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| 1 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 2 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hoqnfp5p9069q6u50.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hoqnfp5p9069q6u50.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 3 | Microstructural features of biomedical cobalt–chromium–molybdenum(CoCrMo) alloy from powder bed fusion to aging heat treatment显示文摘The design freedom of powder bed fusion process selective laser melting(SLM)enables flexibility to manufacture customized,geometrically complex medical implants directly from the CAD models.Cobased alloys have adequate wear and corrosion resistance,fatigue strength,and biocompatibility,which enables the alloys to be widely used in medical devices.This work aims to investigate the evolution of microstructures and their influence on tribological property of CoCrMo alloy processed by SLM and aging heat treatment.The results showed that very weak<110>texture along the building direction and microsegregation along cellular boundaries were produced.The presence of high residual stress and fine cellular dendrite structure has a pronounced hardening effect on the as-SLM and aging-treated alloys at moderate temperatures.Furthermore,the hexagonalεphase transformed from theγmatrix during SLM became significant after subsequent aging at moderate temperatures,which further increased the nanohardness and scratch resistance.High temperature(1150℃)heating caused homogenized recrystallization microstructure free of residual stress andεphase,which sharply decreased the hardness and scratch resistance.The material parallel to the building direction exhibited improved tribological property in both SLMed and aging-treated alloy than that of the material perpendicular to the building direction.The anisotropy in frictional performance may be considered when designing CoCrMo dental implants using laser additive manufacturing. | Haoqing Li Ming Wang Dianjun Lou Weilong Xia Xiaoying Fang | 2020 | Journal of Materials Science & Technology2020，42，10： | 5 |
| 4 | Permian Tectonic Evolution in the Middle Part of Central Asian Orogenic Belt: Evidence from Newly Identified Volcanic Rocks in the Bilutu Area, Inner Mongolia显示文摘In this study, zircon U-Pb ages, geochemical and Lu-Hf isotopic data are presented for the newly identified volcanic rocks which were considered as Bainaimiao group in Bainaimiao Arc Belt(BAB), Inner Mongolia, which could provide important constraints on the evolution of the northern part of North China Block(NCB) and BAB. Basalt to basaltic andesite and andesite to dacite were collected from two sections, which showed eruption ages of 278.2±4.1 Ma and 258.3±3.0 Ma respectively. All samples are characterized by high abundances in Al2O3, LREEs, and LILEs, but depleted in HFSEs. Together with high Mg# ratios and low K/tholeiite to calc-alkaline series, these features indicated that basalt to andesite was likely derived from relatively low degree partial melting of the subduction-fluid related mantle in the spinel phase. And dacite was mainly from the partial melting of crust, then affected by mantle. All samples barely went through fractional crystallization process with the slight Eu anomaly. Compared with the contemporary basalt in NCB, rocks in BAB have a complex composition of zircon and a more positive εHf(t) value(-6.6-6.4), indicating that they had different magma sources of rocks. Though with different basements, NCB and BAB have become an integrated whole before 278 Ma. Therefore, it could be concluded that NCB and BAB belonged to the active continental margin and the PAO had not closed yet until late Permian and then it disappeared gradually and the CAOB developed into a condition of syn-post collision. | WANG Shijie LIU Yang DONG Xiaojie XU Zhongyuan WANG Wenlong LI Shichao SHI Qiang CUI Weilong | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 3 |
