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| 1 | Pattern of latest tectonic motion and its dynamics for active blocks in Sichuan-Yunnan region, China显示文摘Based on the concept of 'active blocks' and spatial distribution of historical earthquakes with surface ruptures as well as major and subordinate active faults. The Sichuan-Yunnan region can be divided into four first-order blocks. They are the Markam block (I), the Sichuan-Yunnan rhombic block (II), Baoshan-Pu'er block (III), and Mizhina-Ximeng block (IV). Cut by sub-ordinate NE-trending active faults, the Sichuan-Yunnan rhombic block (II) can be further divided into two sub-blocks: the northwestern Sichuan sub-block (II1) and the middle Yunnan sub-block (II2), while the Baoshan- Pu'er block (III) can be further divided into three sub-blocks: Baoshan sub-block (III1), Jinggu sub-block (III2), and Mengla sub-block (III3). A quantitative study of offset landforms is carried out and the basic types of active faults and their long-term slip rates along the major boundaries of active blocks of different orders in the Sichuan-Yunnan region are determined, through slip vector analysis, the motion states of the active blocks are clarified and the deformation coordination on the block margins is discussed. It is suggested that the tectonic motion of the blocks in this region is a complex or superimposition of three basic types of motions: southeastward sliding, rotating on vertical axis, and uplifting. The Markam block (I), the northwestern Sichuan sub-block (II1), and middle Yunnan sub-block (II2) have a southeastward horizontal sliding rate of 1-5 mm/a, clockwise rotating angular rate of 1.4-4(/Ma, and uplifting rate of about 1 mm/a. The Baoshan-Pu'er (III) and Mizhina-Ximeng (IV) blocks have also been extensively clockwise rotated. This pattern of motion is a strain response to the collision between the Indian and Eurasian plates and the localized deformation and differential slip on the block margins associated with the northward motion of the Indian Plate. Because a set of transverse thrusts between the blocks absorbs and transforms some components of eastward or southeastward sliding motion, the eastward escape or extrusion of the Tibetan Plateau is limited as 'imbricated thrusting transformation-limited extrusion model'. | XU Xiwei (徐锡伟) WEN Xueze (闻学泽) ZHENG Rongzhang (郑荣章) MA Wentao (马文涛) SONG Fangming (宋方敏) YU Guihua (于贵华) | 2003 | Science China Earth Sciences2003，46，z2： | 127 |
| 2 | Nondestructive Testing and Characterization of Residual Stress Field Using an Ultrasonic Method显示文摘To address the difficulty in testing and calibrating the stress gradient in the depth direction of mechanical components, a new technology of nondestructive testing and characterization of the residual stress gradient field by ultrasonic method is proposed based on acoustoelasticity theory. By carrying out theoretical analysis, the sensitivity coefficients of different types of ultrasonic are obtained by taking the low carbon steel(12%C) as a research object. By fixing the interval distance between sending and receiving transducers, the mathematical expressions of the change of stress and the variation of time are established. To design one sending-one receiving and oblique incidence ultrasonic detection probes, according to Snell law, the critically refracted longitudinal wave(LCR wave) is excited at a certain depth of the fixed distance of the tested components. Then, the relationship between the depth of LCR wave detection and the center frequency of the probe in Q235 steel is obtained through experimental study. To detect the stress gradient in the depth direction, a stress gradient LCR wave detection model is established, through which the stress gradient formula is derived by the relationship between center frequency and detecting depth. A C-shaped stress specimen of Q235 steel is designed to conduct stress loading tests, and the stress is measured with the five group probes at different center frequencies. The accuracy of ultrasonic testing is verified by X-ray stress analyzer. The stress value of each specific depth is calculated using the stress gradient formula. Accordingly, the ultrasonic characterization of residual stress field is realized. Characterization results show that the stress gradient distribution is consistent with the simulation in ANSYS. The new technology can be widely applied in the detection of the residual stress gradient field caused by mechanical processing, such as welding and shot peening. | SONG Wentao XU Chunguang PAN Qinxue SONG Jianfeng | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 27 |
