2.5 on daily outpatient visits for childhood asthma in Shijiazhuang, a heavily polluted city with a high prevalence of childhood asthma in China, for the period 2013-2015, and to evaluate the association between PM2.5 exposure in different national AQGs and outpatient visits for childhood asthma in this city. | FU Gui Qin JIANG Yan Feng LIU Lan Ping LIU Hua Yue ZHOU Ji CUI Xiao Wei WANG Shi Gong | 2018 | Biomedical and Environmental Sciences2018，31，12： | 7 |
| 11 | A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13显示文摘也就是,从海洋的棕色的水藻 Colpomenia sinuosa 的内部织物被孤立的 endophytic 真菌曲霉属菌尼日尔 EN-13 的耕作导致了新 naphthoquinoneimine 衍生物的描述 5,7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl )-2-phenylethylamino]-[1,4]naphthoquinone。新混合物的结构包括 2D NMR 技术, EIMS,和 HR-ESI-MS 根据各种各样的 NMR 分光镜的分析被建立。这项复合显示的中等抗真菌的活动。 | Yi Zhang Xiao Ming Li Chang Yun Wang Bin Gui Wang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 12 | A WRKY transcription factor confers aluminum tolerance via regulation of cell wall modifying genes显示文摘Modification of cell wall properties has been considered as one of the determinants that confer aluminum(Al)tolerance in plants,while how cell wall modifying processes are regulated remains elusive.Here,we present a WRKY transcription factor WRKY47 involved in Al tolerance and root growth.Lack of WRKY47 significantly reduces,while overexpression of it increases Al tolerance.We show that lack of WRKY47 substantially affects subcellular Al distribution in the root,with Al content decreased in apoplast and increased in symplast,which is attributed to the reduced cell wall Al-binding capacity conferred by the decreased content of hemicellulose I in the wrky47-1 mutant.Based on microarray,real time-quantitative polymerase chain reaction and chromatin immunoprecipitation assays,we further show that WRKY47 directly regulates the expression of EXTENSIN-LIKE PROTEIN(ELP)and XYLOGLUCAN ENDOTRANSGLUCOSYLASE-HYDROLASES17(XTH17)responsible for cell wall modification.Increasing the expression of ELP and XTH17 rescued Al tolerance as well as root growth in wrky47-1 mutant.In summary,our results demonstrate that WRKY47 is required for root growth under both normal and Al stress conditions via direct regulation of cell wall modification genes,and that the balance of Al distribution between root apoplast and symplast conferred by WRKY47 is important for Al tolerance. | Chun Xiao Li Jing Ying Yan Jiang Yuan Ren Li Sun Chen Xu Gui Xin Li Zhong Jie Ding Shao Jian Zheng | 2020 | Journal of Integrative Plant Biology2020，62，8： | 7 |
| 13 | A constitutive model for the state-dependent behaviors of rockfill material considering particle breakage显示文摘The particle breakage during specimen compaction had more significant influence on the position of the breakage critical-state line(BCSL)of Tacheng rockfill material(TRM)in the e-lnp’plane than the particle breakage during shearing,based on the large-scale triaxial compression tests on TRM in a wide range of densities and pressures.The state-dependent dilatancy and the plastic modulus were correlated to the breakage index,based on the formulations of the BCSL of TRM in the e-lnp’plane.The state-dependent model considering particle breakage was proposed for TRM within the framework of the generalized plasticity theory.The proposed model contained fourteen material constants.The test data of TRM from Group A were adopted to determine these material constants,while the test data from Group B were used independently to validate the model predictive capacity.The comparisons between model simulations and test data illustrated that the model with consideration of particle breakage could well represent the stress-strain behaviors of TRM,e.g.,the strain hardening and volumetric contraction behaviors at a loose state and the strain softening and volumetric expansion behaviors at a dense state,and also the particle breakage behaviors of TRM. | XIAO Yang LIU HanLong YANG Gui CHEN YuMin JIANG JingShan | 2014 | Science China(Technological Sciences)2014，57，8： | 6 |