| 5 | Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors显示文摘Considering that photodynamic therapy(PDT)-induced oxygen consumption and microvascular damage could exacerbate hypoxia to drive more glycolysis and angiogenesis, a novel approach to potentiate PDT and overcome the resistances of hypoxia is avidly needed. Herein, morpholine-modified PEGylated bilirubin was proposed to co-deliver chlorin e6, a photosensitizer, and diclofenac(Dc). In acidic milieu, the presence of morpholine could enable the nanocarriers to selectively accumulate in tumor cells, while PDT-generated reactive oxidative species(ROS) resulted in the collapse of bilirubin nanoparticles and rapid release of Dc. Combining with Dc showed a higher rate of apoptosis over PDT alone and simultaneously triggered a domino effect, including blocking the activity and expression of lactate dehydrogenase A(LDHA), interfering with lactate secretion, suppressing the activation of various angiogenic factors and thus obviating hypoxia-induced resistance-glycolysis and angiogenesis. In addition, inhibition of hypoxia-inducible factor-1a(HIF-1a) by Dc alleviated hypoxia-induced resistance. This study offered a sequentially responsive platform to achieve sufficient tumor enrichment, on-demand drug release and superior anti-tumor outcomes in vitro and in vivo. | Yang Zhou Fan Tong Weilong Gu Siqin He Xiaotong Yang Jiamei Li Yue-Dong Gao Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 6 | Defining reference genes for quantitative real-time PCR analysis of anther development in rice显示文摘量的即时聚合酶链反应(qPCR ) 是为基因 expressionanalysis 的最精确、广泛地使用的方法之一。然而,为正规化的引用基因的选择为 genomics 的基因 expression.As 开发的精确 quantification 是批评的,采矿大规模数据集象 microarray 和定序 RNA 那样数据成为新引用基因的新 approachfor 利用。在这研究,我们分析了包含不同纸巾和米饭花药和花粉的发展中的阶段的米饭花药和 167 microarraydatasets 的定序 RNA 数据集。我们选择了 5 参考基因,包括的 ACT1, eEF-1, GAPDH, Exp2,和 CCDC72 在以前的研究使用了的 12 候选人基因 andother,并且在八纸巾和花药 inrice 变化 9311 的不同发展阶段和 Yuetai 计算了他们的表达式。UPF3, eIF4A-3, GAPDH,和 PPP6 在米饭为花药开发的 qPCR 分析作为最合适的参考基因被识别。新候选人 referencegenes 比传统地使用的参考基因显示出更多的稳定的表示。这些结果在米饭花药为研究提供一套可靠 referencegenes 发展过程。 | Yanxiao Ji Ping Tu Kun Wang Feng Gao Weilong Yang Yingguo Zhu Shaoqing Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 2 |
| 7 | Microstructure, mechanical and tribological properties of graphite-like amorphous carbon films prepared by unbalanced magnetron sputtering显示文摘 | Yongjun Wang Hongxuan Li Li Ji Fei Zhao Qinghua Kong Yongxia Wang Xiaohong Liu Weilong Quan Huidi Zhou Jianmin Chen | 2010 | Surface & Coatings Technology2010，，8： | 2 |
| 8 | TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat显示文摘Grain development is a crucial determinant of yield and quality in bread wheat(Triticum aestivum L.).However,the regulatory mechanisms underlying wheat grain development remain elusive.Here we report how Ta MADS29 interacts with Ta NF-YB1 to synergistically regulate early grain development in bread wheat.The tamads29 mutants generated by CRISPR/Cas9 exhibited severe grain filling deficiency,coupled with excessive accumulation of reactive oxygen species(ROS)and abnormal programmed cell death that occurred in early developing grains,while overexpression of Ta MADS29 increased grain width and1,000-kernel weight.Further analysis revealed that Ta MADS29 interacted directly with Ta NF-YB1;null mutation in Ta NF-YB1caused grain developmental deficiency similar to tamads29 mutants.The regulatory complex composed of Ta MADS29 and Ta NF-YB1 exercises its possible function that inhibits the excessive accumulation of ROS by regulating the genes involved in chloroplast development and photosynthesis in early developing wheat grains and prevents nucellar projection degradation and endosperm cell death,facilitating transportation of nutrients into the endosperm and wholly filling of developing grains.Collectively,our work not only discloses the molecular mechanism of MADS-box and NF-Y TFs in facilitating bread wheat grain development,but also indicates that caryopsis chloroplast might be a central regulator of grain development rather than merely a photosynthesis organelle.More importantly,our work offers an innovative way to breed high-yield wheat cultivars by controlling the ROS level in developing grains. | Guoyu Liu Runqi Zhang Sen Li Rehmat Ullah Fengping Yang Zihao Wang Weilong Guo Mingshan You Baoyun Li Chaojie Xie Liangsheng Wang Jie Liu Zhongfu Ni Qixin Sun Rongqi Liang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 9 | Enrichment of arsenic, antimony, thallium and selenium in high-arsenic coal from Xingren County, Guizhou Province显示文摘 | Zhanjun YANG Yuegang TANG Xiao ZHENG Juanjuan LI Weilong HAN Shuting YANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 10 | Economic assessment of the mobilized thermal energy storage (M-TES) system for distributed heat supply 显示文摘 | Li Hailong Wang Weilong Yan Jinyue | 2013 | Applied Energy2013，104，： | 1 |
