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| 1 | Assessment and sequencing of air target threat based on intuitionistic fuzzy entropy and dynamic VIKOR显示文摘In view of the fact that traditional air target threat assessment methods are difficult to reflect the combat characteristics of uncertain, dynamic and hybrid formation, an algorithm is proposed to solve the multi-target threat assessment problems. The target attribute weight is calculated by the intuitionistic fuzzy entropy(IFE) algorithm and the time series weight is gained by the Poisson distribution method based on multi-times data. Finally,assessment and sequencing of the air multi-target threat model based on IFE and dynamic Vlse Kriterijumska Optimizacija I Kompromisno Resenje(VIKOR) is established with an example which indicates that the method is reasonable and effective. | ZHANG Kun KONG Weiren LIU Peipei SHI Jiao LEI Yu ZOU Jie | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 24 |
| 2 | Review of the characteristics and graded utilisation of coal gasification slag显示文摘The characteristics of the energy structure of rich coal,less oil and less gas,coupling with a high external dependence on oil and natural gas and the emphasis on the efficient and clean utilisation of coal,have brought opportunities for coal chemical industry.However,with the large-scale popularisation of coal gasification technology,the production and resulting storage of coal gasification slag continue to increase,which not only result in serious environmental pollution and a waste of terrestrial resources,but also seriously affect the sustainable development of coal chemical enterprises.Hence,the treatment of coal gasification slag is extremely important.In this paper,the production,composition,morphology,particle size structure and water holding characteristics of coal gasification slag are introduced,and the methods of carbon ash separation of gasification slag,both domestically and abroad,are summarised.In addition,the paper also summarises the research progress on gasification slag in building materials,ecological restoration,residual carbon utilisation and other high-value utilisation,and ultimately puts forward the idea of the comprehensive utilisation of gasification slag.For large-scale consumption to solve the environmental problems of enterprises and achieve high-value utilisation to increase the economic benefits of enterprises,it is urgent to zealously design a reasonable and comprehensive utilisation technologies with simple operational processes,strong adaptability and economic benefits. | Xiaodong Liu Zhengwei Jin Yunhuan Jing Panpan Fan Zhili Qi Weiren Bao Jiancheng Wang Xiaohui Yan Peng Lv Lianping Dong | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 21 |
| 3 | Investigation on the development of deep space exploration显示文摘Deep space exploration is the term used for the exploration of the Moon and the celestial bodies or space beyond the Moon, which is an important part of human space activities. Firstly, the development of deep space exploration (not including the Moon) during the last few decades is summarized. Secondly, the development trend of different space countries and regions is analyzed. Then the experience and enlightenment of deep space exploration are briefly discussed. Some suggestions for China's future deep space exploration are given in the end. | WU WeiRen LIU WangWang QIAO Dong JIE DeGang | 2012 | Science China(Technological Sciences)2012，55，4： | 14 |
| 4 | Comparative studies on histological and ultra-structure of the pituitary of different ploidy level fishes显示文摘The histological and ultra-structure of the pituitary in diploid red crucian carp(Carassius auratus red var.),triploid crucian carp and allotetraploid hybrids within and after the breeding season were comparatively studied.The result showed that there were six endocrine cell types in the pituitary of these three kinds of fishes,and there was an obvious difference in cell size among different ploidy level fishes.As for the same type of pituitary cells,the cell size was increased gradually with the in- creasing ploidy level.In the breeding season,the allotetraploid hybrids had higher proportion of go- nadotropin cells(GTH)than triploids,and the triploids had higher proportion of GTH than diploids.The results were related to the earlier sexual maturity of allotetraploid hybrids and sterility of triploid cru- cian carp.On the other hand,among the three kinds of fishes,the proportion of somatotropin(STH) cells in triploids crucian carp was the highest,whereas that in allotetraploid hybrids was the lowest. The results might be connected with the faster growth rate of triploids and slower growth rate of al- lotetraploid hybrids.In addition,in GTH cells of meso-adenohypophysis after the breeding season, there were many endocrine particles in triploids,while those endocrine particles were released from the cells in allotetraploids and diploids.This result showed that the sterility of triploid crucian carp might be related to the hormone which was not released from the GTH cells.In a word,the present study indicated that the differences in the structure of pituitary among different ploidy level fishes contributed to their difference in the growth rate and gonadal development. | LONG Yu LIU Shaojun HUANG Weiren ZHANG Jian SUN Yuandong ZHANG Chun CHEN Song LIU Jinghui LIU Yun | 2006 | Science China(Life Sciences)2006，49，5： | 13 |