| 14 | Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice显示文摘Alzheimer's disease(AD)shows cognitive impairments in clinic,which is multifactorial with different etiopathogenic mechanisms such as A|3 deposition,neuroinflammation and neuronal dystrophy involved.Therefore,multi-targets drugs with neuroprotective,anti-amyloidogenic and anti-inflammatory properties will be effective in AD treatment.Epigallocatechin-3-gallate(EGCG)possesses a broad spectrum of pharmacological activities in the prevention and treatment of multiple neurodegenerative diseases.In the present study,we showed that oral administration of EGCG(50 mg/kg)for 4 months significantly attenuated the cognitive deficits in APP/PS1 transgenic mice,which served as AD model.Moreover,EGCG induced an improvement in dendritic integrity and expression levels of synaptic proteins in the brain of APP/PS 1 mice.And EGCG exerted obvious anti-inflammatory effects,which was manifested by alleviating microglia activation,decreasing pro-inflammatory cytokine(IL-β)and increasing anti-inflammatory cytokines(IL-10,IL-β).Furthermore,p-amyloid(AP)plaques were markedly reduced in the hippocampus of 6-month old APP/PS 1 mice after EGCG treatment.In conclusion,these findings indicate that EGCG improves AD-like cognitive impairments through neuroprotective,anti-amyloidogenic and anti-inflammatory effects,thus is a promising therapeutic can didate for AD. | Jian BAO Wei LIU Hong-yan ZHOU Yu-ran GUI You-hua YANG Meng-juan WU Yi-fan XIAO Jin-ting SHANG Gui-feng LONG Xi-ji SHU | 2020 | Current Medical Science2020，40，1： | 6 |
| 15 | Dynamics of Rodent and Rodent-borne Disease during Construction of the Three Gorges Reservoir from 1997 to 2012显示文摘Objective To investigate the impact of impoundment and active public health interventions on rodent populations and rodent-borne diseases in the Three Gorges reservoir region from 1997 to 2012. Methods Surveillance data from 1997 to 2012 were extracted from the Public Health Surveillance System of The Three Gorges established in 1997. Temporal changes in the incidences of hemorrhagic fever with renal syndrome(HFRS) and leptospirosis, rodent density, pathogen-carrying rates, and their correlations were analyzed. Results The average indoor and outdoor rodent densities decreased overall from 1997 to 2012. The average densities decreased by 47.72%(from 4.38% to 2.29%) and 39.68%(from 4.41% to 2.66%), respectively, after impoundment(2003-2012) compared with before impoundment(1997-2002). The average annual incidence rates of HFRS and leptospirosis were 0.29/100,000 and 0.52/100,000, respectively, and decreased by 85.74%(from 0.68/100,000 to 0.10/100,000) and 95.73%(from 1.47/100,000 to 0.065/100,000), respectively, after impoundment compared with before impoundment. Incidences of HFRS and leptospirosis appear to be positively correlated with rodent density in the reservoir area. Conclusion This study demonstrated that rodent density and incidences of rodent-borne diseases decreased and were maintained at low levels during construction of the Three Gorges dam. Measures that reduce rodent population densities could be effective in controlling rodent-borne diseases during large-scale hydraulic engineering construction. | CHANG Zhao Rui LU Liang MAO De Qiang PAN Hui Ming FENG Lian Gui YANG Xiao Bing LIU Feng Feng HE Yuan Yuan ZHANG Jing YANG Wei Zhong | 2016 | Biomedical and Environmental Sciences2016，29，3： | 5 |
| 16 | Convection effect on dendritic growth using phase-field method显示文摘Phase-field model was employed to quantitatively study the effect of convection on pattern selection and growth rate of 2D and 3D dendrite tip,as well as the effect of the different convection velocity on the dendritic growth.The calculated results show that crystal is asymmetric in the priority direction of growth under flow.The dentritic growth is promoted in the upstream region and suppressed in the downstream region.Convection can cause deviation in the dendrite growth direction and the preferred direction of the columnar crystals.It has been found that both primary dendrite stem and secondary dendrite arm deflect significantly towards upstream direction,secondary dendrite arm in upstream direction is more developed than the primary dendrite in downstream direction. | Zhu Changsheng Wang Zhiping Gui Jin Xiao Rongzhen | 2010 | China Foundry2010，7，1： | 5 |
