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您的检索式：作者名="Wenpeng Shan"
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| 1 | Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system显示文摘Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells(MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles(NP)with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel(DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases. | Xusheng Wang Haiyan Chen Xiaowei Zeng Wenpeng Guo Yu Jin Shan Wang Ruiyun Tian Yanjiang Han Ling Guo Jimin Han Yaojiong Wu Lin Mei | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 4 |
| 2 | Constituent Isomerism-Induced Quasicrystal and Frank-KasperσSuperlattices Based on Nanosized Shape Amphiphiles显示文摘Naturally,subtle variations in the chemical structures of constituent molecules may significantly affect their multiscale spatial arrangements,properties,and functions.Deceptively simple spherical assemblies supply an ideal platform to investigate how subtle chemical differences affect hierarchically assembled structures.Here,the authors report two sets of nanosized shape amphiphiles,which were constructed by a triphenylene core and six polyhedral oligomeric silsesquioxane cages peripherally grafted through linkers.The slight differences in these samples are merely several methylene units in their linkers,including several pairs of constituent isomers.These nanosized shape amphiphiles self-assemble into a variety of unconventional spherical packing structures,which include the Frank-Kasperσphase and dodecagonal quasicrystal.Several types of unconventional phase transitions were systematically investigated.The authors alternated the conventional columnar phases of discotic molecules to unconventional spherical packing phases.These unconventional structures may shed light into discovering discotic mesogens-based materials with new properties and functions. | Zebin Su Jiahao Huang Wenpeng Shan Xiao-Yun Yan Ruimeng Zhang Tong Liu Yuchu Liu Qing-Yun Guo Fenggang Bian Xiaran Miao Mingjun Huang Stephen Z.D.Cheng | 2021 | CCS Chemistry2021，3，5： | 0 |
| 3 | Construction of twisted graphene–silicene heterostructures显示文摘Van der Waals stacking of two-dimensional crystals with rotation or mismatch in lattice constants gives rise to rich physical phenomena that are closely related to the strong correlations and band topology.Twisted graphene and silicene heterobilayers have been theoretically predicted to host a tunable transport gap due to the mismatch of Dirac cones in the graphene and silicene layers.However,experimental realization of such twisted structure is challenging.Here,we report the formation of twisted graphene/silicene bilayers on Ru(0001)crystal via intercalation.Different moirépatterns form as single-crystalline graphene grows over different grains of the Ru surface.After silicon intercalation,graphene/silicene bilayers are observed with different twisting angles on top of different grains of the Ru substrate.Our work provides a new pathway towards construction of graphene based twisted heterobilayers. | Guangyuan Han Huan Shan Lizhi Zhang Wenpeng Xu Zhao-Yan Gao Hui Guo Geng Li Hong-Jun Gao | 2023 | Nano Research2023，16，5： | 0 |
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