| 5 | Pre-LOI trajectory maneuvers of the CHANG'E-2 libration point mission显示文摘This paper addresses pre-LOI (before Lissajous orbit insertion) trajectory maneuvers for the libration point mission of CHANG'E-2,which is the first Chinese satellite to fly to the Sun-Earth L2 libration point and the first satellite ever to fly to the L2 point from lunar orbit.First,a transfer trajectory for the mission is designed based on InterPlanetary Superhighway theory under the constraint of the remaining propellant,TT&C (telemetry,track and command) and sunlight conditions.The effects of trajectory maneuver errors on the mission are also analyzed.Second,based on the analysis results,the article investigates the trajectory maneuver schemes for the lunar escape and transfer trajectory maneuvers employing mathematical models and operational strategies.The mission status based on our maneuver schemes is then presented,and the results of control operation and corresponding analysis are provided in detail.Finally,the future trajectory maneuver in the Lissajous orbit is discussed.According to the analysis of the CHANG'E-2 TT&C data,the trajectory maneuver schemes proposed in the article work properly and efficiently. | WU WeiRen LIU Yong LIU Lei ZHOU JianLiang TANG GeShi CHEN YongZhi | 2012 | Science China(Information Sciences)2012，55，6： | 12 |
| 6 | Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver cancer,leading to 74.6 thousand deaths annually.The prognosis of HCC over the last few decades has remained unsatisfactory,and over half of patients with early-stage HCC develop recurrence by the time of follow-up.Immunotherapeutic intervention has emerged as a novel,effective treatment to delay the progression of aggressive tumors and suppress tumor recurrence and metastasis.However,few clinical immunotherapy trials have been conducted in HCC patients,and there is an unmet need for novel therapeutic strategies.The combination of conventional treatments with specific immunotherapeutic approaches may dramatically improve the efficacy of HCC treatment and the clinical outcome of HCC patients.In this review,we briefly summarize immunotherapy strategies and discuss new advances in combined immunotherapeutic approaches for the treatment of patients with liver cancer. | Mengxin Tian Yinghong Shi Weiren Liu Jia Fan | 2019 | Science China(Life Sciences)2019，62，9： | 12 |
| 7 | Porosity and permeability evolution and evaluation in anisotropic porosity multiscale-multiphase-multicomponent structure显示文摘Based on the hybrid hypersingular integral equation-lattice Boltzmann methods (HHIE-LBM), the porosity and permeability evolution and evaluation process in anisotropic saturated porosity multiscale-multiphase-multicomponent (ASP-MS-MP-MC) structures under ultra high temperature and pressure conditions was analyzed on parallel CPU and GPU platforms. First, virtual physical models at multi-spatial scales (2 μm, 5 μm and 10 μm) were restructured by computerized microtomography technology and data. Second, using HHIE-LBM methods, the anisotropic porosity and permeability tensor at core level and pore level under ultra high temperature and pressure conditions were calculated. Third, the evolution and evaluation process of the porosity and permeability as a function of multi temporal spatial scales was investigated. Finally, the relationship between porosity and permeability and ASP-MS-MP-MC structures (micro-meso-macro-scale) was explored. | ZHU BoJing CHENG HuiHong QIAO YanChao LIU Chang SHI YaoLin ZHANG Kai SUN DongSheng LIN WeiRen | 2012 | Chinese Science Bulletin2012，57，4： | 11 |
| 8 | Genetic analysis and fine mapping of an enclosed panicle mutant esp2 in rice (Oryza sativa L.)