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| 1 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 2 | Study on cellular internalization of poly(vinyldiaminotriazine)-based hydrogen bonding type non-viral transgene vector显示文摘Previously we successfully prepared poly(vinyldiaminotriazine)(PVDT)-based non-viral vectors which complexed plasmid DNA via hydrogen bonding with adenine-thymine base pairs. In this report, surface charges and complex sizes of this system were further examined. The results showed that PVDT-based polymer could cover surface charges of DNA resulting in slightly negative or neutral complexes. It was also found that the complex sizes were governed by two events: the aggregation induced by the insta-bility of neutral particles, and more compact complexes produced by PVDT-based polymers. In the study of cellular uptake, chlorpromazine and filipin Ⅲ were used to inhibit clathrin- and caveolae-me- diated endocytosis, respectively. We found that PVDT-based systems were transported into cells via a non-clathrin, non-caveolae mediated endocytosis. This special process was studied by temperature inhibition and kinetics assays. It was revealed that such a pathway was characterized by (i) a more en-ergy dependent process and (ii) a much slow transfection-effective internalization. | YE GuiXiang CAO ZhiQiang LIN Lin CHEN DaYong LIU WenGuang | 2008 | Chinese Science Bulletin2008，53，15： | 3 |
| 3 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 4 | Alternatively spliced BobCAL transcripts alter curd morphotypes in a collection of Chinese cauliflower accessions显示文摘The curd of cauliflower(Brassica oleracea L.var.botrytis)is a modified inflorescence that is consumed as a vegetable.Curd formation is proposed to be due to a mutation in the BobCAULIFLOWER(BobCAL)gene,but the genetic relationship between BobCAL variation and curd morphotypes remains obscure.To address this question,we collected and classified a collection of 78 cauliflower accessions into four subpopulations according to curd surface features:smooth,coarse,granular,and hairy curd morphotypes.Through the cDNA sequencing of BobCAL alleles,we showed that smooth and coarse accessions characterized by inflorescence meristem arrest presented a strong association with the 451T SNP(BobCAL_T),whereas granular and hairy accessions marked with floral organ arrest presented an association with 451G(BobCAL_G).Interestingly,all BobCAL alleles were alternatively spliced,resulting in a total of four alternative splice(AS)variants due to the retention of the fourth and/or seventh introns.Among accessions with BobCAL_G alleles,the total expression of all these AS variants in granular plants was almost equal to that in hairy plants;however,the expression of the individual AS variants encoding intact proteins relative to those encoding truncated proteins differed.Hairy accessions showed relatively high expression of the individual variants encoding intact proteins,whereas granular accessions displayed relatively low expression.In smooth cauliflower,the overexpression of the BobCAL_Ga variant caused an alteration in the curd morphotype from smooth to hairy,concurrent with an increase in the expression levels of downstream floral identity genes.These results reveal that alternative splicing of BobCAL transcripts is involved in the determination of cauliflower curd morphotypes. | Wenguang Cao Biting Cao Xuan Wang Jinjuan Bai Yong-Zhen Xu Jianjun Zhao Xiaorong Li Yuke He Shengwu Hu | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Dispersion Mode of Granular Jet in a Coaxial Air Jet 显示文摘 | Liu Haifeng Cao Wenguang Xu Jianliang | 2012 | Powder Tech- nol2012，217，2： | 1 |
