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| 1 | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis显示文摘MicroRNAs (miRNA ) 指导在基因表示的一个重要角色在植物为到环境条件的发展进程和回答要求了的顺序特定的 posttranscriptional 基因 silencing 玩。然而,很少对 transcriptional 和 miRNA 表示的 posttranscriptional 规定被知道。Histone acetylation 在染色质改变起一个重要作用并且为基因激活被要求。由在 Arabidopsis 的异种分析 miRNAs 和相应主要 miRNAs 的子集的累积,我们显示出那 histone acetyltransferase GCN5 (一般控制非镇压的 protein5 )在 miRNA 上有一般压抑的效果生产,当它为一个子集的表示被要求时(例如压力可诱导) MIRNA 基因。在 miRNA 生产的 GCN5 的一般否定功能多半通过象 DICER LIKE1 (DCL1 ) 那样的 miRNA 机械基因的间接压抑被完成,有锯齿(SE ) ,偏下性的 LEAVES1 (HYL1 ) 和 ARGONAUTE1 (AGO1 ) 。染色质 immunoprecipitation 试金表明 GCN5 指向到 MIRNA 基因的一个子集并且为在这些 loci 的 histone H3 离氨酸 14 的 acetylation 被要求。而且,由 trichostatin 的 histone deacetylation 的抑制一个处理或在 histone deacetylase,基因异种损害了某些 miRNAs 的累积。这些数据一起建议 Arabidopsis GCN5 在 transcriptional 和 posttranscriptional 层次防碍 miRNA 小径, histone acetylation/deacetylation 是涉及 miRNA 的规定的 epigenetic 机制生产。 | Wanhui Kim Moussa Benhamed Caroline Servet David Latrasse Wei Zhang Marianne Delarue Dao-Xiu Zhou | 2009 | Cell Research2009，19，7： | 10 |
| 2 | Graphene oxide-silver/cotton fiber fabric with anti-bacterial and anti-UV properties for wearable gas sensors显示文摘Wearable gas sensors can improve early warning provision for workers in special worksites and can also be used as flexible electronic platforms.Here,the flexible multifunctional gas sensor was prepared by grafting graphene oxide(GO)-Ag onto cotton fabric after swelling.The maximum bacterial inhibition rate of GO-150/cotton fabric was 95.6%for E.coli and 87.6%for S.aureus,while retaining the original high moisture permeability of cotton fabric.So GO/cotton fabric can resist the multiplication of bacteria.At the same time,GO can greatly improve the UV protection performance of cotton fabric used in garments.With increase of the GO concentration,the UV protection ability of composite fabric is enhanced.Finally,GO-Ag/cotton fabric sensors had stable NH3 gassensitive properties and good washing stability.In conclusion,these cotton fabric sensors with antibacterial properties,UV resistance and highly sensitive gas-sensitive properties have potential applications in wearable early warning devices and textile products. | Xia HE Qingchun LIU Ying ZHOU Zhan CHEN Chenlu ZHU Wanhui JIN | 2021 | Frontiers of Materials Science2021，15，3： | 2 |
| 3 | Mechanism of Methane Addition Affects the Ignition Process of n-heptane under Dual Fuel Engine-Like Conditions显示文摘For saving energy and protecting the environment,natural gas has been widely used in internal combustion engines,which makes the study on the ignition characteristics of natural gas/diesel mixtures important.In this work,the effects of trace methane addition on the ignition delay of n-heptane/air mixtures are numerically studied using a detailed n-heptane mechanism under marine engine-like conditions.The simulations are carried out based on the software CHEMKIN-PRO 18.0 with a closed homogeneous reactor.Results show that the prolonged ignition delay times(IDs)of n-heptane/air mixtures are observed over the whole initial temperature range after methane is added,and the increment of IDs in the negative temperature coefficient(NTC)region is significantly higher than that in high temperature region.The sensitivity analysis indicates that both inhibition and promotion effects of important elementary reactions on n-heptane oxidation are weakened because of methane addition.However,the weakening influence on the promoting effect is more prominent.In addition,the inhibition effect of some elementary reactions that are related to the methane oxidation is enhanced.Thus,the IDs of n-heptane/air mixture are prolonged.The analyses of reaction rate of production(ROP)show that the both the production and consumption rates of key radicals decrease significantly in NTC region after methane is added,but it is negligible in the high temperature region.The study can extend the theoretical basis of ignition characteristics of methane/n-heptane blends under elevated temperatures and pressures. | LIU Zongkuan ZHOU Lei ZHAO Wanhui QI Jiayue WEI Haiqiao | 2020 | Journal of Thermal Science2020，29，6： | 1 |
