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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | 顶空固相微萃取-气相色谱质谱分析蓝莓粗提物中的挥发性成分显示文摘通过醇提法提取中国栽培蓝莓品种中的活性物质,采用顶空固相微萃取-气相色谱质谱法(HS-SPME-GCMS)分析了蓝莓粗提物中的挥发性成分,利用面积归一化法定量组分含量。检测出37个化学成分,鉴定了其中的33个化学成分。其中醇类化合物占24.15%,其次是烷烃类化合物,占17.05%,烯烃类化合物占13.61%,酯类化合物占11.97%,还有8.80%的苯和苯酚类化学物,醛、酸、酮类化合物分别为8.79%、8.21%与7.42%。 | 陈燕 孙晓红 孙国伟 任硕 赵勇 Vivian C H Wu 潘迎捷 | 2013 | 食品工业科技2013，34，20： | 11 |
| 5 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 6 | 副溶血性弧菌免疫磁珠的制备及其应用显示文摘研究比较了不同的免疫磁珠(Immunomagnetic Beads,IMBs)富集捕获副溶血性弧菌的能力。采用两种副溶血性弧菌多克隆抗体,分别包被经羧基和甲苯磺酰胺基基团修饰的磁珠,制备完成5个免疫磁珠(IMB-C1、IMB-C2、IMB-T1、IMB-T2和IMB-T3)。研究引入表面抗体浓度作为评价免疫磁珠捕获能力的特征性参数,两种副溶血性弧菌多克隆抗血清包被的羧基磁珠表现出了较高的表面抗体结合能力,分别为34.25fg/μm2和36.73fg/μm2,明显高于甲苯磺酰胺基磁珠。五个免疫磁珠对副溶血性弧菌捕获能力的研究结果表明:在起始菌液浓度为4.32logCFU/mL时(p<0.05),两个羧基磁珠捕获率达到79%和94%,均优于甲苯磺酰胺基磁珠。采用环介导恒温扩增(loop-mediated isothermal amplification,LAMP)技术对免疫磁珠菌体细胞复合物进行体外扩增,结果表明:磁珠的存在并未影响对菌体细胞的后续分子检测。本研究分析比较了不同免疫磁珠的捕获能力,得到羧基磁珠对副溶血性弧菌的捕获能力比甲苯磺酰胺基磁珠强,直接法和间接法偶联方式对免疫磁珠的富集捕获能力无影响。 | 苏晨曦 孙晓红 卢瑛 赵勇 Vivian C H Wu 潘迎捷 | 2012 | 食品工业科技2012，33，17： | 8 |
| 7 | 微量肉汤稀释法测定长裙竹荪多种提取物对食品中常见细菌的抑制效果显示文摘选取长裙竹荪为样品,采用索氏抽提后水蒸馏萃取获得挥发油,同时分别以乙醇、正丁醇、石油醚等有机溶剂萃取得到相应提取物。以8种食品中常见细菌为供试对象,由微量肉汤稀释法测得各类提取物对其的MIC值,作为评价其抑菌效果的指标。结果表明:纯培养环境下,挥发油的抑菌效果优于三种有机溶剂提取物。通过与平板涂布计数结果及其它方法比较分析,进一步证明肉汤稀释法作为测定抑菌效果所具有的优越性。 | 曹奕 孙晓红 陈燕 赵勇 Vivian C H Wu 潘迎捷 | 2013 | 食品工业科技2013，34，7： | 7 |
| 8 | 物种分布模型在古生物学研究中的应用显示文摘物种分布模型(Species distribution models,SDMs)是基于物种的生态位要求,通过将物种已知的分布数据和对应地区的环境数据联系起来,以预测该物种在不同时间和空间下的地理分布的一种数学工具。它为地史时期生物地理分布的重建、生物生态特征的分析及生物与地球环境协同演化研究等提供了一种新的途径。此方法具有研究精度高、预测效果好及应用广泛等优点,尤其适合开展高精度的古生物地理、古生态及生物宏演化等相关研究。文章着重介绍物种分布模型的基本原理及建模流程,在此基础上以笔石种Tang yagraptus typicus Mu作为建模实例进一步说明物种分布建模的详细步骤,最后概述此方法在古生物研究中的适用性及存在的问题。 | 张琳娜 樊隽轩 Melchin M J 陈清 Wu Shuang-ye Goldman D Mitchell C M Sheets H D | 2013 | 古生物学报2013，52，2： | 6 |
| 9 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 10 | A review of the Euplotidae (Hypotrichida, Ciliophora)显示文摘 | Curds C R Wu I C H | 1983 | Bull Br Mus Nat Hist1983，44，： | 3 |
| 11 | A low glitch 10-bit 75-MHz CMOS video D/A converter显示文摘 | WU T JI H C | 1995 | IEEE Journal of Solid-State Circuits1995，30，1： | 2 |
| 12 | Consistency condition and convergence criteria of incompatible element: General formulation of incompatible functions and its application显示文摘 | WU C C Huang M G Pian T H H | 1987 | Computer & Structures1987，27，： | 2 |
| 13 | A rational approach for choosing stress terms for hybrid finite element formulation显示文摘 | T H H Pian C C Wu | 1988 | International Journal for Numerical Methods in Engineering1988，26，： | 2 |
| 14 | A fast algorithm for 2-D direction-of-arrival estimation显示文摘 | Wu Y Liao G So H C | 2003 | Signal Processing2003，83，8： | 1 |
| 15 | A steganographic method for images by pixelvalue differencing 显示文摘 | WU D C Tsai W H | 2003 | Pattern Recognition Letters2003，24，910： | 1 |
| 16 | RAC/ROP GTPases:hubs for signal integration and diversification in plants显示文摘 | Nibau C Wu H M Cheung A Y | 2006 | Trends Plant Sci2006，11，： | 1 |
| 17 | Coefficient of restitution and rotational motions of rockfall impacts显示文摘 | CHAU K T WONG R H C WU J J | 2002 | International Journal of Rock Mechanics & Mining Sciences2002，39，： | 1 |
| 18 | Developmental expression of key steroidogenie enzymes in the brain of protandrous black porgy fisb, Acanthopagrus sehlegeli 显示文摘 | Tomy S Wu G C Huang H R | 2007 | Neuroendoerinol2007，9，8： | 1 |
| 19 | Persistent organic pollutants in water and surface sedimentsof Taihu Lake, China and risk assessment 显示文摘 | Wang H Wang C X Wu W Z | 2003 | Chemosphere2003，50，： | 1 |
| 20 | Mathematical modelling of elliptic helicoid screw transmission systems显示文摘 | Wu D S Lai H Y Chen C K | 2002 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2002，216，2： | 1 |
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