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| 1 | Catheter ablation of atrial fibrillation in elderly population显示文摘Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinicalbenefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volumecenter focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patientswho underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients wasdichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and sur-vival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49% vs.29%, P 〈 0.0001), had a history of hypertension (79% vs. 57%, P 〈 0.0001), diabetes (16% vs. 11%, P 〈 0.01), stroke (9% vs. 6%, P 〈 0.01),coronary/peripheral artery disease (14% vs. 8%, P 〈 0.0001), and CHAzDS2-VASc score (3.1 ± 1.3 vs. 1.5 ± 1.2 s, P 〈 0.0001). Major com-plications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs.1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhyth-mia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2% vs.58.2% (P 〈 0.0001) and 78.2 vs. 83.2% (P 〈 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mor-tality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95% CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF inelderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients. | Josef Kautzner Petr Peichl Marek Sramko Robert Cihak Bashar Aldhoon Dan Wichterle | 2017 | Journal of Geriatric Cardiology2017，14，9： | 9 |
| 2 | Architecture and cell types of the adult subventricular zone: in search of the stem cells显示文摘 | Garcia-Verdugo JM Doctsch F Wichterle H | 1998 | J Neurobiol1998，36，： | 1 |
| 3 | Directed differentitation of embryonic stem cells into mctor neurons显示文摘 | Wichterle H Lieberam I Porter JA | 2002 | Cell2002，110，3： | 1 |
| 4 | Directed differentiation of embryonic stem cells into motor neurons显示文摘 | Wichterle H Lieberam I Porter J A | 2002 | Cell2002，110，： | 1 |
| 5 | Directed differentiation ofembryonic stem cells into motor neurons 显示文摘 | Wichterle H Lieberam I Porter J A | 2002 | Cell2002，110，： | 1 |
| 6 | Electrical Reconnection After Pulmonary Vein Isolation Is Contingent on Contact Force During Initial Treatment: Results From the EFFICAS I Study显示文摘 | Petr Neuzil Vivek Y. Reddy Josef Kautzner Jan Petru Dan Wichterle Dipen Shah Hendrik Lambert Aude Yulzari Erik Wissner Karl-Heinz Kuck | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，： | 1 |
| 7 | Architecture andCell types of the adult subventricular zone: in search of the stemcells显示文摘 | Garcia-Verdugo JM Doetsch F Wichterle H | 1998 | J Neurobiol1998，36，： | 1 |
| 8 | Sinus rhythm restoration andantiarrhythmic drugs withdrawal independently predict functi- onal improvement after catheter ablation for long-standing persi- stent atrial fibrillation显示文摘 | Fiala M Wichterle D Sknouril L | 2011 | Cardiol2011，107，： | 1 |
| 9 | Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension显示文摘 | Strauch B Petrak O Wichterle D | 2006 | Am J Hypertens2006，19，9： | 1 |
| 10 | High-pressure vapor-liquid equilibrium in systems containing carbon dioxide, 1-hexene, and n-hexane显示文摘 | Wagner Z Wichterle I | 1987 | Fluid Phase Equilibria1987，33，1： | 1 |
| 11 | Architecture and cell types of the adult subventricular zone:in search of the stem cells显示文摘 | Garcia-Verdugo JM Doetsch F Wichterle H | 1998 | J Neurobiol1998，36，2： | 1 |
| 12 | physiological mechanisms of atrially induced heart rate turbulence显示文摘 | Wichterle D Malik M | 2005 | J Am Coll Cardiol2005，46，6： | 1 |
| 13 | Heart rate turbulence after atrial and ventricular premature beats:relation to left ventricular function and coupling intervals显示文摘 | Savelieva I Wichterle D Harries M | 2003 | Pacing Clin Electrophysiol2003，26，12： | 1 |
| 14 | Directed differentiation of embryonic stem cell into motor neurons显示文摘 | Wichterle H Lieberam I Porter J A | | 0，，03： | 1 |
| 15 | Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension显示文摘 | STRAUCH B PETRAK O WICHTERLE D | | 0，，09： | 1 |
| 16 | Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy显示文摘 | Rosa J Jr Raska I Wichterle D | | 0，，03： | 1 |
| 17 | In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain显示文摘 | Wichterle H Turnbull DH Nery S | 2001 | Development2001，128，19： | 1 |
| 18 | Isothermal vapor-liquid equilibrium in the quaternary water+2-propanol + acetic acid + isopropyl acetate system with chemical reaction 显示文摘 | Mariana Teodorescu Karel Aim Ivan Wichterle | 2001 | J Chem Eng Data2001，46，2： | 1 |
| 19 | New neurons follow the flow of cerebrospinal fluid in the adult brain显示文摘 | Sawamoto K Wichterle H Gonzalez-Perez O | 2006 | Science2006，311，： | 1 |
| 20 | MicroRNA regulation of neural stem cells and neurogenesis显示文摘 | Shi Y Zhao X Hsieh J Wichterle H Impey S Banerjee S etal | 2010 | J Neurosci2010，30，14： | 1 |
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