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| 1 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 2 | Hydrochemical characteristics and water quality assessment for drinking and agricultural purposes in District Jacobabad,Lower Indus Plain,Pakistan显示文摘Undeniably water is of utmost importance while considering basic necessities.This investigation emphasized on the hydrochemical evaluation and drinking water quality assessment in District Jacobabad located in lower Indus plain,Pakistan.Certainly world's largest irrigation system emerged from Indus Basin,which is underlain by well transmissive aquifer resulting in higher water table.Water supply schemes with their water sources from ground water and surface water provide piped water for drinking purpose to the community.Water samples were collected from all the forty eight supply schemes of which thirty two were found nonfunctional.Analytical parameters were compared with World Health Organization(WHO)and Pakistan Water Quality Standards but adversely substantial samples were found nonpotable.Alkalinity,bicarbonate and nitrate met the standard safe limits while values for EC,TDS,hardness,cations and anions exceeded the limits in numerous samples.SPSS and ArcGIS softwares were used for statistical analysis and spatial distribution of parameters.Hydrochemical facies were developed and suitability assessment of water resources was examined for agricultural use.The ground water type was classified as Na-HCO3 type with high salinity and it required treatment prior to irrigation.The proposed research exhibited the probable drinking water contamination sources and it demanded instant actions to further protect the valuable drinking water resources in District Jacobabad. | Asfandyar Shahab Shihua Qi Muhammad Zaheer Audil Rashid Muhammad Afnan Talib Umer Ashraf | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 2 |
| 3 | Fabrication of NiO coated SiO_2 and SiO_2 coated NiO for the removal of Pb^(2+) ions显示文摘We have prepared silica,SiO2coated NiO and NiO coated SiO2by sol-gel method.The physicochemical properties of the desired materials were investigated by surface charge properties,scanning electron microscopy(SEM),energy dispersive X-ray(EDX) spectroscopy,surface area measurements and X-ray diffraction(XRD) analyses.The point of zero charge(PZC) of the solid was determined by the salt addition method.In coated materials,two PZC values were noted representing the surface charge of their counterparts.The SEM image of SiO2coated NiO displays a uniform coating of silica on the surface of NiO whereas in case of NiO coated SiO2,a honeycomb like appearance was observed with highly porous structures.In the diffractograms of NiO,the characteristic peaks were suppressed in NiO coated silica however,no diffraction peak could be seen in SiO2coated NiO.Batch adsorption technique was applied for the removal of Pb2+ions from aqueous solution.The sorption trend for Pb2+ions was observed in the order of NiO coated SiO2> SiO2coated NiO > NiO > SiO2.This trend confirms that the coated materials have more sorption capacities than their parent counterparts. | Saba Noor Muhammad Waseem Umer Rashid Muhammad Anis-ur-Rehman Wajid Rehman Khalid Mahmood | 2014 | Chinese Chemical Letters2014，25，5： | 1 |
| 4 | Production of biodiesel through optimized alkaline-catalyzed transesterification of rapeseed oil显示文摘 | Umer Rashid Farooq Anwar | 2008 | Fuel2008，87，3： | 1 |
| 5 | Earthquake relief experience of Aga Khan University trauma team 显示文摘 | Umer M Rashid H Zafar H | 2006 | J Pak Med Assoc2006，56，8： | 1 |
| 6 | Production of slow release crystal fertilizer from wastewaters through struvite crystallization-a review显示文摘 | Md Mukhlesur Rahrnan Mohamacl Amran Mohd Salleh Umer Rashid | 2014 | Arabian Journal of Chemistry2014，7，： | 1 |
| 7 | Production of biodiesel through optimized alkaline-catalyzed transesterification of rapeseed oil显示文摘 | Umer Rashid Farooq Anwar | 2008 | Fuel2008，87，： | 1 |
| 8 | Production of biodiesel through optimized alkaline-catalyzed transesterification of rapeseed oil显示文摘 | UMER RASHID FAROOQ ANWAR | 2008 | Fuel2008，87，： | 1 |
| 9 | Salvage of infected non-union of the tibia with an Ilizarov ring fixator显示文摘 | Khan MS Rashid H Umer M | 2015 | J Orthop Surg2015，23，1： | 1 |
| 10 | Nanomaterials in combating cancer: Therapeutic applications and developments显示文摘 | Samina Nazir Tajammul Hussain Attiya Ayub Umer Rashid Alexander John MacRobert | 2013 | Nanomedicine: Nanotechnology Biology and Medicine2013，，： | 1 |
