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| 1 | Relationship between type-2 diabetes and use of metformin with risk of colorectal adenoma in an American population receiving colonoscopy显示文摘 | Mehulkumar K. Kanadiya Gohel D. Tushar Madhusudhan R. Sanaka Prashanthi N. Thota Jay H. Shubrook | 2013 | Journal of Diabetes and Its Complications2013，，： | 1 |
| 2 | 肠道准备质量对腺瘤检出率和结肠镜完成率的影响显示文摘背景和目的:充分的肠道准备对于安全有效的结肠镜检查是非常重要的。结肠镜检查的质量指标应达到至少95%的肠镜完成率和至少25%(50岁以上男性)或15%(50岁以上女性)的腺瘤检出率。本研究旨在探讨肠道准备对腺瘤检出率和肠镜完成率的影响。方法:回顾性纳入2008年1月至2009年12月间接受结肠镜检查的病例。主要结局指标是腺瘤检出率和肠镜完成率(抵达盲肠)。结果:共2519例患者纳入研究,其中1030例(41.0%)肠道准备评价为优,1145例(45.5%)评价为良,240例(9.5%)中等,104例(4.1%)评价为差。肠道准备中、差者肠镜完成率分别为75.4%和72.1%,明显低于肠道准备优、良者(分别为99.9%和99.7%,P<0.001),且前者肠镜完成率质量达标(95%)的比例也明显低于后者(P<0.001)。全组患者中肠镜准备优、良、中、差者腺瘤检出率分别为24.2%、26.8%、32.1%和22.1%,差异无统计学意义(P=0.06),各组腺瘤检出率均质量达标(男性25%,女性15%)。其中女性肠道准备优、良者腺瘤检出率相对更高,男性肠道准备优、良、中者腺瘤检出率相对更高(P<0.001)。多因素分析显示,男性患者腺瘤检出率明显增高,但肠道准备质量对腺瘤检出率并无影响。结论:肠道准备中、差者肠镜完成率明显低于肠道准备优、良者,但肠道准备质量对腺瘤检出率并无影响。 | Tarun Rai Udayakumar Navaneethan Tushar Gohel Amareshwar Podugu Prashanthi N.Thota Ravi P.Kiran Rocio Lopez Madhusudhan R.Sanaka | 2016 | Gastroenterology Report2016，4，2： | 1 |
| 3 | Adenoma detection rate in high-risk patients differs from that in average-risk patients显示文摘 | Madhusudhan R. Sanaka Tarun Rai Udaykumar Navaneethan Tushar D. Gohel Amareshwar Podugu Prashanthi N. Thota Rocio Lopez Ravi P. Kiran Carol A. Burke | 2015 | Gastrointestinal Endoscopy2015，，： | 1 |
| 4 | Adenoma and Sessile Serrated Polyp Detection Rates: Variation by Patient Sex and Colonic Segment but Not Specialty of the Endoscopist显示文摘 | Madhusudhan R. Sanaka Tushar Gohel Amareshwar Podugu Ravi P. Kiran Prashanthi N. Thota Rocio Lopez James M. Church Carol A. Burke | 2014 | Diseases of the Colon & Rectum2014，，9： | 1 |
| 5 | Fish oil-based lipid emulsion:current updates on a promising novel therapy for the management of parenteral nutrition-associated liver disease显示文摘Intestinal failure is characterized by loss of enteral function to absorb necessary nutrients and water to sustain life.Parenteral nutrition(PN)is a lifesaving therapeutic modality for patients with intestinal failure.Lifelong PN is also needed for patients who have short bowel syndrome due to extensive resection or a dysmotility disorder with malabsorption.However,prolonged PN is associated with short-term and long-term complications.Parenteral nutrition-associated liver disease(PNALD)is one of the long-termcomplications associated with the use of an intravenous lipid emulsion to prevent essential fatty acid deficiency in these patients.PNALD affects 30–60%of the adult population on long-term PN.Further,PNALD is one of the indications for isolated liver or combined liver and intestinal transplantation.There is no consensus on how to manage PNALD,but fish oil-based lipid emulsion(FOBLE)has been suggested to play an important role both in its prevention and reversal.There is significant improvement in liver function in those who received FOBLE as lipid supplement compared with those who received soy-based lipid emulsion.Studies have also demonstrated that FOBLE reverses hepatic steatosis and reduces markers of inflammation in patients on long-term PN.Future prospective studies with larger sample sizes are needed to further strengthen the positive role of FOBLE in PNALD. | Shishira Bharadwaj Tushar Gohel Omer J.Deen Robert DeChicco Abdullah Shatnawei | 2015 | Gastroenterology Report2015，3，2： | 0 |
