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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 3 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 4 | Ethylene oligomerization by novel iron(Ⅱ) diimine complexes/MAO显示文摘Two novel Fe(Ⅱ) diimine complexes have been synthesized. In combination with MAO, they generate active catalytic systems that oligomerize ethylene with both high catalytic activity and high selectivity for a-olefins. The effects of substituents on the aryl ring, reaction temperatures and molar ratios of Al/Fe on catalytic activity and product distribution are studied. | WANG Hang, YAN Weidong, JIANG Tao, LIU Binbin, XU Wenqing, MA Jianjiang & HU YouliangState Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Graduate Student of | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 5 | An overview of chronic myeloid leukemia and its animal models显示文摘Chronic myeloid leukemia(CML) is a form of leukemia characterized by the presence of clonal bone marrow stem cells with the proliferation of mature granulocytes(neutrophils, eosinophils, and basophils) and their precursors. CML is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia(Ph) chromosome or t(9;22) translocation(BCR-ABL). CML is now usually treated with targeted drugs called tyrosine kinase inhibitors(TKIs). The mechanism and natural history of CML is still unclear. Here, we summarize the present CML animal disease models and compare them with each other. Meanwhile, we propose that it is a very wise choice to establish zebrafish(Danio rerio) CML model mimics clinical CML. This model could be used to learn more about the mechanism of CML, and to aid in the development of new drugs to treat CML. | MA WeiXu MA Ning CHEN XiaoHui ZHANG YiYue ZHANG WenQing | 2015 | Science China(Life Sciences)2015，58，12： | 6 |
| 6 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 7 | Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene显示文摘The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models. | Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，2： | 4 |
| 8 | Global Uranium Resources in Sedimentary Basins and the Characteristics of Oil, Gas, Coal and Uranium Coexisting in one Basin显示文摘1 Sedimentary-type and Sandstone-type Uranium Resources Over the past three decades,with the success in in-situ leach(ISL)mining of sandstone-type uranium deposits(SUD),the quantity,resources and production | WANG Feifei LIU Chiyang NIU Haiqing DENG Yu MA Huanhuan WANG Wenqing | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 9 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 10 | Boosting Transport Kinetics of Ions and Electrons Simultaneously by Ti3C2Tx(MXene)Addition for Enhanced Electrochromic Performance显示文摘Electrochromic technology plays a significant role in energy conservation,while its performance is greatly limited by the transport behavior of ions and electrons.Hence,an electrochromic system with overall excellent performances still need to be explored.Initially motivated by the high ionic and electronic conductivity of transition metal carbide or nitride(MXene),we design a feasible procedure to synthesize the MXene/WO3−x composite electrochromic film.The consequently boosted electrochromic performances prove that the addition of MXene is an effective strategy for simultaneously enhancing electrons and ions transport behavior in electrochromic layer.The MXene/WO3−x electrochromic device exhibits enhanced transmittance modulation and coloration efficiency(60.4%,69.1 cm^2 C^−1),higher diffusion coefficient of Li+and excellent cycling stability(200 cycles)over the pure WO3−x device.Meanwhile,numerical stimulation theoretically explores the mechanism and kinetics of the lithium ion diffusion,and proves the spatial and time distributions of higher Li+concentration in MXene/WO3−x composite electrochromic layer.Both experiments and theoretical data reveal that the addition of MXene is effective to promote the transport kinetics of ions and electrons simultaneously and thus realizing a high-performance electrochromic device.This work opens new avenues for electrochromic materials design and deepens the study of kinetics mechanism of ion diffusion in electrochromic devices. | Wenting Wu Huajing Fang Hailong Ma Liangliang Wu Wenqing Zhang Hong Wang | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 11 | Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials显示文摘Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical application.Here,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for NRR.Based on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 activation.The synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR performance.This work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design. | Wenqing Zhang Keke Mao Jingxiang Low Hengjie Liu Yanan Bo Jun Ma Qiaoxi Liu Yawen Jiang Jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie Xiong | 2021 | Nano Research2021，14，9： | 2 |