显示文摘The phenomenon of panicle enclosure in rice is mainly caused by the shortening of uppermost internode.Elucidating the molecular mechanism of panicle enclosure will be helpful for solving the problem of panicle enclosure in male sterile lines and creating new germplasms in rice.We acquired a monogenic recessive enclosed panicle mutant,named as esp2 (enclosed shorter panicle 2),from the tissue culture progeny of indica rice cultivar Minghui-86.In the mutant,panicles were entirely enclosed by flag leaf sheaths and the uppermost internode was almost completely degenerated,but the other internodes did not have obvious changes in length.Genetic analysis indicated that the mutant phenotype was controlled by a recessive gene,which could be steadily inherited and was not affected by genetic background.Apparently,ESP2 is a key gene for the development of uppermost internode in rice.Using an F 2 population of a cross between esp2 and a japonica rice cultivar Xiushui-13 as well as SSR and InDel markers,we fine mapped ESP2 to a 14-kb region on the end of the short arm of chromosome 1.According to the rice genome sequence annotation,only one intact gene exists in this region,namely,a putative phosphatidylserine synthase gene.Sequencing analysis on the mutant and the wild type indicated that this gene was inserted by a 5287-bp retrotransposon sequence.Hence,we took this gene as a candidate of ESP2.The results of this study will facilitate the cloning and functional analysis of ESP2 gene. | GUAN HuaZhong DUAN YuanLin LIU HuaQing CHEN ZhiWei ZHUO Ming ZHUANG LiJun QI WenMing PAN RunSen MAO DaMei ZHOU YuanChang WANG Feng WU WeiRen | 2011 | Chinese Science Bulletin2011，56，14： | 6 |
| 9 | Overview of deep space laser communication显示文摘The deep space probe is a vital technology for observing and exploring the universe. It is thus intensifying as an aerospace research focus on an international scale. Despite improving the frequency band,the conventional microwave communication technique has difficulty satisfying the increased demand for the enormous volume of scientific data returning to the Earth. With a carrier frequency that is several orders of magnitude higher than the microwave, free-space optical communication is a robust and promising method for achieving both high bit rates and long distances in deep space communication. In this article, the history of this technology is summarized and the objective laws are formulated, while key techniques and development trends are analyzed. Finally, useful concepts and suggestions are proposed for the development of deep space laser communication in China. | Weiren WU Ming CHEN Zhe ZHANG Xiangnan LIU Yuhui DONG | 2018 | Science China(Information Sciences)2018，61，4： | 6 |
| 10 | Effects of purified zearalenone on selected immunological measurements of blood in post-weaning gilts显示文摘Zearalenone(ZEA), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies have indicated that acute ZEA exposure induced various damages in different species; however, its transparent hematotoxicity in female piglets at dietary levels of 1.1 to 3.2 mg/kg has not been shown. The present study was conducted to investigate the effects of dietary ZEA(1.1—3.2 mg/kg) on hematology, T lymphocyte subset, immunoglobulin, antibody titer, lymphocyte proliferation rate(LPR), and interleukin-2(IL-2) in peripheral blood of post-weaning gilts. A total of 20 female piglets(Landrace × Yorkshire × Duroc),weaned at 42 d with an average body weight of 10.36 ± 1.21 kg were used in the study. Female piglets were kept in a temperature controlled room, divided into four treatments, and fed a diet based on corn-soybean meal-fishmeal-whey, with an addition of 0, 1.1, 2.0, or3.2 mg/kg purified ZEA for 18 d ad libitum. Feed intake and refusal were measured daily and individual pigs were weighed weekly. Blood and serum samples were collected for selected immunological measurements. Female piglets fed different levels of dietary ZEA grew similarly with no difference in feed intake. Hematological values including leukocytes, platelets, lymphocytes, hematocrit, and mean corpuscular hemoglobin(MCH) decreased linearly(P < 0.05) as dietary ZEA increased. Female piglets fed diets containing 2.0 mg/kg ZEA or greater showed significantly decreased CD4+CD8+, CD4+, and CD4+/CD8^+ in comparison to the control(P < 0.05), whereas CD8^+ was significantly increased(P = 0.026) in the gilts which were fed the diet containing 3.2 mg/kg ZEA. Serum immunoglobulin G(IgG) and the antibody titer on d 18 were reduced linearly as dietary ZEA levels increased(P < 0.001). Linear decrease in LPR was observed(P < 0.05). Female piglets fed diets containing 2.0 mg/kg ZEA or more showed significantly decreased IL-2 in comparison to the control(P < 0.05). The results suggested that dietary ZEA at the levels of 1.1 to 3.2 mg/kg can induce different degrees of hematotoxicity and negatively affect immune function in female piglets. | Lijie Yang Weiren Yang Qiang Feng Libo Huang Guiguo Zhang Faxiao Liu Shuzhen Jiang Zaibin Yang | 2016 | Animal Nutrition2016，，3： | 5 |