| 11 | Advances in particulate matter filtration:Materials,performance,and application显示文摘Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human health.Particularly during the current COVID-19 pandemic,effective filtration of the virus is an urgent matter worldwide.In this review,we first introduce some fundamentals about PM,including its source and classification,filtration mechanisms,and evaluation parameters.Advanced filtration materials and their functions are then summarized,among which polymers and MOFs are discussed in detail together with their antibacterial performance.The discussion on the application is divided into end-of-pipe treatment and source control.Finally,we conclude this review with our prospective view on future research in this area. | Xuzheng Ji Jianying Huang Lin Teng Shuhui Li Xiao Li Weilong Cai Zhong Chen Yuekun Lai | 2023 | Green Energy & Environment2023，8，3： | 1 |
| 12 | Sparse representation with morphologic regularizations for single image super-resolution 显示文摘 | LIU Weilong LI Shutao | 2014 | Signal Processing(SO165-1684)2014，98，： | 1 |
| 13 | Lithium ion conductivity in single crystal LiFePO4显示文摘 | Jiying Li Weilong Yao S Martin D Vaknin | 2008 | Solid State Ionics2008，179，： | 1 |
| 14 | Alcohol/water-soluble porphyrins as cathode interlayers in high-performance polymer solar cells显示文摘Three alcohol/water-soluble porphyrins,Zn-TPy PMe I:zinc(II)meso-tetra(N-methyl-4-pyridyl)porphyrin tetra-iodide,ZnTPy PAd Br:zinc(II)meso-tetra[1-(1-adamantylmethyl ketone)-4-pyridyl]porphyrin tetra-bromide and Mn Cl-TPy PAd Br:manganese(III)meso-tetra[1-(1-adamantylmethyl ketone)-4-pyridyl]porphyrin tetra-bromide were employed as cathode interlayers to fabricate polymer solar cells(PSCs).The PC71BM([6,6]-phenyl C71 butyric acid methyl ester)and PCDTBT(poly[N-9″-hepta-decanyl-2,7-carbazole-alt-5,5-(4′,7′-di-2-thienyl-2′,1′,3′-benzothiadiazole)])-blend films were used as active layers in polymer solar cells(PSCs).The PSCs with alcohol/water-soluble porphyrins interlayer showed obviously higher power conversion efficiency(PCE)than those without interlayers.The highest PCE,6.86%,was achieved for the device with Mn ClTPy PAd Br as an interlayer.Ultraviolet photoemission spectroscopic(UPS),carrier mobility,atomic force microscopy(AFM)and contact angle( )characterizations demonstrated that the porphyrin molecules can result in the formation of interfacial dipole layer between active layer and cathode.The interfacial dipole layer can obviously improve the open-circuit voltage(Voc)and charge extraction,and sequentially lead to the increase of PCE. | Tao Jia Weilong Zhou Fenghong Li Yajun Gao Lu Wang Jianxiong Han Jingying Zhang Yue Wang | 2015 | Science China Chemistry2015，58，2： | 1 |
| 15 | Three-dimensional reconstruction of systematic histological sections:application to observations on palatal shelf elevation显示文摘Normal mammalian secondary palate development undergoes a series of processes,including palatal shelf(PS)growth,elevation,adhesion and fusion,and palatal bone formation.It has been estimated that more than 90%of isolated cleft palate is caused by defects associated with the elevation process.However,because of the rapidly completed elevation process,the entire process of elevation will never be easy to clarify.In this article,we present a novel method for three-dimensional(3D)reconstruction of thick tissue blocks from two-dimensional(2D)histological sections.We established multiplanar sections of the palate and tongue in coronal and sagittal directions,and further performed 3D reconstruction to observe the morphological interaction and connection between the two components prior to and during elevation.The method completes an imaging system for simultaneous morphological analysis of thick tissue samples using both synthetic and real data.The new method will provide a comprehensive picture of reorientation morphology and gene expression pattern during the palatal elevation process. | Weilong Liu Xiaoming Wang Yinuo Wang Yahong Wang Jing Zhang Bing Shi Chenghao Li | 2021 | International Journal of Oral Science2021，13，2： | 1 |
