|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Incidence and mortality rate of esophageal cancer has decreased during past 40 years in Hebei Province,China显示文摘Background:Hebei province is located in North of China with of approximately 6% of whole national population.It is known as a high-risk area for esophageal cancer in China and worldwide.The aim of our study was to estimate the esophageal cancer burden and trend in Hebei Province.Methods:Eight cancer registries in Hebei Province submitted cancer registry data to the Hebei Provincial Cancer Registry Center.All data were qualified and compiled for cancer statistics in 2011.The pooled data were stratified by gender and age group(0,1-4,5-9,10-14…80+).Incidence and mortality rates were age-standardized to World Segi's population standard and expressed per 100,000 persons.In addition,proportions and cumulative incidence/mortality rates for esophageal cancer were calculated.Esophageal cancer mortality data during the periods 1973-1975,1990-1992,and 2004-2005 were extracted from the national death surveys.Mortality and incidence rate data from Cixian and Shexian were obtained from population-based cancer registries in each county.Results:The estimated number of newly diagnosed esophageal cancer cases and deaths in 2011 in Hebei Province was 24,318 and 18,226,respectively.The crude incidence rate of esophageal cancer was 33.37/100,000(males,42.18/100,000 and females,24.31/100,000).The age-standardized rate by world standard population(ASRW) was 28.09/100,000,ranking third among all cancers.The esophageal cancer mortality rate was 25.01/100,000(males,31.40/100,000 and females,18.45/100,000),ranking third in deaths among all cancers.The mortality rates of esophageal cancer displayed a significant decreasing trend in Hebei Province from 1973-1975(ASRW =48.69/100,000) to 2004-2005(ASRW =28.02/100,000),with a decreased rate of 42.45%.In Cixian,the incidence of esophageal cancer decreased from 250.76/100,000 to 106.74/100,000 in males and from 153.86/100,000 to 75.41/100,000 in females,with annual percentage changes(APC) of 2.13 and 2.16,while the mortality rates declined with an APC of 2.46 for males and 3.10 for females from 1988 to 2011.In Shexian,the incidence rate decreased from 116.90/100,000 to 74.12/100,000 in males and from 46.98/100,000 to 40.64/100,000 in females,while the mortality rates declined,with an APC of 4.89 in males from 2003 to 2011.Conclusions:Although the incidence and mortality rates of esophageal cancer remain high,an obvious decreasing trend has been observed in Hebei Province,as well as in high-risk regions,such as Cixian and Shexian,over the past 40 years. | Yutong He Yan Wu Guohui Song Yongwei Li Di Liang Jing Jin Denggui Wen Baoen Shan | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 2 | Younger age of onset and multiple primary lesions associated with esophageal squamous cell carcinoma cases with a positive family history of the cancer suggests genetic predisposition显示文摘 | Jia Nan Wen Xiaoduo Zhang Nan YangYi Zhang Liwei Wang Xiaoling Wang Na Wen Denggui | 2014 | Chinese Medical Journal2014，，15： | 16 |
| 3 | Estimated cancer incidence and mortality in Hebei province,2012显示文摘Objective: This study estimates the numbers of new cancer cases and cancer deaths in Hebei province using incidence and mortality data from 9 population-based cancer registries in 2012.Methods: The data of new diagnosed cancer cases and cancer deaths in 2012 were collected from 9 population-based cancer registries of Hebei province in 2015. All the data met the National Central Cancer Registry of China(NCCR) criteria of data quality. The pooled data analysis was stratified by areas(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths in Hebei province were estimated using age-specific rates and corresponding provincial population in 2012. The 10 most common cancers in different groups and the cumulative rates were calculated. Chinese population census in 2000 and Segi's population were used for age-standardized incidence/mortality rates. Results: All cancer registries covered 4,986,847 populations, 6.84% of Hebei provincial population(2,098,547 in urban and 2,888,300 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 76.40% and 4.72%, respectively. The mortality to incidence rate ratio(M/I) was 0.64. In 2012, it is estimated that there were about 187,900 new diagnosed cancer cases and 119,800 cancer deaths in Hebei province. The incidence rate of cancer was 258.12/100,000(275.75/100,000 in males, 239.78/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 210.65/100,000 and 208.50/100,000, with the cumulative incidence rates(0-74 years old) of 24.46%. The cancer incidence and ASIRC were 256.99/100,000 and 211.32/100,000 in urban areas and 258.94/100,000 and 209.99/100,000 in rural areas, respectively. The cancer mortality rate was 164.63/100,000(201.85/100,000 in males, 125.92/100,000 in females). Agestandardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 137.30/100,000 and 137.39/100,000 with the cumulative mortality rate(0-74 years old) of 14.58%, respectively. The cancer mortality rate in rural areas(167.16/100,000) was higher than that in urban areas(161.16/100,000). The most common cancers were lung cancer, stomach cancer, breast cancer, esophageal cancer, liver cancer and