| 3 | Implementation and security analysis of practical quantum secure direct communication显示文摘Rapid development of supercomputers and the prospect of quantum computers are posing increasingly serious threats to the security of communication.Using the principles of quantum mechanics,quantum communication offers provable security of communication and is a promising solution to counter such threats.Quantum secure direct communication(QSDC)is one important branch of quantum communication.In contrast to other branches of quantum communication,it transmits secret information directly.Recently,remarkable progress has been made in proof-of-principle experimental demonstrations of QSDC.However,it remains a technical feat to bring QSDC into a practical application.Here,we report the implementation of a practical quantum secure communication system.The security is analyzed in the Wyner wiretap channel theory.The system uses a coding scheme of concatenation of lowdensity parity-check(LDPC)codes and works in a regime with a realistic environment of high noise and high loss.The present system operates with a repetition rate of 1 MHz at a distance of 1.5 kilometers.The secure communication rate is 50 bps,sufficient to effectively send text messages and reasonably sized files of images and sounds. | Ruoyang Qi Zhen Sun Zaisheng Lin Penghao Niu Wentao Hao Liyuan Song Qin Huang Jiancun Gao Liuguo Yin Gui-Lu Long | 2019 | Light(Science & Applications)2019，8，1： | 15 |
| 4 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 5 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 6 | Role of primary Zr-rich particles on microstructure and magnetic properties of 2:17-type Sm-Co-Fe-Cu-Zr permanent magnets显示文摘Trace Zr addition is essential for achieving desired cellular nanostructure and large coercivity in the pinning-controlled 2:17-type Sm-Co-Fe-Cu-Zr magnets that have served as the strongest high temperature permanent magnets for over 40 years.However,accompanying this is the formation of Zr-rich particles that may deteriorate the hard magnetic properties.Besides the formerly-reported 1:3R Zr-rich platelets,in this work,1–2μm sized Zr6(Co,Fe)23(6:23)particles(Fm 3 m)and 100–200 nm sized 1:3R Zr-rich particles were also found based on combined structural identifications and element mapping analysis.Around such particles,the desired 1:5H cell wall precipitates that provide the strongest pinning force of magnetic domain wall motions are rare,forming the precipitate-free-zones(PFZs).The 1:5H-PFZs and the soft magnetism of both 6:23 and 1:3R Zr-rich particles act as local weak pinning points,which are unfavorable to retain the large magnetization in strong opposite fields and lead to poor squareness.As observed in a Sm25Co45.9Fe19.5Cu5.6Zr4.0(wt.%)magnet,the co-existence of such Zr-rich particles and the associated 1:5H-PFZs leads to a pretty low squareness factor of only 52.89%given the large coercivity of 29.04 kOe.Our findings suggest that careful controlling the Zr content and avoiding its aggregation to form harmful 6:23 and 1:3R Zr-rich particles are essential for achieving high squareness as well as large energy product in the Sm-Co-Fe-Cu-Zr permanent magnets. | Tao Yuan Xin Song Xianglong Zhou Wentao Jia Munzali Musa Jingdong Wang Tianyu Ma | 2020 | Journal of Materials Science & Technology2020，52，18： | 6 |
| 7 | Investigation and Analysis of Rabies Viral Infection and Distribution in China in 2005-2012显示文摘Dear Editor, We report the results of a preliminary investigation of data collected between 2005 and 2012. A National Human Rabies Surveillance program was initiated in high rabies incidence regions in 2005, and subsequently carried out nationally to monitor rabies situation. Our work presents a summary of epidemiological and etiologic rabies surveillance data collected since the implementation of the program. | Wentao Jiao Hao Li Xiaoyan Tao Miao Song Xinxin Shen Zhenyang Guo Yunjiao Zhao Qing Tang Guodong Liang | 2013 | Virologica Sinica2013，28，3： | 6 |
| 8 | CO_(2) mineralization of carbide slag for the production of light calcium carbonates显示文摘The production of polyvinyl chloride by calcium carbide method is a typical chemical process with high coal consumption,leading to massive flue gas and carbide slag emissions.Currently,the carbide slag with high CaO content is usually stacked in residue field,easily draining away with the rain and corroding the soil.In this work,we coupled the treatment of flue gas and carbide slag to propose a facile CO_(2)mineralization route to prepare light calcium carbonate.And the route feasibility was comprehensively evaluated via experiments and simulation.Through experimental investigation,the Ca^(2+) leaching and mineralization reaction parameters were determined.Based on the experiment,a process was built and optimized through Aspen Plus,and the energy was integrated to obtain the overall process energy and material consumption.Finally,the net CO_(2)emission reduction rate of the entire process through the life-cycle assessment method was analyzed.Moreover,the relationship between the parameters and the CO_(2)emission life-cycle assessment was established.The final optimization results showed that the mineralization process required 1154.69 kW·h·(t CO_(2))^(-1) of energy(including heat energy of 979.32 kW·h·(t CO_(2))^(-1) and electrical energy of 175.37 kW·h·(t CO_(2))^(-1)),and the net CO_(2)emission reduction rate was 35.8%.The light CaCO_(3)product can be sold as a high value-added product.According to preliminary economic analysis,the profit of mineralizing can reach more than 2,100 CNY·(t CO_(2))^(-1). | Tongyang Zhang Guanrun Chu Junlin Lyu Yongda Cao Wentao Xu Kui Ma Lei Song Hairong Yue Bin Liang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 4 |
