|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 3 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 4 | Comparison of hemodialysis and peritoneal dialysis survival in The Nether lands 显示文摘 | Liem YS Wong JB Hunink MG | 2007 | Kidney Int2007，71，： | 1 |
| 5 | Unexpected metachronous hernia development in children following laparoscopic unilateral hernia repair with negative evaluation for contralateral patent processus vaginalis显示文摘 | Tam YH Wong YS Pang KK | 2013 | J Laparoendosc Adv Surg Tech A2013，23，3： | 1 |
| 6 | Simple maneuvers to reduce the incidence of false-negative findings for contralateral patent processus vaginalis during laparoscopic hernia repair in children: a comparative study between 2 cohorts显示文摘 | Tam YH Wong YS Chan KW | 2013 | J Pediatr Surg2013，48，4： | 1 |
| 7 | Use of trichosanthin to reduce infection by turnip mosaic virus显示文摘 | WONG YS WANG B | 1996 | Plant Science1996，，： | 1 |
| 8 | Fixation of distal radius fractures using Ao titanium volar distal radius plate显示文摘 | Lec Hc Wong YS Chan Bk el al | 2003 | Hand Surg2003，8，： | 1 |
| 9 | Isolation of PAH-degrading bacteria from mangrove sediments and their biodegradation potential显示文摘 | Guo CL Zhou HW Wong YS | 2005 | Marine Pollution Bull2005，51，： | 1 |
| 10 | Percutaneous reduction and injec- tion of Norian bone cement for the treatment of dis- placed intra-articular calcanealfractures显示文摘 | Wee AT Wong YS | 2009 | Foot An- kle Spec2009，2，2： | 1 |
| 11 | Mitochondria-me-diated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative显示文摘 | Chen TF Zheng WJ Wong YS | | 0，，02： | 1 |
| 12 | Selenoeystine induces easpase- independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation 显示文摘 | Chen TF Wong YS | 2009 | Int J Bioloehem Cell B2009，41，3： | 1 |
| 13 | Comparison of postoperative pain between single-incision laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy:prospective case-control study显示文摘 | Wong JS Cheung YS Fong KW | | 0，，： | 1 |
| 14 | Selenocystine induces reactive oxygen species mediated apoptosis in human cancer cells 显示文摘 | Chen TF Wong YS | 2009 | Biomed Pharmacother2009，63，2： | 1 |
| 15 | Comparison of hemodi alysis and peritoneal dialysis survival in The Netherlands显示文摘 | Liem YS Wong JB Hunink MG | 2007 | Kidney Int2007，71，： | 1 |
| 16 | Pigmentation and antibacterial activity of fast neu- tron- and X- ray- induced strains of Monascus purpureus Went显示文摘 | | 1977 | Plant Physiol1977，60，： | 1 |
| 17 | Simple maneuvers to reduce the incidence of false-negative findings for contralateral patent proeessus vaginalis during laparoscopic hernia repair in children: a comparative study between 2 cohorts显示文摘 | Tam YH Wong YS Chan KW | 2013 | J Pediatr Surg2013，48，4： | 1 |
| 18 | Unexpected metachronous hernia development in children following laparoscopic unilateral hernia repair with negative evaluation for contralateral patent processus vaginalis 显示文摘 | Tam YH Wong YS Pang KK | 2013 | J Laparoendosc Adv Surg Tech A2013，23，3： | 1 |
| 19 | Simple maneuvers to reduce the incidence of false-negafive findings for contralateral patent processus vaginalis durin laparoscopic hernia repair in children: a comparative study between 2 cohorts 显示文摘 | Tam YH Wong YS Chan KW | 2013 | J Pediatr Surg2013，48，4： | 1 |
| 20 | Community structure and standing crop biomass of a mangrove forest in Futian Nature Reserve,Shenzhen,China显示文摘 | Tam NFY Wong YS Lan XY | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员