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| 1 | Prodromal Parkinson’s disease: hype or hope for disease-modification trials?显示文摘The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modification trials in PD has been attributed to a variety of factors related not only to choosing wrong interventions, but also to using inadequate trial designs and target populations. In patients with clinically established PD, neuronal pathology may already have advanced too far to be modified by any intervention. Based on such reasoning, individuals in yet prediagnostic or prodromal disease stages, may provide a window of opportunity to test disease-modifying strategies. There is now sufficient evidence from prospective studies to define diagnostic criteria for prodromal PD and several approaches have been studied in observational cohorts. These include the use of PD-risk algorithms derived from multiple established risk factors for disease as well as follow-up of cohorts with single defined prodromal markers like hyposmia, rapid eye movement sleep behavior disorders, or PD gene carriers. In this review, we discuss recruitment strategies for disease-modification trials in various prodromal PD cohorts, as well as potential trial designs, required trial durations, and estimated sample sizes. We offer a concluding outlook on how the goal of implementing disease-modification trials in prodromal cohorts might be achieved in the future. | Philipp Mahlknecht Kathrin Marini Mario Werkmann Werner Poewe Klaus Seppi | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 2 | Efficacy of benfotiamine versust hiamine on function and glycation products of peripheral nerves in diabetic rats显示文摘 | Stracke H Hammes HP Werkmann D | 2001 | Exp Clin Endocrinol Diabetes2001，，109： | 1 |
| 3 | Efficacy of benfotiamine versus thiamine on fimction and glycation products of peripheral nerves in diabetic rats显示文摘 | Stracke H Hammes HP Werkmann D | 2001 | Exp Clin Endocrinol Diabetes2001，109，6： | 1 |
| 4 | Soft braces in the treatment of Adolescent Idiopathic Scoliosis (AIS)-Review of the literature and description of a new approach显示文摘 | Weiss HR Werkmann M | | 0，，： | 1 |
| 5 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats显示文摘 | Stracke H Hammes HP Werkmann D | | 0，，： | 1 |
| 6 | Continuous age- dependent reference ranges for thyroid hormones in neonates, infants, children and adolescents established using the ADVIA Centaur Analyzer显示文摘 | Hubner U Englisch C Werkmann H | 2002 | Clin Chem Lab Med2002，40，10： | 1 |
| 7 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats 显示文摘 | Stracke H Hammes HP Werkmann D | 2001 | Exp Clin Endocrinol Diabetes2001，109，6： | 1 |
| 8 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats 显示文摘 | Stracke H Hammes HP Werkmann D | 2003 | Exp Clin Endocrinol Diabetes2003，109，： | 1 |
| 9 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats显示文摘 | Stracke H Hammes HP Werkmann D | 2001 | Exp Clin Endocrinol Diabetes2001，109，6： | 1 |
| 10 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats显示文摘 | Stracke H Hammes HP Werkmann D | 2001 | Exp Clin Endocrinol Diabetes2001，109，6： | 1 |
| 11 | Einfluss der schaftsteifigkeit aufdas kolbengerauseh显示文摘 | Werkmann M Bitter A Ktinze | 2011 | MTZ2011，72，78： | 1 |
| 12 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats显示文摘 | H. Stracke H. Hammes D. Werkmann K. Mavrakis I. Bitsch M. Netzel J. Geyer W. K?pcke C Sauerland R. Bretzel K. Federlin | 2001 | Exp Clin Endocrinol Diabetes2001，，06： | 1 |
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