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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Epithelial cancer cell migration a role for chemokine receptors显示文摘 | SCOTTON CJ WILSON JL MELLIKEN D | 2001 | Cancer Res2001，61，13： | 1 |
| 3 | Neointimal response following rotational atherectomy compared to bal-loon angioplasty in a porcine model of coronary in-stent restenosis显示文摘 | McKenna CJ Wilson SH Camrud AR | | 0，，： | 1 |
| 4 | The balance of give and take in caregiver-partner relationships:an examination of self-perceived burden,relationship equity,and quality of life from the perspective of care recipients following stroke显示文摘 | McPherson CJ Wilson KG Chyurlia L | | 0，，02： | 1 |
| 5 | Feeling like a burden to otlaers: A systematic review focusing on the end of life显示文摘 | MePherson CJ Wilson KG | 2007 | Palliat Med2007，21，10： | 1 |
| 6 | A meta-analysis ofthe effects of chemotherapy on cognition in patients with cancer 显示文摘 | Hodgson KD Hutchinson AD Wilson CJ | 2013 | Cancer Treat Rev2013，39，3： | 1 |
| 7 | Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer显示文摘 | Scotton CJ Wilson JL Scott K | 2002 | Cancer Res2002，62，： | 1 |
| 8 | GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides显示文摘 | Phiel CJ Wilson CA Lee VM Klein PS | 2003 | Nature2003，423，6938： | 1 |
| 9 | Abdominal aorticcalcific deposits are an important predictor of vascularmorbidity and mortality显示文摘 | Wilson PW Kauppila LI O'Donnell CJ | | 0，，11： | 1 |
| 10 | Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer 显示文摘 | Scotton CJ Wilson JL Scott K | 2002 | Cancer Res2002，62，： | 1 |
| 11 | Feeling like a burden:exploring the perspectives of patients at theend of life显示文摘 | McPhemon CJ Wilson KG | 2007 | Social Sci- ence Medicine2007，64，2： | 1 |
| 12 | The asso- ciation of suprascapular neuropathy with massive rotator cuff tears: a preliminary report 显示文摘 | MALLON WJ WILSON R J BASAMANIA CJ | 2006 | J Shoulder Elbow Surg2006，15，4： | 1 |
| 13 | Feeling like a burden to others:A systematic review focusing on the end of life显示文摘 | McPherson CJ Wilson KG | 2007 | Palliative Medicine2007，21，10： | 1 |
| 14 | GSK-3α regulates production of A1zheimer′s disease amyloid-beta peptides显示文摘 | Phiel CJ Wilson CA Lee VM | 2003 | Nature2003，423，： | 1 |
| 15 | Reference intervals for plasma apolipoprotein A1 determined with a sfandardized commerercial immunoturbidimetric assay: result from the Framingham Offspring Study显示文摘 | Contois JH Mcnamara JR Lammi-Keefe CJ Wilson PWF Massov T Schaefer EJ | 1996 | Clin Chem1996，42，4： | 1 |
| 16 | The balance of give and take in caregiver partner relationships; An examination of self- perceived burden, relationship equity, and quality of life from the perspective of care recipients following stroke显示文摘 | McPherson CJ Wilson KG Chyurlia L | 2010 | Reha- bil Psychol2010，55，2： | 1 |
| 17 | Feeling like a burden to others: a systematic review focusing on the end of life显示文摘 | Mcpherson CJ Wilson KG | 2007 | Palliative Medicine2007，21，10： | 1 |
| 18 | Feeling like a burden:Exploring the perspectives of patients at the end of life显示文摘 | McPherson CJ Wilson KG Murray MA | 2007 | Soc Sci Med2007，64，： | 1 |
| 19 | Reference intervals for plasma apolipoprotein B determined with a sfandardized commerercial immunoturbidimetric assay: result from the Framingham Offspring Study显示文摘 | Contois JH Mcnamara JR Lmmi-Keefe CJ Wilson PWF Massov T Schaefer EJ | 1996 | Clin Chem1996，42，4： | 1 |
| 20 | Toxicity of rhizonin A, isolated from Rhizopus microsporus, in laboratory animals显示文摘 | Wilson T Rabie CJ Fincham JE et a1 | 1984 | Food and Chemical Toxicology1984，22，4： | 1 |
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