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您的检索式：作者名="Van Diest I"
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| 1 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 2 | Metalloprotease ADAM10 is required for Notch1 site 2 cleavage显示文摘 | van Tetering G van Diest P Verlaan I | | 0，，： | 1 |
| 3 | Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets显示文摘 | M Tenhagen P J van Diest I A Ivanova | 2012 | Endocrine Relate Cancer2012，19，4： | 1 |
| 4 | Comparison of the prognostic value of mitotic frequency and mitotic activity index in breast cancer显示文摘 | Jannink I Van Diest P Baak JP | 1996 | Breast1996，5，： | 1 |
| 5 | Peripheral alpha- helical CRF (9 -41 ) does not re- verse stress -induced mast cell dependent visceral hypersensitivity in maternally separated rats显示文摘 | VAN DEN WIJNGAARD R M STANISOR O I VAN DIEST S A | 2012 | Neurogastroenterol Motil2012，24，28： | 1 |
| 6 | Hyper- ventilation in Patients with Chronic Fatigue Syn- drome: The Role of Coping Strategies显示文摘 | Bogaerts K Hubin M Van Diest I | 2007 | Behav- iour Research and Therapy2007，，45： | 1 |
| 7 | Dyspnea-related anxiety:The Dutch version of the Breathlessness Beliefs Questionnaire 显示文摘 | De Peuter S Janssens T Van Diest I | 2011 | Chron Respir Dis2011，8，1： | 1 |
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