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| 1 | Sedimentary and geochemical evidence of Eocene climate change in the Xining Basin, northeastern Tibetan Plateau显示文摘The northeastern Tibetan Plateau began to grow during the Eocene and it is important to understand the climatic history of Asia during this period of so-called ‘doubthouse' conditions. However, despite major advances in the last few decades,the evolutionary history and possible mechanisms of Eocene climate change in the northeastern Tibetan Plateau remain unclear.The Xining Basin in the northeastern Tibetan Plateau contains a continuous sequence of Early to Late Eocene non-marine sediments which provides the opportunity to resolve long-term climate changes during this period. In this study, we report the results of analyses of lithofacies, sediment color and geochemistry of bulk samples collected from the Xijigou section of the Xining Basin. An abrupt lithofacies change between the Early(~52–40 Ma) and Late Eocene(~40–34 Ma) indicates a change in the depositional environment from a shallow lake to a playa lake in response to a significant climatic shift. During ~52–40 Ma,higher values of sediment redness(a*), redness/lightness(a*/L*) and higher modified Chemical Index of Weathering(CIW′)indicate a relatively warm and humid climate, while from ~40–34 Ma the lower values of a*, a*/L*and lower CIW′ imply subhumid to semi-arid climatic conditions. The paleoclimatic records indicate a long-term(~52–34 Ma) trend of decreasing chemical weathering, consistent with global climate change. An abrupt sharp excursion of the proxy records during ~42–40 Ma suggests a relatively brief warm interval, corresponding to the Middle Eocene Climatic Optimum(MECO). We suggest that global cooling substantially reduced humidity in inner Asia, resulting in sub-humid to semi-arid climatic conditions after 40 Ma in the Xining Basin, which may have been responsible for the long-term trend of decreasing chemical weathering during the Eocene. | Abu Sadat Md SAYEM Zhengtang GUO Haibin WU Chunxia ZHANG Fan YANG Guoqiao XIAO Zhilin HE | 2018 | Science China Earth Sciences2018，61，9： | 6 |
| 2 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 3 | Effects of Location and Extension of Portal Vein Tumor Thrombus on Long-Term Outcomes of Surgical Treatment for Hepatocellular Carcinoma显示文摘 | Xiao-Ping Chen MD PhD FACS Fa-Zu Qiu MD PhD Zai-De Wu MD PhD Zhi-Wei Zhang MD PhD Zhi-Yong Huang MD PhD Yi-Fa Chen MD PhD Bi-Xiang Zhang MD PhD Song-Qing He MD PhD Wan-Guang Zhang MD PhD | 2006 | Annals of Surgical Oncology2006，，7： | 2 |
| 4 | Surgical Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus显示文摘 | Jie Shi MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Nan Li MD Wei-Xing Guo MD Jie Xue MD Wan Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD | 2010 | Annals of Surgical Oncology2010，，8： | 2 |
| 5 | A Comparative Study of Antiviral Therapy After Resection of Hepatocellular Carcinoma in the Immune-Active Phase of Hepatitis B Virus Infection显示文摘 | Nan Li MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Jie Shi MD Wei-Xing Guo MD Jie Xue MD Bing Huang MD Wan-Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD | 2010 | Annals of Surgical Oncology2010，，1： | 2 |
