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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | 静止轴肩搅拌摩擦焊接研究进展及展望显示文摘静止轴肩搅拌摩擦焊(SSFSW)作为固相连接领域中搅拌摩擦焊接(FSW)技术的一种重要衍生方法,显著改善了FSW接头表面过热、温度梯度大以及板厚减薄等问题,在轻质合金、低热导率材料、中厚板以及角焊缝等结构焊接中具有巨大的应用潜力。综述了现阶段SSFSW的主要研究进展,涉及SSFSW过程的基本原理、成形特征、微观组织以及力学性能等,以期SSFSW技术形成系统的认知,并展望了其发展前景。 | 褚强 郝思洁 Devang Sejani Vivek Patel 李文亚 | 2020 | 电焊机2020，50，9： | 5 |
| 3 | Gallbladder perforation:A single-center experience in north India and a step-up approach for management显示文摘Background: Spontaneous gallbladder perforation(GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies. Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. All patients received medical and/or surgical treatment for spontaneous GBP in our department between January 2010 and June 2018. Results: We identifed 151 patients(81 females and 70 males) with mean age of 53 years. Most common presenting features were pain(96.7%), fever(54.3%) and jaundice(31.1%). Most common cause was gallbladder stones(84.8%) followed by common bile duct stones(30.5%), xanthogranulomatous cholecystitis(17.9%) and malignancy(11.9%). As per Niemeier classifcation, 8.6% had type 1 GBP(free perforation in peritoneal cavity), 76.2% had type 2 GBP(localized perforation) and 13.2% had type 3 GBP(cholecystoenteric fstula). About 60% of the perforations were diagnosed preoperatively. Type 1 was more common in patients with diabetes and also had the worst prognosis. Surgery was performed in 109 patients(72.2%). Seven patients(4.6%) had a postoperative morbidity of Clavien-Dindo Ⅲ or higher. There were three mortalities in patients who underwent surgery. Conclusions: High index of suspicion is required for preoperative diagnosis of GBP, especially in types 2 and 3. Laparoscopic cholecystectomy can be difficult in these patients and patients may require open or partial cholecystectomy. Early diagnosis and step-up approach for the treatment of GBP is critical. | Vivek Gupta Abhijit Chandra Vishal Gupta Ravi Patel Amit Dangi Ajay Pai | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 2 |
| 4 | MATLAB-Based modeling to study the effects of partial shading on PV array characteristics显示文摘 | PATEL Hiren AGARWAL Vivek | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 5 | Matlab-Based Modeling to Study the Effects of Partial Shading on PV Array Characteristics 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE transactionsonenergy conversion (S0885-8969)2008，23，1： | 1 |
| 6 | Multi-objective optimization of two stage thermoelectric cooler using a modified teaching-learning-based optimi- zation algorithm 显示文摘 | Rao Venkata Vivek Patel | 2013 | Engineering Applications of Artificial Intelli- gence2013，26，1： | 1 |
| 7 | Maximum Power Point Tracking Scheme for PV Systems Operating Under Partially Shaded Conditions 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 8 | Maximum power point tracking scheme for PV systems operating under partially shaded conditions显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 9 | Matlab-based modeling to study the effects of partial shading on PV array characteristics显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 10 | Maximum power point tracking scheme for PV systems operating under partially shaded conditions显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 11 | β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner显示文摘 | Béla Horváth Partha Mukhopadhyay Malek Kechrid Vivek Patel Galin Tanchian David A. Wink Jürg Gertsch Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，8： | 1 |
| 12 | MATLAB-based modeling to study the effects of partial shading on PV array characteristics 显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
| 13 | Assessing the Bonding Interface Characteristics and Mechanical Properties of Bobbin Tool Friction Stir Welded Dissimilar Aluminum Alloy Joints显示文摘This study focuses on the bonding interface characteristics and mechanical properties of the bobbin tool friction stir welded dissimilar AA6056 and AA2219 aluminum alloy joints using diff erent welding speeds.Voids arise solely in the stir zone at the AA2219 side.A distinct boundary with limited material mixing develops at the middle section of the bonding interface,while excellent material mixing with an irregularly jagged pattern forms at the top and bottom sections of the bonding interface.Increasing the welding speed,the material mixing is rarely changed at the middle section in comparison with the bottom section.Furthermore,a small diff erence between Guinier–Preston dissolution and Q phase precipitation leads to rare change of hardness in the heat aff ected zone(HAZ)at the AA6056 side.The increased hardness of the HAZ at the AA2219 side is attributed to avoidance of the dissolution ofθ’’phase precipitates.A maximum tensile strength of 181 MPa is obtained at 300 mm min-1.Fractures occur at the AA6056 side near the top and bottom surfaces and at the bonding interface in the middle section of the joints.The regions close to the top and bottom surfaces of the joints show a better ductility. | Quan Wen Wenya Li Vivek Patel Luciano Bergmann Benjamin Klusemann Jorge F.dos Santos | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，1： | 1 |
| 14 | MATLAB-Based Modeling to Study the Effects of Partial Occlusion on PV Array Characrerristics显示文摘 | Hiren Patel Vivek Agarwal | | 0，，1： | 1 |
| 15 | Maximum power point tracking scheme for PV systems operating under partially shaded conditions显示文摘 | Patel Hiren Agarwal Vivek | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 16 | Com- parative studies on flow control in rectangular S-duct diffuser using submerged-vortex generators显示文摘 | Akshoy Ranjan Paul Pritanshu Ranjan Vivek kumar patel | 2013 | Aerospace Science and Technolo- gy2013，28，2013： | 1 |
| 17 | Capillary electrophoresis methods for impurity profiling of drugs:A review of the past decade显示文摘Capillary electrophoresis(CE)is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures,analysis of biomolecules,and characterization of biopharmaceuticals.Currently,CE is the method of choice for the analysis of foodstuffs and the determination of adulterants.This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques.It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade.The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples.This review will help scientists,fellow researchers,and students to understand the applications of CE techniques in the impurity profiling of drugs. | Mansi Shah Nrupesh Patel Nagja Tripathi Vivek K.Vyas | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 1 |
| 18 | Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia显示文摘 | Vivek L. Patel Matthieu Mahévas Soo Y. Lee Roberto Stasi Susanna Cunningham-Rundles Bertrand Godeau Julie Kanter Ellis Neufeld Tillmann Taube Ugo Ramenghi Shalini Shenoy Mary J. Ward Nino Mihatov Vinay L. Patel Philippe Bierling Martin Lesser Nichola Coop | 2012 | Blood2012，，25： | 1 |
| 19 | Synthesis and characterization of interpenetrating polymer networks from transesterified castor oil based polyurethane and polystyrene显示文摘 | Dave Vivek J Patel Hasmukh S | 2013 | Journal of Saudi Chemical Society2013，12，2： | 1 |
| 20 | MATLAB-based modeling to study the effects of partial shading on PV array characteristics显示文摘 | Hiren Patel Vivek Agarwal | 2008 | IEEE Transactions on Energy Conversion2008，23，1： | 1 |
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