| 11 | Development of DArT markers for a linkage map of flue-cured tobacco显示文摘Tobacco(Nicotiana tabacum) is one of the most economically important nonfood crops,and flue-cured tobacco accounts for approximately 80% of world tobacco production.An extremely narrow genetic diversity in the tobacco pool has led to a low efficiency of PCR-based molecular markers(such as AFLP and SSR).Diversity Arrays Technology(DArT) is a high-throughput hybridisation-based marker system that has been developed in many plants including wheat,which,like tobacco,has a complex genome.In this study,we developed a tobacco DArT chip that included 7680 representative sequence tags based on typical tobacco accessions.The 1076 DArT markers of flue-cured tobacco were identified and most(82.1%) of their polymorphism information contents(PICs) were greater than 0.4.An integrated linkage map that included 851 markers(238 DArT and 613 SSR),which is the highest density map of flue-cured tobacco to date,was constructed.This chip-based DArT system provides an alternative in high-throughput marker genotyping for tobacco. | LU XiuPing GUI YiJie XIAO BingGuang LI YongPing TONG ZhiJun LIU Yun BAI XueFei WU WeiRen XIA Ling HUTTNER Eric KILIAN Adrzej FAN LongJiang | 2013 | Chinese Science Bulletin2013，58，6： | 4 |
| 12 | Recent development on synthetic biological devices treating bladder cancer显示文摘Synthetic biology is an emerging field focusing on engineering genetic devices and biomolecular systems for a variety of applications from basic biology to biotechnology and medicine.Thanks to the tremendous advances in genomics and the chemical synthesis of DNA in the past decade,scientists are now able to engineer genetic devices and circuits for cancer research and intervention,which offer promising therapeutic strategies for cancer treatment.In this article,we provide a systemic review on recent development achieved by the synthetic biologists,oncologists and clinicians of one National“973”Plan.We expand the synthetic biology toolkits involving DNA,RNA and protein bio-parts to explore various issues in cancer research,such as elucidation of mechanisms and pathways,creation of new diagnostic tools and invention of novel therapeutic approaches.We claimed that the Chinese synthetic biologists are promoting the basic research productions of tumor synthetic biology into the clinic. | Zhicong Chen Anbang He Yuchen Liu Weiren Huang Zhiming Cai | 2016 | Synthetic and Systems Biotechnology2016，1，4： | 4 |
| 13 | Technological breakthroughs and scientific progress of the Chang’e-4 mission显示文摘Chang’e-4 is the first man-made probe that accomplished landing and roving on the far side of the Moon,which is viewed as a new milestone in the history of Lunar exploration.Beginning with a brief introduction to the progress of domestic and foreign Lunar exploration,this paper reviews the implementation process of the Chang’e-4 project,sorts out the technical breakthroughs achieved,summarizes the exploration achievements,and provides references for subsequent Lunar exploration. | Weiren WU Dengyun YU Chi WANG Jizhong LIU Yuhua TANG He ZHANG Zhe ZHANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 14 | Spacecraft angular velocity estimation method using optical flow of stars显示文摘Angular velocity is a crucial parameter for spacecraft navigation, which, at present, is mainly obtained by using gyroscopes. Several studies have been performed on angular velocity estimation using star sensors when data from gyroscopes are not available. Most of the previous angular velocity estimation methods using star sensors are based on information on the attitude or star vector measurements. In this paper,an angular velocity estimation method using the optical flow(OF) directly from the star images is proposed,which, unlike the previous methods, requires star coordinates in two consecutive images only. Because the procedure of star identification is eliminated, the corresponding high computation requirement is reduced.Simulations demonstrate that the proposed method has a robust performance in terms of computational cost and the number of stars in the field of view(FOV) compared with the previous methods. Finally, certain affecting factors are analyzed, including lens distortion, star senor instantaneous FOV(IFOV), star number,and accuracy of the star sensor. | Xiaolin NING Zonghe DING Pingping CHEN Weiren WU Jiancheng FANG Gang LIU | 2018 | Science China(Information Sciences)2018，61，11： | 3 |
| 15 | NEW ITERATIVE SUPER-TRELLIS DECODING WITH SOURCE A PRIORI INFORMATION FOR VLCS WITH TURBO CODES显示文摘A novel Joint Source and Channel Decoding (JSCD) scheme for Variable Length Codes (VLCs) concatenated with turbo codes utilizing a new super-trellis decoding algorithm is presented in this letter. The basic idea of our decoding algorithm is that source a priori information with the form of bit transition probabilities corresponding to the VLC tree can be derived directly from sub-state transitions in new composite-state represented super-trellis. A Maximum Likelihood (ML) decoding algorithm for VLC sequence estimations based on the proposed super-trellis is also described. Simu-lation results show that the new iterative decoding scheme can obtain obvious encoding gain especially for Reversible Variable Length Codes (RVLCs),when compared with the classical separated turbo decoding and the previous joint decoding not considering source statistical characteristics. | Liu Jianjun Tu Guofang Wu Weiren | 2007 | Journal of Electronics(China)2007，24，1： | 3 |