| 11 | Production of biodiesel through optimized alkaline-catalyzed transesterification of rapeseed oil显示文摘 | Rashid Umer Anwar Farooq | 2008 | Fuel2008，87，3： | 1 |
| 12 | Application of response surface methodology(RSM)for optimizing the palm-based pentaerythritol ester synthesis显示文摘 | Nur Atiqah Mohamad Aziz Robiah Yunusa Umer Rashid | 2014 | Industrial Crops and Products2014，62，： | 1 |
| 13 | Synthesis and characterization of poppy seed oil methyl esters显示文摘Response surface methodology(RSM) was used to determine the optimum conditions of the methanolysis of crude poppy seed oil using Na OCH3 as catalyst. The experiments were run according to five levels, four variable central composite rotatable design(CCRD) using RSM. The reaction variables, i.e., molar ratio of methanol/oil(3:1–9:1), catalyst concentration(0.5 wt%–1.25 wt% Na OCH3), reaction temperature(25–65 °C), and reaction time(20–90 min) were studied. We demonstrated that the molar ratio of methanol/oil, catalyst concentration,and reaction temperature were the significant parameters affecting the yield of poppy seed oil methyl esters(PSOMEs). The optimum transesterification reaction conditions, established using the RSM, which offered a89.35% PSOME yield, were found to be 7.5:1 molar ratio of methanol/oil, 0.75% catalyst concentration, 45 °C reaction temperature, and 90 min reaction time. The proposed process provided an average biodiesel yield of more than 85%. A linear correlation was constructed between the observed and predicted values of the yield.The gas chromatography(GC) analyses have shown that PSOMEs contain linoleic-, oleic-, palmitic-, and stearic-acids as main fatty acids. The FTIR spectrum of the PSOMEs was also analyzed to confirm the completion of the transesterification reaction. The fuel properties of the PSOMEs were discussed in light of biodiesel standards(ASTM D 6751 and EN 14214). | Umer Rashid Muhammad Ibrahim Imededdine Arbi Nehdi Saud Ibrahim Al-Resayes Sammi Ullah Muhammad Aamer Mehmood Saira Shahzadi | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 0 |
| 14 | 用磺化葡萄糖固体酸作为催化剂从棕榈脂肪酸馏出物中生产生物柴油:表征与优化(英文)显示文摘A palm fatty acid distillate(PFAD) has been used for biodiesel production.An efficient sulfonated-glucose acid catalyst(SGAC) was prepared by sulfonation to catalyze the esterification reaction.The effect of three variables i.e.methanol-to-PFAD molar ratio,catalyst amount and reaction time,on the yield of PFAD esters was studied by the response surface methodology(RSM).The optimum reaction conditions were:12.2:1 methanol-toPFAD molar ratio,2.9%catalyst concentration and 134 min of time as predicted by the RSM.The reaction under the optimum conditions resulted in 94.5%of the free fatty acid(FFA) conversion with 92.4%of the FAME yield.The properties of the PFAD esters were determined according to biodiesel standards. | Ibrahim M.Lokman Umer Rashid Yun Hin Taufiq-Yap | 2015 | Chinese Journal of Chemical Engineering2015，23，11： | 0 |
| 15 | Application of GIS for the identification and demarcation of selective heavy metal concentrations in the urban groundwater显示文摘地下水是喝水的最适当、广泛地使用的来源,它被污染逐渐地从工业、农业的活动威胁。检查这个问题的严厉, 156 件地下水样品在 Faisalabad 城市里从 52 个不同地区的各种各样的深度( 60110 英尺)被收集,在巴基斯坦的第三个最大的宗主国,并且为金属分析了( Zn , Cu , Cd , Ni , Pb , Mn 和 Fe )在 2009 的集中。Quantification 被使用原子吸收分光光度计技术和结果与为喝的标准谁浇质量相比的火焰做。当 Zn, Cd, Ni 和 Pb 的集中在安全的喝的水的推荐层次上面时,结果证明 Cu, Mn 和 Fe 的层次在 WHO 标准下面。在这些重金属的出现之中的关联分析与 Zn 和 Fe 揭示了 Mn 的高度重要、积极的关联。Cd 的重要、积极的关联也与证明在 Cu-Cd 对之间有强壮的协会并且 Cd 集中在学习区域与地下水的深度变化的 Cu 和地下水深度被发现。重金属出现的地区性的模式为风险区域的鉴定和分界用地理信息系统(GIS ) 被印射。集中地图可以被城市的决策者使用减轻地下水污染。 | Sobia ASHRAF Farhat ABBAS Muhammad IBRAHIM Umer RASHID Shoaib KHALID Hammad Raza AHMAD Khalid Rehman HAKEEM Tahir MAJEED | 2015 | Journal of Geographical Sciences2015，25，2： | 0 |
| 16 | POM analysis and computational interactions of 8-hydroxydiospyrin inside active site of protein tyrosine phosphatase 1B显示文摘Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,andobesity.Inour presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from D.lotus against the PTP1B enzyme.It showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was performed.Binding energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site inhibition.The inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models. | SAUD BAWAZER ASGHAR KHAN ABDUR RAUF TAIBI B EN HADDA YAHYA SAL-AWTHAN OMAR BAHATTAB UMER RASHID INAMULLAH KHAN MUHAMMAD A SIF NAWAZ MD SAHAB UDDIN OLATUNDE AHMED MOHAMMAD A LI SHARIATI | 2021 | BIOCELL2021，45，3： | 0 |
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