| 16 | HITAC-seq enables high-throughput cost-effective sequencing of plasmids and DNA fragments with identity显示文摘DNA sequencing is vital for many aspects of biological research and diagnostics. Despite the development of second and third generation sequencing technologies, Sanger sequencing has long been the only choice when required to precisely track each sequenced plasmids or DNA fragments. Here, we report a complete set of novel barcoding and assembling system, Highly-parallel Indexed Tagmentation-reads Assembled Consensus sequencing(HITAC-seq), that could massively sequence and track the identities of each individual sequencing sample. With the cost of much less than that of single read of Sanger sequencing,HITAC-seq can generate high-quality contiguous sequences of up to 10 kilobases or longer. The capability of HITAC-seq was confirmed through large-scale sequencing of thousands of plasmid clones and hundreds of amplicon fragments using approximately 100 pg of input DNAs. Due to its long synthetic length, HITACseq was effective in detecting relatively large structural variations, as demonstrated by the identification of a~1.3 kb Copia retrotransposon insertion in the upstream of a likely maize domestication gene. Besides being a practical alternative to traditional Sanger sequencing, HITAC-seq is suitable for many highthroughput sequencing and genotyping applications. | Xiang Gao Weipeng Mo Junpeng Shi Ning Song Pei Liang Jian Chen Yiting Shi Weilong Guo Xinchen Li Xiaohong Yang Beibei Xin Haiming Zhao Weibin Song Jinsheng Lai | 2021 | Journal of Genetics and Genomics2021，48，8： | 0 |
| 17 | How temperature and hydrostatic pressure impact organic room temperature phosphorescence from H-aggregation of planar triarylboranes and the application in bioimaging显示文摘Highly efficient persistent organic room temperature phosphorescence(RTP) has attracted increasing attention because of promising applications in fields of chemical sensors, optoelectronic devices, information security, and bioimaging, etc. Wherein,the crystal engineering of H-aggregation offers stabilization for long-lived triplet exciton for RTP, but the related research is rare because of the scarcity of ideal phosphorescent H-aggregate. Herein, we designed planar tricoordinate organoboron derivatives with molecular arrangement in ideal H-aggregation. The integration of Br atom can largely enhance RTP efficiency through increasing SOC effect, while the antiparallel molecular arrangement causes annihilation of triplet exciton. Thanks to good selfassembly property, their RTP can even be observed in PMMA matrix with doping ratio of merely 1 wt%. We further found that the cryogenic temperature contributes to stabilizing triplet exciton in H-aggregation, leading to red-shifted phosphorescence. By applying high hydrostatic pressure, the phosphorescence was largely enhanced and redshifted, demonstrating the crucial role of H-aggregation on RTP property. In phosphorescent tissue imaging of live mouse, nanoparticles of BrBA exhibited high contrast image via eliminating the interference of autofluorescence. | Liangjing Tu Yuanyuan Fan Changjiang Bi Leyi Xiao Yonggang Li Aisen Li Weilong Che Yujun Xie Yufeng Zhang Shuping Xu Weiqing Xu Qianqian Li Zhen Li | 2023 | Science China Chemistry2023，66，3： | 0 |
