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| 1 | Retrieval of aerosol optical depth over bright targets in the urban areas of North China during winter显示文摘Two factors that affect satellite retrieval of Aerosol Optical Depth(AOD) are aerosol model assumptions and the separation of surface reflectance.NASA/MODIS Dense Dark Vegetation(DDV) algorithm has been proven valuable in deriving aerosol distribution and properties over land;however,it cannot be applied to bright targets.As a supplement to the DDV algorithm,an algorithm to retrieve AOD over urban areas in North China in winter is developed using MODIS data,including(1) the generation and analysis of adjacent clear-days surface reflectance using MOD09 product from 2007 to 2008,and(2) seasonal aerosol models derived from AERONET data in Beijing and Xianghe sites.Ground-based measurements using sun photometers were used to validate the retrieved AOD,and the correlation coefficient(r) is up to 0.931.Especially for high AOD values(AOD>0.4),more retrievals meet the inversion accuracy.The temporal variations of retrieval errors over urban,rural and mountain regions were examined,and the results indicated that the variation of blue-band surface reflectance is less than 0.02 in a short period except for unusual weather conditions,the retrieval bias is under 0.08,and the relative error decreases as the AOD increases. | LI ShenShen CHEN LiangFu TAO JinHua HAN Dong WANG ZhongTing SU Lin FAN Meng YU Chao | 2012 | Science China Earth Sciences2012，55，9： | 11 |
| 2 | Optimisation of the double skin facade in hot and humid climates through altering the design parameter combinations显示文摘Architects welcome double skin facade(DSF)due to its aesthetic quality.The first DSF structure was intended to prevent cold weather and strong winds.Nowadays,the application of DSF under different climates has been investigated in many previous studies.Fiowever,little work had been done on the behaviour of DSF in hot and humid climates.Therefore,this paper aimed to extend the application into this specific climate and Guangzhou was selected as the sample city.Both the climate and the design influence the performance of DSF.In this paper,rather than explore how each design parameter influences the performance,the design was evaluated from an overall aspect.The Designbuilder software was used to build the single skin facade(SSF)and double skin facade base model.Annual HVAC energy consumption for both the two models was calculated and compared.An optimisation process was conducted to figure out what kinds of parameter combination could make the design more energy-saving and thermally comfortable.The results indicated that it was possible to design an energy-saving DSF system applied in hot and humid climates compared with the SSF model.The efficiency of the DSF could be further enhanced with a better parameter combination.The optimised options had some features in common,which could provide some inspirations for the application of DSF in hot and humid climates. | Meng Wang Jingxin Hou Zhongting Hu Wei He Hancheng Yu | 2021 | Building Simulation2021，14，3： | 3 |
| 3 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 4 | An Introduction to the Chinese High-Resolution Earth Observation System:Gaofen-1~7 Civilian Satellites显示文摘The Chinese High-resolution Earth Observation System(CHEOS)program has successfully launched 7 civilian satellites since 2010.These satellites are named by Gaofen(meaning high resolution in Chinese,hereafter noted as GF).To combine the advantages of high temporal and comparably high spatial resolution,diverse sensors are deployed to each satellite.GF-1 and GF-6 carry both high-resolution cameras(2m resolution panchromatic and 8m resolution multispectral camera),providing high spatial imaging for land use monitoring;GF-3 is equipped with a C-band multipolarization synthetic aperture radar with a spatial resolution of up to 1 meter,mostly monitoring marine targets;GF-5 carried 6 sensors including hyperspectral camera and directional polarization camera,dedicated to environmental remote sensing and climate research,such as aerosol,clouds,and greenhouse gas monitoring;and GF-7 laser altimeter system payload enables a three-dimensional surveying and mapping of natural resource and land surveying,facilitating the accumulation of basic geographic information.This study provides an overview of GF civilian series satellites,especially their missions,sensors,and applications. | Liangfu Chen Husi Letu Meng Fan Huazhe Shang Jinhua Tao Laixiong Wu Ying Zhang Chao Yu Jianbin Gu Ning Zhang Jin Hong Zhongting Wang Tianyu Zhang | 2022 | Journal of Remote Sensing2022，，1： | 1 |
| 5 | Retrieval of aerosol size distribution from multi-angle polarized measurements assisted by intensity measurements over East China显示文摘 | WANG Zhongting CHEN Liangfu LI Qing | 2012 | Remote Sensing of Environment2012，124，： | 1 |
| 6 | Adjacent strong edge coloring of graphs 显示文摘 | ZHANG Zhongt'u LIU Linzhong WANG Jianfang | 2002 | Applied Mathematics Letters2002，15，： | 1 |
