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| 1 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 2 | Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice显示文摘AIM: Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities. Here, we tested a recombinant adenovirus, AdsFIt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice. METHODS: Murine colorectal carcinoma cells (CT26) were inoculated subcutaneously into Balb/c mice for in vivo studies. Tumor size and survival were determined. 293 cell line was used for propagation of the adenoviral vectors. Human lung cancer line A549 and human umbilical vein endothelial cells were transfected for in vitro experiments. RESULTS: Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 (5×109 PFU/animal) was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation. In spite of these antitumoral effects, the survival time was not improved. According to reduced intratumoral microvessel density in AdsFIt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination. CONCLUSION: In this study we confirmed the value of a systemic administration of AdsFIt1-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice. | Volker Schmitz Miroslaw Kornek Tobias Hilbert Christian Dzienisowicz Esbher Raskopf Christian Rabe Tilman Sauerbruch Cheng Qian Wolfgang H Caselmann | 2005 | World Journal of Gastroenterology2005，11，28： | 4 |
| 3 | Endoscopy in patients with acute leukaemia after intensive chemotherapy显示文摘 | Marcus Gorschlüter Volker Schmitz Ulrich Mey Corinna Hahn-Ast Ingo G.H. Schmidt-Wolf Tilman Sauerbruch | 2008 | Leukemia Research2008，，10： | 1 |
| 4 | Simultaneous splenectomy increases risk for opportunistic pneumonia in patients after liver transplantation显示文摘 | Ulf P. Neumann Jan M. Langrehr Udo Kaisers Martina Lang Volker Schmitz Peter Neuhaus | 2002 | Transplant International2002，，5： | 1 |
| 5 | siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo显示文摘 | Esther Raskopf Annabelle Vogt Tilman Sauerbruch Volker Schmitz | 2008 | Journal of Hepatology2008，，6： | 1 |
| 6 | Spatial contrast sensitivity and the diagnosis of amblyo- pia显示文摘 | VOLKERS AC HAGEMANS KHtVAN DER WILDT GJ SCHMITZ PL | 1987 | J Ophthalmol1987，71，1： | 1 |
| 7 | Combination of Hypoxia and RNA-Interference Targeting VEGF Induces Apoptosis in Hepatoma Cells Via Autocrine Mechanisms显示文摘 | Esther Raskopf Annabelle Vogt Georges Decker Sarah Hirt Katjana Daskalow Thorsten Cramer Jens Standop Maria-Angeles Gonzalez-Carmona Tilman Sauerbruch Volker Schmitz | 2012 | Current Pharmaceutical Biotechnology2012，，11： | 1 |
| 8 | Analysis of the chloroplast protein complexes by blue-native polyacrylamide gel electrophoresis (BN-PAGE)显示文摘 | Marion Kügler Lothar J?nsch Volker Kruft Udo K. Schmitz Hans-Peter Braun | 1997 | Photosynthesis Research1997，，1： | 1 |
| 9 | Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin’s disease: a randomised trial显示文摘 | Norbert Schmitz Beate Pfistner Michael Sextro Markus Sieber Angelo M Carella Matthias Haenel Friederike Boissevain Reinhart Zschaber Peter Müller Hartmut Kirchner Andreas Lohri Susanne Decker Bettina Koch Dirk Hasenclever Anthony H Goldstone Volker Diehl | 2002 | 2002 (9323)2002，，9323： | 1 |
| 10 | Development and validation of an assay for the quantification of 11 nucleotides using LC/LC–electrospray ionization–MS显示文摘 | Jost Klawitter Volker Schmitz Jelena Klawitter Dieter Leibfritz Uwe Christians | 2007 | Analytical Biochemistry2007，，2： | 1 |
| 11 | Polyphosphate/ATP-dependent NAD kinase of Corynebacterium glutamicum: biochemical properties and impact of ppnK overexpression on lysine production显示文摘 | Steffen N. Lindner Henrike Niederholtmeyer Katja Schmitz Siegfried M. Schoberth Volker F. Wendisch | 2010 | Applied Microbiology and Biotechnology2010，，2： | 1 |
| 12 | The Author Reply显示文摘I have read with interest the comment on our manuscript[1]on different outcomes following cava reconstruction in liver transplantation using either cava replacement or piggy-back technique.Since its initial publication by Tsakis in 1989,2]the piggy-back technique has been variously modified. | Volker Schmitz | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 0 |
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