| 16 | Recursive adaptive filter using current innovation for celestial navigation during the Mars approach phase显示文摘Celestial navigation is a commonly used autonomous navigation technique for deep space navigation.A nonlinear filter such as the unscented Kalman filter(UKF) is typically applied in a celestial navigation system(CNS). However, on account of being subject to a number of factors, such as ephemeris errors and centroid determination, the measurement model error of a CNS cannot be accurately determined. The analysis conducted in this study also shows that the measurement model error is time-variant during the Mars approach phase.This implies that covariance matrix of the measurement error R is usually inaccurate, which may induce large estimation errors that even result in filter divergence. Some adaptive methods are able to address this issue.However, traditional adaptive filters, for scaling R, usually require a sequence of innovation and are affected by the statistic window size. A new recursive adaptive UKF(RAUKF) is proposed in this paper, which only uses current innovation to scale R. The navigation performance of the proposed RAUKF method is compared with some traditional adaptive filters through simulations. The results show that this method is better than traditional adaptive filters in a CNS during the Mars approach phase. | Xiaolin NING Zhuo LI Weiren WU Yuqing YANG Jiancheng FANG Gang LIU | 2017 | Science China(Information Sciences)2017，60，3： | 3 |
| 17 | Automated pipeline for superalloy data by text mining显示文摘Data provides a foundation for machine learning,which has accelerated data-driven materials design.The scientific literature contains a large amount of high-quality,reliable data,and automatically extracting data from the literature continues to be a challenge.We propose a natural language processing pipeline to capture both chemical composition and property data that allows analysis and prediction of superalloys.Within 3 h,2531 records with both composition and property are extracted from 14,425 articles,coveringγ′solvus temperature,density,solidus,and liquidus temperatures.A data-driven model forγ′solvus temperature is built to predict unexplored Co-based superalloys with highγ′solvus temperatures within a relative error of 0.81%.We test the predictions via synthesis and characterization of three alloys.A web-based toolkit as an online open-source platform is provided and expected to serve as the basis for a general method to search for targeted materials using data extracted from the literature. | Weiren Wang Xue Jiang Shaohan Tian Pei Liu Depeng Dang Yanjing Su Turab Lookman Jianxin Xie | 2022 | npj Computational Materials2022，，1： | 2 |
| 18 | 3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes显示文摘 | ZHANG Shuo WANG Yuli LIU Wei XIE Yafei LIU Yuqiang XU Weiren TANG Lida WANG Jianwua ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 19 | gem-Dimethyl-bearing C-Glucosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors显示文摘三新奇 gem-dimethyl C 配糖物作为钠葡萄糖 co 搬运被设计 2 (SGLT2 ) 禁止者,和他们的综合体从 D 葡萄糖开始了,三 2-substituted-5-bromobenzoic 酸经由一个灵巧的 8 步协议被完成,与是无水的关键步铝第三级的白酒和苯乙醚的催化氯化物的 Friedel 手艺完化。这三个 SGLT2 禁止者在 vivo 被评估与一鼠标口头的葡萄糖忍耐测试(OGTT ) ,和所有这三混合物的 anti-hyperglycemic 活动与积极控制 Dapagliflozin 的是可比较的。 | Shi, Yongheng Zhao, Guilong Lou, Yuanyuan Wang, Yuli Shao, Hua Liu, Wei Xu, Weiren Tang, Lida | 2011 | Chinese Journal of Chemistry2011，29，6： | 2 |
| 20 | New celestial assisted INS initial alignment method for lunar explorer显示文摘In the future lunar exploration programs of China,soft landing,sampling and returning will be realized.For lunar explorers such as Rovers,Landers and Ascenders,the inertial navigation system(INS) will be used to obtain high-precision navigation information.INS propagates position,velocity and attitude by integration of sensed accelerations,so initial alignment is needed before INS can work properly.However,traditional ground-based initial alignment methods cannot work well on the lunar surface because of its low rotation rate(0.55%).For solving this problem, a new autonomous INS initial alignment method assisted by celestial observations is proposed,which uses star observations to help INS estimate its attitude,gyroscopes drifts and accelerometer biases.Simulations show that this new method can not only speed up alignment,but also improve the alignment accuracy.Furthermore, the impact factors such as initial conditions,accuracy of INS sensors,and accuracy of star sensor on alignment accuracy are analyzed in details,which provide guidance for the engineering applications of this method.This method could be a promising and attractive solution for lunar explorer’s initial alignment. | Weiren Wu Xiaolin Ning Lingling Liu | 2013 | Journal of Systems Engineering and Electronics2013，24，1： | 2 |
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