| 7 | Variation of contact resonance frequency during domain switching in PFM measurements for ferroelectric materials显示文摘Piezoresponse Force Spectroscopy(PFS)is a powerful technique widely used for measuring the nanoscale electromechanical coupling of the ferro-/piezo-electric materials.However,it is found that certain nonferroelectric materials can also generate the“hysteresis-loop-like”responses from the PFS measurements due to many other factors such as electrostatic effects.This work therefore studies the signal of the contact resonance frequency during the PFS measurements.By comparing the results from ferroelectric and non-ferroelectric materials,it is found there are distinct differences between these two types of materials in the variation of the contact resonance frequency during the PFS measurements.A momentary and sharp increase of the contact resonance frequency occurs when the domain is switched by applying the DC bias,which can be regarded as a unique characteristic for the ferroelectric materials.After analyzing the reliability and mechanism of this method,it is proposed that the contact resonance frequency variation at the coercive bias is capable to differentiate the electromechanical responses of the ferroelectric and non-ferroelectric materials during the PFS measurements. | Yue Liu Yao Sun Wanheng Lu Hongli Wang Zhongting Wang Bingxue Yu Tao Li Kaiyang Zeng | 2020 | Journal of Materiomics2020，6，1： | 0 |
| 8 | Superior plating/stripping performance through constructing an artificial interphase layer on metallic Mg anode显示文摘Rechargeable magnesium batteries(RMBs)have attracted tremendous attention in energy storage ap-plications in term of high abundance,high specific capacity and remarkable safety of metallic magne-sium(Mg)anode.However,a serious passivation of Mg anode in the conventional electrolytes leads to extremely poor plating/stripping performance,further hindering its applications.Herein,we propose a convenient method to construct an artificial interphase layer on Mg anode by substitution and alloy-ing reactions between SbCl_(3) and Mg.This Sb-based artificial interphase layer containing mainly MgCl_(2) and Mg_(3) Sb_(2) endows the significantly improved interfacial kinetics and electrochemical performance of Mg anode.The overpotential of Mg plating/stripping in conventional Mg(TFSI)2/DME electrolytes is vastly reduced from over 2 V to 0.25-0.3 V.Combining experiments and calculations,we demonstrate that un-der the uniform distribution of MgCl_(2) and Mg_(3) Sb_(2),an electric field with a favorable potential gradient is formed on the anode surface,which enables swift Mg^(2+)migration.Meanwhile,this layer can inhibit the decomposition of electrolytes to protect anode.This work provides an in-depth exploration of the artificial solid-electrolyte interface(SEI)construction,and a more achievable and safe path to realize the application of metallic Mg anode in RMBs. | Bangpeng Yang Liuyan Xia Rong Li Guangsheng Huang Shuangshuang Tan Zhongting Wang Baihua Qu Jingfeng Wang Fusheng Pan | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 9 | Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure显示文摘Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltransferase-like protein 13(Mettl13)has been shown to regulate protein translation efficiency by acting as a protein lysine methyltransferase,but its role in cardiac pathology remains unexplored.This study aims to characterize the roles and mechanisms of Mettl13 in cardiac contractile function and HF.We found that Mettl13 was downregulated in the failing hearts of mice post-myocardial infarction(MI)and in a cellular model of oxidative stress.Cardiomyocyte-specific overexpression of Mettl13 mediated by AAV9-Mettl13 attenuated cardiac contractile dysfunction and fibrosis in response to MI,while silencing of Mettl13 impaired cardiac function in normal mice.Moreover,Mettl13 overexpression abrogated the reduction in cell shortening,Ca^(2+)transient amplitude and SERCA2a protein levels in the cardiomyocytes of adult mice with MI.Conversely,knockdown of Mettl13 impaired the contractility of cardiomyocytes,and decreased Ca^(2+)transient amplitude and SERCA2a protein expression in vivo and in vitro.Mechanistically,Mettl13 impaired the stability of c-Cbl by inducing lysine methylation of c-Cbl,which in turn inhibited ubiquitination-dependent degradation of SERCA2a.Furthermore,the inhibitory effects of knocking down Mettl13 on SERCA2a protein expression and Ca^(2+)transients were partially rescued by silencing c-Cbl in H_(2)O_(2)-treated cardiomyocytes.In conclusion,our study uncovers a novel mechanism that involves the Mettl13/c-Cbl/SERCA2a axis in regulating cardiac contractile function and remodeling,and identifies Mettl13 as a novel therapeutic target for ischemic HF. | Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang Weijie Du | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
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