| 4 | Identification of Q-Markers from Hedan Tablet by employing “spiderweb”mode and taking compounds'hepatotoxicity into account显示文摘Objective Due to the complicated compounds and the synergistic effect of multi-compounds,the quality control and assessment of Chinese materia medica(CMM)encounters a great challenge about how to identify the key compounds,which are directly correlated with its efficacy and safety.On the guidance of study on quality marker(Q-Marker),identification of Q-Markers was performed from Hedan Tablet(HDT)by the aid of the“spider-web”mode and hepatotoxicity evaluation derived from our previous researches and literatures.Methods By the established ultra performance liquid chromatography with photodiode array detector(UPLC-PDA)method,online UPLC-DPPH·and offline antioxidant assay,21 candidate compounds of HDT were systematically investigated and comprehensively evaluated by the“spider-web”mode for them properties of Q-Marker based on“content-stability-activity”.In addition,the Q-Markers related with hepatotoxicity based on our previous researches and literatures were identified.Results Salvianolic acid B(SaB),quercetin-3-O-glucuronide(Qug),isoquercitrin(IQ)and hyperoside(Hyp)were adopted as the preferable Q-Markers of HDT according to the shaded area(A)of tested compounds in“spider-web”mode.Psoralen(Ps),isopsoralen(IP),psoralenoside(PO)and isopsoralenoside(IPO)were also strongly recommended as Q-Markers closely related with safety by considering hepatotoxicity of the accumulated Ps and IP and conversion between glycoside(PO and IPO)and aglycone(Ps and IP).Conclusion This study provided scientific evidence for quality control and assessment of HDT,and also provided a meaningful reference for application of Q-Markers in CMM. | Danni Wang Jiamin Ding Xiafei Feng Xin Chai Jing Yang Chunlei Liu Yingzi Zeng Wanhui Zhou Yuefei Wang | 2022 | Chinese Herbal Medicines2022，14，4： | 1 |
| 5 | In situ formed cross-linked polymer networks as dual-functional layers for high-stable lithium metal batteries显示文摘Lithium-metal anodes(LMAs)have been recognized as the ultimate anodes for next-generation batteries with high energy density,but stringent assembly-environment conditions derived from the poor moisture stability dramatically hinder the transformation of LMAs from laboratory to industry.Herein,an in situ formed cross-linked polymer layer on LMAs is designed and constructed by a facile thiol-acrylate click chemistry reaction between poly(ethylene glycol)diacrylate(PEGDA)and the crosslinker containing multi thiol groups under UV irradiation.Owing to the hydrophobic nature of the layer,the treated LMAs demonstrate remarkable humid stability for more than 3 h in ambient air(70%relative humidity).The coating humid-resistant protective layer also possesses a dual-functional characterization as solid polymer electrolytes by introducing lithium bis(trifluoromethanesulfonyl)imide in the system in advance.The intimate contact between the polymer layer and LMAs reduces interfacial resistance in the assembled Li/LiFePO_(4)or Li/LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)full cell effectively,and endows the cell with an outstanding cycle performance. | Lei Shi Wanhui Wang Chunjuan Wang Yang Zhou Yuezhan Feng Tiekun Jia Fang Wang Zhiyu Min Ji Hu Zhigang Xue | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
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