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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis显示文摘INTRODUCTIONThere is abundant evidence that stressful insults suchas acute pancreatitis may significantly alter themetabolism of the gut mucosa and therefore itsbarrier integrity,resulting in an increase in mucosalpermeability and subsequent translocation of entericbacteria and their cndotoxins.The fact thatmost bacteria associated with acute pancreatic andperipancreatic infections are of enteric originimplies that the gut plays a major role in | Chen DL Wang WZ Wang JY | 2000 | World Journal of Gastroenterology2000，6，5： | 10 |
| 3 | A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology.显示文摘 | Zhang Y Li HL Wang DL Liu S J Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 4 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 5 | RIVER PATTERNS AND SPATIAL AND TEMPORAL TRANSFORMATION MODES显示文摘Five main modes of spatial transformation of the river patterns and various factors influencing the river systems are discussed in the paper. Representative rivers in China and other countries demonstrate the river pattern transformation in response to some controlling factors. Furthermore, the fluvial processes are studied with historic fluvial deposits in ancient rivers. It is found that there are certain relationships between the modern spatial transformation and the ancient temporal evolution in some river systems. The anastomosing river pattern and its deposits are analyzed with the drilled core samples. Various spatial transformation modes of river patterns have been reported and different temporal evolution modes have been recorded in sediments of the ancient rivers. The braided-meandering transformation, either spatial or temporal, is found to occur more often than other modes. The main factors controlling the spatial transformation and temporal evolution of the river patterns are geotectonic characteristics, sea level fluctuation, climate change, vegetation, composition of sediment in banks and floodplains, flow discharge and sediment load. The order of these factors differs for transformation modes under different conditions. | NI Jinren1,4, WANG Suiji2, 4 and WANG Guangqian3,4 (Prof., Center for Environmental Sciences, Peking University, 100871, Beijing, China Asso. Researcher and DL, Institute of Geographic Sciences and Natural Resources Research, CAS, 100101, Beijing, China | 2000 | International Journal of Sediment Research2000，15，4： | 2 |
| 6 | Heme- heme oxygenase complex seructure of the catalytic site and its implication for oxygen activation显示文摘 | Takahashi S Wang J Rousseau DL | 1994 | J Biol Chem1994，269，2： | 2 |
| 7 | A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells 显示文摘 | Wang D Haviland DL Bums AR | 2007 | PNAS2007，104，11： | 1 |
| 8 | Aspirin and clopidogrel resistance : an emerging clinical entity显示文摘 | Wang TH Bhatt DL Topoi EJ | 2006 | Eur Heart J2006，27，： | 1 |
| 9 | A simple technique for selective radiofrequecy ablation of the slow pathway in atrioventricular node reentrant tachycardia显示文摘 | Wu DL Yeh SJ Wang CC | 1993 | J Am Coll Cardiol1993，21，7： | 1 |
| 10 | Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine显示文摘 | Wang R Doolan DL Le TP | 1998 | Science1998，282，5388： | 1 |
| 11 | Outgrowth of a transformed population derived from normal human mesenehymal stem cell culture 显示文摘 | Wang Y Huso DL Harrington J | 2005 | Cytotherapy2005，7，： | 1 |
| 12 | Genetic modification ofindustrial yeast strains to obtain controllable NewFloflocculation property and lower diacetyl production显示文摘 | Wang DL Wang ZY Liu N | 2008 | Biotechnology Letters2008，30，11： | 1 |
| 13 | Natural Selection and Adaptive Evolution of Leptin in the Ochotona Family Driven by the Cold Environmental Stress 显示文摘 | Wang ZL Zhao XQ Wang DP Qi DL Xu BH Ren YH Tian HF | 2008 | PLoS ONE2008，3，1： | 1 |
| 14 | Iterative deblurring for CT metal artifact reduction显示文摘 | Wang G Snyder DL O'sullivan JA | 1996 | IEEE Transactions on Medical Imaging1996，15，5： | 1 |
| 15 | Production of Submicron Diameter Silk Fibers under Benign Pro- cessing Conditions by Two - Fluid Electrospinning 显示文摘 | Wang M Yu JH Kaplan DL | 2006 | Macromolecules2006，39，3： | 1 |
| 16 | EGFR mutation status and survival after diagnosis of brain metastasis in non small cell lung can- cer显示文摘 | Eichler AF Kahle KT Wang DL | 2010 | Neuro Oncol2010，12，11： | 1 |
| 17 | Prediction of chromosome misalignment among in vitro matured human oocytes by spindle imaging with the PolScope显示文摘 | Wang WH Keefe DL | 2002 | Fertil Steril2002，78，5： | 1 |
| 18 | A modified cytogenetic study for multipiem- yeloma 显示文摘 | Qin YW Wei DL Wang C | 2006 | Chin J Med Genet2006，23，2： | 1 |
| 19 | Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam 显示文摘 | Wang Z Fang JN Ge DL | 2000 | Acta Pharmacol Sin2000，21，12： | 1 |
| 20 | TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction显示文摘 | Ou D Metzger DL Wang X | 2002 | Diabetologia2002，45，12： | 1 |
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