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| 1 | Post-operative computed tomography scan – reliable tool for quality assessment of complete mesocolic excision显示文摘BACKGROUND Quality control in colon cancer surgery is an ongoing debate ever since standardization proved to be highly efficient in improving survival in rectal cancer. Complete mesocolic excision(CME) is widely acclaimed as the new goldstandard in colon cancer resections, thus it is imperative to establish quality criteria of CME in order to make it easily understood and verified by surgeons worldwide. One simple and reproducible tool could be the measurement of arterial stumps postoperatively and a straightforward way to test its reliability is to test it in a comparative study between CME and non-CME surgery.AIM To validate arterial stump measurement as a surgical quality tool by comparing CME with conventional radical colectomies.METHODS This was a retrospective study, carried out on a prospective database. We collected data from two groups of patients, divided according to standard CME with D2 central vascular ligation(group A) and non-standardized surgery(group B). The two groups were compared with regard to the arterial stump length after right-and left-sided colectomies for colon cancer. The actual stump lengths of the ileocolic artery(ICA) and inferior mesenteric artery(IMA) were compared with their theoretical best D2 position of predicted ligation levels(D2 PLLs) for calculating the potential for improvement. Measurements on follow-up computed tomography scans were carried out by three observers. Pathological data were recorded(specimen length, lymph node yield) and correlated with stump length.RESULTS We analysed 58 colectomies. The stump lengths(mean ± SD) in group A were16.97 ± 4.77 mm for ICA and 31.70 ± 15.71 mm for IMA, whereas group B had 49.93 ± 20.29 mm for ICA and 67.24 ± 28.71 mm for IMA. Shorter lengths were obtained in group A, by a mean difference of 35.66 mm(χ~2 = 27.38, P < 0.001),which was significant for all types of colectomies. Except for a 5.85 ± 4.71 mm difference for right colectomies, all the ligations from group A significantly reached their potential height(0.26 ± 12.18 mm from D2 PLL; χ~2 = 0.005, P = 0.944).Apart from three left colectomies, group B failed to reach D2 PLL, by a mean difference of 32.14 ± 26.15 mm(χ~2 = 21.77, P < 0.001). The calculated improvement potentials were significantly shorter in group A than in group B, by a mean of 31.88 mm(χ~2= 22.13, P < 0.001). The large spread of results in group B showed that there is significant variability(P = 0.004) when compared to standard surgery. Significant correlations were found between stump length, specimen length and number of lymph nodes(P = 0.018 and P = 0.008 respectively). No statistical difference was found between observers' measurements(P = 0.866).CONCLUSION Arterial stump monitoring is a significant step in defining surgical quality, as longer stumps contain residual mesocolic tissue and correlate with major prognostic factors. | Cristian Livadaru Stefan Morarasu Tudor Cristian Frunza Florina A Ghitun Elena Florina Paiu-Spiridon Florina Sava Cristina Terinte Dan Ferariu Sorinel Lunca Gabriel Mihail Dimofte | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 2 |
| 2 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 3 | Balancing Stream and Wetland Preservation with Nonpoint Source Pollution Management a Case Study显示文摘 | Tudor A | 1999 | Wat Sci Tech1999，40，10： | 1 |
| 4 | Pitfalls related to the use of endostaplers during video-assisted thoracic surgery 显示文摘 | Gossot D Merlusca G Tudor A | 2009 | Surg Endosc2009，23，1： | 1 |
| 5 | Minimally invasive calcaneo-stop method for idiopathic, flexible pes planovalgus in children显示文摘 | Roth S Sestan B Tudor A | 2007 | Foot Ankle Int2007，28，9： | 1 |
| 6 | Integrin dependent activation of the JNK signaling pathway by me- chanical stress显示文摘 | PEREIRA A M TUDOR C KANGER J S | 2011 | PLoSOne2011，6，26： | 1 |
| 7 | The influence of moisture content variation on fungal pigment formation in spalted wood显示文摘 | Tudor D Robinson S C Cooper P A | | 0，，01： | 1 |
| 8 | The influence of pH on pigment formation by lignicolous fungi显示文摘 | Tudor D Robinson S C Cooper P A | | 0，，： | 1 |
| 9 | Perinatal outcome associated with nuchal umbilical cord显示文摘 | Bernad ES Craina M Tudor A | 2012 | Clin Exp Obstet Gyneeol2012，39，： | 1 |
| 10 | Multidimensional bifractional Brownian motion: It6 and Tanaka's formulas显示文摘 | Es-Sebaiy K Tudor C A | 2007 | Stochastics and Dynamics2007，7，3： | 1 |
| 11 | Factors affecting crop insurance purchase decisions by farmers in northern Illinois显示文摘 | GINDER M SPAULDING A D TUDOR K W | 2009 | Agricultural Finance Re- view2009，69，1： | 1 |
| 12 | Postoperative blood loss management in total knee arthroplasty: a comparison of four dif-ferent methods 显示文摘 | Madarevic T Tudor A Sestan B | | Knee Surg Sports Traumatol Arthmsc0，19，6： | 1 |
| 13 | Maximum likelihood estimators and random walks in long memory models显示文摘 | Bertin K Torres S Tudor C A | 2010 | Statistics :A Journal of Theoretical and Applied Statistics2010，4，： | 1 |
| 14 | The Arabidopsis MADS-box gene AGL3 is widely expressed and encodes a sequence-specific DNA-binding protein 显示文摘 | Huang H Tudor M Weiss C A Ma H | 1995 | Plant Mol Biol1995，28，： | 1 |
| 15 | On the bifractional brownian mo- tion显示文摘 | RUSSO F TUDOR C A | 2006 | Stochastic Processes and Applications2006，116，5： | 1 |
| 16 | Chaos expansion and asymptotic behavior of the Pareto distribution 显示文摘 | TUDOR C A | 2014 | Statistics and Probability Letters2014，91，3： | 1 |
| 17 | Advances in control of frost on evaporator coils with an applied electric field 显示文摘 | TUDOR V OHADI M SALEHI M A | 2005 | International Journal of Heat and Mass Transfer2005，48，2122： | 1 |
| 18 | Sample path properties of bifractional Brownian motion显示文摘 | TUDOR C A XIAO Y M | 2007 | Bernoulli2007，13，4： | 1 |
| 19 | Se blood loss management in total knee arthroplasty: a compareison of four different methods 显示文摘 | Madarevic T Tudor A | 2011 | Knee Surg Sports Traumatol Arthrose2011，19，6： | 1 |
| 20 | Efficacy of an acidic vaginal gel on vaginal pH and interleukin-6 levels in low-risk pregnant women: a double- blind, randomized placebo-controlled trial 显示文摘 | Patemoster DM Tudor L Milani M Maggino T Ambrosi- ni A | 2004 | J Matern Fetal Neonatal Med2004，15，3： | 1 |
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