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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 3 | Differential toxicity and environmental fates of hexachlorocyclohexane isomers显示文摘 | Willett K L Ulrich E M Hites R A | 1998 | Environ Sci Technol1998，32，15： | 2 |
| 4 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 5 | Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB显示文摘 | Kauffmann-Zeh A Rodriguez-Viciana P Ulrich E | 1997 | Nature1997，385，6616： | 1 |
| 6 | Measurement of index modulation along an optical fiber Bragg grating显示文摘 | Krug P A Stolte R Ulrich R | 1995 | Opt Lett1995，20，17： | 1 |
| 7 | The chemistry of fluorescent Bodipy dyes:Versatility unsurpassed 显示文摘 | Ulrich G Ziessel R Harriman A | 2008 | Angew Chem Int Ed2008，47，7： | 1 |
| 8 | Methylprednisolone therapy in deceased donors reduces inflammation in donor liver and improves outcome after liver transplantation:a prospective randomized controlled trial显示文摘 | Kotsch K Ulrich F Reulzel-Selke A | 2008 | Ann Surg2008，248，6： | 1 |
| 9 | Fast-track surgery:the Heidelberg experience显示文摘 | Kremer M Ulrich A Büchler MW | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 10 | Organically modified aluminosilicate mesostructures from block copolymer phases显示文摘 | TEMPLIN M FRANCK A DUCHESNE A LEIST H ZHANG Y M ULRICH R SCHADLER V WIESNER U | 1997 | Science1997，278，5344： | 1 |
| 11 | Resectable rectal cancer: which patient does not need preoperative radiotherapy?显示文摘 | Kulu Y Ulrich A Btichler MW | 2012 | Dig Dis2012，302，： | 1 |
| 12 | Measurement of dynamic electrical and mechanical properties of resistance spot welding显示文摘 | GEDEON S A SORENSEN C D ULRICH K T | 1987 | Welding Journal1987，66，12： | 1 |
| 13 | Mono(2-ethylhexyl) phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay显示文摘 | Norbert H Kleinsasser Ulrich A | 2004 | Toxicology Letters2004，148，： | 1 |
| 14 | Differential toxicity and environmental fates of HCH isomers显示文摘 | Willett K L Ulrich E M Hites R A | 1998 | Environ Sci Technol1998，32，15： | 1 |
| 15 | A Si bipolar phase and frequency detector IC for clock extraction up to 8 Gb/s显示文摘 | Ansgar Pottb(a)cker Ulrich Langmann Hans-Ulrich Schreiber | 1992 | IEEE Journal of Solid-State Circuits1992，27，12： | 1 |
| 16 | Differential toxicity and environmental fates of hexaehlorcyelohexane isomers显示文摘 | Willett K L Ulrich E M Hires R A | 1998 | Environmental Sciellce and Technology1998，32，： | 1 |
| 17 | An- thrax,toxins and vaccines : a 125-year journey targeting Bacillus anthracis 显示文摘 | Tournier JN Ulrich RG Quesnel-Hellmann A | 2009 | Expert Rev Anti Infect Ther2009，7，2： | 1 |
| 18 | Genetic and biochemical analyses of Escherichia coli mu- tants altered in the temperature-dependent regulation of membrane lipid composition 显示文摘 | ULRICH A K DE MENDOZA D GARWIN J L | 1983 | J Bacteriol1983，154，1： | 1 |
| 19 | Effects of magnesium deficiency on the photosynthesis and respiration of leaves of sugar beet显示文摘 | TERRY N ULRICH A | 1974 | Plant Physiology1974，54，： | 1 |
| 20 | Signal transduction by receptor with tyrosine kinase activity显示文摘 | Ulrich A Schlessinper J | 1990 | Cell1990，61，： | 1 |
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