| 9 | Classification of Imagined Speech EEG Signals with DWT and SVM显示文摘With the development of human-computer interaction technology,brain-computer interface(BCI)has been widely used in medical,entertainment,military,and other fields.Imagined speech is the latest paradigm of BCI and represents the mental process of imagining a word without making a sound or making clear facial movements.Imagined speech allows patients with physical disabilities to communicate with the outside world and use smart devices through imagination.Imagined speech can meet the needs of more complex manipulative tasks considering its more intuitive features.This study proposes a classification method of imagined speech Electroencephalogram(EEG)signals with discrete wavelet transform(DWT)and support vector machine(SVM).An open dataset that consists of 15 subjects imagining speaking six different words,namely,up,down,left,right,backward,and forward,is used.The objective is to improve the classification accuracy of imagined speech BCI system.The features of EEG signals are first extracted by DWT,and the imagined words are clas-sified by SVM with the above features.Experimental results show that the proposed method achieves an average accuracy of 61.69%,which is better than those of existing methods for classifying imagined speech tasks. | ZHANG Lingwei ZHOU Zhengdong XU Yunfei JI Wentao WANG Jiawen SONG Zefeng | 2022 | Instrumentation2022，9，2： | 4 |
| 10 | Metal-Organic Framework Materials for Electrochemical Supercapacitors显示文摘Exploring new materials with high stability and capacity is full of challenges in sustainable energy conversion and storage systems.Metal-organic frameworks(MOFs),as a new type of porous material,show the advantages of large specific surface area,high porosity,low density,and adjustable pore size,exhibiting a broad application prospect in the field of electrocatalytic reactions,batteries,particularly in the field of supercapacitors.This comprehensive review outlines the recent progress in synthetic methods and electrochemical performances of MOF materials,as well as their applications in supercapacitors.Additionally,the superiorities of MOFs-related materials are highlighted,while major challenges or opportunities for future research on them for electrochemical supercapacitors have been discussed and displayed,along with extensive experimental experiences. | Ziwei Cao Roya Momen Shusheng Tao Dengyi Xiong Zirui Song Xuhuan Xiao Wentao Deng Hongshuai Hou Sedat Yasar Sedar Altin Faith Bulut Guoqiang Zou Xiaobo Ji | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 11 | Thermodynamics of strange quark matter with the density-dependent bag constant显示文摘The thermodynamics of strange quark matter with density dependent bag constant are studied self-consistently in the framework of the general ensemble theory and the MIT bag model.In our treatment,an additional term is found in the expression of pressure.With the additional term,the zero pressure locates exactly at the lowest energy state,indicating that our treatment is a self-consistently thermodynamic treatment.The self-consistent equations of state of strange quark matter in both the normal and color-flavor-locked phase are derived.They are both softer than the inconsistent ones.Strange stars in both the normal and color-flavor locked phase have smaller masses and radii in our treatment.It is also interesting to find that the energy density at a star surface in our treatment is much higher than that in the inconsistent treatment for both phases.Consequently,the surface properties and the corresponding observational properties of strange stars in our treatment are different from those in the inconsistent treatment. | ZHU MingFeng LIU GuangZhou YU Zi XU Yan SONG WenTao | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 3 |
