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您的检索式：作者名="Wantong Wu"
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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Scanning tunneling spectroscopic study of monolayer 1T-TaS2 and 1T-TaSe2显示文摘The isostructural and isoelectronic transition-metal-dichalcogenides 1T-TaS2 and 1T-TaSe2 are layered materials with intricate electronic structures.Combining the molecular beam epitaxy growth,scanning tunneling microscopy measurements and first-principles calculations,we prepare monolayer 1T-TaS2 and TaSe2 and explore their electronic structures at the atomic scale.Both two-dimensional(2D)compounds exhibit commensurate charge density wave phase at low temperature.The conductance mapping identifies the contributions from different Ta atoms to the local density of states with spatial and energy resolution.Both 1T-TaS2 and 1T-TaSe2 monolayer are shown to be insulators,while the former has a Mott gap and the latter is a regular band insulator. | Haicheng Lin Wantong Huang Kun Zhao Shuang Qiao Zheng Liu Jian Wu Xi Chen Shuai-Hua Ji | 2020 | Nano Research2020，13，1： | 1 |
| 3 | Asymptotic stability of travling wave fronts in nonlocal reaction-diffusion equations with delay显示文摘 | Wu Shiliang Li Wantong Liu Sanyang | 2009 | J Math Anal Appl2009，360，： | 1 |
| 4 | Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs)to elicit durable and effective humoral immune responses显示文摘Virus-like particle(VLP)vaccines had shown great potential during the COVID-19 pandemic,and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures.However,the time-consuming and complicated processes in establishing a current recombinant-protein-based VLP vaccine has limited its quick launch to the out-bursting pandemic.To simplify and optimize VLP vaccine design,we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax),with subunit receptor-binding domain(RBD)proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA)nanoparticles for vaccination against SARS-CoV-2.The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses.Using this modular preparation system,we identified that VPNVax with surface protein coverage of 20%-25% had the best immunostimulatory activity,which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant.Moreover,the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design.This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics. | Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen | 2024 | National Science Review2024，11，3： | 0 |
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