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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Attenuation of mitochondrial,but not cytosolic,Ca^(2+) overload reduces myocardial injury induced by ischemia and reperfusion显示文摘瞄准:mitochondrial Ca2+ 的变细([Ca2+] m ) ,然而并非 cytosolic Ca2+([Ca2+] c ) ,超载改进可收缩的恢复。我们假设了那变细[Ca2+] m,然而并非[Ca2+] c,超载对 ischemia/reperfusion-induced 损害授与 cardioprotection。方法:从孤立的酒的老鼠心,房间生存能力,和在孤立的老鼠短暂的电子上导致的 Ca2+ 的梗塞尺寸室的 myocytes 被测量。我们决定了 BAPTAAM 的效果,一座Ca2+螯岩山,在废除两个的超载的集中[Ca2+] c 并且[Ca2+] m ,和钌红,Ca2+的 mitochondrial uniporter 的一个禁止者搬运,在废除超载的集中[Ca2+] m ,然而并非[Ca2+] c ,在 ischemia/reperfusion 导致的心脏的损害上。结果:两个的变细[Ca2+] m 并且[Ca2+]由 BAPTAAM 的 c ,和变细[Ca2+] m ,然而并非[Ca2+] c ,由钌红的超载,减少了心脏的损害观察,显示重要性[Ca2+]在响应 ischemia/reperfusion 的 cardioprotection 和可收缩的恢复的 m 。结论:学习用一条原因效果途径提供了不含糊的证据那变细[Ca2+] m,然而并非[Ca2+] c,超载为对 ischemia/reperfusion-induced 损害的 cardioprotection 负责。我们也证实了以前的观察那变细[Ca2+] m,然而并非[Ca2+] c,旁边钌红改进可收缩的恢复追随者 ischemia/reperfusion。 | Chun-mei CAO Wing-yee YAN Jing LIU Kenneth WL KAM Shi-zhong ZHAN James SK SHAM Tak-ming WONG | 2006 | Acta Pharmacologica Sinica2006，27，7： | 4 |
| 3 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans 显示文摘 | Tan WL Wong TL Wong MC | 2012 | Clin Oral Implants Res2012，23，5： | 1 |
| 5 | The Incidence of Neuro- Ophthalmic Diseases in Singapore: a prospective study in public hospitals 显示文摘 | Lim SA Wong WL Fu E | 2009 | Ophthalmic Epidemiol2009，2，： | 1 |
| 6 | Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices显示文摘 | Wong WR Shyu WL Tsai JW | 2009 | Dermatol Surg2009，35，5： | 1 |
| 7 | Molecular genetics of glyco- gen-storage disease type I a in Chinese patients of Taiwan 显示文摘 | Wong LJ Hwu WL Dai P Chen TJ | 2001 | Mol Genet Metab2001，72，2： | 1 |
| 8 | Trentment of patients with chronic hepatitis B who have failed previous antiviral treatment with pegylated interferon alphα-2a 显示文摘 | Chan HL Wong WL Chim AM | 2008 | Antivir Ther2008，13，4： | 1 |
| 9 | Localize dpachyder modaetyly intuberous sclerosis 显示文摘 | Lo WL Wong CK | 1993 | Clin Exp Dermatol1993，18，： | 1 |
| 10 | Forward shifting of posterior dural sac during flexion cervical magnetic resonance imaging in Hirayama disease:an initial study on normal subjects compared to patients with Hirayama disease 显示文摘 | Lai V Wong YC Poon WL | 2011 | Eur J Radiol2011，80，3： | 1 |
| 11 | Development of electrochemical calci- um sensors by using silicon nanowires modified with phosphoty- rosine]显示文摘 | Bi X Wong WL Ji W | 2008 | Biosens Bioelect2008，23，10： | 1 |
| 12 | Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices 显示文摘 | Wong WR Shyu WL Tsai JW | 2009 | Dermatol Surg2009，35，： | 1 |
| 13 | Breakage of intramedullary femoral guide rod during total knee arthro- plasty: Acase report 显示文摘 | Chan WL Yen CH Wong KK | 2006 | J Orthop Surg2006，14，1： | 1 |
| 14 | A prospective study of PET-FDG of head a imaging for the assessment and neck squamous cell carcinoma显示文摘 | Wong WL Chevretton EB McGurk M | 1997 | Clin Otolaryngol1997，22，3： | 1 |
| 15 | Tripe palms:a significant cutaneous sign of internal malignancy显示文摘 | Lo WL Wong CK | 1992 | Dermatology1992，185，： | 1 |
| 16 | FLT PET-CT in evaluation of treatment response显示文摘 | Sanghera B Wong WL Sonoda LI | 2014 | Indian J Nucl Med India2014，29，2： | 1 |
| 17 | Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices显示文摘 | Wong WR Shyu WL Tsai JW | 2009 | J Amer Soci for Derm Surg2009，35，： | 1 |
| 18 | Differential effects of glial cell line- derived neurotrophic factor and neurturin in RET/GFRalphal - expressing cells显示文摘 | Lee RH Wong WL Chan CH | 2006 | J Neurosci Res2006，83，1： | 1 |
| 19 | Cryosurgery as a treatment for advanced stage hepatocellular carcinoma显示文摘 | Wong WL | 1998 | Cancer1998，82，7： | 1 |
| 20 | Monoclonal antibody based ELISAs for measurement of activins in biological fluids显示文摘 | Wong WL Garg SJ Woodruff T | | 0，，： | 1 |
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