| 12 | Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis显示文摘Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate,the roles of lipid metabolism in metastasis remain largely unknown.In this study,using esophageal squamous cell carcinoma(ESCC)as a pulmonary metastasis model,we find that the enzyme fatty acid 2-hydroxylase(FA2H),which catalyzes the hydroxylation of free fatty acids(FAs),is enriched in a subpopulation of ESCC cells with high metastatic potential,and that FA2H knockdown markedly mitigates metastatic lesions.Moreover,increased FA2H expression is positively associated with poor survival in patients with ESCC.Lipidomics analysis identifies that two dihydroceramides—Cer(d18:0/24:0)and Cer(d18:0/24:1)—are increased in FA2H-depleted metastasizing ESCC cells.Upon administration,Cer(d18:0/24:0)and Cer(d18:0/24:1)impair the formation of overt metastases in a mouse experimental metastasis model.Then,forkhead box protein C2(FOXC2)and FA2H are found to be co-upregulated in metastatic ESCC cell populations and ESCC specimens,and FA2H expression is further experimentally verified to be transcriptionally induced by FOXC2,which is boosted per se by tumour necrosis factorα(TNFα),a critical pro-metastasis cytokine in the tumour microenvironment,in metastasizing cells.Together,these results demonstrate that TNFα-FOXC2-FA2H is a novel signaling axis to promote metastasis,and its downstream dihydroceramide products could be promising drugs to intervene in metastasis. | Xuantong Zhou Furong Huang Gang Ma Wenqing Wei Nan Wu Zhihua Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 13 | TPC in the leaves of 116 sweet potato ( Ipomoea batatas L.) varieties and Pushu 53 leaf extracts显示文摘 | Wenqing Xu Lixiang Liu Bing Hu Yi Sun Hong Ye Daifu Ma Xiaoxiong Zeng | 2010 | Journal of Food Composition and Analysis2010，，6： | 1 |
| 14 | Spatial spillover and regional economic growth in China显示文摘 | Chong-En Bai Hong Ma Wenqing Pan | 2012 | China Economic Review2012，，4： | 1 |
| 15 | Initial fluctuation effect on elliptic flow in Au+Au collision at 1 GeV/A显示文摘How the initial fluctuation affects on the elliptic flow is investigated by investigating the rapidity, transverse 4-velocity, centrality dependencies of elliptic flow for Au+Au at 1 GeV/A with the help of an Isospin Quantum Molecular Dynamics (IQMD). In addition, we compare the flow calculated with respect to participant plane created by the initial geometry in coordinate space with the flow reconstructed by the experimental event-plane method, and compare the flow with the experimental data of the FOPI collaboration. It shows that there exists some discrepancy between the flows reconstructed by the above two methods. | WANG Jia MA Yugang ZHANG Guoqiang FANG Deqing HAN Lixin SHEN Wenqing | 2013 | Nuclear Science and Techniques2013，24，3： | 1 |
| 16 | Controlled synthesis of Nd(OH) 3 and Nd 2 O 3 nanoparticles by microemulsion method显示文摘 | Wenqing Zhu Jin Ma Lei Xu Wenzhao Zhang Yashao Chen | 2010 | Materials Chemistry and Physics2010，，： | 1 |
| 17 | Application of smog chambers in atmospheric process studies显示文摘Smog chamber experimental systems,which have been widely used in laboratory simulation for studying atmospheric processes,are comprehensively reviewed in this paper.The components,development history,main research topics and main achievements of smog chambers are introduced.Typical smog chambers in the world,including their volumes,wall materials,light sources and features,are summarized and compared.Key factors of smog chambers and their influences on the simulation of the atmospheric environment are discussed,including wall loss,wall emission and background pollutants.The features of next-generation smog chambers and their application prospect in future studies of the atmospheric environment are also outlined in this paper. | Biwu Chu Tianzeng Chen Yongchun Liu Qingxin Ma Yujing Mu Yonghong Wang Jinzhu Ma Peng Zhang Jun Liu Chunshan Liu Huaqiao Gui Renzhi Hu Bo Hu Xinming Wang Yuesi Wang Jianguo Liu Pinhua Xie Jianmin Chen Qian Liu Jingkun Jiang Junhua Li Kebin He Wenqing Liu Guibin Jiang Jiming Hao Hong He | 2022 | National Science Review2022，9，2： | 1 |
| 18 | Comprehensive Evaluation of New Self-cultivated Sugarcane Lines by Grey Relational Analysis显示文摘The grey relational analysis( GRA) was used to evaluate the 10 sugarcane lines by 13 main agronomic characters. The result showed that the grey correlation degree of self-cultivated lines GNY08- 320(0. 7502),GNY08- 336(0. 7409),GNY08- 186(0. 7369),and GNY08- 225(0. 7277) were higher than ROC22(CK),so the 4 lines can be further tested,and the others were worse than CK that should be further observed or eliminated. | Wenqing MA Qiang GUO Chizhang WEI Hengrui LI Chong PENG Zhenhua LIANG | 2014 | Asian Agricultural Research2014，6，9： | 1 |
| 19 | Heritable expansion of the genetic code in mouse and zebrafish显示文摘 | Yuting Chen Ji Ma Wenqing Lu Meilin Tian Marion Thauvin Chonggang Yuan Michel Volovitch Qian Wang Jeff Holst Mingyao Liu Sophie Vriz Shixin Ye Lei Wang Dali Li | 2017 | Cell Research2017，27，2： | 1 |
| 20 | Large-Scale Forward Genetic Screening Analysis of Development of Hematopoiesis in Zebrafish显示文摘Zebrafish 是为造血作用的调查的一个有力的模型。以便与造血的缺点孤立新奇异种, zebrafish 屏蔽的大规模 mutagenesis 被执行。由获得特定的造血的标记, 52 异种基于特定的 phenotypic 特点被鉴别然后分类类型进四。每异种代表了调整造血作用的相关方面的基因的一个通常认为的变化,包括早巨噬细胞开发,早 granulopoiesis,胚胎的 myelopoiesis,和权威的红血球生成 / 淋巴细胞增殖。我们的方法应该为在 zebrafish 的基因屏蔽的另外的类型是适用的。另外,我们识别了的异种的进一步的学习可以帮助揭开造血作用的分子的基础。 | Kun Wang Zhibin Huang Lingfeng Zhao Wei Liu Xiaohui Chen Ping Meng Qing Lin Yali Chi Mengchang Xu Ning Ma Yiyue Zhang Wenqing Zhang | 2012 | Journal of Genetics and Genomics2012，39，9： | 1 |
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