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    题名 作者 年代 出处 被引量
1The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants.Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan 2020Molecular Plant2020,13,7:51
2Earthquake-induced soft-sediment deformation structures in the Mesoproterozoic Wumishan Formation,North China,and their geologic implications显示文摘Soft-sediment structures are key to defining seismites. Two soft-sediment deformation horizons, bounded by undeformed carbonate strata, have been found in the Wumishan Formation in the Jumahe region, 175 km southwest of Beijing. One is in the lowest part of Wumishan Formation; and the other is in the uppermost part of Litho-member I. The soft-sediment structures in these two horizons fall into three categories: mould-and-sag structures, hydraulic shatterings and liquefaction dikes. The mould-and-sag structures are divided into two types: one developed in tidal-flat sediments, accompa-nied by many liquefaction-related structures and characterized by autochthonous post-earthquake sediments in sags, and the other type developed in deep-water environments, is not associated with liquefaction structures, and is overlain immediately by seismogenic tsunamites. The hydraulic shat-terings are composed of pockets of fluidization conglomerate, sand intrusions, and syndepositional faults. The liquefaction dikes fall into two categories: hydraulic-fracturing dikes and lateral-spreading dikes. The former are steep, planar, and pinch out upwards. The latter are snake-like and characterized by no diapir-related drag structures in surrounding rocks. Examination of the attitudes and strati-graphic positions of these structures suggests that these soft-sediment structures are seismogenic, and consequently, are seismites. Most seismites in the Wumishan Formation are developed near the former western, margin fault of Yanliao rift. This occurrence suggests that they could be related to movements on this fault. Other geological implications are discussed.ZHANG ChuanHeng WU ZhengJie GAO LinZhi WANG Wei TIAN YanLin MA Chao 2007Science China Earth Sciences2007,50,3:15
3Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies.Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li 2020Cell Research2020,30,3:14
4Characteristics and Morbidity of the Tuberculosis Epidemic--China,2019显示文摘Introduction:The year 2019 was crucial for the implementation of China’s National“13th 5-Year”Tuberculosis(TB)Control Plan.We conducted this study to evaluate the characteristics and progress towards controlling TB in China.Methods:We collected and analyzed the pulmonary tuberculosis(PTB)data of China between January 1,2015 and December 31,2019 from the National Notifiable Disease Reporting System(NNDRS).Results:In 2019,there were 775,764 PTB cases reported in NNDRS,of which 349,307 were bacteriologically-confirmed(Bac+)cases.The PTB case notification rate(CNR)was 55.55 per 100,000,and the Bac+CNR was 25.01 per 100,000.From 2018 to 2019,the number of PTB cases fell by 6.3%,but the number of Bac+cases increased by 25.9%.The annual decrease in the rate of reported PTB was 3.4% from 2015 to 2019.The 5 provincial-level administrative divisions(PLADs)with the highest PTB CNR were as follows:Tibet(182.38 per 100,000),Xinjiang(169.05 per 100,000),Qinghai(134.53 per 100,000),Guizhou(102.51 per 100,000),and Hainan(90.22 per 100,000).The rate of reported PTB was 74.84 per 100,000 for males and 35.40 per 100,000 for females.There were 8,116 cases(1.0%)among children aged 0–14 years,and 197,730 cases(25.5%)among adults aged 65 years and over.Of the reported cases,470,932 were farmers,which was the most common occupation at 60.7%.Conclusions and Implications for Public Health Practice:The TB epidemic has decreased dramatically year by year.Most PTB cases were in the central and western regions of China,and the high-risk groups were farmers and elderly people aged 65 years and over.Wei Chen Hui Zhang Xin Du Tao Li Yanlin Zhao 2020China CDC weekly2020,2,12:13