| 18 | Optimization of Blade Geometry of Savonius Hydrokinetic Turbine Based onGenetic Algorithm显示文摘Savonius hydrokinetic turbine is a kind of turbine set which is suitable for low-velocity conditions.Unlike conventional turbines,Savonius turbines employ S-shaped blades and have simple internal structures.Therefore,there is a large space for optimizing the blade geometry.In this study,computational fluid dynamics(CFD)numerical simulation and genetic algorithm(GA)were used for the optimal design.The optimization strategies and methods were determined by comparing the results calculated by CFD with the experimental results.The weighted objective function was constructed with the maximum power coefficient Cp and the high-power coefficient range R under multiple working conditions.GA helps to find the optimal individual of the objective function.Compared the optimal scheme with the initial scheme,the overlap ratioβincreased from 0.2 to 0.202,and the clearance ratioεincreased from 0 to 0.179,the blade circumferential angleγincreased from 0°to 27°,the blade shape extended more towards the spindle.The overall power of Savonius turbines was maintained at a high level over 22%,R also increased from 0.73 to 1.02.In comparison with the initial scheme,the energy loss of the optimal scheme at high blade tip speed is greatly reduced,and this reduction is closely related to the optimization of blade geometry.As R becomes larger,Savonius turbines can adapt to the overall working conditions and meet the needs of its work in low flow rate conditions.The results of this paper can be used as a reference for the hydrodynamic optimization of Savonius turbine runners. | Jiahao Lu Fangfang Zhang Weilong Guang Yanzhao Wu Ran Tao Xiaoqin Li Ruofu Xiao | 2023 | Energy Engineering2023，120，12： | 0 |
| 19 | Fabrication of novel thin-film composite membrane based on ultrathin metal-organic framework interlayer for enhancing forward osmosis performance显示文摘To improve operation efficiency,an interlayered thin-film composite forward osmosis(iTFC-FO)membrane was designed by introducing an ultrathin and porous interlayer based on aluminum tetra-(4-carboxyphenyl)porphyrin(a stable metal-organic framework nanosheet,Al-MOF).Surface characterization results revealed that Al-MoF spread evenly in the macro-porous substrate,and provided a flat and smooth reaction interface with moderate hydrophilicity and uniform small aperture.The resultant polyamide(PA)layer had a thin base(without intrusion into substrate)and crumpled surface(with abundant leaves).The leaves size and cross-linking degree of PA layer firstly increased and then decreased with the Al-MOF loading.Compared to the original membrane,the iTFC-FO showed an enhanced water permeability and a reduced reverse sodium flux in both modes of active layer facing feed solution(ALFS)and active layer facing draw solution(AL-DS).To be specific,the specific reverse sodium flux(reverse sodium flux/pure water flux)decreased from 0.27 g/L to 0.04 g/L in the AL-FS mode,while from 1.36 g/L to 0.23 g/L in the AL-DS mode with 2 mol/L NaCl as DS.Moreover,the iTFC-FO maintained high stability and high permeability under high-salinity and contaminated environment.This study offers a new possibility for the rational fabrication of high-performance TFC-FO membranes. | Hao Liu Bo Li Pin Zhao Rongming Xu Chuyang Y.Tang Weilong Song Zunaira Habib Xinhua Wang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 20 | An Augmented IB Method&Analysis for Elliptic BVP on Irregular Domains显示文摘The immersed boundary method is well-known,popular,and has had vast areas of applications due to its simplicity and robustness even though it is only first order accurate near the interface.In this paper,an immersed boundary-augmented method has been developed for linear elliptic boundary value problems on arbitrary domains(exterior or interior)with a Dirichlet boundary condition.The new method inherits the simplicity,robustness,and first order convergence of the IB method but also provides asymptotic first order convergence of partial derivatives.Numerical examples are provided to confirm the analysis. | Zhilin Li Baiying Dong Fenghua Tong Weilong Wang | 2019 | Computer Modeling in Engineering & Sciences2019，，4： | 0 |
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