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| 1 | NKX6.3 protects against gastric mucosal atrophy by downregulatingβ-amyloid production显示文摘BACKGROUND Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis.Thus, we hypothesized that transcription factor NKX6.3 might be involved in maintaining gastric epithelial homeostasis by regulating amyloid β(Aβ)production.AIM To determine whether NKX6.3 might protect against gastric mucosal atrophy by regulating Aβ production.METHODS We identified NKX6.3 depletion induced cell death by cell count and Western blot assay. Production and mechanism of Aβ oligomer were analyzed by enzymelinked immunosorbent assay, Western blot, immunoprecipitation, real-timequantitative polymerase chain reaction and immunofluorescence analysis. We further validated the correlation between expression of NKX6.3, Helicobacter pylori CagA, Aβ oligomer, apolipoprotein E(ApoE), and β-secretase 1(Bace1) in 55 gastric mucosae.RESULTS NKX6.3 depletion increased both adherent and floating cell populations in HFE-145 cells. Expression levels of cleaved caspase-3,-9, and poly ADP ribose polymerase were elevated in floating HFE-145^(shNKX6.3) cells. NKX6.3 depletion produced Aβ peptide oligomers, and increased expression of ApoE, amyloid precursor protein, Aβ, Bace1, low-density lipoprotein receptor, nicastrin, high mobility group box1, and receptor for advanced glycosylation end product proteins. In immunoprecipitation assay, γ-secretase complex was stably formed only in HFE-145^(shNKX6.3) cells. In gastric mucosae with atrophy, expression of Aβpeptide oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Treatment with recombinant Aβ 1-42 produced Aβoligomeric forms and decreased cell viability in HFE-145^(shNKX6.3) cells. Additionally,NKX6.3 depletion increased expression of inflammatory cytokines and cyclooxygenase-2.CONCLUSION NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. | Jung Hwan Yoon Yeon Soo Lee Olga Kim Hassan Ashktorab Duane T Smoot Suk Woo Nam Won Sang Park | 2019 | World Journal of Gastroenterology2019，25，3： | 6 |
| 2 | 神经连接蛋白-3缺乏可阻止高分级神经胶质瘤生长显示文摘在一项新的研究中,来自美国国家卫生研究院、斯坦福大学、达纳法伯癌症研究所和哈佛医学院的研究人员发现某些侵袭性脑瘤的生长能够通过切断它们获取大脑中神经细胞产生的一种信号分子加以阻止.这些研究人员发现当这种被称作神经连接蛋白-3(neuroligin-3,NLGN3)的信号分子缺乏时,或者当利用药物干扰这种信号分子时,人高分级神经胶质瘤不能够在小鼠大脑中扩散. | Venkatesh H S Tam L T Woo P J | 2017 | 临床误诊误治2017，30，11： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Regulatory CD4^+ CD25^+ T ceils in tumors from patients with early-stage non-small cell lung cancer and latestage ovarian cancer显示文摘 | Woo E Y Chu C S Goletz T J | 2001 | Cancer Res2001，61，： | 1 |
| 5 | Synergic induction of hu- man periodontal ligament fibroblast cell death by nitric oxide and N-methyl-D-aspartic acid receptor antagonist显示文摘 | Seo T Cha S Woo KM | 2011 | J Pe- riodontal Implant Sci2011，41，1： | 1 |
| 6 | Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin显示文摘 | HANAKAWA Y SELWOOD T WOO D | 2003 | J Invest Dermatol2003，121，2： | 1 |
| 7 | A combinatorial analysis of boundary data structure schemata显示文摘 | WOO T C | 1985 | Institute of Electrical and Electronic Engineers Computer Graphics and Applications1985，5，3： | 1 |
| 8 | The role of permafrost and seasonal frost in the hydrology of northern wetlands in North America显示文摘 | Woo M-K Winter T C | 1993 | Journal of Hydrology1993，，141： | 1 |
| 9 | Patting directions for mould and die design显示文摘 | CHEN L L CHOU S Y WOO T C | 1993 | Computer-Aided Design1993，25，12： | 1 |
| 10 | Tne yin and yang of neu- rotrophin action显示文摘 | Lu B Pang P T Woo N H | 2005 | Nat Rev Neurosci2005，6，8： | 1 |
| 11 | Capacity fading mechanism of LiFePO4-based lithium secondary batteries for stationary energy storage 显示文摘 | KIM J H WOO S C PARK M S KIM K J YIM T KIM J S KIMY J | 2013 | Journal of Power Sources2013，229，： | 1 |
| 12 | 1,3-Propanesultone as an effective functional additive to enhance the electrochemical performance of over-lithiated layered oxides显示文摘 | YIM T SU H K WOO S G | 2014 | Rsc Advances2014，4，19： | 1 |
| 13 | A Novel Complex Orthogonal Design for Space--Time Coding in Sensor Networks显示文摘 | Woo T | 2007 | Wirel Pers Commun2007，43，4： | 1 |
| 14 | Disilanylenearylene oligomers and polymers from dehydropolymerization of 1,4 - RH2SiCsH&iH2R (R = Methyl, Ethyl, and Hexyl) 显示文摘 | IMORI T WOO H G WALZER J F | 1993 | Chem Mater1993，5，： | 1 |
| 15 | Distribution of in situ forces in the anterior cruciate ligament in response to rotatory loads 显示文摘 | Gabriel M T Wong E K Woo S L Y | 2004 | Journal of Orthopaedics Research2004，22，1： | 1 |
| 16 | Prodigiosin 25-C and metacycloprodigiosin suppress the bone resorption by oste- oclasts显示文摘 | Woo J T Ohba Y Nagai K | 1997 | Biosci Biotechnol Biochem1997，61，： | 1 |
| 17 | Partial visibility for selecting a parting direction in mold and die design显示文摘 | CHEN L L CHOU S Y WOO T C | 1995 | Journal of Manufacturing Systems1995，14，5： | 1 |
| 18 | Benchmark radar targets for the validation of computational electromagnetics programs显示文摘 | Woo A C Wang H T G Schuh M J | 1993 | IEEE Trans on Antennas Propagat1993，135，： | 1 |
| 19 | Atomic and electronic structure of unreduced and reduced CeO2 surfaces:A first-principles study显示文摘 | Yang Z Woo K T Baudin M | 2004 | J Chem Phys2004，120，： | 1 |
| 20 | Exercise trainingim- proves cardiac autonomic nervous system activity in type 1 dia- betic children显示文摘 | SHIN K MORITANI T WOO J | 2014 | J Phys Ther Sci2014，26，1： | 1 |
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