colorectal cancer, which accounted for 72.31% of all cancer cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer and colorectal cancer were the major causes of cancer death in Hebei province, which accounted for 75.24% of all cancer deaths. The cancer spectrum differs between urban and rural, males and females in both incidence and mortality rates.Conclusions: The most common cancers were lung cancer, stomach cancer, esophageal cancer, breast cancer, liver cancer and colorectal cancer in Hebei province. | Yutong He Di Liang Daojuan Li Jingbo Zhai Junqing Zhu Jing Jin Denggui Wen Baoen Shan | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 4 | Early Age of Onset, Multiple Primary Malignancies and Poor Prognosis Are Indicative of an Inherited Predisposition to Esophageal Squamous Cell Carcinoma in Familial Rather Than Sporadic Disease- An Update Based on 14- to 23-year Follow-up显示文摘<正> OBJECTIVE To demonstrate the effects of an inheritedpredisposition to familial esophageal squamous cellcarcinoma (ESCC) through the comparison and analysis of theclinicopathologic differences between familial and sporadic ESCCcases.METHODS Differences in age of onset, prevalence rates ofdouble primary ESCC, and survival rates between familial ESCC (n= 476) and sporadic ESCC cases (n = 1226) were analyzed.RESULTS Overall, familial ESCC cases showed a significantlyyounger age of onset (51.9 ± 8.2 vs. 53.4 ± 8.0, P_(t-test) = 0.00), asignificantly higher prevalence rate for double ESCC (2.73 % vs.1.22%, adjusted with TNM:χ_(MH)~2= 4.029, P = 0.045), and a lowersurvival rate than in sporadic cases (P_(wald) = 0.04). The familial casesshowed both a younger age of onset and poorer survival in mostsubgroups, and the differences were more marked in early-stagerather than in the late-stage disease groups.CONCLUSION Theses findings confirm the existence of familialas opposed to sporadic ESCC. By the theory of the 'two-hit' originof cancer, these findings also suggest that the 'first hit', a geneticpredisposition, can affect the age of onset, number of primarycarcinomas, and the prognosis for familial ESCC patients. | Shijie Wang Denggui Wen Liwei Zhang Lizhen Wei Wendi Zou Peng Qin | 2009 | Clinical oncology and cancer resexreh2009，6，6： | 1 |
| 5 | Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population显示文摘 | Jianhui Zhang Rainer B. Zotz Yan Li Rui Wang Sybille Kiel Wolfgang A. Schulz Denggui Wen Zhifeng Chen Liwei Zhang Shijie Wang Helmut E. Gabbert Mario Sarbia | 2004 | Journal of Cancer Research and Clinical Oncology2004，，10： | 1 |
| 6 | NATURAL HISTORY OBSERVATION FOR ESOPHAGEAL AND CARDIA PRECURSORS BY REPETITIVE ENDOSCOPIC SCREENING OF 301 SUBJECTS IN SHEXIAN显示文摘OBJECTIVE To investigate the natural history of fast developing esopha- geal and cardia precursors. METHODS Repetitive endoscopic screenings were performed among 40-69-year-olds in the high-incidence areas for esophageal cancer in Shexian. RESULTS The initial diagnosis and the lag-time for 7 subsequently identified severe dysplasia(SD)subjects were as follows:in one subject 13 months after a baseline diagnosis of normal epithelium,in another subject 7 months after a baseline diagnosis of base cell hyperplasia(BCH),in four subjects 3,4,4,and 10.5 months after baseline diagnosis of mild dysplasia (mD),and in one subject 12.5 months after a baseline diagnosis of moder- ate dysplasia(MD).The initial diagnosis and the lag-time for 6 subsequently identified carcinomas in situ or intramucosal carcinoma cases were:in one case 48 months after a baseline diagnosis of mD,in 2 cases 4 and 13 months after baseline diagnoses of MD,and in the other 3 cases 3.5,9,and 17.5 months after baseline diagnoses of SD.The initial diagnosis and lag- time for 3 subsequently identified invasive cancer cases were:in one case 50 months after a baseline diagnosis of MD,in 2 cases 14 and 19 months after baseline diagnoses of SD.In addition,during a 4-year-fol ow-up of 18 subjects after endoscopic mucosa resection,9 of them were found to have developed precursors again at other sites,and also additional findings were obtained for 11 of the 16 dysplasia cases by repetitive biopsy in less than 2 months after the initial endoscopy. CONCLUSION A 5-year screening interval for BCH and mD,and a 3-year interval for MD may be too long for the fast developing precursors.Periodic screenings with shorter intervals should be considered to control the number of interval cases due to fast development,multifocal carcinogenesis,and false negative results inherent in one-time endoscopic biopsy sampling. | Denggui Wen Shijie Wang Liwei Zhang Yingsai Li Weifang Yu Xiaoling Wang Junhe Wang Suping Li Yongwei Li Shunping Wang Limian Er Caifen Ma | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 1 |
| 7 | Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population显示文摘 | Jianhui Zhang Rainer B. Zotz Yan Li Rui Wang Sybille Kiel Wolfgang A. Schulz Denggui Wen Zhifeng Chen Liwei Zhang Shijie Wang Helmut E. Gabbert Mario Sarbia | 2004 | Journal of Cancer Research and Clinical Oncology2004，，10： | 1 |
| 8 | A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area显示文摘 | Denggui Wen Baoen Shan Shijie Wang Liwei Zhang Lizhen Wei Wendi Zhou Qing Peng | 2010 | European Journal of Medical Genetics2010，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员