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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | hS1R2(SIRT1) functions as an NAD-dependent p53 deacetylase显示文摘 | Vaziri H Dessain S K Ng Eaton E | 2001 | Cell2001，107，2： | 1 |
| 3 | Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation 显示文摘 | Wieler S Gagne JP Vaziri H | 2003 | J Biol Chem2003，278，18： | 1 |
| 4 | Integrated forms of Mindlin's equations显示文摘 | Vaziri H Simpson B Pappin J W | 1982 | Géotechnique1982，32，3： | 1 |
| 5 | An analytical model for stability analysis of rock layers over a circular opening显示文摘 | Vaziri H H Jalali J S IslamR | 2001 | Intemational Joumal of Solids and Structures2001，38，21： | 1 |
| 6 | From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence:The telomere loss/DNA damage model of cell aging显示文摘 | Vaziri H Benchimol S | 1996 | Exp Gerontol1996，31，12： | 1 |
| 7 | Telomere length predicts replicative capacity of human fibroblasts显示文摘 | Allsopp RC Vaziri H Patterson C | | 0，，： | 1 |
| 8 | Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes显示文摘 | Vaziri H Schachter F Uchida I | 1993 | Am J Hum Genet1993，52，4： | 1 |
| 9 | Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span 显示文摘 | Vaziri H Benchimol S | 1998 | Curr Biol1998，8，5： | 1 |
| 10 | Integrated forms of Mindlin's equation显示文摘 | Vaziri H Simpson B Pappin J W Simpson L | 1982 | Géotechnique1982，32，3： | 1 |
| 11 | Buckling of columns under variably distributed axial loads显示文摘 | VAZIRI H H XIE J | 1992 | Comput Struct1992，45，3： | 1 |
| 12 | Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation显示文摘 | Wieler S Gagné J P Vaziri H | | 0，，21： | 1 |
| 13 | Effect of cyclosporine on HMG-CoA reductase, cholestrerol 7 alpha-hydroxylase, LDL receptor, HDL receptor, VLDL receptor, and lipoprotein lipase expressions显示文摘 | Liang K Azad H | 2000 | J Pharmacol Exp Ther2000，294，2： | 1 |
| 14 | Monitoring Systems for Warning Impending Failures in Slopes and Open Pit- mines显示文摘 | Vaziri A Moore L Ali H | 2010 | Natural Hazards2010，55，2： | 1 |
| 15 | hSIR2 (SIRT1) functions as an NAD-dependent p53 deaeetylase 显示文摘 | VAZIRI H DESSAIN S K NG CATON E | 2001 | Cell2001，107，： | 1 |
| 16 | Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span显示文摘 | Vaziri H Benchimol S | 1998 | Curr Biol1998，8，5： | 1 |
| 17 | Dynamic crushing and energy absorption of regular, irregular and functionally graded cellular structures显示文摘 | Ajdari A Nayeb-Hashemi H Vaziri A | 2011 | International Journal of Solids and Structures2011，48，3： | 1 |
| 18 | Role of HDL dysfunction in end-stage renal disease: a double-edged sword显示文摘 | Moradi H Vaziri ND Kashyap ML | 2013 | J Ren Nutr2013，23，： | 1 |
| 19 | Telomere length predicts replicative capacity of human fibrohlasts显示文摘 | Allsopp R C Vaziri H | 1992 | Proceedings of the National Academy of Sciences1992，89，10： | 1 |
| 20 | Investigation of the fracture mechanism and mechanical properties of polystyrene/silica nanocomposite in various silica contents显示文摘 | Vaziri H S Abadyan M Nouri M | 2011 | Journal of materials science2011，46，17： | 1 |
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