| 6 | Tong-type identity and the mean square of the error term for an extended Selberg class显示文摘In 1956, Tong established an asymptotic formula for the mean square of the error term of the summatory function of the Piltz divisor function d3(n). The aim of this paper is to generalize Tong's method to a class of Dirichlet series L(s) which satisfies a functional equation. Let a(n) be an arithmetical function related to a Dirichlet series L(s), and let E(x) be the error term of ′n xa(n). In this paper, after introducing a class of Diriclet series with a general functional equation(which contains the well-known Selberg class), we establish a Tong-type identity and a Tong-type truncated formula for the error term of the Riesz mean of the coefficients of this Dirichlet series L(s). This kind of Tong-type truncated formula could be used to study the mean square of E(x) under a certain assumption. In other words, we reduce the mean square of E(x) to the problem of finding a suitable constant σ*which is related to the mean square estimate of L(s). We shall represent some results of functions in the Selberg class of degrees 2–4. | CAO XiaoDong TANIGAWA Yoshio ZHAI WenGuang | 2016 | Science China Mathematics2016，59，11： | 1 |
| 7 | Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion显示文摘 | Maolan Li Jun Shen Xiangsong Wu Bingtai Zhang Rui Zhang Hao Weng Qian Ding Zhujun Tan Guofeng Gao Jiasheng Mu Jiahua Yang Yijun Shu Runfa Bao Qichen Ding Wenguang Wu Yang Cao Yingbin Liu | 2013 | Medical Oncology2013，，2： | 1 |
| 8 | A study of thermoresponsive poly(N-isopropylac- rylamide )/polyarginine bioconjugate non-viral transgene vectors显示文摘 | Cheng Nan Liu Wenguang Cao Zhiqiang | 2006 | Biomaterials2006，27，28： | 1 |
| 9 | Biomaterials显示文摘 | Cheng Nan Liu Wenguang Cao Zhiqiang | 2006 | 27(28):4984-49922006，27，28： | 1 |
| 10 | Dispersion mode of granular jel in a coaxial air jet显示文摘 | Liu Haifeng Cao Wenguang Xu Jianliang | 2012 | Powder Technolo gy2012，217，： | 1 |
| 11 | Character ization of the granular jet in a coaxial gas stream显示文摘 | Liu Haifeng Cao Wenguang Xu Jianliang | 2012 | Powder Technology2012，225，： | 1 |
| 12 | The haplotype-resolved T2T genome of teinturier cultivar Yan73 reveals the genetic basis of anthocyanin biosynthesis in grapes显示文摘Teinturier grapes are characterized by the typical accumulation of anthocyanins in grape skin,flesh,and vegetative tissues,endowing them with high utility value in red wine blending and nutrient-enriched foods developing.However,due to the lack of genome information,the mechanism involved in regulating teinturier grape coloring has not yet been elucidated and their genetic utilization research is still insufficient.Here,the cultivar‘Yan73’was used for assembling the telomere-to-telomere(T2T)genome of teinturier grapes by combining the High Fidelity(HiFi),Hi-C and ultralong Oxford Nanopore Technologies(ONT)reads.Two haplotype genomes were assembled,at the sizes of 501.68 Mb and 493.38 Mb,respectively.In the haplotype 1 genome,the transposable elements(TEs)contained 32.77%of long terminal repeats(LTRs),while in the haplotype 2 genome,31.53%of LTRs were detected in TEs.Furthermore,obvious inversions were identified in chromosome 18 between the two haplotypes.Transcriptome profiling suggested that the gene expression patterns in‘Cabernet Sauvignon’and‘Yan73’were diverse depending on tissues,developmental stages,and varieties.The transcription program of genes in the anthocyanins biosynthesis pathway between the two cultivars exhibited high similarity in different tissues and developmental stages,whereas the expression levels of numerous genes showed significant differences.Compared with other genes,the expression levels of VvMYBA1 and VvUFGT4 in all samples,VvCHS2 except in young shoots and VvPAL9 except in the E-L23 stage of‘Yan73’were higher than those of‘Cabernet Sauvignon’.Further sequence alignments revealed potential variant gene loci and structure variations of anthocyanins biosynthesis related genes and a 816 bp sequence insertion was found in the promoter of VvMYBA1 of‘Yan73’haplotype 2 genome.The‘Yan73’T2T genome assembly and comparative analysis provided valuable foundations for further revealing the coloring mechanism of teinturier grapes and the genetic improvement of grape coloring traits. | Kekun Zhang Mengrui Du Hongyan Zhang Xiaoqian Zhang Shuo Cao Xu Wang Wenrui Wang Xueqiang Guan Penghui Zhou Jin Li Wenguang Jiang Meiling Tang Qiuling Zheng Muming Cao Yongfeng Zhou Keqin Chen Zhongjie Liu Yulin Fang | 2023 | Horticulture Research2023，10，11： | 0 |
