| 2 | Association of TNF-α promoter polymorphisms with the outcome of persistent HBV infection in a northeast Chinese Han population显示文摘肿瘤坏死因素 --(TNF-) 在致病和长期的肝炎 B 的临床的结果起一个重要作用病毒(HBV ) 感染。这研究的目的是在一张东北汉语汉人口评估在 TNF- 的功能的多型性和坚持的 HBV 感染的不同结果之间的关系。这里, 189 HBV 自发地恢复了题目(SR ) ,包括 180 长期的肝炎 B (CHB ) 的 571 个感染 HBV 的病人, 196 肝肝硬化(LC ) ,和 195 hepatocellular 癌(HCC ) 个人在这研究被注册。所有样品用聚合酶链反应限制碎片长度多型性方法是为 TNF- 857C/T 和 863C/A 的 genotyped。857CC 遗传型的频率与 SR 题目的相比在 CHB 和 LC 个人是显著地更高的(P= 0.03,或 = 1.57, 95% CI 1.042.39 和 P= 0.03,或 = 1.57, 95% CI 1.042.35,分别地) 。在等位基因 857C 的分发的重要差别为 CHB 对 SR 被观察(P= 0.01,或 = 1.52, 95% CI 1.082.13 ) 并且 LC 对 SR (P= 0.02,或 = 1.47, 95% CI 1.062.04 ) 队。另外, 863AA 遗传型的频率比 SR 题目的在 CHB 和 LC 病人是显著地更高的( P= 0.01 ,或= 3.90 ,95% CI 1.3511.23 和 P= 0.01 ,或= 3.83 ,95% CI 1.3410.96 ,分别地),并且等位基因 863A 频率是显著地在比 SR 控制的 CHB , LC ,和 HCC 队更普通( P= 0.004 ,或= 1.72 ,95% CI 1.192.50 ;P= 0.001,或 = 1.81, 95% CI 1.262.61 和 P= 0.001,或 = 1.90, 95% CI 1.332.73,分别地) 。我们的数据也表明 haplotype CA 强烈与坚持的 HBV 感染被联系。这些结果在学习人口建议在 TNF- 倡导者变体和坚持的 HBV 感染的不同结果之间的一个协会。 | Bing Qiui Xi Wang Peiyi Zhang Chunlin Shi Jiye Zhang Wenliang Qiu Wenduo Wang Dongfu Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，8： | 4 |
| 3 | Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even death.Although studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains unclear.In the current study,we demonstrated that STING activation was pivotal in RA pathogenesis.As the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating RA.The fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in macrophages.Intra-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING pathway.We concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA. | Haotian Shen Lulu Jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang | 2023 | Bioactive Materials2023，，6： | 1 |
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