5Association of miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region of SET8 and TP53 codon 72 polymorphism with non-small cell lung cancer in Chinese population显示文摘这研究的目的是识别是否在 3-untranslated 区域( 3-UTR )的 miR-502-binding 地点单身者核苷酸多型性( SNP )使蛋白质 8 包含域( SET8 )并且肿瘤蛋白质 p53 ( TP53 ) codon 72 多型性为非小的房间肺癌症与风险被联系( NSCLC ),独立地或联合,在从南部的汉的中国人民之中。SET8 和 TP53 codon 的遗传型外部血 DNA 的 72 多型性用在 164 个 NSCLC 盒子和 199 控制上在 casecontrol 研究定序的聚合酶链反应限制碎片长度多型性和直接 DNA 被检测。SET8 TT (机会比率,或 = 2.173, 95% 信心间隔, CI = 1.0454.517 ) 或 TP53 GG (或 = 2.579, 95% CI = 1.3664.870 ) 遗传型被分别地与 SET8 CC 或 TP53 CC 遗传型作比较与 NSCLC 的增加的风险联系。类似的结果在 SET8 后退的模型被获得(或 = 2.074, 95% CI = 1.0194.221, P < 0.05 ) ,并且 TP53 codon 的主导、后退的模型 72 被执行,分别地(或 = 1.809, 95% CI = 1.1592.825, P < 0.05;或 = 1.933, 95% CI = 1.0963.409, P < 0.05 ) 。另外,在 SET8 和 TP53 多型性之间的相互作用增加了 NSCLC 的风险在一多样地举止,与 OR 是 3.032 (95%CI = 1.5805.816 ) 为带 SET8 TT 和 TP53 GG 遗传型的题目。因此,在 SET8 和 TP53 codon 的 3-UTR 的 miR-502-binding 地点 SNP 72 多型性可以是到在中国人口的 NSCLC 的基因危险性的标记,并且在 NSCLC 的发生有一个可能的 genegene 相互作用。Shaodi Yang Haiyan Guo Benjie Wei Shengcui Zhu Yanlin Cai Pei Jiang Jianxin Tang 2014Acta Biochimica et Biophysica Sinica2014,46,2:12
6A New Species of the Asi an Toad Genus Megophrys sensu lato (Anura: Megophryidae) from Guizhou Province, China显示文摘We describe a new species of the genus Megophr ys from Guizhou Province, China. Molecular phylogenetic analyses based on mitochondrial DNA and nuclear DNA sequences all strongly supported the new species as an independent clade nested into the Megophrys clade and sister to M. minor. On morphology,the new species is distinguished from its congeners by a combination of the following characters:(1) small body size with SVL < 39.2 mm in male and SVL < 40.4 mm in female;(2) vomerine teeth absent;(3) tongue not notched behind;(4) a small horn-like tubercle at the edge of each upper eyelid;(5) tympanum distinctly visible, rounded;(6) two or three metacarpal tubercles in hand;(7) relative finger lengths: Ⅰ< Ⅱ< Ⅴ< Ⅲ;(8) toes without webbing;(9) heels overlapped when thighs are positioned at right angles to the body;(10) tibiotarsal articulation reaching tympanum to eye when leg stretched forward;(11) an internal single subgular vocal sac in male;(12) in breeding male, the nuptial pads with black nuptial spines on the dorsal bases of the first and second fingers.Jing LIU Shize LI Gang WEI Ning XU Yanlin CHENG Bin WANG Jun WU 2020Asian Herpetological Research2020,11,1:4
7Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control.Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang 2022China CDC weekly2022,4,29:4
8Application of third-party mediation for medical disputes: an introduction of Chinese experience显示文摘Cao Yanlin Wang Jiangjun Zheng Xueqian Jin Qinghan Tian Yongquan Wen Xuebin Wei Zhanying Li Wu 2014Chinese Medical Journal2014,,14:4
9Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition.Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao 2022National Science Review2022,9,7:4
10Optimized pre-treatment of high strength food waste digestate by high content aluminum-nanocluster based magnetic coagulation显示文摘Coagulation-based pre-treatment efficiency of high strength digestate of food waste(HSDFW) anaerobic digestion is negated by organic ligand-catalyzed decomposition of coagulants. In this study, an efficient HSDFW pre-treatment method, magnetic seeds(MS) coagulation, was employed by using highly stable Keggin Al_(30) nanocluster(PAC_(30)), MS and polyacrylamide(PAM), and its operation was optimized by evaluating the performance of removing turbidity, total suspended solids(TSS), chemical oxygen demand(COD), and total phosphorous(TP) phosphate. Results showed that at the optimum dosage of 4.82 g/L, PAC_(30) demonstrated excellent removals as high