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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | 显示文摘 | Sousa V C Leite E R Varela J A | 2002 | J Europ Ceram Soc2002，22，： | 1 |
| 3 | Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells显示文摘 | Gonzalez-Rey E Chorny A Varela N | 2007 | Arthritis and rheumatism2007，56，2： | 1 |
| 4 | Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host显示文摘 | VARELA M SCHNETTLER E CAPORALE M | 2013 | PLoS Pathog2013，9，10： | 1 |
| 5 | Nebulette mutations are as- sociated with dilated cardiomyopathy and endocardial fibroelastosis 显示文摘 | Purevjav E Varela J Morgado M | 2010 | J Am Coil Cardiol2010，56，18： | 1 |
| 6 | Laparoscoplc biomesh hiatoplasty and sleeve gastrecto- my in a morbidly obese patient with hiatal hernia显示文摘 | Varela J E | 2009 | Surg Obes Re lat Dis2009，5，6： | 1 |
| 7 | Microstructural and optical characterization of CaWO 4 and SrWO 4 thin films prepared by a chemical solution method显示文摘 | M.A.M.A Maurera A.G Souza L.E.B Soledade F.M Pontes E Longo E.R Leite J.A Varela | 2003 | Materials Letters2003，，5： | 1 |
| 8 | Out-of-plane Behaviour of Confined Masonry Walls 显示文摘 | Varela - Rivera J L Navarrete-Macias D Fernandez- Baqueiro L E | 2011 | Engineering Structures2011，33，5： | 1 |
| 9 | Effect of ammonium nitrogen supplementation of grape juice on wine volatiles and non- volatiles composition of the aromatic grape variety Albarifio 显示文摘 | VILANOVA M SIEBERT T E VARELA C | 2012 | Food Chem2012，133，1： | 1 |
| 10 | Predictive value of HER2 and topoisomerase Ⅱ alpha in response to primarydoxoruhicin in breast cancer 显示文摘 | Arriola E Moreno A Varela M | 2006 | EurJ Cancer2006，42，17： | 1 |
| 11 | Single-incision laparoscopic cholecystectomy:initial evaluation of a large series of patients显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 12 | Single incision laparoscopic chole- cystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，： | 1 |
| 13 | Single-incision laparoscopic cholecystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 14 | Psychological consequences among adults following the 1999 earthquake in Athens, Greece显示文摘 | Varela E Koustouki V Davos CH | 2008 | Disasters2008，32，2： | 1 |
| 15 | 2009 Nobel Prize in Physiology or Medicine: telomeres and telomerase显示文摘 | Varela E Blaseo MA | 2010 | Oncogene2010，29，11： | 1 |
| 16 | Predictive value ofHER-2 and Topoisomerase II alpha in response to primarydoxorubicin in breast cancer 显示文摘 | Arriola E Moreno A Varela M | 2006 | Eur J Cancer2006，42，17： | 1 |
| 17 | The influence of temperature on the galvanic corrosion of a cast iron-stainless steel couple显示文摘 | Varela F E Kurata Y Sanada N | 1997 | Corrosion Science1997，39，4： | 1 |
| 18 | The effect of Ta2O5 and Cr2O3 on the electrical properties of TiO2 varistors显示文摘 | Sousa V C Leite E R Varela J A | 2002 | J Europ Ceram Soc2002，22，： | 1 |
| 19 | Psychological consequences among adults following the 1999 earthquake in Athens, Greece显示文摘 | Varela E Koustouki V Davos CH | 2008 | Disasters2008，32，2： | 1 |
| 20 | SnO2, ZnO and related polycrystalline compound semiconductors: an overview and review on the voltage-dependent resistance (non-ohmic) feature 显示文摘 | BUENO P R VARELA J A LONGO E | 2008 | Journal of the European Ceramic Society2008，28，3： | 1 |
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