| 12 | Water-trapping and drag-reduction effects of fish Ctenopharyngodon idellus scales and their simulations显示文摘In the last decades, surface drag reduction has been re-emphasized because of its practical values in engineering applications,including vehicles, aircrafts, ships, and fuel pipelines. The bionic study of drag reduction has been attracting scholars' attentions. Here, it was determined that the delicate microstructures on the scales of the fish Ctenopharyngodon idellus exhibit remarkable drag-reduction effect. In addition, the underlying drag-reduction mechanism was carefully investigated. First,exceptional morphologies and structures of the scales were observed and measured using a scanning electron microscope and3-dimensional(3D) microscope. Then, based on the acquired data, optimized 3D models were created. Next, the mechanism of the water-trapping effect of these structures was analyzed through numerical simulations and theoretical calculations. It was determined that there are many microcrescent units with certain distributions on its surface. In fact, these crescents are effective in generating the 'water-trapping' effect and forming a fluid-lubrication film, thus reducing the skin friction drag effectively.Contrasting to a smooth surface, the dynamics finite-element analysis indicated that the maximum drag-reduction rate of a bionic surface is 3.014% at 0.66 m/s flow rate. This study can be used as a reference for an in-depth analysis on the bionic drag reduction of boats, underwater vehicles, and so forth. | WU LiYan JIAO ZhiBin SONG YuQiu REN WenTao NIU ShiChao HAN ZhiWu | 2017 | Science China(Technological Sciences)2017，60，7： | 3 |
| 13 | Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion显示文摘Dear Editor,Precise editing of specific genomic sites holds great promise in basic research and modern crop breeding,and some cytosine base editors(CBEs)have been developed for this purpose(Komor et al.,2016;Zong et al.,2018). | Zhi-Hong Liu Shanjie Tang Wentao Hu Ruo Lv Hailiang Mei Rongxin Yang Xianwei Song Xiaofeng Cao Dong Wang | 2022 | Science China(Life Sciences)2022，65，1： | 3 |
| 14 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 15 | CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a显示文摘Objective: CSN6 is a vital subunit of the constitutive photomorphogenesis 9(COP9) signalosome(CSN), which is responsible for development disorders and promotes ubiquitin-26 S proteasome-dependent degradation in vitro and vivo.Its role in the tumor development of gastric cancer remains unclear.In this study, we investigated the role of CSN6 in gastric cancer progression.Methods: Human gastric cancer samples were collected and immunohistochemistry was performed to identify the role of CSN6 in gastric cancer.The cell proliferation was measured by CCK-8 and the EdU incorporation method.Immunofluorescence localization and a co-immunoprecipitation study were used to show the interaction between the protein CSN6 and p16.Ubiquitination assay was performed to validate whether ubiquitination is involved in CSN6-mediated p16 degradation.BALB/c nude mice were used to produce a tumor model in order to test the effect of CSN6 on cancer growth in vivo.Results: CSN6 expression was dramatically increased in gastric cancer tissues compared with paired adjacent non-tumor tissues and CSN6 was correlated with worse overall and disease-specific survival.Additionally, we also found that CSN6 downregulated p16 protein expression, thereby promoting gastric cancer cell growth and proliferation.Moreover, CSN6 interacted with p16 and a proteasome activator REGγ(PA28γ), thereby facilitating ubiquitin-independent degradation of p16.Conclusions: CSN6 promoted the loss of p16-mediated tumor progression and played an important role in regulating ubiquitin-independent proteasomal degradation of p16. | Wenqi Du Zongxiang Liu Wentao Zhu Tongtong Li Zhiman Zhu Lulu Wei Jun Song Dongsheng Pei | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 16 | Effects of different Chinese herbal prescriptions on cytokines in autoimmune prostatitis rats显示文摘OBJECTIVE:To observe and compare the effects of Chinese herbal prescriptions for promoting blood circulation,clearing heat,removing toxicity,and dispersing stagnated liver-Qi on cytokines in model rats with experimental autoimmune prostatitis(EAP) to provide an experimental basis for the use of Chinese herbal prescriptions in the treatment of chronic prostatitis.METHODS:One-hundred and ten male Wistar rats were randomly divided into 11 groups:blank group;model group;Huoxuehuayu(promoting blood circulation to remove blood stasis) high,middle,and low dose groups;Qingrejiedu(clearing heat and removing toxicity) high,middle,and low dose groups;and Shuganliqi(dispersing stagnated liver-Qi) high,middle,and low dose groups.Except the blank group,rats in all groups were injected subcutaneously in multiple points on days 0 and 30 with prostatic protein extractive solution(60 mg/ml_),and intraperitoneally injected with diphtheria-pertussis and tetanus vaccine(DPT vaccine) to establish the EAP model.Model rats were administrated high,middle,and low doses of Chinese herbal prescriptions and were sacrificed after 4 weeks.Pathological changes in the prostate gland were observed with HE staining and changes in serum interleukin-6(IL-6),interleukin-8(IL-8),and prostaglandin E_2(PGE_2) levels were detected with enzyme-linked immunosorbent assay.RESULTS:Compared with the blank group,serum PGE_2,IL-6,and IL-8 levels in the model group were significantly