as 98.93% ± 0.1% of turbidity, 98.04% ± 0.1% of TSS, 58.28% ± 0.3% of total COD, 99.98% ± 0.01% of TP and 99.50% ± 0.01% of dissolved phosphate, respectively. Apparent molecular weight(AMW) and three-dimensional excitation-emission matrix(3 D-EEM) fluorescence spectroscopy analyses demonstrated more efficient removal of dissolved organic matter(DOM), particularly non-biodegradable and hydrophobic components by PAC_(30) than commercial coagulant. The sedimentation was much improved from 40 min by coagulation/flocculation to about 5 min settling by MS coagulation. The PAC_(30) based magnetic coagulation(MC) presents theoretical guidance on a cost-effective and much less footprint pre-treatment alternative for high strength wastewater.Tharindu Ritigala Hailu Demissie Yanlin Chen Jiaxi Zheng Libing Zheng Jinxing Zhu Hua Fan Jiao Li Dongsheng Wang Sujithra KWeragoda Rohan Weerasooriya Yuansong Wei 2021Journal of Environmental Sciences2021,33,6:4
11Underreporting of Notifiable Pulmonary Tuberculosis Cases to the National Tuberculosis Information Management System--China,2015显示文摘What is already known about this topic?Tuberculosis(TB)notification data and the underreporting rate are major sources used in estimating TB incidence.China’s TB Information Management System(TBIMS)was launched in 2005 but has not yet been evaluated for sensitivity.What is added by this report?The average underreporting rate of pulmonary TB to TBIMS in selected facilities was 8.23%.However,provincial TB or infectious disease-specific health facilities,or general health facilities had higher underreporting rates.Children,migrants,and drug resistant TB patients had higher chances to be underreported than other populations.What are the implications for public health practice?Underreporting surveys should be routinely implemented in the future.This will be vital for enhancing TB reporting and the transfer mechanisms in TB or infectious disease-specific hospitals,or general hospitals and improving the case information registration procedures in designated health facilities(DHFs).Tao Li Wei Chen Yanlin Zhao Lixia Wang Mingting Chen Xin Du Hui Zhang 2020China CDC weekly2020,2,12:4
12Photocatalytic degradation of 4-tert-octylphenol in a spiral photoreactor system显示文摘A spiral photoreactor system(SPS) was developed for the degradation of 4-tert-octylphenol(4-t-OP) in aqueous phase.4-t-OP was previously considered as a endocrine disrupting compound frequently present in water.The direct photodegradation reaction caused by the SPS was found to accord with the characteristic of apparent first-order reaction with reaction rate constant k = 4.8 × 10-2 min-1.However,the direct photodegradation reaction could not make the 4-t-OP mineralized.The photodegradation efficiency increased from 88% to 91.2% in 45 min irradiation period after the internal surface of SPS was sintered with TiO2 thin film as catalyst.Catalyst concentration,number of catalyst coating layers and initial concentration of 4-t-OP were proven to be the factors affecting the photocatalytic degradation performance of the SPS on aqueous 4-t-OP.The degradation mechanism was investigated and the byproducts were analyzed using total organic carbon analyzer(TOC) and LC-MS.The possible chemical structures of the products were suggested.SPS with single layer of TiO2 prepared by sintering 13.6% of TiO2 precursor was proven to be more efficient than most of previous systems for removal of 4-t-OP from aqueous phase.28.3% of the 4-t-OP was mineralized in 45 min according to the decreased amount of TOC value.Yanlin Wu Haixia Yuan Xiaoxuan Jiang Guanran Wei Chunlei Li Wenbo Dong 2012Journal of Environmental Sciences2012,24,9:3
13A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield显示文摘Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response.Wenshu Wang Weipeng Wang Yanlin Pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma 2022The Crop Journal2022,10,4:3