| 17 | Altered Expression of Matrix Metalloproteinases and Tight Junction Proteins in Rats following PEMF-Induced BBB Permeability Change显示文摘Objective To investigate the expression of occludin,ZO‐1,MMP‐2,and MMP‐9 in cerebral microvasculature following Pulse Electromagnetic Field(PEMF) induced BBB permeability change.Methods Sprague‐Dawley rats were randomized into PEMF and sham exposed groups(n=8).After exposure to PEMF at 0.5,1,3,6,and 12 h,BBB permeability was measured by Evans‐Blue extravasation.The expression of occludin,ZO‐1,MMP‐2,and MMP‐9 were detected by real‐time quantitative reverse transcriptase PCR and western blotting.MMP‐2 and MMP‐9 activity were detected by EnzChek gelatinase assay.Results Compared with the sham group,PEMF exposure led to increased permeability of the BBB to EB,which was prolonged after exposure.BBB permeability became progressively more severe,and recovered at 6 h.The gene and protein expression of occludin and ZO‐1 were significantly decreased,while MMP‐2 and MMP‐9 expression were significantly increased after exposure to PEMF.All levels of expression recovered 12 h following PEMF.Conclusion Changes to BBB permeability were related to the alteration expression of tight junction proteins and matrix metalloproteinase after exposure to PEMF. | ZHANG Ya Mei ZHOU Yan QIU Lian Bo DING Gui Rong PANG Xiao Feng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 5 |
| 18 | A successful case of combined liver and kidney transplantation for autosomal dominant polycystic liver and kidney disease显示文摘Withadvancesintransplantation,multiorgantransplantationhasbecomeatreatmentofchoiceforendstageorganfailurewhichcannotberever... | HE Xiao Shun, HUANG Jie Fu, CHEN Gui Hua, ZHENG Ke Li and YE Xiao Ming | 1999 | World Journal of Gastroenterology1999，5，1： | 5 |
| 19 | Characterization of Class 1 Integron Gene Cassettes among Clinical Bacteria Isolated from One Large Hospital in Northern China显示文摘班在不同种类之中的 1 integron 和复杂基因盒子临床在北中国孤立在这研究被描绘。383 临床孤立从北中国,和包含广泛地在克之中散布的基因盒子的班 1 integrons 被获得否定临床孤立被观察。我们发现 1 integron 显示出的班与克的 multidrug 抵抗显型的积极关联否定细菌。另外,我们发现那孤立属于一种怀有基因盒子数组的不同类型,当基因盒子数组的一样的类型在不同种类被观察时孤立。在 isolates 之中的基因盒子数组的差异显示了 multidrug 抵抗的复杂性在临床在北中国孤立。 | CHEN Xia LI Gui Xi ZHANG Hong YUAN Min HOU Xiao Ping YU Hui Lan LI Juan | 2013 | Biomedical and Environmental Sciences2013，26，12： | 5 |
| 20 | Comparative analysis of the clinical outcomes between wavefront-guided and conventional femtosecond LASIK in myopia and myopia astigmatism显示文摘AIM:To compare the clinical outcomes of wavefront guided femtosecond LASIK(WFG LASIK)and conventional femtosecond LASIK(NWFG LASIK)in eyes with myopia and myopia astigmatism.METHODS:This was a retrospective,nonrandomized,comparative investigation enrolling 236 eyes of 122 patients(18-50 y)with low&moderate and high myopia.The WFG group including 97 eyes(50 patients)undergone WFG LASIK and the NWFG group including 139 eyes(72 patients)undergone conventional LASIK.Mean efficacy index,high order aberrations(HOAs),pupil size and the quality of visual questionnaire were evaluated 6 mo postoperatively.RESULTS:There is no difference between WFG group(-0.054±0.049 in logMAR)and NWFG group(-0.040±0.056)in uncorrected distance visual acuity(UDVA)postoperatively.The myopia astigmatism is higher in WFG group than that in NWFG group(P<0.05).However,the mean efficacy index(MEI)in the WFG group(1.09±0.106)is better than that in the NWFG group(1.036±0.124;P<0.001).Increased HOAs were observed in NWFG group(0.30±0.196)than that in WFG group(0.146±0.188;P<0.001).The pupil size is larger in WFG group(5.15±0.76 mm)than that in NWFG group(4.32±0.52 mm).The patients are satisfied with the clinical surgery,yet WFG group showed better visual quality using the questionnaire survey.Meanwhile,high myopia would result in worse MEI,HOAs and visual quality than low&moderate myopia.CONCLUSION:WFG and NWFG FS-LASIK are both effective and safe procedures to correct low&moderate and high myopia,but WFG FS-LASIK gives a better postoperative MEI,aberrometric control and predictable outcome.Meanwhile,WFG FS-LASIK is better than NWFG FS-LASIK in correction of myopia astigmatism.Low&moderate myopia allow better clinical outcomes than high myopia using any surgical method. | Xiao Gui Rui Zhang Sha Li Na Zhao Hao-Rui Zhang Yu-Kun Zhou Chen-Yang Huan Chun-Yan Zhao Hong-Ying Wang Hong-Yuan Song Wei Shen Jian-Hua Zhang | 2021 | International Journal of Ophthalmology(English edition)2021，14，10： | 5 |
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