higher(P < 0.05).Compared with the model group,serum PGE_2,IL-6,and IL-8 levels in the Qingrejiedu low dose and middle dose groups were significantly lower(P < 0.05),with the lower dose having a more obvious effect.Serum PGE_2,IL-6,and IL-8 levels in the Huoxuehuayu high dose group(P < 0.05),IL-6 and IL-8 levels in the Huoxuehuayu middle dose group(P < 0.05),and the IL-8level in the Huoxuehuayu low dose group were significantly lower than those in the model group(P < 0.05).There were significant differences in PGE_2 and IL-6 levels among the different dose groups of Shuganliqi drugs(P < 0.05).Compared with the model group,serum PGE_(2/) IL-6,and IL-8levels in the Shuganliqi high dose group(P <0.05) and IL-8 level in the Shuganliqi low dose group were significantly lower(P < 0.05),while the Shuganliqi middle dose group did not change significantly(P > 0.05).CONCLUSION:Therefore,in TCM treatment of autoimmune prostatitis,different treatment methods should select different doses.For prescriptions that clear heat and remove toxicity,low doses should be used.For prescriptions that promote blood circulation to remove blood stasis and for prescriptions that disperse stagnated liver-Qi,high doses should be used. | Song Guohong Zhang Qiumei Pang Baozhen He Lijuan Saimaiti Julaiti Tulahong Aisikeer Gao Xuan You Lina Wuxiuer Reyihan Zhou Wentao Pang Qingyang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 2 |
| 17 | Effect of soil stiffness on bearing characteristics of large-diameter and supev long steel pipe pile based on FLAC3D显示文摘 | Zhang MingYuan Gao Hongyuan Li Yan Song HuaZhu Peng WenTao | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 18 | ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT NK0238显示文摘It has previously been shown that tryptophan, the biosynthesis precursor ofPeganum harmala alkaloids, and its derivatives have anti-TMV activity bothin vitro and in vivo. Further exploration of this led to the identification of NK0238as a highly effective agent for the prevention and control of diseases caused byplant viruses, but the existing routes are unsuitable for its large-scale synthesis.This study optimized a route for two-step synthesis of this virucide candidate viareaction of L-tryptophan with triphosgene to produce L-tryptophan-N-carboxylicanhydride, which then reacts with n-octylamine to give NK0238 at up to 94%yield and nearly 97% HPLC purity. In addition, the route was used for thepreparation of NK0238 on a > 40 g scale permitting further assessment of itsantivirus activity in the greenhouse and field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both ingreenhouse and field experiments. The toxicity tests showed that NK0238 wasnot acutely toxic to birds, fish, honey bees and silkworms. The optimized routeprovides a solid foundation for its large-scale synthesis and subsequent efficacyand toxicity studies, its excellent activity and safety make NK0238 a promisingdrug candidate for further development. | Wentao XU Hao TIAN Hongjian SONG Yuxiu LIU Yongqiang LI Qingmin WANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 1 |
| 19 | Effect of Different Ionic Liquids on 5-Hydroxymethylfurfural Preparation from Glucose in DMA over AlCl_(3):Experimental and Theoretical Study显示文摘In this work,effect of different ionic liquids(ILs)on 5-hydroxymethylfurfural(HMF)preparation from glucose in N,N-dimethylacetamide(DMA)over AlCl3 was revealed by a combined experimental and computational study.ILs used as cocatalysts in this work included N-methyl-2-pyrrolidone hydrogen sulfate([NMP]HSO_(4)),N-methyl-2-pyrrolidone methyl sulfate([NMP]CH_(3)SO_(3)),N-methyl-2-pyrrolidone chlorine([NMP]Cl)and N-methyl-2-pyrrolidone bromide([NMP]Br)which were endowed with the same cation but different anions.According to the conclusion that fructose was intermediate product from glucose to HMF,we found fructose was transformed to more by-products by[NMP]H_(S)O_(4),making HMF yield decline significantly when glucose was treated as substrate.Neither glucose nor fructose could be converted by[NMP]CH_(3)SO_(3)efficiently,leading to its no influence on glucose conversion to HMF.[NMP]Br had a higher selectivity for HMF from fructose than[NMP]Cl and AlCl3.Besides,Al^(3+)preferred to combine with Br−,slightly decreasing both the overall free energy barrier for glucose isomerization and activation barrier for H-shift at 393.15 K.So a high HMF yield of 57%was obtained from glucose catalyzed by AlCl3 together with[NMP]Br under mild conditions. | Yan Yang Wentao Liu Ningning Wang Haijun Wang Wei Li Zhanxin Song | 2015 | Chinese Journal of Chemistry2015，33，5： | 1 |
| 20 | Improving permeability and antifouling performance of polyethersulfone ultrafiltration membrane by incorporation of ZnO-DMF dispersion containing nano-ZnO and polyvinylpyrrolidone显示文摘 | ZHAO Song YAN Wentao SHI Mengqi | 2015 | Journal of Membrane Science2015，478，： | 1 |
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