14The Impact of COVID-19 on Tuberculosis Patients’Behavior of Seeking Medical Care——China,2020显示文摘Summary What is already known on this topic?The coronavirus disease 2019(COVID-19)pandemic has disrupted the tuberculosis(TB)service system.However,the impact on TB patients in China remains unknown.What is added by this report?This report firstly addressed the impact of COVID-19 on TB patients in China.About half of TB patients did not revisit the hospital due to personal reasons.The reasons for irregular medication and postponing or cancelling examination after full treatment course were different.Yinyin Xia Fei Huang Hui Chen Ni Wang Xin Du Wei Chen Tao Li Shitong Huan Miaomiao Sun Jianjun Liu Yanlin Zhao 2021China CDC weekly2021,3,26:2
15Practical Experiences of Delivering Multidrug-Resistant Tuberculosis Comprehensive Supportive Care Services in China显示文摘Summary What is already known about this topic?The World Health Organization consolidated guidelines on recommend care for tuberculosis(TB)and support for multidrug-resistant TB(MDR-TB)patients.But guidelines have not provided detailed guidance or tools for health services providers to implement comprehensive patient care.Yunzhou Ruan Ling Li Lin Xu Yanlin Zhao Li Zhong Zhixiang Xu Kai Wang Wei Su Renzhong Li 2021China CDC weekly2021,3,26:2
16Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades.Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU 2023Advances in Atmospheric Sciences2023,40,8:2
17Surface modification of hydrophobic PMMA intraocular lens by the immobi- lization of hydroxycthyl methacrylate for improving application in ophthalmology显示文摘Wei Yanlin Ya Yashao Liu Peng 2011Plasma Chemistry and Plasma Processing2011,31,:1
18A reversible fluorescence sensor based on insoluble β-cyclodextrin polymer for direct determination of bisphenol A (BPA) 显示文摘Wang Xu Zeng Hulie Wei Yanlin 2006Sensors and Actuators B: Chemical2006,114,2:1
19An investigation on microwave transmissivity at frequencies of 18.7 and 36.5 GHz for diverse forest types during snow season显示文摘Forests have invariably been considered as an obstacle in retrieving land surface parameters from spaceborne passive microwave brightness temperature(T_(B))observations.For quantifying the effect of forests on microwave signals,several models have been developed.However,these models rarely reveal the dependence of microwave radiation on forest types,which can hardly meet the needs of high-accuracy retrieval of terrestrial parameters in forested regions.A ground-based microwave radiometric observation experiment was designed to investigate the dependence of microwave radiation on frequency,polarization,and forest type.Downward TB at 18.7-and 36.5-GHz for horizontal-and vertical-polarization from the forest canopy was measured at 14 sample plots in Northeast China,along with snowpack and forest structural parameters.By providing fits to experimental data,new empirical transmissivity models for three forest types were developed,as a function of woody stem volume and depending on the frequency/polarization.The proposed models give diverse asymptotic transmissivity saturation levels and the corresponding saturation point of woody stem volume for different forest types.Root-mean-square error results between T_(B) simulations and Advanced Microwave Scanning Radiometer-2 observations are approximately 3-6 K.This study provides an experimental and theoretical reference for further development of inversion models for snow parameters in forested areas.Wang Guangrui Li Xiaofeng Chen Xiuxue Jiang Tao Zheng Xingming Wei Yanlin Wan Xiangkun Wang Jian 2021International Journal of Digital Earth2021,14,10:1
20New green- emitting barium zinc silicate: Eu2+-doped Baz Zn3 Si3 Oll 显示文摘WEI Donglei HUANG Yanlin KIM II S 2013Mater Lett2013,99,:1
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