| 6 | Higher prevalence of colon polyps in patients with Barrett’s esophagus:a case-control study显示文摘Background and aims:Barrett’s esophagus(BE)and colorectal neoplasms share similar risk factors.Previous studies have shown variable prevalence of colon polyps in patients with BE.Our aims were to determine the prevalence and incidence of colon polyps in patients with BE,compared to those without BE.Methods:In this case-control study,the study group included patients,aged 50–75 years,with biopsy-proven BE,who underwent colonoscopy at Cleveland Clinic from January 2002 to December 2011.The control group consisted of age-and sex-matched patients who underwent colonoscopy and also an endoscopy with no evidence of BE during the same time period.Exclusion criteria for both groups were family-or personal previous history of colon cancer or polyps,prior colonic resection,inflammatory bowel disease and familial polyposis syndromes.Patient demographics,comorbidities,medication use and endoscopic and colonoscopic details were collected,including biopsy results.Results:A total of 519 patients were included in the study;173 patients with BE in the study group and 346 without BE in the control group.Mean age at index colonoscopy was 618 years and 75%of patients were male.On index colonoscopy,patients with BE were more likely to have polyps than controls(45%vs 32%,respectively;P=0.003).Patients underwent between one and five colonoscopies during the follow-up.On multivariate analysis—after adjusting for age,gender and diabetes—patients with BE were 80%more likely to have any type of polyp,and 50%more likely to have adenomas found during colonoscopy.Conclusions:Patients with BE had higher prevalence and incidence of colon polyps.This has important clinical implications for screening and surveillance in BE patients. | Arthi Kumaravel Prashanthi N.Thota Hyun-Ju Lee Tushar Gohel Mehulkumar K.Kanadiya Rocio Lopez Madhusudhan R.Sanaka | 2014 | Gastroenterology Report2014，2，4： | 0 |
| 7 | 医生对肝癌高危患者筛查的态度显示文摘背景与目的:对具有肝癌风险的患者进行筛查有助于肝癌的早期诊断,从而改善预后。肝癌最常见的病因包括慢性病毒性肝炎(如乙肝、丙肝)和肝硬化。本研究目的是评估医生对肝癌高危患者筛查的认识。方法:来自3个医疗中心的300名医生受邀参加了此次邮件问卷调查。主要结局指标是医生对目前的肝癌筛查指南的认识。通过问卷收集人口统计学资料及临床资料。结果:300名受邀的医生中有177人(59.0%)完成了问卷,其中机构医生129人,住院医生46人,规培医生2人。按照专业,内科医生占62.1%,家庭医生占16.4%,胃肠专科医生占15.3%,肿瘤科医生占3.4%,其他2.8%。分别有163名(92.1%)和167名(94.4%)的医生会对由慢性乙型和丙型肝炎继发的肝硬化患者进行肝癌筛查;其中35%的医生采用每6月一次的甲胎蛋白(AFP)检测进行筛查,22.0%的医生采用每6月一次的影像学筛查。而有22名(12.4%)医生不会进行血清AFP检测,33名(18.6%)医生从未使用过影像学筛查。结论:大多数参加调查的医生都会对高危人群进行肝癌筛查,但最合理的筛查方法(如影像学检查)并没有为大多数医生采用,他们更多的是依赖AFP的检测。 | Shishira Bharadwaj Tushar D Gohel | 2016 | Gastroenterology Report2016，4，3： | 0 |
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