| 13 | An anti-bacterial porous shape memory self-adaptive stiffened polymer for alveolar bone regeneration after tooth extraction显示文摘The regeneration of alveolar bone after tooth extraction is critical for the placement of dental implants.Developing a rigid porous scaffold with defect shape adaptability is of great importance but challenging for alveolar bone regeneration.Herein,we design and synthesize a biocompatible poly(L-glutamic acid)-g-poly(ε-caprolactone)(PLGA-g-PCL)porous shape memory(SM)polymer.The PLGA-g-PCL is then copolymerized with acryloyl chloride grafted poly(ω-pentadecalactone)(PPDLDA)having a higher phase transition temperature than shape recovery temperature to maintain stiffness after shape recovery to resist chewing force.The hybrid pol-ydopamine/silver/hydroxyapatite(PDA/Ag/HA)is coated to the surface of(PLGA-g-PCL)-PPDL scaffold to afford the anti-bacterial activity.The porous SM scaffold can be deformed into a compact size and administered into the socket cavity in a minimally invasive mode,and recover its original shape with a high stiffness at body tem-perature,fitting well in the socket defect.The SM scaffold exhibits robust antibacterial activity against Staphy-lococcus aureus(S.aureus).The porous microstructure and cytocompatibility of PLGA allow for the ingrowth and proliferation of stem cells,thus facilitating osteogenic differentiation.The micro-CT and histological analyses demonstrate that the scaffold boosts efficient new bone regeneration in the socket of rabbit mandibular first premolar.This porous shape memory self-adaptive stiffened polymer opens up a new avenue for alveolar bone regeneration. | Weijun Zhang Meilin Yu Yongqiang Cao Zihan Zhuang Kunxi Zhang Dong Chen Wenguang Liu Jingbo Yin | 2023 | Bioactive Materials2023，，3： | 0 |
| 14 | Recent progress in Li and Mn rich layered oxide cathodes for Li-ion batteries显示文摘Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy density.The stable structure and superior performance of LMR oxides make them one of the most promising candidates for the next-generation cathode materials.However,the commercialization of these materials is hindered by several drawbacks,such as low initial Coulombic efficiency,the degradation of voltage and capacity during cycling,and poor rate performance.This review summarizes research progress in solving these concerns of LMR cathodes over the past decade by following three classes of strategies:morphology design,bulk design,and surface modification.We elaborate on the processing procedures,electrochemical performance,mechanisms,and limitations of each approach,and finally put forward the concerns left and the possible solutions for the commercialization of LMR cathodes. | Yiwei Li Zhibo Li Cong Chen Kai Yang Bo Cao Shenyang Xu Ni Yang Wenguang Zhao Haibiao Chen Mingjian Zhang Feng Pan | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 15 | A light-weight on-line action detection with hand trajectories for industrial surveillance显示文摘Most of the intelligent surveillances in the industry only care about the safety of the workers.It is meaningful if the camera can know what,where and how the worker has performed the action in real time.In this paper,we propose a light-weight and robust algorithm to meet these requirements.By only two hands'trajectories,our algorithm requires no Graphic Processing Unit(GPU)acceleration,which can be used in low-cost devices.In the training stage,in order to find potential topological structures of the training trajectories,spectral clustering with eigengap heuristic is applied to cluster trajectory points.A gradient descent based algorithm is proposed to find the topological structures,which reflects main representations for each cluster.In the fine-tuning stage,a topological optimization algorithm is proposed to fine-tune the parameters of topological structures in all training data.Finally,our method not only performs more robustly compared to some popular offline action detection methods,but also obtains better detection accuracy in an extended action sequence. | Peiyuan Ni Shilei Lv Xiaoxiao Zhu Qixin Cao Wenguang Zhang | 2021 | Digital Communications and Networks2021，7，1： | 0 |