| 6 | 2004年加拿大预防血透病人医院血流感染的成本-效益分析显示文摘目的:血液透析相关的血流感染是一个严重的公共健康问题,因为加拿大的血液透析病人从1996年到2005翻了一番。本研究目的在于确定加拿大医院血流感染的成本,估算在综合性医院中建立感染控制项目的成本,并进行成本-效益分析。材料与方法:用加拿大医院感染监测项目的数据来估算医院血流感染的发生率。用加拿大健康信息所数据来估算2004年加拿大平均一次血流感染住院的额外成本。建立和维护一个感染控制项目的成本用美国疾病预防与控制中心1985年的成本换算为2004年的加拿大成本来估算。假设感染控制项目能降低医院血流感染病例的20%~30%。结果:2004年的加拿大15278名血液透析病人中估计共有2524人发生血流感染。全年用于治疗血流感染的成本估计为4901万加元。医院血流感染预防和人力资源的总投资成本为815万加元。建立医院感染控制项目后能带来1452万加元的医疗成本节约。效益成本比在1.0:1到1.8:1之间。结论:本研究提供的证据表明,如果医院感染控制项目能降低20%~30%的感染,该项目的经济效益将远超过增加的成本。医院感染控制项目将带来双重效益:节约货币成本的同时改善医疗质量。 | Zhiyong Hong MD DrPH Jun Wu PhD Crystal O'Leary BHSc Clem Tisdell James Gomes Shi-Wu Wen Howard Njoo 李洪超 | 2010 | 中国药物经济学2010，，1： | 2 |
| 7 | Molecular and serological characteristics of the glutathione S-transferase of Schistosoma japonicum and Schistosoma mansoni显示文摘 | Tiu WU Davern KM Wright MD | 1988 | Parasite Immunol1988，10，6： | 1 |
| 8 | Effect of aging on the expression,NOS and cell death in the mouse cochlear spiral ganglion显示文摘 | Wu MD Kimura M Inafuku S | 1997 | Okajimas Folia Anat Jpn1997，74，5： | 1 |
| 9 | Effect of oxymatrine on the TGF beta -Smad signaling pathway in rats with CCI4 -in- duced hepatic fibrosis显示文摘 | WU XL ZW Z JIANG MD | 2008 | World J Gastroenterol2008，14，13： | 1 |
| 10 | Prospective study of hemostatic factors and incidence of coronary Communities study显示文摘 | Folsom AR Wu KK Rosanond MD | 1997 | Circulation1997，96，： | 1 |
| 11 | Heme oxygenase-1 in environmental toxin-induced lung disease显示文摘 | Wu ML Layne MD Yet SF | 2012 | Toxicol Mech Methods2012，22，5： | 1 |
| 12 | The Successful Medical Treatment of a Case of Paecilomyces lilacinus Keratitis显示文摘 | Pei-Chen Wu MD Chien-Hsiung Lai MD | 2010 | Cornea2010，29，3： | 1 |
| 13 | Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100, 000 bacteria per ml: a systematic re-view 显示文摘 | Wei Q Wu JC Roderick MD | 2005 | J Urol2005，173，： | 1 |
| 14 | Vaccinationwith peptide mimetics of the gp41 prehairpin fusionintermediate yields neutralizing antisera against HIV-1isolates 显示文摘 | Bianchi E Joyce JG Miller MD Liang XP Finotto MA McKenna P Citron MA Hepler RW Hrin R Nahas D Wu CW Montefiori D Shiver JW Kim PS | 2010 | Proc Natl Acad Sci USA2010，107，10： | 1 |
| 15 | Vitamin B6Points PC6 Injection During Acupuncture Can Relieve Nausea and Vomiting in Patients With Ovarian Cancer显示文摘 | Qi You MD Hongli Yu MD Donglai Wu MD et al | 2009 | International Journal of Gynecological Cancer2009，19，4： | 1 |
| 16 | Secondary metabolites isolated from the fungus Monascus Pilosus显示文摘 | Cheng MJ Wu MD Chen IS | | 0，，5： | 1 |
| 17 | Development of novel selfhealing and antibacterial dental composite containing calcium phosphate nanoparticles显示文摘 | Wu J Weir MD Melo MA | 2015 | J Dent2015，43，3： | 1 |
| 18 | Catalytic Decomposition of Biomass Tars With Iron Oxide Cata- lysts 显示文摘 | Md Azhar Uddin Hiroshi Tsuda Shengji Wu | 2008 | Fuel2008，87，： | 1 |
| 19 | Epidermal Growth Factor Receptor Mutations and Their Correlation with Gefitinib Therapy in Patients with Non-small Cell Lung Cancer:A MetaAnalysis Based on Updated Individual Patient Data from Six Medical Centers in Mainland China显示文摘 | Wu Yi-Long MD | 2007 | Intemational Association for the Study of Lung Cancer2007，2，5： | 1 |
| 20 | Molecular and serological characteristics of the gtutathione-S-transferase of Schistosoma japonicum and Schistosoma mansoni显示文摘 | Tiu WU Davern KM Wright MD | 1988 | Parasite Immunol1988，10，6： | 1 |
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