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| 1 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 4 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 5 | Impact of age on transcatheter aortic valve implantation outcomes:a comparison of patients aged≤ 80 years versus patients > 80 years显示文摘 | Frank van der Kley Philippe J van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen Jeroen J Bax Martin J Schalij Victoria Delgado | 2016 | Journal of Geriatric Cardiology2016，13，1： | 2 |
| 6 | Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes显示文摘 | Kuznetsov Y G Victoria J G Robinson W E | 2003 | J Virol2003，77，11： | 1 |
| 7 | A survey of outlier detection methodologies显示文摘 | Victoria J Hodge Jim Austin | 2004 | Artificial Intelligence Review2004，22，2： | 1 |
| 8 | Enzymes of phospholipids metabolism in the plasma of Acanthamoeba castellanii显示文摘 | Victoria E J Korn ED | 1975 | J Lipid Res1975，16，1： | 1 |
| 9 | Mouse DNA ‘fingerprints' : analysis of chromosome localization and germ-line stability of hypervariable loci in recombinant inbred strains显示文摘 | Alec J J Victoria W Robert K | 1987 | Nucleic Acids Research1987，15，7： | 1 |
| 10 | Singing teaching as a therapy for chronic respiratory disease-a randomised controlled trial and qualitative evaluation显示文摘 | Victoria M Phoene Cave Victoria J | 2010 | BMC Pulmonary Medicine2010，10，： | 1 |
| 11 | Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 ( HIV - 1 ) inte-grase and HIV - 1 replication at nontoxic concentrations 显示文摘 | REINKE R A KING P J VICTORIA J G | 2002 | J Med Chem2002，45，： | 1 |
| 12 | Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms显示文摘 | JAMES C O VICTORIA J F OLIVIER A | 2005 | Nature2005，437，： | 1 |
| 13 | Ocean acidification: the other CO2 problem显示文摘 | SCOTT C D VICTORIA J F RICHARD A F | 2009 | Annual Review of Marine Science2009，1，： | 1 |
| 14 | Spread of metals through an invertebrate food chain as influenced by a plant that hyperaccumulates nickel显示文摘 | Lynsey R Peterson Victoria Trivett Alan J M Baker | 2003 | Chemoecology2003，，13： | 1 |
| 15 | Evidence of tissue-specific allelopathic activity in euthamia graminifolia and Solidago canadensis (Asteraceae)显示文摘 | Victoria M butgko Richard J Jensen | 2002 | the American Midland Naturalist2002，148，2： | 1 |
| 16 | Geographical distribution of four sugarcane yellow leaf virus genotypes 显示文摘 | Ahmad Y A Royer M Daugrois J H Costet L Lett J M Victoria J I Girard J C Rott P | 2006 | Plant Disease2006，90，9： | 1 |
| 17 | N- Hydroxybenzimidazole inhibitors of the transcription factor LcrF in yersinia: novel antivirulence agents 显示文摘 | Kim Oak K Garrity Lynne K Bartlett Victoria J | 2009 | Journal of Medicinal Chemistry2009，52，18： | 1 |
| 18 | NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors显示文摘 | Victoria C Foletta Matthew J Prior Nicole Stupka | 2009 | J Physiol2009，587，7： | 1 |
| 19 | Online conditional anomaly detection in muhivariate data for transformer monitoring 显示文摘 | Catterson Victoria M McArthur Stephen D J Moss Gra- ham | 2010 | IEEE Transactions on Power Deliver2010，25，4： | 1 |
| 20 | Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice 显示文摘 | Keylock P Victoria J Matthew A | 2008 | Am J Physiol Regul Integr Comp Physio2008，1294，： | 1 |
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