| 16 | PROG1 acts upstream of LAZY1 to regulate rice tiller angle as a repressor显示文摘Rice tiller angle,as a component of plant architecture,affects rice grain yield via plant density.However,the molecular mechanism underlying rice tiller angle remains elusive.We report that the key domestication gene PROSTRATE GROWTH 1(PROG1)controls rice tiller angle by regulating shoot gravitropism and LAZY1(LA1)-mediated asymmetric distribution of auxin.Acting as a transcriptional repressor,PROG1 negatively regulates the expression of LA1 in light-grown rice seedlings.Overexpression of LA1 partially rescued the larger tiller angle of the PROG1 complementation transgenic plant(prog1-D).Double-mutant analysis showed that PROG1 acts upstream of LA1 to regulate shoot gravitropism and tiller angle.Mutation of Suppressors of lazy1(SOL1),encoding DWARF3(D3)acting in the strigolactone signal pathway,suppressed the large tiller angle of prog1-D by rescuing the transcription of LA1.The discovery of a light-sensitive PROG1-LA1 transcription regulatory module controlling rice shoot gravitropism and tiller angle sheds light on the genetic control of rice tiller angle. | Han Zhang Xiang Li Dajun Sang Linzhou Huang Yuqi Song Mengchen Du Jiajia Cao Wenguang Wang | 2023 | The Crop Journal2023，11，2： | 0 |
| 17 | Rational design of CO_(2)electroreduction cathode via in situ electrochemical phase transition显示文摘CO_(2)electroreduction reaction(CO_(2)RR),combined with solid oxide electrolysis cells(SOECs),is a feasible technology for the storage of renewable electric energy,while its development is limited by the catalytic activity and stability on cathodes.Here,a novel garnet oxide(Gd_(3)Fe_(5)O_(12))cathode is designed,where the garnet oxide is converted to perovskite oxide and iron via in situ electrochemical phase transition during CO_(2)electroreduction,resulting in high activity with Faradaic efficiency close to 100%and great stability over 1000 h galvanostatic test.A variety of experimental characterizations and density functional theory calculations indicate that in situ exsolved Fe clusters can effectively enhance the adsorption energies of intermediates and lowering the CO_(2)dissociation barriers.Microkinetic modelling confirms that CO_(2)RR goes through a dissociative adsorption mechanism and the electronic transfer for CO_(2)dissociation is the rate-determining step. | Shiqing Hu Huan Li Xue Dong Zhongwei Cao Bingjie Pang Liming Zhang Wenguang Yu Jianping Xiao Xuefeng Zhu Weishen Yang | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
| 18 | Isolation and phylogenetic analysis of feline calicivirus strains from various region of China显示文摘Feline calicivirus(FCV)is an important feline pathogen mainly causing upper respiratory tract disease,conjunctivitis,and stomatitis,and it is classifed into genotype I and genotype II.To investigate the prevalence and molecular characteristics of FCV,this study collected 337 cat swab samples from animal hospitals in diferent regions of China from 2019 to 2021.The positive detection rate of FCV was 29.9%(101/337)by RT-PCR.Statistical analysis showed that FCV prevalence was signifcantly associated with living environment(p=0.0004),age(p=0.031)and clinical symptoms(p=0.00),but not with sex(p=0.092)and breed(p=0.171).The 26 strains of FCV were isolated using F81 cells.Phylogenetic analysis showed that 10 isolates belonged to genotype I,and 16 isolates belonged to genotype II.These 26 isolates were highly genetically diverse,of which HB7 isolate had three same virulence-related amino acid loci with VSD strains.Potential loci distinguishing diferent genotypes were identifed from 26 isolates,suggesting the genetic relationship between diferent genotypes.In addition,selection pressure analysis based on capsid protein of 26 isolates revealed that the protein is under diversifying selection.This study reveals the genetic diversity of FCV and provides a reference for the screening of vaccine candidate strains and the development of vaccines with better cross-protection efects. | Longlong Cao Qiuyan Li Kaituo Shi Liting Wei Hehao Ouyang Zijun Ye Wenguang Du Jiawen Ye Xiaochen Hui Jiakang Li Shengbo Cao Dengyuan Zhou | 2022 | Animal Diseases2022，2，3： | 0 |
| 19 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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