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| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | ON THE CONVERGENCE OF ASYNCHRONOUS NESTEDMATRIX MULTISPLITTING METHODS FOR LINEARSYSTEMS显示文摘1.IntroductionTherehasbeenalotofliterature(see[1]--[61and[12])ontheparalleliterativemethodsforthelarge--scalesystemoflinearequationsinthesenseofmatrixmultisplittingsincethepioneeringworkofO'LearyandWhite(see[l])waspublishedin1985.Oneofthemostrecentre... | Bai, ZZ Wang, DR Evans, DJ | 1999 | Journal of Computational Mathematics1999，17，6： | 3 |
| 3 | Gel formation in extracted organic phase and FT-IR characterization显示文摘IN the early 1980s, Wu and co-workers indicated that the saponification of acidic extractants,such as di(2-ethylhexyl) phosphoric acid (D2EHPA), 2-ethylhexyl phosphoric acid mono 2-ethylhexylester (PC88A), and naphthenic acid (NA), is a process of the formation of a wa-ter-in-oil (w/o) microemulsion in the organic phase. From then on, the aggregation behav-ior of this sort of extractant and metal-extractant complex in bulk phases has been investigatedfor about twenty years. The microstructure and properties of organic aggregates were ex- | Shen, YH Wang, DJ Wu, JG | 1997 | Chinese Science Bulletin1997，42，14： | 2 |
| 4 | Expression of heavy-chain variable domain of mAb against Encephalitis Type B virus in transgenic tobacco显示文摘SINCE the first report on immunoglobulin gene expression in plant by Hiatt et al. in 1989,analogous researches have been further developed. Up to now, it has become a new method touse transgenic plants and plant cells to produce antibodies and study disease-resistance breedingof crops, plant metabolism and growth, which is an organic combination of immunologyand plant sciences at molecular level. According to recent reports, both higher and lowerplants, such as tobacco, Arabidopsis, calli of maize and unicellular green alga, can | Wu, YQ Xiong, XM Zeng, JZ Zhang, J Wang, DJ Huang, HL | 1997 | Chinese Science Bulletin1997，42，12： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine 显示文摘 | WANG DJ DOWLING TC MEADOWS D | 2004 | Circulation2004，110，12： | 1 |
| 7 | In Vivo Correlation between Blood T2^* and Oxygen Saturation显示文摘 | Li D Waight DJ Wang Y | 1998 | J Magn Reson Imaging1998，8，6： | 1 |
| 8 | A study of quantum confinement properties of photogenerated charges in zno nanoparticles by surface photovoltage spectroscopy显示文摘 | LIN Y H WANG DJ ZHAO Q D | 2004 | J Phys Chern B2004，108，10： | 1 |
| 9 | Smads,p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells显示文摘 | Xu DJ Zhao YZ Wang J | 2012 | BMB Rep2012，45，4： | 1 |
| 10 | Clustering of cardio- vascular disease risk factors among obese schoolchildren: the Taipei Children Heart Study显示文摘 | Chu NF Rimm EB Wang DJ | 1998 | Am J Clin Nutr1998，67，6： | 1 |
| 11 | Macrophages promoterenal fibrosis through direct and indirect mechanisms显示文摘 | Nikolic-Paterson DJ Wang S Lan HY | 2014 | Kidney Int Suppl2014，4，1： | 1 |
| 12 | Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine 显示文摘 | WANG DJ DOWLING TC MEADOWS D | 2004 | Circulation2004，110，12： | 1 |
| 13 | Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects显示文摘 | Licht DJ Wang J Silvestre DW | 2004 | J Thorac Cardiovasc Surg2004，128，6： | 1 |
| 14 | Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects显示文摘 | Licht DJ Wang J Silvestre DW | 2004 | J Thorac Cardiovasc Surg2004，128，84： | 1 |
| 15 | Identification of a novel tamily of oligodendrocyte lineage-specific basic helix loop-helix transcription factors 显示文摘 | Zhou Q Wang S Anderson DJ | 2000 | Neuron2000，25，2： | 1 |
| 16 | Epigenetic control of microRNA expression and aging显示文摘 | Liang R Bates DJ Wang E | 2009 | Curr Genomics2009，10，3： | 1 |
| 17 | Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice显示文摘 | Cefalu WT Wang ZQ Schneider DJ | 2004 | Acta Diabetol2004，41，1： | 1 |
| 18 | A new method of stabilizing the elevated laminate in open-door laminoplasty using an anchor system显示文摘 | Wang JM Roh KJ Kim DJ | 1998 | J Bone joint Surg Br1998，80，6： | 1 |
| 19 | Influence of adsorbed oxygen on the surface photovoltage and photoluminescence of ZnO nanorods显示文摘 | LIN Y H WANG DJ ZHAO Q D | 2006 | Nanotechnology2006，17，： | 1 |
| 20 | Optimum nitrogen use and reduced nitrogen loss for production of rice and wheat in the Yangtse Delta Region 显示文摘 | Wang DJ Liu Q Lin JH | 2004 | Environmental Geochemistry and Health2004，26，2： | 1 |
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